{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:11:04Z","timestamp":1789168264527,"version":"build-2803163510"},"reference-count":89,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    Lactic acid bacteria-derived exopolysaccharides (EPS) are natural and safe functional biomolecules whose antioxidant potential is largely dependent on their specific chemical structures. Accumulating evidence suggests that LAB-EPS may exert indirect regulatory effects on oxidative stress-related diseases like autism spectrum disorder via modulating intestinal microecology and relieving oxidative stress in the gut-brain axis. In this study, a novel EPS (EPS-ZZU) was isolated from\n                    <jats:italic>Lactiplantibacillus plantarum<\/jats:italic>\n                    ZZU-1 of traditional fermented Suancai. Structural characterization revealed a 2.141 kDa molecular weight, with mannose, glucose and ribose in a 34.40:26.35:12.24 molar ratio, composed of \u03b1-configuration pyranose units. EPS-ZZU exhibited over 90% scavenging rates against the typical free radicals, including hydroxyl radical (\u22c5OH), 1,1-diphenyl-2-picrylhydrazyl radical (DPPH\u2022), superoxide anion (O\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2022\u2063\u2013<\/jats:sup>\n                    ) and 2,2\u2019-azinobis (3-ethylbenzothiazoline-6-sulfonate) cation radical (ABTS\u2022\n                    <jats:sup>+<\/jats:sup>\n                    ) at a concentration of 5 mg\/mL, which was comparable to that of vitamin C (Vc). In a one-month mouse trial, EPS-ZZU significantly alleviated autism-like behaviors (social deficits, repetitive actions) by reducing oxidative stress and inflammation, enhancing intestinal barrier integrity, and reshaping gut microbiota-enriching beneficial taxa (\n                    <jats:italic>Adlercreutzia, Christensenellaceae<\/jats:italic>\n                    ) and inhibiting pathogens (\n                    <jats:italic>Erysipelatoclostridium<\/jats:italic>\n                    ). Metabolomics confirmed upregulated indole-3-acetate and downregulated cognitive impairment-associated metabolites (asymmetric dimethylarginine, homogentisic acid). These findings highlight EPS-ZZU\u2019s therapeutic potential for autism and provide a new idea for developing more bioactive bacterial EPS antioxidants.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2026.1806688","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:59:18Z","timestamp":1783490358000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Isolation and characterization of a novel exopolysaccharide from the fermented probiotic Lactiplantibacillus plantarum ZZU-1 and its application for attenuating autism-like behaviors"],"prefix":"10.3389","volume":"17","author":[{"given":"Shuai","family":"Zhao","sequence":"first","affiliation":[{"name":"School of Biological Engineering, Henan University of Technology","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyi","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Biological Engineering, Henan University of Technology","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanyan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Biological Engineering, Henan University of Technology","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Biological Engineering, Henan University of Technology","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziliang","family":"Meng","sequence":"additional","affiliation":[{"name":"College of International Education, Henan University of Technology, Zhengzhou","place":["Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Biological Engineering, Henan University of Technology","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyi","family":"Mao","sequence":"additional","affiliation":[{"name":"School of Biological Engineering, Henan University of Technology","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenchen","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Biological Engineering, Henan University of Technology","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haowei","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Biological Engineering, Henan University of Technology","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1016\/j.ijbiomac.2020.06.190","article-title":"Exopolysaccharides from probiotic bacteria and their health potential.","volume":"162","author":"Angelin","year":"2020","journal-title":"Int. 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