{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T06:52:22Z","timestamp":1781679142097,"version":"3.54.5"},"reference-count":90,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Application and Promotion of Digitalized Antibiotic-Without Gan-Tasting Livestock Product Production Technology","award":["2023-3-110"],"award-info":[{"award-number":["2023-3-110"]}]},{"name":"Gansu Province Talent Program Project","award":["2024QNTD27"],"award-info":[{"award-number":["2024QNTD27"]}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    This study examines how varying levels of fermented\n                    <jats:italic>Cordyceps militaris<\/jats:italic>\n                    mushroom substrate (CMMS) in laying hen diets affect production performance, digestive health, immunity, cecal microbiota, metabolites, and quorum-sensing functions. Fermentation reduced CMMS dry matter, NDF, and phosphorus content (\n                    <jats:italic>p<\/jats:italic>\n                    \u202f&amp;lt;\u202f0.05). Replacing 30% of the diet with fermented CMMS significantly improved laying rate, egg weight, feed intake, and feed efficiency (\n                    <jats:italic>p<\/jats:italic>\n                    \u202f&amp;lt;\u202f0.05), while enhancing yolk color, Haugh units, and lipase activity. A 20% substitution increased nutrient digestibility and immunoglobulin levels (\n                    <jats:italic>p<\/jats:italic>\n                    \u202f&amp;lt;\u202f0.05). Metagenomic analysis revealed increased abundance of Phocaeicola, Alistipes, and Parabacteroides (\n                    <jats:italic>p<\/jats:italic>\n                    \u202f&amp;lt;\u202f0.05) with enhanced energy metabolism and specific gene families. Metabolomic analysis identified 1,529 differentially expressed metabolites, with carboxylic acids being most prevalent (21.20%), and enhanced taurine\/hypotaurine metabolism and GPI-anchor biosynthesis. Parabacteroides showed negative correlations with certain metabolites, while Alistipes correlated positively with PemK\/MazF family genes (\n                    <jats:italic>p<\/jats:italic>\n                    \u202f&amp;lt;\u202f0.001). CMMS fermented feed proportions influence cecal microbiota, their metabolites, and quorum sensing in laying hens, affecting production, digestibility, immunity, metabolism, and health, demonstrating CMMS potential as alternative poultry nutrition.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2026.1807060","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T05:55:32Z","timestamp":1781675732000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Multi-omics analysis reveals the potential for fermented Cordyceps militaris mushroom substrate in laying hens"],"prefix":"10.3389","volume":"17","author":[{"given":"Hailong","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Forestry Engineering, Gansu Forestry Voctech University","place":["Tianshui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Ma","sequence":"additional","affiliation":[{"name":"College of Forestry Engineering, Gansu Forestry Voctech University","place":["Tianshui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Jia","sequence":"additional","affiliation":[{"name":"College of Forestry Engineering, Gansu Forestry Voctech University","place":["Tianshui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujing","family":"Li","sequence":"additional","affiliation":[{"name":"College of Forestry Engineering, Gansu Forestry Voctech University","place":["Tianshui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Forestry Engineering, Gansu Forestry Voctech University","place":["Tianshui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Forestry Engineering, Gansu Forestry Voctech University","place":["Tianshui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Forestry Engineering, Gansu Forestry Voctech University","place":["Tianshui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Forestry Engineering, Gansu Forestry Voctech University","place":["Tianshui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjie","family":"Li","sequence":"additional","affiliation":[{"name":"College of Forestry Engineering, Gansu Forestry Voctech University","place":["Tianshui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxiong","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Forestry Engineering, Gansu Forestry Voctech University","place":["Tianshui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoshun","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Gansu Agricultural University","place":["Lanzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Hou","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Gansu Agricultural University","place":["Lanzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjie","family":"Dong","sequence":"additional","affiliation":[{"name":"College of Forestry Engineering, Gansu Forestry Voctech University","place":["Tianshui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"3007","DOI":"10.62019\/vqy19m89","article-title":"Exploring the role of gut BACTERIA in digestive system of cow","volume":"2","author":"Akram","year":"2025","journal-title":"J. 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