{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T06:42:16Z","timestamp":1776235336417,"version":"3.50.1"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2023-ZF-8"],"award-info":[{"award-number":["2023-ZF-8"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    The transition from minimally invasive adenocarcinoma (MIA) to invasive adenocarcinoma (IAC) marks a decisive turning point in lung cancer progression. While the bacterial microbiome is a recognized component of the tumor microenvironment, the specific contribution of the lung mycobiome to this invasive shift remains largely obscure. Using an integrated multi-omics approach, this study maps the fungal ecosystem dynamics across the MIA-to-IAC spectrum. Notably, invasive tissues exhibited a significant elevation in fungal diversity, a finding that stands in sharp contrast to the traditional view of disease-associated microbial loss. We identified\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    as the pivotal biomarker distinguishing invasive from indolent lesions. Crucially, functional integration reveals that this fungal enrichment is not merely an association but appears to actively orchestrate a pro-tumorigenic shift in the host\u2019s immune and metabolic landscape. These findings uncover a novel fungal-driven mechanism of tumor invasiveness, suggesting that the lung mycobiome serves as both a hidden driver of progression and a valuable target for early therapeutic intervention.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2026.1811749","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T05:42:00Z","timestamp":1776231720000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Multi-omics landscape of lung mycobiome dysbiosis: Candida albicans drives the invasive progression of lung adenocarcinoma"],"prefix":"10.3389","volume":"17","author":[{"given":"Haoshuai","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, China-Japan Friendship Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingyu","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, China-Japan Friendship Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongxiang","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, China-Japan Friendship Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, China-Japan Friendship Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanjia","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, China-Japan Friendship Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiduo","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, China-Japan Friendship Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weijie","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, China-Japan Friendship Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaoyang","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, China-Japan Friendship Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, China-Japan Friendship Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenrong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, China-Japan Friendship Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41568-018-0081-9","article-title":"The lung microenvironment: An important regulator of tumour growth and metastasis.","volume":"19","author":"Altorki","year":"2019","journal-title":"Nat. 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