{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T06:58:10Z","timestamp":1780901890869,"version":"3.54.1"},"reference-count":71,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Amyotrophic lateral sclerosis (ALS) is a progressive and incurable neurodegenerative disease that not only affects motor function but is also associated with gastrointestinal and emotional disturbances. Recent research highlights the potential role of gut microbiota and diet in modulating these symptoms, suggesting a complex interaction between nutrition, intestinal health, and presence of anxiety and depression in ALS patients. This study aims to investigate the relationship between dietary intake, gut microbiota composition, and presence of anxiety and depression in patients with amyotrophic lateral sclerosis (ALS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>A cross-sectional study conducted with a sample of 48 patients with bulbar-onset or spinal-onset ALS from different regions of Spain. Dietary intake was assessed through 24-h records and food frequency questionnaires, while anxiety and depression were evaluated using validated scales that formed a latent factor called emotional distress. Stool consistency was assessed following the Bristol Stool Scale and the abundance of bacterial microbiota was quantified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Confirmatory factor analysis identified a nutritional factor composed of vitamins B1, B2, B9, C, and fiber, revealing a significant inverse association with anxiety and depression levels. The predictive model revealed both direct and indirect effects of this factor on presence of anxiety and depression, mediated by\n                      <jats:italic>Bacteroides<\/jats:italic>\n                      abundance and stool consistency.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This model explained 19% of the variance in psychological distress. Our findings suggest that a diet rich in B vitamins, C vitamin and fiber may help improve emotional well-being in patients with ALS, highlighting the importance of nutritional strategies, as well as the role of\n                      <jats:italic>Bacteroides<\/jats:italic>\n                      related to stool consistency in patients with ALS.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmicb.2026.1815390","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T06:05:44Z","timestamp":1780898744000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Interplay between B vitamins, fiber, and Bacteroides abundance: a predictive model for anxiety and depression in amyotrophic lateral sclerosis"],"prefix":"10.3389","volume":"17","author":[{"given":"Claudia Emmanuela","family":"Sanchis-Sanchis","sequence":"first","affiliation":[{"name":"Doctoral School, Catholic University of Valencia San Vicente M\u00e1rtir","place":["Valencia, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Sancho-Cantus","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Catholic University of Valencia San Vicente M\u00e1rtir","place":["Valencia, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Sanchis-Sanchis","sequence":"additional","affiliation":[{"name":"Doctoral School, Catholic University of Valencia San Vicente M\u00e1rtir","place":["Valencia, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Privado","sequence":"additional","affiliation":[{"name":"Department of Methodology of Behavioral Sciences, Universidad Complutense de Madrid, Campus de Somosaguas","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J.","family":"Roig","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, San Jorge University","place":["Zaragoza, Spain"]},{"name":"BIAMICS, Bioinformatics Services Ltd.","place":["Zaragoza, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Cuerda-Ballester","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Catholic University of Valencia San Vicente M\u00e1rtir","place":["Valencia, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Bargues-Navarro","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Catholic University of Valencia San Vicente M\u00e1rtir","place":["Valencia, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Cubero-Plazas","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Catholic University of Valencia San Vicente M\u00e1rtir","place":["Valencia, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palmira","family":"Mart\u00ednez Bol\u00f3s","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Catholic University of Valencia San Vicente M\u00e1rtir","place":["Valencia, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth Gabriela","family":"C\u00e1rdenas Salazar","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Catholic University of Valencia San Vicente M\u00e1rtir","place":["Valencia, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Enrique de la Rubia","family":"Ort\u00ed","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Catholic University of Valencia San Vicente M\u00e1rtir","place":["Valencia, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"103767","DOI":"10.1016\/j.sjbs.2023.103767","article-title":"Types of fiber and gut microbiota composition and diversity among arab females","volume":"30","author":"Aljuraiban","year":"2023","journal-title":"Saudi J. 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