{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:30:06Z","timestamp":1790656206831,"version":"4.1.0"},"reference-count":120,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    <jats:italic>Alistipes<\/jats:italic>\n                    , a bacterial genus under phylum Bacteroidetes, widely colonizes the gut. Since the first report of\n                    <jats:italic>Alistipes<\/jats:italic>\n                    in 2003, 13 species and 3 subspecies have been successfully isolated and identified from human feces, urine, appendiceal lesions, and rectal abscesses.\n                    <jats:italic>Alistipes<\/jats:italic>\n                    was reported to enhance the efficacy of immunotherapies in cancer treatment, while the detailed descriptions of other biological functions of this bacterium are lacking. This review summarizes the roles and potential mechanisms of\n                    <jats:italic>Alistipes<\/jats:italic>\n                    and its metabolites in inflammatory bowel diseases, digestive cancer, lung cancer, prostate and bladder cancer, and aging. Based on existing research, this narrative review provides a conceptual framework and emphasizes prospects for potential clinical value in diagnostics and therapeutics.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2026.1822008","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T05:42:50Z","timestamp":1779342170000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["The role of the Alistipes genus in intestinal inflammation, cancer, and aging: a narrative review"],"prefix":"10.3389","volume":"17","author":[{"given":"Yan","family":"Zhang","sequence":"first","affiliation":[{"name":"Center of Reproductive Medicine, Weifang People's Hospital, Shandong Second Medical University","place":["Weifang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlong","family":"Xie","sequence":"additional","affiliation":[{"name":"Center of Reproductive Medicine, Weifang People's Hospital, Shandong Second Medical University","place":["Weifang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Medical Research Center, Weifang People's Hospital, Shandong Second Medical University","place":["Weifang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Zhao","sequence":"additional","affiliation":[{"name":"Center of Reproductive Medicine, Weifang People's Hospital, Shandong Second Medical University","place":["Weifang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Weifang People's Hospital, Shandong Second Medical University","place":["Weifang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilan","family":"Sun","sequence":"additional","affiliation":[{"name":"Center of Reproductive Medicine, Weifang People's Hospital, Shandong Second Medical University","place":["Weifang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honggang","family":"Wang","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Weifang People's Hospital, Shandong Second Medical University","place":["Weifang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Medical Research Center, Weifang People's Hospital, Shandong Second Medical University","place":["Weifang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1038\/s41586-023-06234-x","article-title":"Y chromosome loss in cancer drives growth by evasion of adaptive immunity","volume":"619","author":"Abdel-Hafiz","year":"2023","journal-title":"Nature"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2323","DOI":"10.3390\/ijms25042323","article-title":"Detailed characterization of the lung-gut microbiome axis reveals the link between PD-L1 and the microbiome in non-small-cell lung cancer patients","volume":"25","author":"Ankudavicius","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"110231","DOI":"10.1016\/j.cbi.2022.110231","article-title":"Short chain fatty acids: fundamental mediators of the gut-lung axis and their involvement in pulmonary diseases","volume":"368","author":"Ashique","year":"2022","journal-title":"Chem. Biol. Interact."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"113627","DOI":"10.1016\/j.biopha.2022.113627","article-title":"Shouhui Tongbian capsule ameliorates constipation via gut microbiota-5-HT-intestinal motility axis","volume":"154","author":"Bai","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"100593","DOI":"10.1016\/j.nmni.2019.100593","article-title":"Corynebacterium pacaense sp. nov., Alistipes megaguti sp. nov., Alistipes provencensis sp. nov., 3 new bacteria isolated from fresh human stool specimens","volume":"32","author":"Bellali","year":"2019","journal-title":"New Microbes New Infect."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/s41575-020-0286-8","article-title":"Global burden of irritable bowel syndrome: trends, predictions and risk factors","volume":"17","author":"Black","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1038\/nrmicro.2017.50","article-title":"Transmission of the gut microbiota: spreading of health","volume":"15","author":"Browne","year":"2017","journal-title":"Nat. Rev. Microbiol."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/nrmicro.2016.142","article-title":"Emerging pathogenic links between microbiota and the gut-lung axis","volume":"15","author":"Budden","year":"2017","journal-title":"Nat. Rev. Microbiol."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"14241","DOI":"10.1038\/s41598-018-32583-z","article-title":"Nod2 deficiency in mice is associated with microbiota variation favouring the expansion of mucosal CD4+ LAP+ regulatory cells","volume":"8","author":"Butera","year":"2018","journal-title":"Sci. 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Adv."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1053\/j.gastro.2023.03.214","article-title":"American Gastroenterological Association-American College of Gastroenterology clinical practice guideline: pharmacological management of chronic idiopathic constipation","volume":"164","author":"Chang","year":"2023","journal-title":"Gastroenterology"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"lxae118","DOI":"10.1093\/jambio\/lxae118","article-title":"Gut microbial signatures of patients with diarrhea-predominant irritable bowel syndrome and their healthy relatives","volume":"135","author":"Chen","year":"2024","journal-title":"J. Appl. Microbiol."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1288525","DOI":"10.3389\/fmicb.2023.1288525","article-title":"Elucidating the causal association between gut microbiota and intrahepatic cholangiocarcinoma through Mendelian randomization analysis","volume":"14","author":"Chen","year":"2023","journal-title":"Front. Microbiol."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1390722","DOI":"10.3389\/fmicb.2024.1390722","article-title":"Immune cells mediated the causal relationship between the gut microbiota and lung cancer: a Mendelian randomization study","volume":"15","author":"Chen","year":"2024","journal-title":"Front. Microbiol."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1890","DOI":"10.7150\/jca.92699","article-title":"Causal relationships between gut microbiota, immune cell, and non-small cell lung cancer: a two-step, two-sample Mendelian randomization study","volume":"15","author":"Chen","year":"2024","journal-title":"J. Cancer"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"946248","DOI":"10.3389\/fimmu.2022.946248","article-title":"Gut microbiota, leaky gut, and autoimmune diseases","volume":"13","author":"Christovich","year":"2022","journal-title":"Front. Immunol."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"4586","DOI":"10.1073\/pnas.1000097107","article-title":"Composition, variability, and temporal stability of the intestinal microbiota of the elderly","volume":"108","author":"Claesson","year":"2011","journal-title":"Proc. Natl. Acad. Sci. 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J. Mol. Sci."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.1016\/j.jaci.2015.09.059","article-title":"IL-6 promotes an increase in human mast cell numbers and reactivity through suppression of suppressor of cytokine signaling 3","volume":"137","author":"Desai","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"2204746","DOI":"10.1080\/2162402X.2023.2204746","article-title":"Non-small cell lung cancer patients treated with anti-PD1 immunotherapy show distinct microbial signatures and metabolic pathways according to progression-free survival and PD-L1 status","volume":"12","author":"Dora","year":"2023","journal-title":"Onco Targets Ther"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"e0146162","DOI":"10.1371\/journal.pone.0146162","article-title":"Pglyrp-regulated gut microflora Prevotella falsenii, Parabacteroides distasonis and Bacteroides eggerthii enhance and Alistipes finegoldii attenuates colitis in mice","volume":"11","author":"Dziarski","year":"2016","journal-title":"PLoS One"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1038\/s41564-022-01103-1","article-title":"Gut microbial \u03b2-glucuronidases regulate host luminal proteases and are depleted in irritable bowel syndrome","volume":"7","author":"Edwinson","year":"2022","journal-title":"Nat. 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Oncol."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"e0401223","DOI":"10.1128\/spectrum.04012-23","article-title":"Combining fecal microbiome and metabolomics reveals diagnostic biomarkers for esophageal squamous cell carcinoma","volume":"12","author":"Gao","year":"2024","journal-title":"Microbiol. Spectrum"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1038\/s41575-022-00605-x","article-title":"The gut microbiome as a modulator of healthy ageing","volume":"19","author":"Ghosh","year":"2022","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.ymben.2023.09.008","article-title":"Metabolic engineering of commensal bacteria for gut butyrate delivery and dissection of host-microbe interaction","volume":"80","author":"Gong","year":"2023","journal-title":"Metab. Eng."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.7150\/jca.52943","article-title":"Integrative analysis of metabolome and gut microbiota in patients with pancreatic ductal adenocarcinoma","volume":"13","author":"Guo","year":"2022","journal-title":"J. Cancer"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"2007","DOI":"10.1038\/s41598-023-29136-4","article-title":"Gut microbial signature in lung cancer patients highlights specific taxa as predictors for durable clinical benefit","volume":"13","author":"Haberman","year":"2023","journal-title":"Sci. Rep."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1136\/gutjnl-2022-328389","article-title":"Gut microbiota influence anastomotic healing in colorectal cancer surgery through modulation of mucosal proinflammatory cytokines","volume":"72","author":"Hajjar","year":"2023","journal-title":"Gut"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1007\/s00203-022-02954-2","article-title":"Tumor tissue-specific bacterial biomarker panel for colorectal cancer: Bacteroides massiliensis, Alistipes species, Alistipes onderdonkii, Bifidobacterium pseudocatenulatum, Corynebacterium appendicis","volume":"204","author":"Hasan","year":"2022","journal-title":"Arch. Microbiol."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"116458","DOI":"10.1016\/j.envres.2023.116458","article-title":"STAT3 as a newly emerging target in colorectal cancer therapy: tumorigenesis, therapy response, and pharmacological\/nanoplatform strategies","volume":"233","author":"Hashemi","year":"2023","journal-title":"Environ. 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Pathog."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1591697","DOI":"10.3389\/fmicb.2025.1591697","article-title":"Correlation of the intestinal flora and its metabolites with the colonic transport function in functional constipation","volume":"16","author":"Hu","year":"2025","journal-title":"Front. Microbiol."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"427","DOI":"10.4056\/sigs.3336746","article-title":"Non-contiguous-finished genome sequence and description of Alistipes obesi sp. nov","volume":"7","author":"Hugon","year":"2013","journal-title":"Stand. Genomic Sci."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"2136","DOI":"10.1093\/ibd\/izae080","article-title":"Anti-inflammatory effects of Bacteroidota strains derived from outstanding donors of fecal microbiota transplantation for the treatment of ulcerative colitis","volume":"30","author":"Ishikawa","year":"2024","journal-title":"Inflamm. Bowel Dis."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/s41586-020-2729-3","article-title":"Host-microbiota maladaptation in colorectal cancer","volume":"585","author":"Janney","year":"2020","journal-title":"Nature"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1016\/j.bioactmat.2025.06.046","article-title":"Oral oncolytic magnetotactic bacteria elicit anti-colorectal tumor immunity and reprogram microbiota metabolism","volume":"51","author":"Jiang","year":"2025","journal-title":"Bioact. Mater."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"8096","DOI":"10.1038\/srep08096","article-title":"Dysbiosis gut microbiota associated with inflammation and impaired mucosal immune function in intestine of humans with non-alcoholic fatty liver disease","volume":"5","author":"Jiang","year":"2015","journal-title":"Sci. Rep."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1186\/s12866-024-03416-z","article-title":"Gut microbes on the risk of advanced adenomas","volume":"24","author":"Jing","year":"2024","journal-title":"BMC Microbiol."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1053\/j.gastro.2020.11.050","article-title":"Longitudinal changes in fecal calprotectin levels among pregnant women with and without inflammatory bowel disease and their babies","volume":"160","author":"Kim","year":"2021","journal-title":"Gastroenterology"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"aau4760","DOI":"10.1126\/scitranslmed.aau4760","article-title":"Neurogenesis and prolongevity signaling in young germ-free mice transplanted with the gut microbiota of old mice","volume":"11","author":"Kundu","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"315","DOI":"10.4056\/sigs.2685971","article-title":"Non-contiguous finished genome sequence and description of Alistipes timonensis sp. nov","volume":"6","author":"Lagier","year":"2012","journal-title":"Stand. Genomic Sci."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s40168-014-0050-9","article-title":"Microbial shifts in the aging mouse gut","volume":"2","author":"Langille","year":"2014","journal-title":"Microbiome"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"8343","DOI":"10.1007\/s00253-021-11617-z","article-title":"Metagenomic analysis of gut microbiome reveals a dynamic change in Alistipes onderdonkii in the preclinical model of pancreatic cancer, suppressing its proliferation","volume":"105","author":"Lee","year":"2021","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"781697","DOI":"10.3389\/fonc.2021.781697","article-title":"The relationship between gut microbiome features and chemotherapy response in gastrointestinal Cancer","volume":"11","author":"Li","year":"2021","journal-title":"Front. Oncol."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"717","DOI":"10.4251\/wjgo.v11.i9.717","article-title":"Correlation between invasive microbiota in margin-surrounding mucosa and anastomotic healing in patients with colorectal cancer","volume":"11","author":"Li","year":"2019","journal-title":"World J. Gastrointest. Oncol."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/s41392-023-01502-8","article-title":"Inflammation and aging: signaling pathways and intervention therapies","volume":"8","author":"Li","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.ajt.2022.11.011","article-title":"Oral administration of the commensal Alistipes onderdonkii prolongs allograft survival","volume":"23","author":"Li","year":"2023","journal-title":"Am. J. Transplant."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1007\/s00335-024-10042-7","article-title":"Predicting the potential deterioration of Barrett's esophagus based on gut microbiota: a Mendelian randomization analysis","volume":"35","author":"Li","year":"2024","journal-title":"Mamm. Genome"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1042\/CS20210778","article-title":"Gut microbiota-derived butyrate regulates gut mucus barrier repair by activating the macrophage\/WNT\/ERK signaling pathway","volume":"136","author":"Liang","year":"2022","journal-title":"Clin. Sci. (Lond.)"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/j.chom.2025.03.012","article-title":"Multi-cohort analysis reveals colorectal cancer tumor location-associated fecal microbiota and their clinical impact","volume":"33","author":"Lin","year":"2025","journal-title":"Cell Host Microbe"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"e0160724","DOI":"10.1128\/msystems.01607-24","article-title":"Gut commensal Alistipes shahii improves experimental colitis in mice with reduced intestinal epithelial damage and cytokine secretion","volume":"10","author":"Lin","year":"2025","journal-title":"mSystems"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"e270","DOI":"10.1002\/imt2.270","article-title":"Gut-X axis","volume":"4","author":"Lin","year":"2025","journal-title":"iMeta"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1186\/s12967-023-04119-1","article-title":"Identification of colorectal cancer progression-associated intestinal microbiome and predictive signature construction","volume":"21","author":"Liu","year":"2023","journal-title":"J. Transl. Med."},{"key":"ref65","doi-asserted-by":"publisher","first-page":"100928","DOI":"10.1016\/j.neo.2023.100928","article-title":"Gut microbiota-derived short-chain fatty acids promote prostate cancer progression via inducing cancer cell autophagy and M2 macrophage polarization","volume":"43","author":"Liu","year":"2023","journal-title":"Neoplasia"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"2348441","DOI":"10.1080\/19490976.2024.2348441","article-title":"Commensal microbiota-derived metabolite agmatine triggers inflammation to promote colorectal tumorigenesis","volume":"16","author":"Lu","year":"2024","journal-title":"Gut Microbes"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.3389\/fmicb.2020.01474","article-title":"Metagenomics study reveals changes in gut microbiota in centenarians: a cohort study of Hainan centenarians","volume":"11","author":"Luan","year":"2020","journal-title":"Front. Microbiol."},{"key":"ref68","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.nmni.2016.12.010","article-title":"'Tidjanibacter massiliensis' gen. Nov., sp. nov., a new bacterial species isolated from human colon","volume":"17","author":"Mailhe","year":"2016","journal-title":"New Microbes New Infect."},{"key":"ref69","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1093\/ibd\/izae179","article-title":"The composition of the fecal and mucosa-adherent microbiota varies based on age and disease activity in ulcerative colitis","volume":"31","author":"Malham","year":"2025","journal-title":"Inflamm. Bowel Dis."},{"key":"ref70","doi-asserted-by":"publisher","first-page":"e003334","DOI":"10.1136\/jitc-2021-003334","article-title":"Gut microbiome is associated with the clinical response to anti-PD-1 based immunotherapy in hepatobiliary cancers","volume":"9","author":"Mao","year":"2021","journal-title":"J. Immunother. 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