{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:46:38Z","timestamp":1782283598292,"version":"3.54.5"},"reference-count":109,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    Gastric cancer remains one of the leading causes of cancer mortality worldwide, characterized by marked geographic disparities that cannot be fully explained by the distribution of\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    infection alone. Although\n                    <jats:italic>H. pylori<\/jats:italic>\n                    is recognized as the principal etiological agent, reductionist models centered exclusively on infection prevalence and eradication fail to account for the complex heterogeneity of gastric cancer risk across populations. In this narrative review, we propose a multiscale ecological framework that integrates infectious, host, environmental, microbial, and socioeconomic determinants to reinterpret gastric carcinogenesis as an emergent phenomenon arising from dynamic interactions across biological and geographic scales. Drawing on current epidemiological, molecular, and systems biology evidence, we examine how\n                    <jats:italic>H. pylori<\/jats:italic>\n                    interacts with host genetic susceptibility, epigenetic alterations, microbial community dynamics, dietary exposures, environmental modifiers, and structural social determinants to shape the trajectory of the Correa precancerous cascade. This integrative perspective helps explain key epidemiological paradoxes, including the persistence of high gastric cancer incidence in regions with comparable infection prevalence and the incomplete risk reduction observed after bacterial eradication in advanced mucosal injury. We further highlight the concept of persistent molecular and microenvironmental \u201ccarcinogenic memory,\u201d whereby epigenetic alterations and dysbiotic microecological states sustain oncogenic potential even after elimination of the infectious agent. By framing gastric carcinogenesis as a complex ecological process rather than a pathogen-driven event, this model bridges mechanistic insights with population-level patterns and provides a conceptual platform for more effective prevention strategies. Ultimately, this framework supports a shift toward integrated approaches that combine early detection, targeted eradication, environmental modification, microbiome-aware strategies, and equitable health policies to reduce the global burden of gastric cancer.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2026.1823306","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T05:48:05Z","timestamp":1782280085000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Rethinking gastric carcinogenesis: a multiscale ecological model of risk beyond Helicobacter pylori"],"prefix":"10.3389","volume":"17","author":[{"given":"Juan Sebasti\u00e1n","family":"Fr\u00edas-Ordo\u00f1ez","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Digestive Endoscopy, Faculty of Medicine, Universidad Nacional de Colombia","place":["Bogot\u00e1, Colombia"]},{"name":"Gastroenterology and Digestive Endoscopy Unit, Gastroenterology Center","place":["Bogot\u00e1, Colombia"]},{"name":"Hospital Internacional de Colombia","place":["Bucaramanga, Colombia"]},{"name":"Colombian Research Group on Helicobacter pylori","place":["Bogot\u00e1, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Dar\u00edo","family":"Portillo-Mi\u00f1o","sequence":"additional","affiliation":[{"name":"Colombian Research Group on Helicobacter pylori","place":["Bogot\u00e1, Colombia"]},{"name":"Division of Research, Instituto Departamental de Salud de Nari\u00f1o (IDSN)","place":["Pasto, Colombia"]},{"name":"Master\u2019s Program in Epidemiology, Department of Public Health and Epidemiology, Faculty of Health Sciences, Pontificia Universidad Javeriana","place":["Cali, Colombia"]},{"name":"Grupo de Investigaci\u00f3n en Ciencias y Salud (GICIENSA), Faculty of Health Sciences, Medicine Program, Universidad de Nari\u00f1o","place":["Pasto, Colombia"]},{"name":"Hospital Universitario Departamental de Nari\u00f1o","place":["Pasto, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hernando","family":"Marulanda-Fernandez","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Digestive Endoscopy, Faculty of Medicine, Universidad Nacional de Colombia","place":["Bogot\u00e1, Colombia"]},{"name":"Gastroenterology and Digestive Endoscopy Unit, Gastroenterology Center","place":["Bogot\u00e1, Colombia"]},{"name":"Colombian Research Group on Helicobacter pylori","place":["Bogot\u00e1, Colombia"]},{"name":"Hospital Central de la Polic\u00eda","place":["Bogot\u00e1, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeison","family":"Carlosama","sequence":"additional","affiliation":[{"name":"Grupo Interdisciplinario de Investigaci\u00f3n Salud-Enfermedad (GIISE), Universidad Cooperativa de Colombia","place":["Pasto, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Otero-Parra","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Digestive Endoscopy, Faculty of Medicine, Universidad Nacional de Colombia","place":["Bogot\u00e1, Colombia"]},{"name":"Gastroenterology and Digestive Endoscopy Unit, Gastroenterology Center","place":["Bogot\u00e1, Colombia"]},{"name":"Colombian Research Group on Helicobacter pylori","place":["Bogot\u00e1, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Augusto","family":"Urrego","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Digestive Endoscopy, Faculty of Medicine, Universidad Nacional de Colombia","place":["Bogot\u00e1, Colombia"]},{"name":"Gastroenterology and Digestive Endoscopy Unit, Gastroenterology Center","place":["Bogot\u00e1, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elder","family":"Otero-Ramos","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Digestive Endoscopy, Faculty of Medicine, Universidad Nacional de Colombia","place":["Bogot\u00e1, Colombia"]},{"name":"Gastroenterology and Digestive Endoscopy Unit, Gastroenterology Center","place":["Bogot\u00e1, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Otero Regino","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Digestive Endoscopy, Faculty of Medicine, Universidad Nacional de Colombia","place":["Bogot\u00e1, Colombia"]},{"name":"Gastroenterology and Digestive Endoscopy Unit, Gastroenterology Center","place":["Bogot\u00e1, Colombia"]},{"name":"Colombian Research Group on Helicobacter pylori","place":["Bogot\u00e1, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2367","DOI":"10.1002\/ijc.24219","article-title":"DNA methylation of microRNA genes in gastric mucosae of gastric cancer patients: its possible involvement in the formation of epigenetic field defect","volume":"124","author":"Ando","year":"2009","journal-title":"Int. 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