{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T22:29:16Z","timestamp":1788733756501,"version":"build-2803163510"},"reference-count":354,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    The long-term presence of humans in space depends on reducing reliance on Earth's resupply of materials and resources.\n                    <jats:italic>In situ<\/jats:italic>\n                    resource utilization (ISRU) represents a sustainable approach to support human activities in space by converting local materials into consumables, propellants, and structural feedstocks. In parallel, bioregenerative life support systems (BLSS) primarily sustain internal loop closure (LC) by regenerating air, H\n                    <jats:sub>2<\/jats:sub>\n                    O, nutrients, and food from habitat-contained streams. Traditional ISRU concepts have primarily focused on abiotic technologies that process rocks, regolith, and atmospheric components to extract O\n                    <jats:sub>2<\/jats:sub>\n                    , H\n                    <jats:sub>2<\/jats:sub>\n                    O, and metals, although biotic approaches are also under investigation. Biological and bio-hybrid approaches, guided by microorganisms and other living systems, could complement these technologies by supporting both external resource conversion and internal LC in future space exploration. In this review, we adopt a resource-centric framework to compare abiotic, biotic, and coupled resources acquisition pathways across the main functional domains relevant to both ISRU and BLSS, treated as operationally distinct but architecturally coupled subsystems within a broader resource-management framework. We discuss the main functional domains required for human settlement, spanning external resource conversion (O\n                    <jats:sub>2<\/jats:sub>\n                    , CO\n                    <jats:sub>2<\/jats:sub>\n                    , H\n                    <jats:sub>2<\/jats:sub>\n                    , CH\n                    <jats:sub>4<\/jats:sub>\n                    , H\n                    <jats:sub>2<\/jats:sub>\n                    O, materials, manufacturing, energy) and internal regenerative functions (food production, air and H\n                    <jats:sub>2<\/jats:sub>\n                    O revitalization, and waste recycling). For each domain, we describe representative abiotic (e.g., MOXIE, ROXY, molten-regolith electrolysis, fission surface power, and advanced solar arrays) and biotic systems, for both ISRU-relevant bioprocesses (e.g., biomining, biopolymer production) and BLSS components (e.g., plant-growth and microbial recycling loops). The most realistic path toward sustainable human settlements beyond Earth orbit lies in coupled ISRU-BLSS architectures in which external resource acquisition and internal regenerative loops are coordinated across shared material and energy flows.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2026.1837116","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T13:49:26Z","timestamp":1779803366000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Integrating resource utilization and bioregenerative life support systems for sustainable space exploration"],"prefix":"10.3389","volume":"17","author":[{"given":"Mattia","family":"Esposito","sequence":"first","affiliation":[{"name":"Department of Environmental Sciences, Informatics and Statistics, University of Venice Ca' Foscari","place":["Venice, Italy"]},{"name":"INAF-OACN, Osservatorio Astronomico di Capodimonte","place":["Naples, Italy"]},{"name":"Institute of Biomolecular Chemistry, National Research Council, CNR-ICB","place":["Pozzuoli, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Tonietti","sequence":"additional","affiliation":[{"name":"INAF-OACN, Osservatorio Astronomico di Capodimonte","place":["Naples, Italy"]},{"name":"CNR-IPCF, Institute for Chemical and Physical Processes, National Research Council","place":["Messina, Italy"]},{"name":"Department of Science and Technology, University Parthenope","place":["Naples, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Santomartino","sequence":"additional","affiliation":[{"name":"Department of Biological and Environmental Engineering, Cornell University","place":["Ithaca, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donato","family":"Giovannelli","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Naples Federico II","place":["Naples, Italy"]},{"name":"National Research Council, Institute of Marine Biological Resources and Biotechnologies, CNR-IRBIM","place":["Ancona, Italy"]},{"name":"Department of Marine and Coastal Science, Rutgers University","place":["New Brunswick, NJ, United States"]},{"name":"Woods Hole Oceanographic Institution, Department of Marine Chemistry and Geochemistry, Woods Hole","place":["MA, United States"]},{"name":"Earth-Life Science Institute, Tokyo Institute of Technology","place":["Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Chianese","sequence":"additional","affiliation":[{"name":"Department of Science and Technology, University Parthenope","place":["Naples, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Rotundi","sequence":"additional","affiliation":[{"name":"INAF-OACN, Osservatorio Astronomico di Capodimonte","place":["Naples, Italy"]},{"name":"Department of Science and Technology, University Parthenope","place":["Naples, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida","family":"Romano","sequence":"additional","affiliation":[{"name":"Institute of Biomolecular Chemistry, National Research Council, CNR-ICB","place":["Pozzuoli, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annarita","family":"Poli","sequence":"additional","affiliation":[{"name":"Institute of Biomolecular Chemistry, National Research Council, CNR-ICB","place":["Pozzuoli, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Finore","sequence":"additional","affiliation":[{"name":"Institute of Biomolecular Chemistry, National Research Council, CNR-ICB","place":["Pozzuoli, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelina","family":"Cordone","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Naples Federico II","place":["Naples, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Di Donato","sequence":"additional","affiliation":[{"name":"INAF-OACN, Osservatorio Astronomico di Capodimonte","place":["Naples, Italy"]},{"name":"Institute of Biomolecular Chemistry, National Research Council, CNR-ICB","place":["Pozzuoli, Italy"]},{"name":"Department of Science and Technology, University Parthenope","place":["Naples, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"140003","DOI":"10.1063\/5.0234754","article-title":"Water measurement on the moon. 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