{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:00:21Z","timestamp":1780470021646,"version":"3.54.1"},"reference-count":188,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    Against the backdrop of widespread implementation of intrapartum prophylaxis for group B streptococcus (\n                    <jats:italic>GBS<\/jats:italic>\n                    ),\n                    <jats:italic>E. coli<\/jats:italic>\n                    has emerged as a major pathogen of early-onset neonatal sepsis (EOS) and neonatal meningitis. Vaginal colonization of pregnant women with highly virulent\n                    <jats:italic>E. coli<\/jats:italic>\n                    is not uncommon and has been associated with adverse obstetric outcomes, including preterm birth, chorioamnionitis, and neonatal infection. Available evidence suggests that the maternal colonization rate is approximately 20\u201330%, and vertical transmission during delivery occurs frequently. Colonizing strains often harbor virulence determinants associated with extraintestinal pathogenic\n                    <jats:italic>E. coli<\/jats:italic>\n                    (ExPEC), with virulence profiles resembling those of uropathogenic\n                    <jats:italic>E. coli<\/jats:italic>\n                    and neonatal meningitis-associated strains. Although most exposed neonates may remain asymptomatically colonized, once invasive infection occurs, the disease can rapidly progress to sepsis or meningitis, resulting in substantial mortality and long-term neurodevelopmental sequelae. In recent years, the spread of multidrug-resistant strains, particularly extended-spectrum\n                    <jats:italic>\u03b2<\/jats:italic>\n                    -lactamase (ESBL)-producing isolates, has further complicated perinatal prevention and empirical treatment. This review summarizes current advances in perinatal\n                    <jats:italic>E. coli<\/jats:italic>\n                    infection, with a focus on maternal colonization and vertical transmission, pathogenic mechanisms, clinical manifestations, antimicrobial resistance trends, and emerging preventive strategies.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2026.1840209","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:00:43Z","timestamp":1780466443000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Research Progress on perinatal E. coli infection"],"prefix":"10.3389","volume":"17","author":[{"given":"Yuning","family":"Lin","sequence":"first","affiliation":[{"name":"Medical Laboratory, Xiamen Humanity Hospital, Fujian Medical University","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Medical Laboratory, Xiamen Humanity Hospital, Fujian Medical University","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Xie","sequence":"additional","affiliation":[{"name":"Medical Laboratory, Xiamen Humanity Hospital, Fujian Medical University","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyi","family":"Lv","sequence":"additional","affiliation":[{"name":"Medical Laboratory, Xiamen Humanity Hospital, Fujian Medical University","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songping","family":"Chen","sequence":"additional","affiliation":[{"name":"Medical Laboratory, Xiamen Humanity Hospital, Fujian Medical University","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Jin","sequence":"additional","affiliation":[{"name":"Medical Laboratory, Xiamen Humanity Hospital, Fujian Medical University","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianning","family":"Wu","sequence":"additional","affiliation":[{"name":"Medical Laboratory, Zhangzhou Yuanshan Hospital","place":["Zhangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"452","DOI":"10.3389\/fimmu.2017.00452","article-title":"How Escherichia coli circumvent complement-mediated killing","volume":"8","author":"Abreu","year":"2017","journal-title":"Front. 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