{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T06:01:57Z","timestamp":1785132117878,"version":"3.55.0"},"reference-count":80,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014013","name":"UK Research and Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014013","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014013","name":"UK Research and Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014013","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Minist\u00e8re de l\u2019Enseignement Sup\u00e9rieur, de la Recherche et de l\u2019innovation"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    Quorum sensing (QS) enables bacteria to coordinate collective behaviors, including the production of secondary metabolites with potential biotechnological applications, through the synthesis and detection of small signaling molecules. In\n                    <jats:italic>Streptomyces<\/jats:italic>\n                    , QS is well-described and mainly mediated by 2,3-disubstituted\n                    <jats:italic>\u03b3<\/jats:italic>\n                    -butyrolactones (GBLs), which play key roles in the regulation of secondary metabolism and spore production. Despite their importance, GBL-based QS systems remain poorly characterized in other actinomycetal genera. Here, we investigated the distribution, structure, and function of GBL biosynthetic and regulatory systems within the genus\n                    <jats:italic>Rhodococcus<\/jats:italic>\n                    , focusing on the biocontrol strain\n                    <jats:italic>Rhodococcus erythropolis<\/jats:italic>\n                    R138. Comparative genomic analyses revealed that the\n                    <jats:italic>scbA<\/jats:italic>\n                    and\n                    <jats:italic>scbR<\/jats:italic>\n                    homologs, which are involved in GBL biosynthesis and detection, respectively, are widely conserved among\n                    <jats:italic>Rhodococcus<\/jats:italic>\n                    species and are organized within a conserved GBL gene cluster. Structural modeling using AlphaFold showed a high degree of conservation between ScbA and ScbR from\n                    <jats:italic>Streptomyces coelicolor<\/jats:italic>\n                    and their homologs in\n                    <jats:italic>R. erythropolis<\/jats:italic>\n                    R138. By combining liquid chromatography\u2013mass spectrometry analyses with a GBL-specific reporter assay, we demonstrated that\n                    <jats:italic>R. erythropolis<\/jats:italic>\n                    R138 produces biologically active GBL(\u2212like) molecules. Production of the investigated GBL molecules required the\n                    <jats:italic>scbA<\/jats:italic>\n                    gene, which restored spore production and promoted colony development in the\n                    <jats:italic>scbA<\/jats:italic>\n                    -deleted\n                    <jats:italic>S. coelicolor<\/jats:italic>\n                    strain during interaction with\n                    <jats:italic>R. erythropolis<\/jats:italic>\n                    R138. Transcriptional analyses further showed that both ScbR and a LuxR-like regulator may contribute to the fine-tuned regulation of\n                    <jats:italic>scbA<\/jats:italic>\n                    expression, revealing a complex regulatory network controlling GBL biosynthesis. This study provides novel and unexpected insights into the involvement of a LuxR homolog in regulating a QS system in Gram-positive bacteria. Together, these results demonstrate that functional GBL-based QS systems are conserved and active in\n                    <jats:italic>R. erythropolis<\/jats:italic>\n                    and likely widespread in the genus. This study expands current knowledge of QS in\n                    <jats:italic>Actinomycetota<\/jats:italic>\n                    and highlights the potential role of GBL signaling in regulating biotechnologically and ecologically relevant traits in\n                    <jats:italic>Rhodococcus<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2026.1849643","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T05:41:28Z","timestamp":1785130888000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Characterization of a quorum-sensing communication based on gamma-butyrolactones in Rhodococcus erythropolis"],"prefix":"10.3389","volume":"17","author":[{"given":"H\u00e9lo\u00efse","family":"Bizi\u00e8re-Maco","sequence":"first","affiliation":[{"name":"Laboratory of Bacterial Communication and Anti-Infectious Strategies (CBSA UR4312, Formerly LMSM EA4312), University Rouen Normandie, University Caen Normandie, Normandie University","place":["Rouen, France"]},{"name":"International Research Federation NOR-SEVE, University of Sherbrooke","place":["Sherbrooke, QC, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Jordier","sequence":"additional","affiliation":[{"name":"Laboratory of Bacterial Communication and Anti-Infectious Strategies (CBSA UR4312, Formerly LMSM EA4312), University Rouen Normandie, University Caen Normandie, Normandie University","place":["Rouen, France"]},{"name":"International Research Federation NOR-SEVE, University of Sherbrooke","place":["Sherbrooke, QC, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Francisco","family":"Barbosa-de-Bessa","sequence":"additional","affiliation":[{"name":"Laboratory of Ecology and Biology of Interactions, UMR CNRS 7267, University of Poitiers","place":["Poitiers, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quentin Blancart","family":"Remaury","sequence":"additional","affiliation":[{"name":"UMR CNRS 7285, Institute of Environmental and Material Chemistry of Poitiers (IC2MP), University of Poitiers, Team Certified by the League Against Cancer","place":["Poitiers, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Perrier","sequence":"additional","affiliation":[{"name":"Laboratory of Bacterial Communication and Anti-Infectious Strategies (CBSA UR4312, Formerly LMSM EA4312), University Rouen Normandie, University Caen Normandie, Normandie University","place":["Rouen, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florie","family":"Desriac","sequence":"additional","affiliation":[{"name":"Laboratory of Bacterial Communication and Anti-Infectious Strategies (CBSA UR4312, Formerly LMSM EA4312), University Rouen Normandie, University Caen Normandie, Normandie University","place":["Rouen, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charly Alex","family":"Dupont","sequence":"additional","affiliation":[{"name":"Laboratory of Bacterial Communication and Anti-Infectious Strategies (CBSA UR4312, Formerly LMSM EA4312), University Rouen Normandie, University Caen Normandie, Normandie University","place":["Rouen, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Chevalier","sequence":"additional","affiliation":[{"name":"Laboratory of Bacterial Communication and Anti-Infectious Strategies (CBSA UR4312, Formerly LMSM EA4312), University Rouen Normandie, University Caen Normandie, Normandie University","place":["Rouen, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack A.","family":"Connolly","sequence":"additional","affiliation":[{"name":"Manchester Institute of Biotechnology, Department of Chemistry, School of Nature Sciences, Faculty of Science and Engineering, University of Manchester","place":["Manchester, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eriko","family":"Takano","sequence":"additional","affiliation":[{"name":"Manchester Institute of Biotechnology, Department of Chemistry, School of Nature Sciences, Faculty of Science and Engineering, University of Manchester","place":["Manchester, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annabelle","family":"Merieau","sequence":"additional","affiliation":[{"name":"Laboratory of Bacterial Communication and Anti-Infectious Strategies (CBSA UR4312, Formerly LMSM EA4312), University Rouen Normandie, University Caen Normandie, Normandie University","place":["Rouen, France"]},{"name":"International Research Federation NOR-SEVE, University of Sherbrooke","place":["Sherbrooke, QC, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Verdon","sequence":"additional","affiliation":[{"name":"Laboratory of Ecology and Biology of Interactions, UMR CNRS 7267, University of Poitiers","place":["Poitiers, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Latour","sequence":"additional","affiliation":[{"name":"Laboratory of Bacterial Communication and Anti-Infectious Strategies (CBSA UR4312, Formerly LMSM EA4312), University Rouen Normandie, University Caen Normandie, Normandie University","place":["Rouen, France"]},{"name":"International Research Federation NOR-SEVE, University of Sherbrooke","place":["Sherbrooke, QC, Canada"]},{"name":"Biocontrol and Biostimulation for Agroecology Association (ABBA)","place":["Paris, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Barbey","sequence":"additional","affiliation":[{"name":"Laboratory of Bacterial Communication and Anti-Infectious Strategies (CBSA UR4312, Formerly LMSM EA4312), University Rouen Normandie, University Caen Normandie, Normandie University","place":["Rouen, France"]},{"name":"International Research Federation NOR-SEVE, University of Sherbrooke","place":["Sherbrooke, QC, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"88","DOI":"10.3390\/microorganisms12010088","article-title":"Biotechnological key genes of the Rhodococcus erythropolis MGMM8 genome: genes for bioremediation, antibiotics, plant protection, and growth 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