{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T22:30:19Z","timestamp":1794436219730,"version":"4.9.1"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Bloodstream infection (BSI) is a common complication in adults with acute leukemia (AL), and the problem of multidrug-resistant (MDR) bacterial infection is exacerbated by inappropriate antibiotic use; therefore, identifying its clinical features and risk factors is critical to improving clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>LASSO regression was employed for variable selection, followed by multivariate logistic regression to identify independent risk factors for multidrug-resistant bacterial bloodstream infection. Given the limited number of 30-day mortality events, LASSO regression combined with univariate logistic regression was used to preliminarily explore factors associated with 30-day mortality. Internal validation was performed using the bootstrap method with 1,000 resamples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median age of the patients was 56 years. The 30-day all-cause mortality rate was 10.5%. Gram-negative bacteria accounted for 71.053% of the infections, with\n                      <jats:italic>Escherichia coli (E. coli)<\/jats:italic>\n                      and\n                      <jats:italic>Klebsiella pneumoniae (K. pneumoniae)<\/jats:italic>\n                      being most common. Among the 105 identified MDR isolates (55.263%), both Gram-negative and Gram-positive bacteria exhibited high resistance rates to fluoroquinolones and penicillins. Invasive procedures and hypoproteinemia were identified as independent risk factors for MDR bacterial infection. Septic shock, CRP, and the AST\/ALT ratio may be associated with an increased risk of 30-day mortality, whereas length of hospitalization may serve as a protective factor. Given the limited number of events, the study may have been underpowered to detect a definitive survival impact of MDR infection, warranting validation in larger cohorts.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study provides important epidemiological data on blood infections in patients with AL in northeastern China, and provides a reference basis for optimizing infection prevention and control strategies based on local pathogens.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmicb.2026.1850927","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T05:40:18Z","timestamp":1780551618000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical characteristics and risk factor analysis of multidrug-resistant bacterial bloodstream infections in adult acute leukemia patients"],"prefix":"10.3389","volume":"17","author":[{"given":"Xiaodan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Second Affiliated Hospital of Dalian Medical University","place":["Dalian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuiqing","family":"He","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Second Affiliated Hospital of Dalian Medical University","place":["Dalian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weigong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Laboratory of Genetic Testing, Dalian Innovation Institute of Stem Cell and Precision Medicine","place":["Dalian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Second Affiliated Hospital of Dalian Medical University","place":["Dalian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingya","family":"Bu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Second Affiliated Hospital of Dalian Medical University","place":["Dalian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(25)00619-X","article-title":"Empirical and targeted antimicrobial therapy in patients with febrile neutropenia and haematological malignancy or after haematopoietic cell transplantation: Recommendations from the 10th European Conference on Infections in Leukaemia.","author":"Averbuch","year":"2025","journal-title":"Lancet Infect Dis."},{"key":"B2","doi-asserted-by":"publisher","first-page":"106571","DOI":"10.1016\/j.jinf.2025.106571","article-title":"Epidemiology of resistant bacterial infections in patients with hematological malignancies or undergoing hematopoietic cell transplantation in Europe: A systematic review by the European Conference on Infections in Leukemia (ECIL).","volume":"91","author":"Baccelli","year":"2025","journal-title":"J. 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