{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:55:42Z","timestamp":1791262542033,"version":"4.1.0"},"reference-count":58,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    Coenocytic algae are organisms that undergo karyokinesis without cytokinesis, resulting in multinucleated cells. Most research on bacterial communities in coenocytic algae has used 16S rRNA sequencing, primarily focusing on the order Bryopsidales of green coenocytic algae. Recent studies have analyzed metagenome-assembled genomes (MAGs) from algal hosts across multiple taxa, such as Chlorophyta, Phaeophyta, and Rhodophyta, revealing further insights into bacterial biosynthetic machinery and potential symbiotic relationships. Given the cosmopolitan distribution of coenocytic algae, such as\n                    <jats:italic>Bryopsis<\/jats:italic>\n                    ,\n                    <jats:italic>Caulerpa<\/jats:italic>\n                    ,\n                    <jats:italic>Codium<\/jats:italic>\n                    , and the yellow-green alga\n                    <jats:italic>Vaucheria<\/jats:italic>\n                    , and their unique morphology, there is a need to better understand their associated bacterial communities. To address this, filaments of\n                    <jats:italic>Vaucheria bursata<\/jats:italic>\n                    LB2067 were sequenced using the Illumina NovaSeq instrument, and all publicly available short- and long-read datasets from coenocytic algae were screened for MAG recovery. All recovered MAGs from both Bryopsidales and Vaucheriales showed a high dominance of Pseudomonadota at the phylum level, but no consistent patterns at the order or family levels. Core metabolic pathways, including glycolysis, the TCA cycle, and amino acid biosynthesis, were present across MAGs from both coenocytic and non-coenocytic algae. Pathways with significantly higher completeness in coenocytic-associated MAGs included protein secretion (Sec-SRP), which showed the strongest effect, motility (flagellar assembly), thiamin biosynthesis, and polyhydroxybutyrate (PHB) synthesis (Mann\u2013Whitney\n                    <jats:italic>U<\/jats:italic>\n                    ,\n                    <jats:italic>p<\/jats:italic>\n                    adj &amp;lt; 0.05). Notably, N-acetylglutaminylglutamine amide (NAGGN) biosynthetic gene clusters (BGCs) were found only in MAGs from coenocytic orders, whereas polysaccharide utilization loci (PULs) were present in all MAGs analyzed. These results indicate that bacterial communities associated with coenocytic algae are complex, with diverse survival strategies adapted to challenging and variable environments.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2026.1851259","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:26:08Z","timestamp":1791260768000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Genomic insights into bacterial communities of coenocytic algae using metagenome-assembled genomes"],"prefix":"10.3389","volume":"17","author":[{"given":"Gerardo","family":"Laureano","sequence":"first","affiliation":[{"name":"Department of Sciences and Technology, Inter American University of Puerto Rico","place":["Barranquitas, PR, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xochitl","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Dr. James Youngblom Center for Sustainable Biotechnology, Department of Biological Sciences, California State University Stanislaus","place":["Turlock, CA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Scoles","sequence":"additional","affiliation":[{"name":"Dr. James Youngblom Center for Sustainable Biotechnology, Department of Biological Sciences, California State University Stanislaus","place":["Turlock, CA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Johne","sequence":"additional","affiliation":[{"name":"Dr. James Youngblom Center for Sustainable Biotechnology, Department of Biological Sciences, California State University Stanislaus","place":["Turlock, CA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coralys M.","family":"Col\u00f3n S\u00e1ez","sequence":"additional","affiliation":[{"name":"Department of Sciences and Technology, Inter American University of Puerto Rico","place":["Barranquitas, PR, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yerlianys M.","family":"Hern\u00e1ndez Ortiz","sequence":"additional","affiliation":[{"name":"Department of Sciences and Technology, Inter American University of Puerto Rico","place":["Barranquitas, PR, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Soleyman","sequence":"additional","affiliation":[{"name":"Dr. James Youngblom Center for Sustainable Biotechnology, Department of Biological Sciences, California State University Stanislaus","place":["Turlock, CA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00f3n E.","family":"Rivera-Vic\u00e9ns","sequence":"additional","affiliation":[{"name":"Department of Sciences and Technology, Inter American University of Puerto Rico","place":["Barranquitas, PR, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alok","family":"Arun","sequence":"additional","affiliation":[{"name":"Dr. James Youngblom Center for Sustainable Biotechnology, Department of Biological Sciences, California State University Stanislaus","place":["Turlock, CA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"3982","DOI":"10.3390\/polym14193982","article-title":"Polyhydroxybutyrate (PHB)-based biodegradable polymer from Agromyces indicus: enhanced production, characterization, and optimization","volume":"14","author":"Adnan","year":"2022","journal-title":"Polymers"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"fiv067","DOI":"10.1093\/femsec\/fiv067","article-title":"Hologenome theory supported by cooccurrence networks of species-specific bacterial communities in siphonous algae (Caulerpa)","volume":"91","author":"Aires","year":"2015","journal-title":"FEMS Microbiol. Ecol."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/s41586-019-0965-1","article-title":"A new genomic blueprint of the human gut microbiota","volume":"568","author":"Almeida","year":"2019","journal-title":"Nature"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"4522","DOI":"10.3390\/ijms22094522","article-title":"Microbial and genetic resources for cobalamin (vitamin B12) biosynthesis: from ecosystems to industrial biotechnology","volume":"22","author":"Balabanova","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"W46","DOI":"10.1093\/nar\/gkad344","article-title":"antiSMASH 7.0: new and improved predictions for detection, regulation, chemical structures and visualisation","volume":"51","author":"Blin","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"W32","DOI":"10.1093\/nar\/gkaf334","article-title":"antiSMASH 8.0: extended gene cluster detection capabilities and analyses of chemistry, enzymology, and regulation","volume":"53","author":"Blin","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1038\/s41587-019-0209-9","article-title":"Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2","volume":"37","author":"Bolyen","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"5825","DOI":"10.1093\/molbev\/msab293","article-title":"eggNOG-mapper v2: functional annotation, orthology assignments, and domain prediction at the metagenomic scale","volume":"38","author":"Cantalapiedra","year":"2021","journal-title":"Mol. Biol. Evol."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"5315","DOI":"10.1093\/bioinformatics\/btac672","article-title":"GTDB-Tk v2: memory friendly classification with the genome taxonomy database","volume":"38","author":"Chaumeil","year":"2022","journal-title":"Bioinformatics"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1038\/s41592-023-01940-w","article-title":"CheckM2: a rapid, scalable and accurate tool for assessing microbial genome quality using machine learning","volume":"20","author":"Chklovski","year":"2023","journal-title":"Nat. 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Biochem."},{"key":"ref13","first-page":"335","article-title":"Community profiles of bacterial endosymbionts in four species of Caulerpa","volume":"37","author":"Delbridge","year":"2004","journal-title":"Symbiosis"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1086\/BBLv223n1p138","article-title":"16S rDNA-based metagenomic analysis of bacterial diversity associated with two populations of the kleptoplastic sea slug Elysia chlorotica and its algal prey Vaucheria litorea","volume":"223","author":"Devine","year":"2012","journal-title":"Biol. Bull."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"e1002195","DOI":"10.1371\/journal.pcbi.1002195","article-title":"Accelerated profile HMM searches","volume":"7","author":"Eddy","year":"2011","journal-title":"PLoS Comput. 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Bacteriol."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"11019","DOI":"10.3390\/ijms241311019","article-title":"Metagenomic insights reveal the microbial diversity and associated algal-polysaccharide-degrading enzymes on the surface of red algae among remote regions","volume":"24","author":"Gu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"e26458","DOI":"10.1371\/journal.pone.0026458","article-title":"Who is in there? Exploration of endophytic bacteria within the siphonous green seaweed Bryopsis (Bryopsidales, Chlorophyta)","volume":"6","author":"Hollants","year":"2011","journal-title":"PLoS One"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"5114","DOI":"10.1038\/s41467-018-07641-9","article-title":"High throughput ANI analysis of 90K prokaryotic genomes reveals clear species boundaries","volume":"9","author":"Jain","year":"2018","journal-title":"Nat. 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J. Mol. Sci."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"e02593-20","DOI":"10.1128\/AEM.02593-20","article-title":"The reliability of metagenome-assembled genomes (MAGs) in representing natural populations: insights from comparing MAGs against isolate genomes derived from the same fecal sample","volume":"87","author":"Meziti","year":"2021","journal-title":"Appl. Environ. Microbiol."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"985","DOI":"10.3390\/microorganisms13050985","article-title":"Metagenome-assembled genomes (MAGs): advances, challenges, and ecological insights","volume":"13","author":"Mirete","year":"2025","journal-title":"Microorganisms"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"fuaa058","DOI":"10.1093\/femsre\/fuaa058","article-title":"The protective role of PHB and its degradation products against stress situations in bacteria","volume":"45","author":"M\u00fcller-Santos","year":"2021","journal-title":"FEMS Microbiol. Rev."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"e00722-25","DOI":"10.1128\/mra.00722-25","article-title":"High-quality metagenome-assembled genomes of bacteria associated with long-term cultivated giant coenocytic green alga Bryopsis","volume":"14","author":"Ochiai","year":"2025","journal-title":"Microbiol. Resour. Announc."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1186\/s40168-023-01557-3","article-title":"Comparing genomes recovered from time-series metagenomes using long- and short-read sequencing technologies","volume":"11","author":"Orellana","year":"2023","journal-title":"Microbiome"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1146\/annurev-animal-091020-075907","article-title":"Advances in microbiome research for animal health","volume":"9","author":"Peixoto","year":"2021","journal-title":"Annu. Rev. Anim. Biosci."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"D590","DOI":"10.1093\/nar\/gks1219","article-title":"The SILVA ribosomal RNA gene database project: improved data processing and web-based tools","volume":"41","author":"Quast","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1002\/lno.10739","article-title":"The effects of warming and ocean acidification on growth, photosynthesis, and bacterial communities for the marine invasive macroalga Caulerpa taxifolia","volume":"63","author":"Roth-Schulze","year":"2018","journal-title":"Limnol. Oceanogr."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"12652","DOI":"10.1073\/pnas.1003063107","article-title":"Osmotically induced synthesis of the dipeptide N-acetylglutaminylglutamine amide is mediated by a new pathway conserved among bacteria","volume":"107","author":"Sagot","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"000685","DOI":"10.1099\/mgen.0.000685","article-title":"Bakta: rapid and standardized annotation of bacterial genomes via alignment-free sequence identification","volume":"7","author":"Schwengers","year":"2021","journal-title":"Microb. Genomics"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1038\/s41564-018-0171-1","article-title":"Recovery of genomes from metagenomes via a dereplication, aggregation and scoring strategy","volume":"3","author":"Sieber","year":"2018","journal-title":"Nat. Microbiol."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1111\/1574-6941.12297","article-title":"Seaweed-microbial interactions: key functions of seaweed-associated bacteria","volume":"88","author":"Singh","year":"2014","journal-title":"FEMS Microbiol. Ecol."},{"key":"ref45","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-540-77587-4","volume-title":"Handbook of Hydrocarbon and Lipid Microbiology","author":"Timmis","year":"2010"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1186\/s40168-018-0541-1","article-title":"MetaWRAP\u2014a flexible pipeline for genome-resolved metagenomic data analysis","volume":"6","author":"Uritskiy","year":"2018","journal-title":"Microbiome"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.tim.2019.03.002","article-title":"The macroalgal holobiont in a changing sea","volume":"27","author":"Van Der Loos","year":"2019","journal-title":"Trends Microbiol."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"e00184-24","DOI":"10.1128\/mra.00184-24","article-title":"Draft genome of the marine bacterium Alteromonas gracilis strain J4 isolated from the green coenocytic alga Caulerpa prolifera","volume":"13","author":"Van Duijnhoven","year":"2024","journal-title":"Microbiol. Resour. Announc."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1111\/j.1365-2672.2007.03335.x","article-title":"Bacterial synthesis of biodegradable polyhydroxyalkanoates","volume":"102","author":"Verlinden","year":"2007","journal-title":"J. Appl. Microbiol."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"e57923","DOI":"10.1371\/journal.pone.0057923","article-title":"The variability of the 16S rRNA gene in bacterial genomes and its consequences for bacterial community analyses","volume":"8","author":"V\u011btrovsk\u00fd","year":"2013","journal-title":"PLoS One"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s00248-025-02563-8","article-title":"Advancements in algal microbiome research: a game-changer for climate resilience and invasion success?","volume":"88","author":"Vila Dupl\u00e1","year":"2025","journal-title":"Microb. Ecol."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"857901","DOI":"10.3389\/fmicb.2022.857901","article-title":"Metagenome-assembled genomes from Pyropia haitanensis microbiome provide insights into the potential metabolic functions to the seaweed","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Microbiol."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"782","DOI":"10.3389\/fmicb.2018.00782","article-title":"Distribution patterns of polyphosphate metabolism pathway and its relationships with bacterial durability and virulence","volume":"9","author":"Wang","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"e01422-21","DOI":"10.1128\/msystems.01422-21","article-title":"Functional insights into the kelp microbiome from metagenome-assembled genomes","volume":"7","author":"Weigel","year":"2022","journal-title":"mSystems"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"e1005595","DOI":"10.1371\/journal.pcbi.1005595","article-title":"Unicycler: resolving bacterial genome assemblies from short and long sequencing reads","volume":"13","author":"Wick","year":"2017","journal-title":"PLoS Comput. Biol."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1093\/bioinformatics\/btv638","article-title":"MaxBin 2.0: an automated binning algorithm to recover genomes from multiple metagenomic datasets","volume":"32","author":"Wu","year":"2016","journal-title":"Bioinformatics"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"e02025-23","DOI":"10.1128\/aem.02025-23","article-title":"Metagenomic insights into the dynamic degradation of brown algal polysaccharides by kelp-associated microbiota","volume":"90","author":"Zhang","year":"2024","journal-title":"Appl. Environ. Microbiol."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"W115","DOI":"10.1093\/nar\/gkad328","article-title":"dbCAN3: automated carbohydrate-active enzyme and substrate annotation","volume":"51","author":"Zheng","year":"2023","journal-title":"Nucleic Acids Res."}],"container-title":["Frontiers in Microbiology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2026.1851259\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:26:10Z","timestamp":1791260770000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmicb.2026.1851259\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,6]]},"references-count":58,"alternative-id":["10.3389\/fmicb.2026.1851259"],"URL":"https:\/\/doi.org\/10.3389\/fmicb.2026.1851259","relation":{},"ISSN":["1664-302X"],"issn-type":[{"value":"1664-302X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,6]]},"article-number":"1851259"}}