{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:21:18Z","timestamp":1792182078484,"version":"4.4.0"},"reference-count":120,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>The global spread of antimicrobial resistance (AMR) has intensified the search for alternatives to conventional antibiotics in animal production systems. Bacteriophages can be engineered beyond narrow-spectrum antibacterial agents into multifunctional biological platforms that integrate direct killing, immune modulation, and antigen delivery. We summarize recent advances across livestock, poultry, and aquaculture, delineating mechanistic distinctions between lytic phage therapy, phage display-derived interventions, and engineered platforms including CRISPR-Cas-enabled theranostic systems. However, as detailed below, most evidence remains preclinical, and translational gaps are substantial. Unlike prior descriptive reviews, we analyze translational bottlenecks\u2014host range constraints, pharmacokinetic limitations, regulatory fragmentation\u2014and assess the existing research evidence for claimed advantages such as microbiota preservation and biofilm penetration while upfront acknowledging inconsistent experimental outcomes and inherent application limitations behind these beneficial effects. We conclude that realizing phages\u2019 therapeutic potential in veterinary medicine requires coordinated progress in synthetic biology, scalable manufacturing, and regulatory harmonization within a One Health framework.<\/jats:p>","DOI":"10.3389\/fmicb.2026.1851321","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T22:17:46Z","timestamp":1785968266000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Application of bacteriophages in the prevention and control of bacterial infectious diseases in animals"],"prefix":"10.3389","volume":"17","author":[{"given":"Junyao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The Second Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Nephrology Department, Affiliated Hospital of Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haihua","family":"Yu","sequence":"additional","affiliation":[{"name":"Physical Examination Center, The Second Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyi","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Medical Research Center, Second Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songbai","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, First Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Medical Research Center, Second Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiying","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Second Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Second Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yicun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Research Center, Second Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"3132","DOI":"10.3390\/molecules30153132","article-title":"Synthetic and functional engineering of bacteriophages: approaches for tailored bactericidal, diagnostic, and delivery platforms","volume":"30","author":"Alessa","year":"2025","journal-title":"Molecules"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2892","DOI":"10.1093\/jac\/dkaf293","article-title":"Phages connect the biological dots of antimicrobial resistance: from genesis and spread to alternative treatment modules","volume":"80","author":"Anastassopoulou","year":"2025","journal-title":"J. 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