{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T07:41:04Z","timestamp":1793691664166,"version":"4.5.1"},"reference-count":51,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Xuanfei Baidu decoction (XFBD), one of China\u2019s recommended prescriptions for COVID-19, has demonstrated clinical efficacy in mitigating gastrointestinal inflammation associated with SARS-CoV-2 infection, yet its exact therapeutic mechanism remains incompletely understood, necessitating further\n                      <jats:italic>in vivo<\/jats:italic>\n                      investigation. In this study, we utilized a fruit fly (\n                      <jats:italic>Drosophila melanogaster<\/jats:italic>\n                      ) model of intestinal inflammation to assess the therapeutic potential and underlying mechanisms of XFBD in ameliorating intestinal inflammation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We induced intestinal inflammation in\n                      <jats:italic>D. melanogaster<\/jats:italic>\n                      by dextran sulfate sodium (DSS) administration. We examined XFBD\u2019s protective effects on\n                      <jats:italic>D. melanogaster<\/jats:italic>\n                      \u2019s intestine and explored changes in the IMD and JNK-JAK\/STAT signaling pathways. Furthermore, we analyzed the intestinal microbiota through 16S rRNA gene sequencing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>XFBD effectively mitigated DSS-induced intestinal inflammation, leading to a significant extension of the flies\u2019 lifespan. It enhanced the integrity of intestinal barrier while reducing reactive oxygen species (ROS) levels in intestine. Additionally, XFBD restored the disrupted intestinal microbiota by regulating immune homeostasis, notably inhibiting the IMD, Toll, and JNKJAK\/STAT pathways. Furthermore, the reintroduction of symbiotic microbiota partially alleviated the DSS-induced dysregulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In conclusion, our study underscores the therapeutic potential of XFBD for intestinal inflammation, providing valuable insights into its key mechanisms and highlighting the pivotal role of symbiotic microbiota in anti-inflammatory responses and immune pathway regulation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmicb.2026.1853715","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T05:39:37Z","timestamp":1781069977000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Xuanfei Baidu decoction alleviates intestinal inflammation and modulates microbiota distribution by suppressing IMD\/NF-\u03baB and JNK signaling pathways"],"prefix":"10.3389","volume":"17","author":[{"given":"Yidong","family":"Xu","sequence":"first","affiliation":[{"name":"Faculty of Medicine, School of Pharmaceutical Science and Technology, Tianjin University","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Li","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, School of Pharmaceutical Science and Technology, Tianjin University","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaodong","family":"Miao","sequence":"additional","affiliation":[{"name":"Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxi","family":"Liu","sequence":"additional","affiliation":[{"name":"First Teaching Hospital of Tianjin University of Traditional Chinese Medicine","place":["Tianjin, China"]},{"name":"National Clinical Research Center for Chinese Medicine","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiya","family":"Zang","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, School of Pharmaceutical Science and Technology, Tianjin University","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghao","family":"Meng","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, School of Pharmaceutical Science and Technology, Tianjin University","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, School of Pharmaceutical Science and Technology, Tianjin University","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengwen","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for the Creation of Modern Traditional Chinese Medicine, Evidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiguang","family":"Yuchi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, School of Pharmaceutical Science and Technology, Tianjin University","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwen","family":"Wang","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, School of Pharmaceutical Science and Technology, Tianjin University","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1177\/01410768211032850","article-title":"Symptoms, complications and management of long COVID: a review","volume":"114","author":"Aiyegbusi","year":"2021","journal-title":"J. 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