{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T21:56:48Z","timestamp":1781647008209,"version":"3.54.5"},"reference-count":73,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20GM130460"],"award-info":[{"award-number":["P20GM130460"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006940","name":"University of Mississippi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006940","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    Members of the genus\n                    <jats:italic>Novosphingobium<\/jats:italic>\n                    are well known for the biosynthesis of glycosphingolipids. Here, we are reporting two recently discovered species belonging to this genus, which were isolated from a potted tomato plant in Oxford, Mississippi, USA. The cells of both strains grew aerobically, were rod-shaped, and formed yellow colonies. According to the 16S rRNA gene and whole genome-based phylogeny, both strains have the highest similarity to\n                    <jats:italic>N. clariflavum<\/jats:italic>\n                    164\n                    <jats:sup>\n                      <jats:italic>T<\/jats:italic>\n                    <\/jats:sup>\n                    . Genomes of both strains had a G + C content of 64 mol %, and assemblies with four circular contigs: two plasmids and two larger sequences over a megabase long. The analysis of the ortho Average Nucleotide Identity scores, along with digital DNA-DNA hybridization values, demonstrated that the two strains are distinct and unique species. Comparative genomic analysis with the reference strains of the genus\n                    <jats:italic>Novosphingobium<\/jats:italic>\n                    showed that the central metabolic pathways of these strains appeared to be similar, with slight variation consistent with prior reports of strains within the genus. Using MS\/MS fragmentation data, glycosphingolipids with a hexuronic acid head-group could be annotated. A Sequence Similarity Network of the glycosyltransferase genes within these organisms showed a homolog of the known bacterial gene responsible for adding glucuronic acid to ceramide, consistent with the MS\/MS analysis. These strains' major isoprenoid quinone was Q-10, and their predominant polyamine was spermidine. The phenotypic, chemotaxonomic, and genotypic features of strains BL-8A and BL-8H lead to the conclusion that these are two novel species of the genus\n                    <jats:italic>Novosphingobium<\/jats:italic>\n                    , for which the names\n                    <jats:italic>Novosphingobium oxfordense<\/jats:italic>\n                    (type strain = BL-8A\n                    <jats:sup>\n                      <jats:italic>T<\/jats:italic>\n                    <\/jats:sup>\n                    = NRRL B-65725\n                    <jats:sup>\n                      <jats:italic>T<\/jats:italic>\n                    <\/jats:sup>\n                    = LMG 34032\n                    <jats:sup>\n                      <jats:italic>T<\/jats:italic>\n                    <\/jats:sup>\n                    = ATCC TSD-464\n                    <jats:sup>\n                      <jats:italic>T<\/jats:italic>\n                    <\/jats:sup>\n                    ) and\n                    <jats:italic>Novosphingobium mississippiense<\/jats:italic>\n                    (type strain = BL-8H\n                    <jats:sup>\n                      <jats:italic>T<\/jats:italic>\n                    <\/jats:sup>\n                    = NRRL B-65726\n                    <jats:sup>\n                      <jats:italic>T<\/jats:italic>\n                    <\/jats:sup>\n                    = LMG 34033\n                    <jats:sup>\n                      <jats:italic>T<\/jats:italic>\n                    <\/jats:sup>\n                    = ATCC TSD-465\n                    <jats:sup>\n                      <jats:italic>T<\/jats:italic>\n                    <\/jats:sup>\n                    ) are proposed.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2026.1862985","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T21:24:47Z","timestamp":1781645087000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Isolation and characterization of Novosphingobium oxfordense sp. nov. and Novosphingobium mississippiense sp. nov. from soil, with LC-MS\/MS and genome-based investigation of their glycosphingolipid production"],"prefix":"10.3389","volume":"17","author":[{"given":"Tahir","family":"Ali","sequence":"first","affiliation":[{"name":"Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi","place":["Oxford, MS, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul D.","family":"Boudreau","sequence":"additional","affiliation":[{"name":"Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi","place":["Oxford, MS, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"W276","DOI":"10.1093\/nar\/gkz282","article-title":"AutoMLST: an automated web server for generating multi-locus species trees highlighting natural product potential","volume":"47","author":"Alanjary","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"B2","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/1471-2164-9-75","article-title":"The RAST server: rapid annotations using subsystems technology","volume":"9","author":"Aziz","year":"2008","journal-title":"BMC Genomics"},{"key":"B3","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s42770-022-00900-4","article-title":"Genomic and physiological characterization of Novosphingobium terrae sp. nov., an alphaproteobacterium isolated from Cerrado soil containing a mega-sized chromid","volume":"54","author":"Belmok","year":"2023","journal-title":"Braz. 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