{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T15:51:43Z","timestamp":1786636303199,"version":"build-2736575974"},"reference-count":162,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    High-fructose diet (HFD) has emerged as a critical dietary risk factor for metabolic syndrome, non-alcoholic fatty liver disease (NAFLD), and cardiovascular disease. This review delineates the molecular mechanisms underlying the pathological cascade linking high-fructose intake, gut dysbiosis, chronic inflammation, and accelerated aging. At the metabolic level, excess fructose is rapidly phosphorylated by ketohexokinase (KHK), depleting intracellular ATP while driving overproduction of uric acid and reactive oxygen species (ROS). These events activate the NLRP3 inflammasome and NF-\u03baB signaling, promoting hepatic\n                    <jats:italic>de novo<\/jats:italic>\n                    lipogenesis. At the microbial level, chronic fructose loading selectively depletes butyrate-producing taxa (\n                    <jats:italic>Faecalibacterium prausnitzii<\/jats:italic>\n                    ,\n                    <jats:italic>Roseburia<\/jats:italic>\n                    spp.) while enriching Gram-negative Proteobacteria pathobionts, elevating luminal lipopolysaccharide (LPS) concentrations. Butyrate deficiency downregulates tight junction proteins (ZO-1, occludin, claudin-1), compromising intestinal barrier integrity, enabling systemic LPS translocation and establishing metabolic endotoxemia. At the inflammatory level, circulating LPS sustains TLR4\u2013MyD88\u2013NF-\u03baB axis activation, driving chronic overexpression of TNF-\u03b1, IL-6, and IL-1\u03b2, establishing a self-reinforcing \u201cinflammaging\u201d network centered on the dysbiosis \u2192 leaky gut \u2192 endotoxemia \u2192 NF-\u03baB\u202f\u2192\u202fNLRP3 loop. At the aging level, sustained inflammatory signaling accelerates biological aging through five interconnected pathways: (1) cellular senescence and paracrine propagation of the senescence-associated secretory phenotype (SASP); (2) ROS-mediated telomeric oxidative damage coupled with DNA damage response\u2013NF-\u03baB activation; (3) mitochondrial dysfunction driving SASP transcription via the mtROS\u2013cGAS\u2013STING axis; (4) inflammation-induced epigenetic clock acceleration through aberrant DNMT3A\/B targeting and asymmetric H3K27ac\/me3 remodeling; and (5) immunosenescence encompassing TEMRA accumulation, Treg dysfunction, and M1 macrophage polarization, closing a self-sustaining inflammatory loop. At the intervention level, five strategic categories are synthesized: dietary modification (fructose restriction, Mediterranean diet); probiotic and prebiotic microbial restoration; bile acid FXR\/TGR5 modulation with exogenous SCFA supplementation; senolytic, NAD\u207a precursor, and mTOR\/AMPK-targeted pharmacotherapy; and fecal microbiota transplantation for systemic reconstitution. Clinical evidence demonstrates measurable improvements in glycemic regulation, insulin sensitivity, and SASP attenuation, though individual responses are substantially modulated by baseline microbiota composition. This review provides an integrative framework for understanding HFD-driven accelerated aging and establishes an evidence base for multilevel, precision-guided anti-inflammaging interventions.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2026.1865281","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:55:50Z","timestamp":1786632950000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["High-fructose diet\u2013induced gut dysbiosis as a mechanistic driver of chronic inflammation and accelerated biological aging: a comprehensive review"],"prefix":"10.3389","volume":"17","author":[{"given":"Xin-zhu","family":"Xu","sequence":"first","affiliation":[{"name":"Liaoning University of Traditional Chinese Medicine","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mo-si","family":"Dong","sequence":"additional","affiliation":[{"name":"Liaoning University of Traditional Chinese Medicine","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-yu","family":"Dai","sequence":"additional","affiliation":[{"name":"Liaoning University of Traditional Chinese Medicine","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Liaoning University of Traditional Chinese Medicine","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan-chi","family":"Dong","sequence":"additional","affiliation":[{"name":"Liaoning University of Traditional Chinese Medicine","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Jin","sequence":"additional","affiliation":[{"name":"Liaoning University of Traditional Chinese Medicine","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1084\/jem.20180794","article-title":"Microbiome-microglia connections via the gut-brain axis","volume":"216","author":"Abdel-Haq","year":"2019","journal-title":"J. Exp. Med."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1136\/gutjnl-2020-323071","article-title":"Gut microbiota-derived metabolites as central regulators in metabolic disorders","volume":"70","author":"Agus","year":"2021","journal-title":"Gut"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1016\/j.chom.2018.05.003","article-title":"Gut microbiota regulation of tryptophan metabolism in health and disease","volume":"23","author":"Agus","year":"2018","journal-title":"Cell Host Microbe"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"e143","DOI":"10.1017\/cts.2021.801","article-title":"Excess dietary fructose does not alter gut microbiota or permeability in humans: a pilot randomized controlled study","volume":"5","author":"Alem\u00e1n","year":"2021","journal-title":"J. Clin. Transl. 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Med."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1146\/annurev-immunol-081022-021207","article-title":"Structural mechanisms of NLRP3 Inflammasome assembly and activation","volume":"41","author":"Fu","year":"2023","journal-title":"Annu. Rev. Immunol."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"10.3390\/nu11102277","DOI":"10.3390\/nu11102277","article-title":"Regulation of gut microbiota and metabolic Endotoxemia with dietary factors","volume":"11","author":"Fuke","year":"2019","journal-title":"Nutrients"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s12016-021-08899-6","article-title":"Immunology of aging: the birth of Inflammaging","volume":"64","author":"Fulop","year":"2023","journal-title":"Clin. Rev. 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