{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:15:19Z","timestamp":1788243319578,"version":"build-2803163510"},"reference-count":70,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Acinetobacter baumannii<\/jats:italic>\n                      (\n                      <jats:italic>A. baumannii<\/jats:italic>\n                      ) is a Gram-negative coccobacillus that can cause a variety of infectious diseases. The Quorum Sensing (QS) system is a widespread mechanism regulating group behavior in bacteria, playing a crucial role in the virulence regulation of several Gram-negative pathogenic bacteria. The aim of this study was to investigate the effects of the\n                      <jats:italic>A. baumannii<\/jats:italic>\n                      quorum sensing system on capsule production and pathogenicity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this work, a clinical carbapenem-resistant\n                      <jats:italic>A. baumannii<\/jats:italic>\n                      with mucoid colonies (CRAB110) was used to construct an\n                      <jats:italic>abaI<\/jats:italic>\n                      knockout strain (CRAB110\u0394\n                      <jats:italic>abaI<\/jats:italic>\n                      ) using CRISPR\/Cas9 system. Afterwards, changes in capsule production, bacterial virulence, and host immune responses were evaluated by assessing bacterial phenotypes, physiology, gene expression, and effects on the host.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The results showed that CRAB110\u0394\n                      <jats:italic>abaI<\/jats:italic>\n                      significantly affected capsule production, virulence, and immunity compared with CRAB110. Mice infected with CRAB110\u0394\n                      <jats:italic>abaI<\/jats:italic>\n                      exhibited a reduction in inflammation compared to those infected with CRAB110. A comparison of the transcriptomes of CRAB110 and CRAB110\u0394\n                      <jats:italic>abaI<\/jats:italic>\n                      identified differentially expressed genes related to polysaccharide synthesis (\n                      <jats:italic>wza<\/jats:italic>\n                      ,\n                      <jats:italic>wzb<\/jats:italic>\n                      ,\n                      <jats:italic>wzc<\/jats:italic>\n                      ), galactose metabolism (\n                      <jats:italic>GalM<\/jats:italic>\n                      ), ABC transport, and amino acid metabolism. Mouse lung transcriptomic and cellular Western blot data indicated that quorum sensing (QS) exerts its pro-inflammatory effect through\n                      <jats:italic>Acinetobacter baumannii<\/jats:italic>\n                      by influencing the IL-17 and NF-\u03baB pathways.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This study suggests that the\n                      <jats:italic>abaI<\/jats:italic>\n                      gene boosts capsule production and pathogenicity of\n                      <jats:italic>A. baumannii<\/jats:italic>\n                      , providing new insights for clinical management of drug-resistant\n                      <jats:italic>A. baumannii<\/jats:italic>\n                      diseases and a foundation for new antimicrobial drugs.\n                    <\/jats:p>\n                  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