{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T06:01:28Z","timestamp":1781157688578,"version":"3.54.1"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Dental caries, a highly prevalent oral disease, significantly compromises oral health. Dental biofilms represent a key etiological factor in caries pathogenesis and pose challenges for eradication due to their protective extracellular matrix.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Herein, we rationally designed a ferro-polydopamine nanozyme (FPN) featuring a flower-like morphology and remarkable peroxidase-like (POD-like) activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Significantly, FPN efficiently catalyzed low-concentration H\n                      <jats:sub>2<\/jats:sub>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                      under mildly acidic conditions, exhibiting potent antibacterial activity against\n                      <jats:italic>Streptococcus mutans<\/jats:italic>\n                      (\n                      <jats:italic>S. mutans<\/jats:italic>\n                      ) and robust anti-biofilm efficacy\n                      <jats:italic>in vitro<\/jats:italic>\n                      . Furthermore, enamel disks treated synergistically with FPN and low-dose H2O2 demonstrated significantly inhibited enamel demineralization compared to untreated controls under acidogenic challenge, indicating FPN\u2019s remarkable preventive capacity against early caries.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      Collectively, this study demonstrates that FPN, enabled by its superior POD-like activity and biocompatibility, holds substantial translational potential for significantly reducing clinical H\n                      <jats:sub>2<\/jats:sub>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                      concentrations while effectively preventing early dental caries.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmicb.2026.1870312","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T05:48:38Z","timestamp":1781156918000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Flower-like ferro-polydopamine nanozymes with peroxidase-like activity for early caries prevention"],"prefix":"10.3389","volume":"17","author":[{"given":"Pei","family":"Wang","sequence":"first","affiliation":[{"name":"School of Stomatology, Jiangxi Medical College, Nanchang University","place":["Nanchang, China"]},{"name":"Jiangxi Provincial Key Laboratory of Oral Diseases","place":["Nanchang, China"]},{"name":"Jiangxi Provincial Clinical Research Center for Oral Diseases","place":["Nanchang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqiang","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Stomatology, Jiangxi Medical College, Nanchang University","place":["Nanchang, China"]},{"name":"Jiangxi Provincial Key Laboratory of Oral Diseases","place":["Nanchang, China"]},{"name":"Jiangxi Provincial Clinical Research Center for Oral Diseases","place":["Nanchang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Stomatology, Jiangxi Medical College, Nanchang University","place":["Nanchang, China"]},{"name":"Jiangxi Provincial Key Laboratory of Oral Diseases","place":["Nanchang, China"]},{"name":"Jiangxi Provincial Clinical Research Center for Oral Diseases","place":["Nanchang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Mu","sequence":"additional","affiliation":[{"name":"School of Medicine and Dentistry, Griffith University","place":["Gold Coast, QL, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Stomatology, Jiangxi Medical College, Nanchang University","place":["Nanchang, China"]},{"name":"Jiangxi Provincial Key Laboratory of Oral Diseases","place":["Nanchang, China"]},{"name":"Jiangxi Provincial Clinical Research Center for Oral Diseases","place":["Nanchang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"r1070","DOI":"10.1136\/bmj.r1070","article-title":"Oral disease must be central in policies to improve global health.","volume":"389","author":"Benzian","year":"2025","journal-title":"BMJ"},{"key":"B2","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/s41368-025-00400-9","article-title":"Structure insight into FtsZ function maintaining under acid stress of Streptococcus mutans.","volume":"18","author":"Chen","year":"2026","journal-title":"Int. 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