{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T06:07:53Z","timestamp":1789106873836,"version":"build-2803163510"},"reference-count":61,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>High-salt diet (HSD) has been shown to influence cognition and emotional behavior in mice via gut microbiota modulation, yet its chronic effects in Alzheimer\u2019s disease (AD) pathology remain poorly understood. This study aimed to investigate whether long-term HSD exacerbates cognitive and emotional deficits in APP\/PS1 transgenic mice and to explore the underlying gut\u2013brain axis mechanisms involving microbiota dysbiosis, peripheral and central inflammation, hippocampal neuronal integrity, and metabolic alterations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Six-month-old male APP\/PS1 mice were randomly assigned to a normal diet (ND, 0.4% NaCl,\n                      <jats:italic>n<\/jats:italic>\n                      = 43) or high-salt diet (HSD, 8% NaCl,\n                      <jats:italic>n<\/jats:italic>\n                      = 41) for 6 months. Body weight, water intake, and blood pressure were monitored regularly (\n                      <jats:italic>n<\/jats:italic>\n                      = 10 per group). Behavioral phenotypes were assessed via open field, elevated plus maze, marble burying, light\u2013dark box, and novel object recognition tests (\n                      <jats:italic>n<\/jats:italic>\n                      = 10). Hippocampal neuronal density was quantified by Nissl staining in CA1 and CA2, and dendritic complexity was evaluated by Golgi staining with Sholl analysis (\n                      <jats:italic>n<\/jats:italic>\n                      = 4). Gut microbiota composition was profiled by 16S rRNA sequencing (ND:\n                      <jats:italic>n<\/jats:italic>\n                      =13; HSD:\n                      <jats:italic>n<\/jats:italic>\n                      = 12), and inflammatory cytokine expression (TNF-\u03b1, IL-6, and IL-1\u03b2) in brain and liver was measured by RT-PCR and ELISA (\n                      <jats:italic>n<\/jats:italic>\n                      = 4). Hippocampal metabolomics was performed using LC\u2013MS (ND:\n                      <jats:italic>n<\/jats:italic>\n                      = 8; HSD:\n                      <jats:italic>n<\/jats:italic>\n                      = 7). Correlation analyses integrated microbial, inflammatory, metabolic, and neuropathological data.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>HSD significantly altered gut microbiota structure, as shown by reduced \u03b1-diversity, distinct \u03b2-diversity (PCoA), and differential abundance of taxa including Prevotellaceae, Rikenellaceae, and Ruminococcaceae (LEfSe). Concurrently, HSD elevated pro-inflammatory cytokine expression in both brain and liver, reduced neuronal density in hippocampal CA1\/CA2, and impaired dendritic arborization. Behaviorally, HSD-treated mice exhibited aggravated emotional disorders (anxiety- and compulsive-like behaviors) and worsened cognitive impairment in novelty recognition. Hippocampal metabolomics revealed substantial shifts in amino acid, energy, and neurotransmitter metabolic pathways. Spearman correlation analyses demonstrated significant interconnections among specific gut microbial genera, inflammatory markers, neuronal damage indices, and differential metabolites.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion and conclusion<\/jats:title>\n                    <jats:p>Long-term high-salt intake exacerbates cognitive decline and emotional disturbances in APP\/PS1 mice, likely through a cascading gut\u2013brain axis pathway: HSD-induced microbiota dysbiosis promotes peripheral and central inflammation, which in turn drives hippocampal neuronal damage and metabolic reprogramming. The strong correlations among microbial shifts, metabolic alterations, and neuropathological changes suggest that gut microbiota may serve as a critical mediator of HSD\u2019s deleterious effects on AD-related brain functions. These findings provide new mechanistic insights into dietary risk factors in AD and highlight potential microbiota\u2013metabolite targets for therapeutic intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmicb.2026.1884427","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T05:31:34Z","timestamp":1789104694000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Gut microbiota dysbiosis is associated with hippocampal neuronal damage and behavioral alterations in APP\/PS1 mice with high-salt diet"],"prefix":"10.3389","volume":"17","author":[{"given":"Huanmin","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Clinical Rehabilitation, School of Medicine, Xi\u2019an Siyuan University","place":["Xi\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxin","family":"Kou","sequence":"additional","affiliation":[{"name":"Department of Clinical Rehabilitation, School of Medicine, Xi\u2019an Siyuan University","place":["Xi\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shiyan Taihe Hospital, Affiliated Hospital of Hubei University of Medicine","place":["Shiyan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingzhuan","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Ordnance Industry General Hospital","place":["Xi\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Ordnance Industry General Hospital","place":["Xi\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulang","family":"Fei","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Nanyang Medical College","place":["Nanyang, Henan Province, China"]},{"name":"Zhang Zhongjing Chinese Medical Research Institute, Nanyang Medical College","place":["Nanyang, Henan Province, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e70266","DOI":"10.1111\/1756-185X.70266","article-title":"Impact of gut microbiota and probiotics on rheumatoid arthritis: a potential treatment challenge","volume":"28","author":"Ajith","year":"2025","journal-title":"Int. J. Rheum. Dis."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1080\/1028415X.2025.2567429","article-title":"Microbiota-gut-brain axis and probiotics: potential therapeutic strategies for treating Alzheimer\u2019s disease","volume":"29","author":"Ajith","year":"2025","journal-title":"Nutr. Neurosci."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1038\/nprot.2006.205","article-title":"Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study \u2018recognition memory\u2019","volume":"1","author":"Bevins","year":"2006","journal-title":"Nat. Protoc."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"183","DOI":"10.3389\/fnbeh.2015.00183","article-title":"Spontaneous object recognition: a promising approach to the comparative study of memory","volume":"9","author":"Blaser","year":"2015","journal-title":"Front. Behav. Neurosci."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1111\/j.1440-1681.2005.04206.x","article-title":"Translation of salt retention to central activation of the sympathetic nervous system in hypertension","volume":"32","author":"Brooks","year":"2005","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"109570","DOI":"10.1016\/j.jnutbio.2024.109570","article-title":"High salt diet exacerbates cognitive deficits and neurovascular abnormalities in APP\/PS1 mice and induces AD-like changes in wild-type mice","volume":"125","author":"Chen","year":"2024","journal-title":"J. Nutr. Biochem."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1478557","DOI":"10.3389\/fnagi.2024.1478557","article-title":"Gut microbiota dysbiosis in patients with Alzheimer\u2019s disease and correlation with multiple cognitive domains","volume":"16","author":"Chen","year":"2024","journal-title":"Front. Aging Neurosci."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1111\/nyas.15299","article-title":"Short-chain fatty acids mediate gut microbiota-brain communication and protect the blood-brain barrier integrity","volume":"1545","author":"Chenghan","year":"2025","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"102730","DOI":"10.1016\/j.conb.2023.102730","article-title":"Functional effects of gut microbiota-derived metabolites in Alzheimer\u2019s disease","volume":"81","author":"Choi","year":"2023","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"43","DOI":"10.3389\/fpsyt.2018.00043","article-title":"Behavioral phenotyping of dopamine transporter knockout rats: compulsive traits, motor stereotypies, and anhedonia","volume":"9","author":"Cinque","year":"2018","journal-title":"Front. 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Res."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1700134","DOI":"10.1002\/mnfr.201700134","article-title":"High salt diet impairs memory-related synaptic plasticity via increased oxidative stress and suppressed synaptic protein expression","volume":"61","author":"Ge","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.3390\/nu14061171","article-title":"High-salt diet induces depletion of lactic acid-producing bacteria in murine gut","volume":"14","author":"Hamad","year":"2022","journal-title":"Nutrients"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/S0140-6736(18)31138-3","article-title":"Action on salt China","volume":"392","author":"He","year":"2018","journal-title":"Lancet"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"2351","DOI":"10.3390\/biomedicines12102351","article-title":"The association between gut microbiota and serum biomarkers in children with atopic dermatitis","volume":"12","author":"Kalashnikova","year":"2024","journal-title":"Biomedicine"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"wrae226","DOI":"10.1093\/ismejo\/wrae226","article-title":"Biotics and bacterial function: impact on gut and host health","volume":"18","author":"Kandari","year":"2024","journal-title":"ISME J."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"102570","DOI":"10.1016\/j.arr.2024.102570","article-title":"Gut microbiome and Alzheimer\u2019s disease: what we know and what remains to be explored","volume":"102","author":"Kapoor","year":"2024","journal-title":"Ageing Res. 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Biotechnol."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"11731","DOI":"10.3390\/ijms252111731","article-title":"High-salt diet accelerates neuron loss and anxiety in APP\/PS1 mice through Serpina3n","volume":"25","author":"Ma","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"114778","DOI":"10.1016\/j.physbeh.2024.114778","article-title":"Gut microbiota dysbiosis in Alzheimer\u2019s disease (AD): insights from human clinical studies and the mouse AD models","volume":"290","author":"Manfredi","year":"2025","journal-title":"Physiol. Behav."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1080\/1028415X.2022.2161132","article-title":"Sodium chloride-induced changes in oxidative stress, inflammation, and dysbiosis in experimental multiple sclerosis","volume":"27","author":"Mart\u00edn-Hersog","year":"2024","journal-title":"Nutr. Neurosci."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"e81447","DOI":"10.7759\/cureus.81447","article-title":"Gut microbiota and mental health: a comprehensive review of gut-brain interactions in mood disorders","volume":"17","author":"Mehta","year":"2025","journal-title":"Cureus"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"300","DOI":"10.3390\/ijms24010300","article-title":"Alterations to cerebral perfusion, metabolite profiles, and neuronal morphology in the hippocampus and cortex of male and female mice during chronic exposure to a high-salt diet","volume":"24","author":"Meissner","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1832","DOI":"10.1016\/j.clnu.2024.05.036","article-title":"Modulation of gut microbiome in the treatment of neurodegenerative diseases: a systematic review","volume":"43","author":"Mincic","year":"2024","journal-title":"Clin. Nutr."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s40168-018-0433-4","article-title":"High salt diet exacerbates colitis in mice by decreasing Lactobacillus levels and butyrate production","volume":"6","author":"Miranda","year":"2018","journal-title":"Microbiome"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1093\/femsre\/fuy002","article-title":"Biochemistry of complex glycan depolymerisation by the human gut microbiota","volume":"42","author":"Ndeh","year":"2018","journal-title":"FEMS Microbiol. Rev."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.3390\/antiox13121504","article-title":"Dietary strategies to mitigate Alzheimer\u2019s disease: insights into antioxidant vitamin intake and supplementation with microbiota-gut-brain Axis cross-talk","volume":"13","author":"Ngah","year":"2024","journal-title":"Antioxidants (Basel)"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"123187","DOI":"10.1016\/j.lfs.2024.123187","article-title":"Gut microbiota as a modulator of type 1 diabetes: a molecular perspective","volume":"359","author":"Nikola","year":"2024","journal-title":"Life Sci."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1021\/acschemneuro.5c00063","article-title":"Interplay of neuroinflammation and gut microbiota dysbiosis in Alzheimer\u2019s disease using diffusion kurtosis imaging biomarker in 3 \u00d7 Tg-AD mouse models","volume":"16","author":"Palanivelu","year":"2025","journal-title":"ACS Chem. Neurosci."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.clnesp.2024.02.019","article-title":"Gut instincts: unveiling the connection between gut microbiota and Alzheimer\u2019s disease","volume":"60","author":"Peddinti","year":"2024","journal-title":"Clin Nutr ESPEN"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1017\/S0007114519000680","article-title":"Gut Prevotella as a possible biomarker of diet and its eubiotic versus dysbiotic roles: a comprehensive literature review","volume":"122","author":"Precup","year":"2019","journal-title":"Br. J. Nutr."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1161\/01.HYP.0000151325.83008.b4","article-title":"Obesity-associated hypertension: new insights into mechanisms","volume":"45","author":"Rahmouni","year":"2005","journal-title":"Hypertension"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"122588","DOI":"10.1016\/j.envpol.2023.122588","article-title":"Phenotypically plastic responses to freshwater salinization in larval amphibians: induced tolerance and induced sensitivity","volume":"337","author":"Relyea","year":"2023","journal-title":"Environ. Pollut."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"5449","DOI":"10.1002\/cphy.c230012","article-title":"Human gut microbiota in cardiovascular disease","volume":"14","author":"Ronen","year":"2024","journal-title":"Compr. Physiol."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"2233679","DOI":"10.1080\/19490976.2023.2233679","article-title":"Alterations in fecal \u03b2-defensin-3 secretion as a marker of instability of the gut microbiota","volume":"15","author":"Saqib","year":"2023","journal-title":"Gut Microbes"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"109590","DOI":"10.1016\/j.jnutbio.2024.109590","article-title":"Anti-obesity effect of butyrate links to modulation of gut microbiome and epigenetic regulation of muscular circadian clock","volume":"127","author":"Shon","year":"2024","journal-title":"J. Nutr. Biochem."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1111\/jch.13546","article-title":"The science of salt: updating the evidence on global estimates of salt intake","volume":"21","author":"Thout","year":"2019","journal-title":"J. Clin. Hypertens."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1186\/s12876-025-03929-5","article-title":"Changes in microbial and metabolic profiles of mice fed with long-term high salt diet","volume":"25","author":"Tian","year":"2025","journal-title":"BMC Gastroenterol."},{"key":"ref51000","doi-asserted-by":"crossref","first-page":"177016","DOI":"10.1016\/j.ejphar.2024.177016","article-title":"\u201cRegulation of hippocampal miRNA expression by intestinal flora in anxiety-like mice.\u201d","volume":"984","author":"Tong","year":"2024","journal-title":"Eur J Pharmacol"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1038\/ki.2012.345","article-title":"Chronic kidney disease alters intestinal microbial flora","volume":"83","author":"Vaziri","year":"2013","journal-title":"Kidney Int."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"674","DOI":"10.3390\/biology13090674","article-title":"High-salt diet and intestinal microbiota: influence on cardiovascular disease and inflammatory bowel disease","volume":"13","author":"Wang","year":"2024","journal-title":"Biology"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"85","DOI":"10.3390\/foods13010085","article-title":"Red cabbage modulates composition and co-occurrence networks of gut microbiota in a rodent diet-induced obesity model","volume":"13","author":"Wu","year":"2023","journal-title":"Foods"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"178350","DOI":"10.1016\/j.ejphar.2025.178350","article-title":"Chronic high-salt diet induces cognitive impairment and anxiety through gut microbiota alterations","volume":"1008","author":"Xu","year":"2025","journal-title":"Eur. J. Pharmacol."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"e70091","DOI":"10.1111\/cns.70091","article-title":"The gut microbiota modulates neuroinflammation in Alzheimer\u2019s disease: elucidating crucial factors and mechanistic underpinnings","volume":"30","author":"Yang","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"7970","DOI":"10.1038\/s41598-024-57998-9","article-title":"Dietary salt promotes cognition impairment through GLP-1R\/mTOR\/p70S6K signaling pathway","volume":"14","author":"Yang","year":"2024","journal-title":"Sci. Rep."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1186\/1471-2105-13-134","article-title":"Primer-BLAST: a tool to design target-specific primers for polymerase chain reaction","volume":"13","author":"Ye","year":"2012","journal-title":"BMC Bioinformatics"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"e0340322","DOI":"10.1128\/spectrum.03403-22","article-title":"A high-salt diet exacerbates liver fibrosis through Enterococcus-dependent macrophage activation","volume":"11","author":"Zhang","year":"2023","journal-title":"Microbiol. Spectrum"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s12974-024-03031-9","article-title":"Exercise mimetics: a novel strategy to combat neuroinflammation and Alzheimer\u2019s disease","volume":"21","author":"Zhao","year":"2024","journal-title":"J. Neuroinflammation"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"102637","DOI":"10.1016\/j.arr.2024.102637","article-title":"The complex relationship between gut microbiota and Alzheimer\u2019s disease: a systematic review","volume":"104","author":"Zhou","year":"2025","journal-title":"Ageing Res. 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