{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T06:27:52Z","timestamp":1786343272150,"version":"build-2736575974"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Chroogomphus rutilus<\/jats:italic>\n                      (CR) is an edible mushroom valued for its bioactive polysaccharides and flavonoids. It possesses antioxidant and anti-inflammatory properties; however, whether it can confer protection against the onset of ulcerative colitis (UC) remains unclear.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Initial network pharmacology analysis was performed to evaluate the potential influence of the flavonoid fraction of CR (CRF) on UC-related targets involved in inflammatory signaling and oxidative stress. The effects of CRF pretreatment were subsequently investigated in a mouse model of dextran sulfate sodium (DSS)-induced colitis. Mice received oral CRF pretreatment at doses of 100 or 400 mg\/kg, followed by induction of acute colitis with 3% DSS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CRF pretreatment suppressed colonic proinflammatory cytokine expression and preserved antioxidant defense. 16S rRNA gene sequencing revealed that CRF modulated the gut microbiota composition by suppressing potentially harmful bacteria, such as\n                      <jats:italic>Bacteroides<\/jats:italic>\n                      and\n                      <jats:italic>Erysipelatoclostridium<\/jats:italic>\n                      , and enriching beneficial genera including\n                      <jats:italic>Bifidobacterium<\/jats:italic>\n                      ,\n                      <jats:italic>Dubosiella<\/jats:italic>\n                      , and\n                      <jats:italic>Faecalibaculum<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>These correlative findings suggest that CRF pretreatment attenuates DSS-induced colitis, and that this attenuation is accompanied by reduced inflammation, alleviated oxidative stress, and microbiota remodeling. The data support the hypothesis that CRF acts through multi-target preventive effects, highlighting its potential as a candidate functional food ingredient for further development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmicb.2026.1886708","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T05:30:27Z","timestamp":1786339827000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Flavonoids from Chroogomphus rutilus attenuate DSS-induced colitis, exhibiting anti-inflammatory, antioxidant, and gut microbiota-modulating effects"],"prefix":"10.3389","volume":"17","author":[{"given":"Dan","family":"Wang","sequence":"first","affiliation":[{"name":"Liaoning Provincial Professional Technology Innovation Center of Meat Processing and Quality-Safety Control, College of Food and Health, Jinzhou Medical University","place":["Jinzhou, Liaoning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Luo","sequence":"additional","affiliation":[{"name":"Liaoning Provincial Professional Technology Innovation Center of Meat Processing and Quality-Safety Control, College of Food and Health, Jinzhou Medical University","place":["Jinzhou, Liaoning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Liaoning Provincial Professional Technology Innovation Center of Meat Processing and Quality-Safety Control, College of Food and Health, Jinzhou Medical University","place":["Jinzhou, Liaoning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Shang","sequence":"additional","affiliation":[{"name":"Liaoning Provincial Professional Technology Innovation Center of Meat Processing and Quality-Safety Control, College of Food and Health, Jinzhou Medical University","place":["Jinzhou, Liaoning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xizhu","family":"Wang","sequence":"additional","affiliation":[{"name":"Liaoning Provincial Professional Technology Innovation Center of Meat Processing and Quality-Safety Control, College of Food and Health, Jinzhou Medical University","place":["Jinzhou, Liaoning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.3390\/foods13132129","article-title":"Characterization of functional ingredients extracted with ethanol solvents from Ponkan (Citrus reticulata) by-products using the microwave vacuum drying method combined with ultrasound-assisted extraction","volume":"13","author":"Chang","year":"2024","journal-title":"Foods"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"312","DOI":"10.3390\/biology14030312","article-title":"Probiotic fermentation of Astragalus membranaceus and Raphani semen ameliorates cyclophosphamide-induced immunosuppression through intestinal short-chain fatty acid-dependent or -independent regulation of B cell function","volume":"14","author":"Chen","year":"2025","journal-title":"Biology"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"674341","DOI":"10.3389\/fimmu.2021.674341","article-title":"Juglone suppresses inflammation and oxidative stress in colitis mice","volume":"12","author":"Chen","year":"2021","journal-title":"Front. 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