{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T06:05:37Z","timestamp":1784786737528,"version":"3.55.0"},"reference-count":55,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    Plant-associated biocontrol bacteria play a pivotal role in advancing sustainable agriculture by minimizing the reliance on toxic chemical pesticides. The order\n                    <jats:italic>Burkholderiales<\/jats:italic>\n                    is an underexplored yet highly promising group of microorganisms, characterized by a broad ecological distribution and considerable potential for application in sustainable agricultural systems. In this study, we aimed to isolate and characterize a potential biocontrol strain belonging to\n                    <jats:italic>Burkholderiales<\/jats:italic>\n                    , with the goal of contributing to eco-friendly agricultural practices and mining previously unexploited secondary metabolites. A novel bacterial strain,\n                    <jats:italic>Pseudoduganella<\/jats:italic>\n                    sp. D-3-1, was isolated from Cangma Mountain and characterized to possess potent antifungal activity and a high iron-chelating capacity. Whole-genome sequencing revealed that its complete genome spans 6,875,892 bp and encodes 6035 predicted coding sequences (CDSs), including a complete violacein biosynthesis pathway. Genome mining uncovered a diverse array of secondary metabolite biosynthetic gene clusters (BGCs), notably a non-ribosomal peptide synthetase (NRPS) gene cluster, designated the pseudodubactin cluster, which encodes a catecholate-type siderophore structurally related to turnerbactin. Through high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), gene knockout, heterologous expression, and bioinformatics analysis, four turnerbactin analogs (\n                    <jats:bold>1<\/jats:bold>\n                    -\n                    <jats:bold>4<\/jats:bold>\n                    ) were identified for the first time from\n                    <jats:italic>Pseudoduganella<\/jats:italic>\n                    sp., including two novel compounds: pseudodubactin A (\n                    <jats:bold>2<\/jats:bold>\n                    ), and pseudodubactin B (\n                    <jats:bold>4<\/jats:bold>\n                    ). Additionally, HR-ESI-MS analysis detected two uncharacterized siderophores, designated as compound\n                    <jats:bold>5<\/jats:bold>\n                    and compound\n                    <jats:bold>6<\/jats:bold>\n                    , that are structurally distinct from the turnerbactin analogs. These findings indicate that\n                    <jats:italic>Pseudoduganella<\/jats:italic>\n                    sp. D-3-1 is a promising source of bioactive natural products, particularly violacein and diverse siderophores, highlighting its potential as a biological control agent for sustainable and eco-friendly agriculture.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2026.1888443","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T05:38:01Z","timestamp":1784785081000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Complete genome sequence and mass spectrometry assist mining siderophore turnerbactin analogs in a non-model Pseudoduganella strain with biocontrol potential"],"prefix":"10.3389","volume":"17","author":[{"given":"Xuan","family":"Luo","sequence":"first","affiliation":[{"name":"School of Medicine, Linyi University","place":["Linyi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianhui","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Medicine, Linyi University","place":["Linyi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyun","family":"Cao","sequence":"additional","affiliation":[{"name":"School of Medicine, Linyi University","place":["Linyi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianping","family":"Bai","sequence":"additional","affiliation":[{"name":"Helmholtz International Lab for Anti-infectives, State Key Laboratory of Microbial Technology, Shandong University","place":["Qingdao, Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Helmholtz International Lab for Anti-infectives, State Key Laboratory of Microbial Technology, Shandong University","place":["Qingdao, Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Xing","sequence":"additional","affiliation":[{"name":"School of Medicine, Linyi University","place":["Linyi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinbei","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Medicine, Linyi University","place":["Linyi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenkang","family":"Li","sequence":"additional","affiliation":[{"name":"School of Medicine, Linyi University","place":["Linyi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiping","family":"Ni","sequence":"additional","affiliation":[{"name":"Shandong Provincial Key Laboratory of Field Crop Physiology, Ecology, and Efficient Production (Under Construction)","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Medicine, Linyi University","place":["Linyi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhong","sequence":"additional","affiliation":[{"name":"Institute of Synthetic Biology Industry, Hunan University of Arts and Science","place":["Changde, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baohang","family":"Huang","sequence":"additional","affiliation":[{"name":"Helmholtz International Lab for Anti-infectives, State Key Laboratory of Microbial Technology, Shandong University","place":["Qingdao, Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Medicine, Linyi University","place":["Linyi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Tu","sequence":"additional","affiliation":[{"name":"Helmholtz International Lab for Anti-infectives, State Key Laboratory of Microbial Technology, Shandong University","place":["Qingdao, Shandong, China"]},{"name":"Institute of Synthetic Biology Industry, Hunan University of Arts and Science","place":["Changde, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huawei","family":"Xin","sequence":"additional","affiliation":[{"name":"School of Medicine, Linyi University","place":["Linyi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Medicine, Linyi University","place":["Linyi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1332864","DOI":"10.3389\/fpls.2023.1332864","article-title":"A plant's perception of growth-promoting bacteria and their metabolites","volume":"14","author":"Abou Jaoude","year":"2023","journal-title":"Front. 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