{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T06:27:21Z","timestamp":1786688841418,"version":"build-2736575974"},"reference-count":62,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    <jats:italic>Xylaria papulis<\/jats:italic>\n                    Lloyd, an endophytic fungus, was isolated from the stem of\n                    <jats:italic>Andrographis paniculata<\/jats:italic>\n                    Willd., commonly known as green chiretta, which is native to India and Sri Lanka. To date, no report is available on the epigenetic modulation of\n                    <jats:italic>X. papulis<\/jats:italic>\n                    using the histone methyltransferase inhibitor UNC1999. Hence, this study aims to evaluate the independent effect of this probe. The fungal culture was evaluated for antioxidant (2,2-diphenyl-1-picrylhydrazyl and 2,2\u2032-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid radical scavenging assays) and antibacterial potential against six human pathogens:\n                    <jats:italic>Staphylococcus epidermidis<\/jats:italic>\n                    (ATCC 12223), methicillin-susceptible\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (MSSA) (ATCC 25923), methicillin-resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (MRSA) (MU50),\n                    <jats:italic>Enterobacter cloacae<\/jats:italic>\n                    (ATCC 13047),\n                    <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                    (ATCC 700603), and\n                    <jats:italic>E. coli<\/jats:italic>\n                    (ATCC 25922). The crude extract, which was recovered from the samples treated with 250\u202fnM of UNC1999, exhibited enhanced antioxidant and antibacterial efficacy against\n                    <jats:italic>S. epidermidis<\/jats:italic>\n                    (ATCC 12223), MSSA (ATCC 25923), MRSA (MU50),\n                    <jats:italic>E. cloacae<\/jats:italic>\n                    (ATCC 13047), and\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    (ATCC 700603), compared to the control. The chemical profiles of crude extracts, both treated and untreated, were analyzed using gas chromatography\u2013mass spectrometry and ultra-high-performance liquid chromatography along with high-resolution mass spectrometry). The results highlighted the capacity of UNC1999 to modulate the synthesis of cryptic metabolites in\n                    <jats:italic>X. papulis<\/jats:italic>\n                    , displaying antimicrobial and anticancer potential. This study underlines the importance of further research into the molecular mechanisms regulating these epigenetically modulated metabolic pathways.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2026.1894461","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T05:33:31Z","timestamp":1786685611000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A metabolomics approach to target the effect of histone protein methyltransferase-specific probe UNC1999 on cryptic metabolites in an endophytic fungus Xylaria papulis Lloyd"],"prefix":"10.3389","volume":"17","author":[{"given":"Shubham","family":"Vishwakarma","sequence":"first","affiliation":[{"name":"Department of Botany, Institute of Science, Banaras Hindu University","place":["Varanasi, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay Hind","family":"Nishad","sequence":"additional","affiliation":[{"name":"Department of Botany, Institute of Science, Banaras Hindu University","place":["Varanasi, India"]},{"name":"Plant Tissue Culture and Genetic Engineering Lab, Department of Biotechnology, National Agri-Food and Biomanufacturing Institute (NABI), Ministry of Science and Technology (Government of India)","place":["Mohali, Punjab, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Anjali","sequence":"additional","affiliation":[{"name":"Department of Botany, Institute of Science, Banaras Hindu University","place":["Varanasi, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shagun","family":"Sinha","sequence":"additional","affiliation":[{"name":"Department of Botany, Institute of Science, Banaras Hindu University","place":["Varanasi, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajnish","family":"Bharti","sequence":"additional","affiliation":[{"name":"Department of Botany, Institute of Science, Banaras Hindu University","place":["Varanasi, India"]},{"name":"Department of Botany, D.A.V.P.G. 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