{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T06:52:09Z","timestamp":1785912729256,"version":"3.56.0"},"reference-count":69,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    Ulcerative colitis (UC) remains a challenging chronic inflammatory bowel disease with limited treatment options. This study investigates the protective role of\n                    <jats:italic>Weissella confusa<\/jats:italic>\n                    RY-1, a potential probiotic strain isolated from human gastric fluid, in a dextran sulfate sodium (DSS)-induced murine colitis model. Administration of\n                    <jats:italic>W. confusa<\/jats:italic>\n                    RY-1 significantly ameliorated colitis symptoms in mice subjected to a 10-day colitis induction model, as demonstrated by improved body weight recovery, reduced disease activity index (DAI) scores, attenuated colon shortening, and restored colonic histoarchitecture. The probiotic treatment enhanced intestinal barrier integrity through upregulation of tight junction proteins ZO-1 and Occludin. 16S rRNA sequencing revealed substantial modulation of gut microbiota, characterized by reduced abundance of pro-inflammatory\n                    <jats:italic>Escherichia-Shigella<\/jats:italic>\n                    and enrichment of beneficial\n                    <jats:italic>Akkermansia<\/jats:italic>\n                    . Metabolomic analysis further demonstrated metabolic reshaping with elevated anti-inflammatory linoleic acid and decreased succinic acid levels. These findings collectively indicate that\n                    <jats:italic>W. confusa<\/jats:italic>\n                    RY-1 exerts protective effects against colitis through multiple mechanisms including barrier reinforcement, microbiota modulation, and metabolic reprogramming, suggesting its promising potential as a novel probiotic-based intervention for ulcerative colitis.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2026.1896924","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T06:28:36Z","timestamp":1785911316000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Weissella confusa RY-1 ameliorates DSS-induced colitis by restoring intestinal barrier, modulating gut microbiota, and reprogramming microbial metabolism"],"prefix":"10.3389","volume":"17","author":[{"given":"Huaqin","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Affiliated Hospital of Zunyi Medical University","place":["Zunyi, Guizhou, China"]},{"name":"School of Laboratory Medicine, Zunyi Medical University","place":["Zunyi, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Affiliated Hospital of Zunyi Medical University","place":["Zunyi, Guizhou, China"]},{"name":"School of Laboratory Medicine, Zunyi Medical University","place":["Zunyi, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Affiliated Hospital of Zunyi Medical University","place":["Zunyi, Guizhou, China"]},{"name":"School of Laboratory Medicine, Zunyi Medical University","place":["Zunyi, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Affiliated Hospital of Zunyi Medical University","place":["Zunyi, Guizhou, China"]},{"name":"School of Laboratory Medicine, Zunyi Medical University","place":["Zunyi, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Affiliated Hospital of Zunyi Medical University","place":["Zunyi, Guizhou, China"]},{"name":"School of Laboratory Medicine, Zunyi Medical University","place":["Zunyi, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changjin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Affiliated Hospital of Zunyi Medical University","place":["Zunyi, Guizhou, China"]},{"name":"School of Laboratory Medicine, Zunyi Medical University","place":["Zunyi, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilu","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Affiliated Hospital of Zunyi Medical University","place":["Zunyi, Guizhou, China"]},{"name":"School of Laboratory Medicine, Zunyi Medical University","place":["Zunyi, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Affiliated Hospital of Zunyi Medical University","place":["Zunyi, Guizhou, China"]},{"name":"School of Laboratory Medicine, Zunyi Medical University","place":["Zunyi, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Affiliated Hospital of Zunyi Medical University","place":["Zunyi, Guizhou, China"]},{"name":"School of Laboratory Medicine, Zunyi Medical University","place":["Zunyi, Guizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2427","DOI":"10.3390\/microorganisms10122427","article-title":"The Weissella genus: clinically treatable Bacteria with antimicrobial\/probiotic effects on inflammation and Cancer","volume":"10","author":"Ahmed","year":"2022","journal-title":"Microorganisms"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e85345","DOI":"10.1371\/journal.pone.0085345","article-title":"Interleukin-6 modulation of intestinal epithelial tight junction permeability is mediated by JNK pathway activation of claudin-2 gene","volume":"9","author":"Al-Sadi","year":"2014","journal-title":"PLoS One"},{"key":"ref3","first-page":"233","article-title":"Roles of mucosal bacteria and succinic acid in colitis caused by dextran sulfate sodium in mice","volume":"47","author":"Ariake","year":"2000","journal-title":"J. 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