{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T06:27:09Z","timestamp":1786688829669,"version":"build-2736575974"},"reference-count":152,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    Dental caries remains a prevalent global health burden driven by dysbiosis of the biofilm microbiome. Antimicrobial peptides (AMPs), characterized by a low risk of resistance development and immunomodulatory potential, have emerged as promising alternatives to conventional antimicrobials; however, their clinical translation is still constrained by physiological instability, cytotoxicity, limited oral substantivity, and substantial regulatory and economic barriers. This review systematically summarizes recent advances in the mechanisms of action, rational design, and translational strategies of AMPs for the prevention and management of dental caries. The article first outlines updated mechanistic concepts, highlighting a shift from the classical stable pore-forming model toward transient water channel formation and lipid flip-flop models, and further discusses microbiome-oriented ecological modulation strategies aimed at preserving beneficial commensals and suppressing cariogenic dysbiosis. In addition, structure\u2013activity relationships are examined in depth, with emphasis on how diverse optimization approaches can balance peptide activity, toxicity, stability, selectivity, and manufacturability. The review also delineates the major barriers that impede clinical translation, including production cost, GMP-compatible manufacturing, batch consistency, delivery format, and regulatory definability. Potential strategies are discussed, including molecular farming in plant bioreactors, recombinant or synthetic production platforms, covalent immobilization,\n                    <jats:italic>in situ<\/jats:italic>\n                    biomimetic systems, and pH-responsive delivery systems for improving local bioavailability within cariogenic microenvironments. Finally, we emphasize that most current evidence remains preclinical and that no generalizable clinical framework for AMP-based caries prevention has yet been established. Future development should integrate mechanism-guided design, microbiome-level evaluation, standardized safety and efficacy endpoints, scalable manufacturing, and controlled clinical validation.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2026.1899522","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T05:32:48Z","timestamp":1786685568000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Optimization strategies for antimicrobial peptides in dental caries prevention and management: from emerging mechanisms of action to clinical translation"],"prefix":"10.3389","volume":"17","author":[{"given":"Hongzhao","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Cariology and Endodontics, The First Affiliated Hospital of Xinjiang Medical University (The Affiliated Stomatology Hospital of Xinjiang Medical University)","place":["Urumqi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizinigaer","family":"Yasen","sequence":"additional","affiliation":[{"name":"Department of Cariology and Endodontics, The First Affiliated Hospital of Xinjiang Medical University (The Affiliated Stomatology Hospital of Xinjiang Medical University)","place":["Urumqi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Cariology and Endodontics, The First Affiliated Hospital of Xinjiang Medical University (The Affiliated Stomatology Hospital of Xinjiang Medical University)","place":["Urumqi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Cariology and Endodontics, The First Affiliated Hospital of Xinjiang Medical University (The Affiliated Stomatology Hospital of Xinjiang Medical University)","place":["Urumqi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyu","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cariology and Endodontics, The First Affiliated Hospital of Xinjiang Medical University (The Affiliated Stomatology Hospital of Xinjiang Medical University)","place":["Urumqi, China"]},{"name":"Stomatology Disease Institute of Xinjiang Uyghur Autonomous Region, Xinjiang Medical University","place":["Urumqi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cariology and Endodontics, The First Affiliated Hospital of Xinjiang Medical University (The Affiliated Stomatology Hospital of Xinjiang Medical University)","place":["Urumqi, China"]},{"name":"Stomatology Disease Institute of Xinjiang Uyghur Autonomous Region, Xinjiang Medical University","place":["Urumqi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.bcp.2016.09.018","article-title":"Antimicrobial peptides (AMPs): ancient compounds that represent novel weapons in the fight against bacteria","volume":"133","author":"Ageitos","year":"2017","journal-title":"Biochem. 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Agents Chemother."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1080\/08927014.2017.1374378","article-title":"Antibacterial activity of a novel antimicrobial peptide [W7]KR12-KAEK derived from KR-12 against Streptococcus mutans planktonic cells and biofilms","volume":"33","author":"Da Silva","year":"2017","journal-title":"Biofouling"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/S1360-1385(01)01922-7","article-title":"Medical molecular farming: production of antibodies, biopharmaceuticals and edible vaccines in plants","volume":"6","author":"Daniell","year":"2001","journal-title":"Trends Plant Sci."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"103714","DOI":"10.1016\/j.drudis.2023.103714","article-title":"Immunogenicity risk assessment of synthetic peptide drugs and their impurities","volume":"28","author":"De Groot","year":"2023","journal-title":"Drug Discov. Today"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"778645","DOI":"10.3389\/fmedt.2021.778645","article-title":"Drug delivery systems for the oral administration of antimicrobial peptides: promising tools to treat infectious diseases","volume":"3","author":"Deshayes","year":"2022","journal-title":"Front. Med. Technol."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.peptides.2013.11.020","article-title":"Antimicrobial and anti-biofilm effect of Bac8c on major bacteria associated with dental caries and streptococcus mutans biofilms","volume":"52","author":"Ding","year":"2014","journal-title":"Peptides"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"2994","DOI":"10.1128\/AAC.06327-11","article-title":"Strand length-dependent antimicrobial activity and membrane-active mechanism of arginine- and valine-rich \u03b2-hairpin-like antimicrobial peptides","volume":"56","author":"Dong","year":"2012","journal-title":"Antimicrob. 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Rev."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"e00037-22","DOI":"10.1128\/mmbr.00037-22","article-title":"Antimicrobial peptides and small molecules targeting the cell membrane of Staphylococcus aureus","volume":"87","author":"Ganesan","year":"2023","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"9388","DOI":"10.1038\/srep09388","article-title":"Hydrophobic mismatch demonstrated for membranolytic peptides and their use as molecular rulers to measure bilayer thickness in native cells","volume":"5","author":"Grau-Campistany","year":"2015","journal-title":"Sci. Rep."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"e47722","DOI":"10.1371\/journal.pone.0047722","article-title":"Beyond Streptococcus mutans: dental caries onset linked to multiple species by 16S rRNA community analysis","volume":"7","author":"Gross","year":"2012","journal-title":"PLoS One"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"7569","DOI":"10.1073\/pnas.1506207112","article-title":"Precision-guided antimicrobial peptide as a targeted modulator of human microbial ecology","volume":"112","author":"Guo","year":"2015","journal-title":"Proc. Natl. Acad. Sci."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/j.bbrc.2020.10.095","article-title":"TVH-19, a synthetic peptide, induces mineralization of dental pulp cells in vitro and formation of tertiary dentin in vivo","volume":"534","author":"Han","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"6545","DOI":"10.1021\/bi0273563","article-title":"Mechanism of lipid bilayer disruption by the human antimicrobial peptide, LL-37","volume":"42","author":"Henzler Wildman","year":"2003","journal-title":"Biochemistry"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1016\/j.colsurfb.2016.02.003","article-title":"Role of amphipathicity and hydrophobicity in the balance between hemolysis and peptide\u2013membrane interactions of three related antimicrobial peptides","volume":"141","author":"Hollmann","year":"2016","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1007\/s00784-024-06139-7","article-title":"Constructing two bifunctional tooth-targeting antimicrobial peptides for caries management: an in vitro study","volume":"29","author":"Hu","year":"2024","journal-title":"Clin. Oral Investig."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"104552","DOI":"10.1016\/j.jdent.2023.104552","article-title":"Dynamic killing effectiveness of mouthrinses and a D-enantiomeric peptide on oral multispecies biofilms grown on dental restorative material surfaces","volume":"134","author":"Hu","year":"2023","journal-title":"J. Dent."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1021\/acs.jpcb.8b10864","article-title":"Impacts of the terminal charged residues on polyproline conformation","volume":"123","author":"Huang","year":"2019","journal-title":"J. Phys. Chem. B"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"104596","DOI":"10.1016\/j.jdent.2023.104596","article-title":"Amyloid hexapeptide prevent dental caries by antibiofilm formation","volume":"135","author":"Huang","year":"2023","journal-title":"J. Dent."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1886","DOI":"10.3892\/etm.2017.5631","article-title":"Selective activities of STAMPs against streptococcus mutans","volume":"15","author":"Huo","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"e0175483","DOI":"10.1371\/journal.pone.0175483","article-title":"Streptococcal adhesin SspA\/B analogue peptide inhibits adherence and impacts biofilm formation of streptococcus mutans","volume":"12","author":"Ito","year":"2017","journal-title":"PLoS One"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"103546","DOI":"10.1016\/j.micpath.2019.103546","article-title":"Antimicrobial peptides Pep19-2.5 and Pep19-4LF inhibit streptococcus mutans growth and biofilm formation","volume":"133","author":"Jannadi","year":"2019","journal-title":"Microb. Pathog."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"3176","DOI":"10.1021\/acsinfecdis.4c00107","article-title":"Cocktail approach with polyserotonin nanoparticles and peptides for treatment of streptococcus mutans","volume":"10","author":"Jeon","year":"2024","journal-title":"ACS Infect. Dis."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1093\/abbs\/gmx091","article-title":"D-amino acid substitution enhances the stability of antimicrobial peptide polybia-CP","volume":"49","author":"Jia","year":"2017","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1159\/000508458","article-title":"The pH-responsive property of antimicrobial peptide GH12 enhances its anticaries effects at acidic pH","volume":"55","author":"Jiang","year":"2021","journal-title":"Caries Res."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1002\/bip.20911","article-title":"Effects of net charge and the number of positively charged residues on the biological activity of amphipathic \u03b1-helical cationic antimicrobial peptides","volume":"90","author":"Jiang","year":"2008","journal-title":"Biopolymers"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"e12887","DOI":"10.1111\/eos.12887","article-title":"Development and evaluation of a chewing gum containing antimicrobial peptide GH12 for caries prevention","volume":"130","author":"Jiang","year":"2022","journal-title":"Eur. J. Oral Sci."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"e00527-20","DOI":"10.1128\/AEM.00527-20","article-title":"Antimicrobial peptide GH12 prevents dental caries by regulating dental plaque microbiota","volume":"86","author":"Jiang","year":"2020","journal-title":"Appl. Environ. Microbiol."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"e01423","DOI":"10.1128\/AEM.01423-18","article-title":"Effects of antimicrobial peptide GH12 on the cariogenic properties and composition of a cariogenic multispecies biofilm","volume":"84","author":"Jiang","year":"2018","journal-title":"Appl. Environ. Microbiol."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"2159375","DOI":"10.1080\/20002297.2022.2159375","article-title":"Targeting cariogenic pathogens and promoting competitiveness of commensal bacteria with a novel pH-responsive antimicrobial peptide","volume":"15","author":"Jiang","year":"2023","journal-title":"J. Oral Microbiol."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"1267389","DOI":"10.3389\/fmicb.2023.1267389","article-title":"Antimicrobial peptide temporin derivatives inhibit biofilm formation and virulence factor expression of streptococcus mutans","volume":"14","author":"Jiang","year":"2023","journal-title":"Front. Microbiol."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"26236","DOI":"10.1021\/acs.jafc.4c09488","article-title":"Temporin-derived peptides disrupt the exopolysaccharide matrix of streptococcus mutans to prevent related dental caries","volume":"72","author":"Jiang","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1177\/154405910708600507","article-title":"Self-assembling peptide scaffolds promote enamel remineralization","volume":"86","author":"Kirkham","year":"2007","journal-title":"J. Dent. Res."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.tips.2019.04.012","article-title":"The vast structural diversity of antimicrobial peptides","volume":"40","author":"Koehbach","year":"2019","journal-title":"Trends Pharmacol. Sci."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.3390\/microorganisms9061249","article-title":"Comparison of a short linear antimicrobial peptide with its disulfide-cyclized and cyclotide-grafted variants against clinically relevant pathogens","volume":"9","author":"Koehbach","year":"2021","journal-title":"Microorganisms"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"e2517944122","DOI":"10.1073\/pnas.2517944122","article-title":"Structural pores not required: antimicrobial peptides induce ion permeabilization of lipid membranes through transient water channels","volume":"122","author":"Koynarev","year":"2025","journal-title":"Proc. Natl. Acad. Sci."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"e02340-16","DOI":"10.1128\/AAC.02340-16","article-title":"Intracellular targeting mechanisms by antimicrobial peptides","volume":"61","author":"Le","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"01","DOI":"10.3389\/fnins.2017.00073","article-title":"Membrane active antimicrobial peptides: translating mechanistic insights to design","volume":"11","author":"Li","year":"2017","journal-title":"Front. 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