{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T12:14:26Z","timestamp":1788524066742,"version":"build-2803163510"},"reference-count":58,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    Methicillin-resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (MRSA) infections remain a major public health challenge because of limited therapeutic options and the increasing prevalence of multidrug resistance. In this study, carrier-free quercetin-zinc supramolecular assemblies (Qct-Zn NPs) were fabricated through coordination-associated self-assembly and characterized using TEM, UV-Vis spectroscopy, FTIR, DLS, XPS, and zeta potential analyses. Qct-Zn NPs exhibited potent antibacterial activity against multiple MRSA clinical isolates, with enhanced efficacy compared with quercetin or ZnSO\n                    <jats:sub>4<\/jats:sub>\n                    alone. Time-kill assays demonstrated rapid bactericidal activity, while biofilm assays revealed significant inhibition of biofilm formation and reduction of viable bacteria within mature MRSA biofilms. Mechanistic investigations suggested that Qct-Zn NP treatment was associated with membrane-associated ultrastructural changes, altered intracellular ATP levels, and ROS-associated responses.\n                    <jats:italic>In vivo<\/jats:italic>\n                    studies using murine systemic MRSA infection models showed that Qct-Zn NPs reduced bacterial burdens and systemic inflammatory responses while improving survival outcomes. Importantly, antibacterial efficacy was retained when treatment initiation was delayed to 6 h post-infection under the tested experimental conditions. Together with their favorable hemocompatibility and low cytotoxicity, these findings demonstrate that coordination-driven self-assembly of natural flavonoids and biocompatible metal ions represents a potential strategy for developing antimicrobial materials against drug-resistant staphylococcal infections.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2026.1908591","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:18:05Z","timestamp":1788520685000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Self-assembled quercetin-zinc supramolecular nanoparticles exhibit strong antibacterial and anti-biofilm activity against methicillin-resistant Staphylococcus aureus"],"prefix":"10.3389","volume":"17","author":[{"given":"Ying","family":"Chen","sequence":"first","affiliation":[{"name":"Clinical Research Center, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine","place":["Nanjing, China"]},{"name":"Department of Pharmacy, Nanjing University of Chinese Medicine","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu-Zhen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Tuberculosis, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Xiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Clinical Research Center, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le-Le","family":"Xiong","sequence":"additional","affiliation":[{"name":"Clinical Research Center, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Yu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion, The Second Affiliated Hospital of Nanchang University","place":["Nanchang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Ming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Provincial Key Laboratory of Biotechnology, College of Life Sciences, Northwest University","place":["Xi'an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Xuan","family":"Cui","sequence":"additional","affiliation":[{"name":"Clinical Research Center, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Peng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Nanjing University of Chinese Medicine","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bai-Ling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion, The Second Affiliated Hospital of Nanchang University","place":["Nanchang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Clinical Research Center, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1002\/ptr.7352","article-title":"O-Glycoside quercetin derivatives: biological activities, mechanisms of action, and structure-activity relationship for drug design, a review","volume":"36","author":"Alizadeh","year":"2022","journal-title":"Phytother. 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