{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T06:27:13Z","timestamp":1786602433970,"version":"build-2736575974"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Taraxacum mongolicum<\/jats:italic>\n                      Hand.-Mazz. is rich in dietary fiber and has been reported to exhibit hypoglycemic activity. This study investigated the effects of lactic acid bacteria (LAB)-fermented dandelion Jiangshui (JS) on glucose metabolism and pancreatic and renal histopathology in hyperglycemic mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Lactiplantibacillus plantarum<\/jats:italic>\n                      A1 and\n                      <jats:italic>Lacticaseibacillus paracasei<\/jats:italic>\n                      strains A3 and L2, previously isolated from traditional JS by our research team, were used to prepare dandelion JS by fermentation. Forty-five 5-week-old male C57BL\/6 mice were randomly assigned to a normal control group, a model group, and a JS intervention group. Mice in the JS group received LAB-fermented dandelion JS by gavage, whereas mice in the other groups received an equal volume of normal saline for 14 consecutive weeks. Body weight, glucose-related biochemical indicators, and pancreatic and renal histopathology were monitored throughout the experiment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with the model group, the JS group showed attenuated increases in blood glucose, higher levels of the anti-inflammatory cytokine IL-10, increased hepatic antioxidant enzyme activities, including glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and catalase (CAT), lower malondialdehyde (MDA) content, and less severe pancreatic and renal lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>These findings suggest that LAB-fermented dandelion JS may have potential to improve glucose regulation and alleviate inflammation, oxidative stress, and pancreatic and renal injury in hyperglycemic mice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmicb.2026.1910064","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T05:33:17Z","timestamp":1786599197000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of lactic acid bacteria-fermented dandelion Jiangshui on blood glucose levels in hyperglycemic mice"],"prefix":"10.3389","volume":"17","author":[{"given":"Xian-Gang","family":"Meng","sequence":"first","affiliation":[{"name":"Department of Bioengineering, School of Biological and Pharmaceutical Engineering, Lanzhou Jiaotong University","place":["Lanzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-ni","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, School of Biological and Pharmaceutical Engineering, Lanzhou Jiaotong University","place":["Lanzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, School of Biological and Pharmaceutical Engineering, Lanzhou Jiaotong University","place":["Lanzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-kai","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, School of Biological and Pharmaceutical Engineering, Lanzhou Jiaotong University","place":["Lanzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, School of Biological and Pharmaceutical Engineering, Lanzhou Jiaotong University","place":["Lanzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, School of Biological and Pharmaceutical Engineering, Lanzhou Jiaotong University","place":["Lanzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuan-Jie","family":"Che","sequence":"additional","affiliation":[{"name":"Innovation Center of Functional Genomics and Molecular Diagnostics Technology of Gansu Province, Engineering Laboratory for Biochips of Gansu Province","place":["Lanzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Wen","family":"Gui","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, School of Biological and Pharmaceutical Engineering, Lanzhou Jiaotong University","place":["Lanzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"ref19","doi-asserted-by":"publisher","first-page":"18","DOI":"10.7324\/JAPS.2023.142387","article-title":"Lactic acid bacteria fermented foods: Impact on immune system and consequences over type 2 diabetes mellitus","volume":"13","author":"Ahmad","year":"2023","journal-title":"J. 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