{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T06:27:25Z","timestamp":1787120845022,"version":"build-2736575974"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to characterize the effects of Xiaoqinglong decoction (XQLD) on the microbiota of the gut\u2013lung axis at three key sites\u2014the nasal cavity, lungs, and gut\u2014in Allergic rhinitis (AR) mice, with particular attention to site-specific response patterns and their potential links to AR disease resolution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An ovalbumin-induced AR mouse model was established, with mice assigned to control, AR, loratadine, and XQLD groups. Intervention outcomes were assessed via behavioral observation, ELISA, histopathology, and 16S rRNA gene sequencing, followed by correlation analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with the AR group, XQLD significantly reduced nasal symptoms, serum OVA-sIgE and IL-4 levels, and nasal mucosal injury. AR induction markedly altered the nasal and gut microbiota, whereas the lung microbiota remained relatively stable. XQLD significantly increased nasal\n                      <jats:italic>Oxalobacteraceae<\/jats:italic>\n                      and significantly decreased gut\n                      <jats:italic>Rikenellaceae<\/jats:italic>\n                      and\n                      <jats:italic>Odoribacter<\/jats:italic>\n                      . Gut\n                      <jats:italic>Lactobacillaceae<\/jats:italic>\n                      ,\n                      <jats:italic>Lactobacillus<\/jats:italic>\n                      , and\n                      <jats:italic>Allobaculum<\/jats:italic>\n                      showed upward trends, whereas\n                      <jats:italic>Helicobacter<\/jats:italic>\n                      showed a slight downward trend. Several nasal and gut taxa were significantly associated with nasal symptoms and Th2-related inflammatory indicators.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>XQLD differentially modulates the gut\u2013lung axis microbiota in AR mice, with the most marked changes observed in the gut, which may correlate with its therapeutic effects and merit further mechanistic exploration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmicb.2026.1917709","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T05:45:25Z","timestamp":1787118325000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Xiaoqinglong decoction on gut\u2013lung axis microbiota in allergic rhinitis mice"],"prefix":"10.3389","volume":"17","author":[{"given":"Jie","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Medicine, Jishou University","place":["Jishou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Medicine, Jishou University","place":["Jishou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang-Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Medicine, Jishou University","place":["Jishou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ling","family":"Mao","sequence":"additional","affiliation":[{"name":"School of Medicine, Jishou University","place":["Jishou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luo-Qin","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Medicine, Jishou University","place":["Jishou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-Lan","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Medicine, Jishou University","place":["Jishou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gan-Long","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Medicine, Jishou University","place":["Jishou, China"]},{"name":"People\u2019s Hospital of Jishou City","place":["Jishou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"863779","DOI":"10.3389\/fcimb.2022.863779","article-title":"Mechanisms by which traditional Chinese medicines influence the Intestinal Flora and Intestinal barrier","volume":"12","author":"Che","year":"2022","journal-title":"Front. 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