{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:09:51Z","timestamp":1789564191047,"version":"build-2803163510"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    Chemical investigation of\n                    <jats:italic>Streptomyces<\/jats:italic>\n                    sp. YD248 led to the isolation of utahmycin C (\n                    <jats:bold>1<\/jats:bold>\n                    ), a new glycosylated member of the rare bacterial 1,3-dimethyl-2-azaanthraquinone family. Its structure was established by NMR spectroscopy and high-resolution mass spectrometry, revealing a\n                    <jats:italic>\u03b2<\/jats:italic>\n                    -D-glucuronic acid substituent attached to the azaanthraquinone core. Unusual long-range\n                    <jats:italic>\n                      <jats:sup>5<\/jats:sup>\n                      J\n                    <\/jats:italic>\n                    HMBC correlations prompted validation by density functional theory (DFT) through NMR chemical shift calculations, which showed excellent agreement with the experimental data. Bioinformatics analysis identified a biosynthetic gene cluster (BGC) homologous to the reported Erd gene cluster associated with utahmycin A biosynthesis. This study expands the structural diversity of bacterial azaanthraquinones.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2026.1921234","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:49:06Z","timestamp":1789562946000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Utahmycin C, a new glycosylated derivative of a rare azaanthraquinone produced by Streptomyces sp. YD248"],"prefix":"10.3389","volume":"17","author":[{"given":"Fatemeh M.","family":"Tajabadi","sequence":"first","affiliation":[{"name":"School of Medical Sciences, Faculty of Medicine and Health, University of Sydney","place":["Sydney, NSW, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Piggott","sequence":"additional","affiliation":[{"name":"School of Natural Sciences, Macquarie University","place":["Sydney, NSW, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Errington","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, Faculty of Medicine and Health, University of Sydney","place":["Sydney, NSW, Australia"]},{"name":"Sydney Infectious Diseases Institute, University of Sydney","place":["Sydney, NSW, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousef","family":"Dashti","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, Faculty of Medicine and Health, University of Sydney","place":["Sydney, NSW, Australia"]},{"name":"Sydney Infectious Diseases Institute, University of Sydney","place":["Sydney, NSW, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"3346","DOI":"10.1016\/j.tetlet.2012.04.073","article-title":"Katorazone, a new yellow pigment with a 2-azaquinone-phenylhydrazone structure produced by Streptomyces sp. 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