{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T06:01:52Z","timestamp":1789970512166,"version":"4.0.1"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Inroduction<\/jats:title>\n                    <jats:p>\n                      Emerging evidence links fecal\n                      <jats:italic>Desulfovibrio<\/jats:italic>\n                      (DSV) abundance with Parkinson\u2019s disease (PD) severity. While probiotics may relieve symptoms, their direct effects on DSV remain unexplored.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study evaluated the inhibitory potential of 32 probiotic and potential probiotic strains against three DSV strains isolated from three individual PD patients. Antimicrobial activity was quantified using agar well diffusion and microplate assays, and the operational minimum inhibitory con centration (MIC\u2089\u2080) was determined based on the total crude dry matter content of cell-free supernatants (CFS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All tested lactic acid bacteria (LAB) strains, except\n                      <jats:italic>Limosilactobacillus reuteri<\/jats:italic>\n                      Hambi410, inhibited DSV. Quantitative micro assay results showed that\n                      <jats:italic>Lacticaseibacillus rhamnosus<\/jats:italic>\n                      LGG exhibited the highest inhibition (up to 44.82% \u00b1 8.31%) after neutralization and catalase treatment. Among the eight tested\n                      <jats:italic>Bifidobacterium<\/jats:italic>\n                      strains,\n                      <jats:italic>Bifidobacterium bifidum<\/jats:italic>\n                      CUL-17 and\n                      <jats:italic>Bifidobacterium longum<\/jats:italic>\n                      E-96664 exhibited inhibitory effects comparable to those observed in LAB. The MIC\u2089\u2080 values revealed that\n                      <jats:italic>Lactobacillus acidophilus<\/jats:italic>\n                      Hambi1448 and\n                      <jats:italic>Lactiplantibacillus plantarum<\/jats:italic>\n                      E98 were the most potent, with MIC\u2089\u2080 values ranging from 25.2 to 29.8 mg\/mL. Spearman\u2019s correlation confirmed a significant inverse relationship between initial pH and inhibition zones (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.001). Crucially, analysis of covariance (ANCOVA) demonstrated that strain specific inhibitory variations remained highly significant (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.005) after statistically controlling for the confounding effect of acidification, which is consistent with the involvement of non-acidic bioactive metabolites. Probiotic Bacillus strains showed no direct inhibition but are discussed for their role in alleviating PD-related constipation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>These findings demonstrate that specific probiotics can target PD-derived DSV, offering a novel strategy for microbiome-based PD management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmicb.2026.1925465","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T05:36:43Z","timestamp":1789969003000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeted in vitro suppression of Parkinson\u2019s disease-associated Desulfovibrio by selective probiotic and potential probiotic strains"],"prefix":"10.3389","volume":"17","author":[{"given":"Sima","family":"Talebzadeh","sequence":"first","affiliation":[{"name":"Faculty of Agriculture and Forestry, Department of Microbiology, University of Helsinki","place":["Helsinki, Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per Erik Joakim","family":"Saris","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture and Forestry, Department of Microbiology, University of Helsinki","place":["Helsinki, Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2269","DOI":"10.1128\/AEM.64.6.2269-2272.1998","article-title":"Antagonistic activity of Lactobacillus plantarum C11: two new two-peptide bacteriocins, plantaricins EF and JK, and the induction factor plantaricin a","volume":"64","author":"Anderssen","year":"1998","journal-title":"Appl. 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