{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T13:26:09Z","timestamp":1787232369654,"version":"build-2736575974"},"reference-count":125,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    Intestinal fucosylation, the enzymatic addition of fucose to glycoconjugates, represents a pivotal regulatory mechanism that modulates host\u2013microbiota crosstalk in the gastrointestinal tract. This review comprehensively synthesizes current advances in the molecular mechanisms, multilevel regulatory networks, and functional implications of intestinal mucosal fucosylation. This review focuses on \u03b1(1,2)-fucosylation catalyzed by fucosyltransferase 2 (FUT2)\u2014a reaction that determines the secretor status and modifies critical glycoconjugates, including mucins and human milk oligosaccharides. This review examines the dynamic regulation of epithelial fucosylation by host-derived factors\u2014including immune mediators [notably interleukin-22 (IL-22) secreted by group 3 innate lymphoid cells (ILC3s)], the enteric nervous system (ENS), and microbial signals. Furthermore, this review details how fucosylated glycans shape the gut microbial ecosystem by serving as selective nutrient sources for beneficial symbionts\u2014including\n                    <jats:italic>Bifidobacterium<\/jats:italic>\n                    and\n                    <jats:italic>Bacteroides<\/jats:italic>\n                    species\u2014while concurrently enhancing colonization resistance against enteric pathogens. Dysregulation of this axis is increasingly associated with a spectrum of human pathologies, including inflammatory bowel disease (IBD), metabolic dysfunction, and enteric infections. Finally, this review discusses emerging therapeutic strategies targeting the modulation of intestinal fucosylation and its downstream physiological consequences, with particular emphasis on personalized approaches informed by host genetic determinants\u2014most notably\n                    <jats:italic>FUT2<\/jats:italic>\n                    secretor status.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2026.1926158","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T12:42:16Z","timestamp":1787229736000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["FUT2-mediated intestinal fucosylation: a master regulator of host-microbiota symbiosis in health and disease"],"prefix":"10.3389","volume":"17","author":[{"given":"Lifen","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, The Second Hospital of Dalian Medical University, Dalian","place":["Liaoning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nianzhu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The Second Hospital of Dalian Medical University, Dalian","place":["Liaoning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2164152","DOI":"10.1080\/19490976.2022.2164152","article-title":"Human milk oligosaccharides, antimicrobial drugs, and the gut microbiota of term neonates: Observations from the KOALA birth cohort study.","volume":"15","author":"Barnett","year":"2023","journal-title":"Gut Microbes"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1093\/glycob\/cwt045","article-title":"Mucin-type O-glycans and their roles in intestinal homeostasis.","volume":"23","author":"Bergstrom","year":"2013","journal-title":"Glycobiology"},{"key":"B3","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1126\/science.aay7367","article-title":"Proximal colon-derived O-glycosylated mucus encapsulates and modulates the microbiota.","volume":"370","author":"Bergstrom","year":"2020","journal-title":"Science"},{"key":"B4","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1093\/glycob\/cwab105","article-title":"How microbial glycosyl hydrolase activity in the gut mucosa initiates microbial cross-feeding.","volume":"32","author":"Berkhout","year":"2022","journal-title":"Glycobiology"},{"key":"B5","doi-asserted-by":"publisher","first-page":"e0068621","DOI":"10.1128\/mSphere.00686-21","article-title":"The Influence of FUT2 and FUT3 polymorphisms and nasopharyngeal microbiome on respiratory infections in breastfed Bangladeshi infants from the microbiota and health study.","volume":"6","author":"Binia","year":"2021","journal-title":"mSphere"},{"key":"B6","doi-asserted-by":"publisher","first-page":"e0020025","DOI":"10.1128\/spectrum.00200-25","article-title":"Proteomic and N-glycomic comparison of synthetic and bovine whey proteins and their effect on human gut microbiomes in vitro.","volume":"13","author":"Bolino","year":"2025","journal-title":"Microbiol. 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