{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T12:08:17Z","timestamp":1788782897948,"version":"build-2803163510"},"reference-count":73,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with depression exhibit significant gut microbiota dysbiosis; however, visualized studies into dysbiosis-related microbial signatures in depression remain limited. To identify characteristic differential genera in depressed individuals, this study adopted a knowledge graph\u2013based visualization analysis to clarify the associations between intestinal microbial dysbiosis and depression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A search strategy was constructed and literature searches were conducted in 7 databases, including Web of Science, PubMed, Scopus, Cochrane Library, CNKI, Wanfang Database and VIP Net (VIP). The search cutoff date was April 1, 2026. The included literature was strictly screened according to the PRISMA guidelines. EndNote 25 was used to sort and trace the literature meeting the inclusion criteria. GRADE system, Cochrane ROB2.0, and JBI scale were used for quality evaluation and evidence grading of RCTs and cross-sectional studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 159 valid studies from 21 countries were ultimately included, involving 25310 patients with depression. The bacterial community taxa predominantly consisted of\n                      <jats:italic>Bacillota, Bacteroidota<\/jats:italic>\n                      , and\n                      <jats:italic>Actinomycetota<\/jats:italic>\n                      , among which\n                      <jats:italic>Bacillota<\/jats:italic>\n                      was overwhelmingly dominant.\n                      <jats:italic>Ascomycota<\/jats:italic>\n                      predominated within the fungal community. For bacteria, 73 genera including\n                      <jats:italic>Faecalibacterium<\/jats:italic>\n                      and\n                      <jats:italic>Butyricicoccus<\/jats:italic>\n                      , alongside 66 species such as\n                      <jats:italic>Levilactobacillus brevis<\/jats:italic>\n                      and\n                      <jats:italic>Bifidobacterium animalis<\/jats:italic>\n                      , exhibited depleted abundances. Such reductions were linked to diminished production of butyrate-producing commensal beneficial bacteria. 43 genera (e.g.,\n                      <jats:italic>Escherichia<\/jats:italic>\n                      and\n                      <jats:italic>Coprobacillus<\/jats:italic>\n                      ) and 21 species (including\n                      <jats:italic>Escherichia-Shigella<\/jats:italic>\n                      and\n                      <jats:italic>Clostridium bolteae<\/jats:italic>\n                      ) belonging to pro-inflammatory and pathogenic microbes showed elevated levels. 25 genera represented bidirectionally altered taxa with both increased and decreased abundances, exemplified by\n                      <jats:italic>Bifidobacterium<\/jats:italic>\n                      and\n                      <jats:italic>Bacteroides<\/jats:italic>\n                      . Regarding fungi, 16 taxa including\n                      <jats:italic>Aureobasidium<\/jats:italic>\n                      and\n                      <jats:italic>Saccharomyces cerevisiae boulardii<\/jats:italic>\n                      were less abundant, whereas 10 taxa such as\n                      <jats:italic>Candida<\/jats:italic>\n                      and\n                      <jats:italic>Saccharomyces<\/jats:italic>\n                      had higher abundances.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Dysbiosis in patients with depression was characterized by markedly decreased abundances of protective microbes including\n                      <jats:italic>Faecalibacterium<\/jats:italic>\n                      and\n                      <jats:italic>Aureobasidium<\/jats:italic>\n                      , accompanied by concurrent enrichment of pathogenic bacteria such as\n                      <jats:italic>Escherichia<\/jats:italic>\n                      and\n                      <jats:italic>Candida<\/jats:italic>\n                      in the gut. Taxa exhibiting bidirectional abundance shifts may be affected by confounders including age and gender, which requires further high quality clinical validation. Targeted modulation of disrupted microbiota, development of strain-specific biologics, and species-level profiling of microbial variations will enhance the therapeutic benefits of microecological preparations for depression adjuvant treatment.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmicb.2026.1937281","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:19:15Z","timestamp":1788779955000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Characteristics of gut microbiota dysbiosis in patients with depression: a visual analysis of knowledge maps"],"prefix":"10.3389","volume":"17","author":[{"given":"Chenggui","family":"Xu","sequence":"first","affiliation":[{"name":"The Second Clinical Medical School, Yunnan University of Chinese Medicine","place":["Kunming, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouyao","family":"Zhang","sequence":"additional","affiliation":[{"name":"The First Clinical Medical School, Yunnan University of Chinese Medicine","place":["Kunming, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Liao","sequence":"additional","affiliation":[{"name":"The Second Clinical Medical School, Yunnan University of Chinese Medicine","place":["Kunming, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Exian","family":"Shan","sequence":"additional","affiliation":[{"name":"The Second Clinical Medical School, Yunnan University of Chinese Medicine","place":["Kunming, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengbin","family":"Zhao","sequence":"additional","affiliation":[{"name":"The Second Clinical Medical School, Yunnan University of Chinese Medicine","place":["Kunming, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruilu","family":"Liu","sequence":"additional","affiliation":[{"name":"The Second Clinical Medical School, Yunnan University of Chinese Medicine","place":["Kunming, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Wang","sequence":"additional","affiliation":[{"name":"The Second Clinical Medical School, Yunnan University of Chinese Medicine","place":["Kunming, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjie","family":"Yin","sequence":"additional","affiliation":[{"name":"The Second Clinical Medical School, Yunnan University of Chinese Medicine","place":["Kunming, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiantao","family":"Tai","sequence":"additional","affiliation":[{"name":"The Second Clinical Medical School, Yunnan University of Chinese Medicine","place":["Kunming, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghe","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Second Clinical Medical School, Yunnan University of Chinese Medicine","place":["Kunming, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.jad.2016.05.038","article-title":"Possible association of Bifidobacterium and Lactobacillus in the gut microbiota of patients with major depressive disorder.","volume":"202","author":"Aizawa","year":"2016","journal-title":"J. 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