{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:11:23Z","timestamp":1790143883931,"version":"4.0.1"},"reference-count":66,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Jilin Provincial Scientific and Technological Development Program of China","award":["YDZJ202401538ZYTS"],"award-info":[{"award-number":["YDZJ202401538ZYTS"]}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Insectivorous bats consume insects that are rich in proteins and chitin, which may impose specific requirements on microbial-mediated nutrient transformation. However, the composition and functional potential of their gut microbiota remain poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this study, the greater horseshoe bat (\n                      <jats:italic>Rhinolophus ferrumequinum<\/jats:italic>\n                      ), a Chiropteran species belonging to the family Rhinolophidae, was investigated to characterize fecal microbial communities and fecal metabolic profiles through the integration of 16S rRNA gene sequencing and untargeted metabolomics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The fecal microbiota of\n                      <jats:italic>Rhinolophus ferrumequinum<\/jats:italic>\n                      exhibited diverse bacterial communities, with\n                      <jats:italic>Lactococcus<\/jats:italic>\n                      ,\n                      <jats:italic>Fusobacterium<\/jats:italic>\n                      , and\n                      <jats:italic>Enterococcus<\/jats:italic>\n                      as dominant genera, collectively accounting for approximately 45% of the total bacterial relative abundance. Functional prediction suggested enrichment of pathways involved in lipid and amino acid metabolism, particularly tryptophan and tyrosine metabolism. Correlation analysis further identified associations between several bacterial genera, including\n                      <jats:italic>Acinetobacter<\/jats:italic>\n                      ,\n                      <jats:italic>Serratia<\/jats:italic>\n                      ,\n                      <jats:italic>Fusobacterium<\/jats:italic>\n                      , and\n                      <jats:italic>Mycoplasma<\/jats:italic>\n                      , and lipid-related metabolites, particularly acylcarnitines and bile acid-associated metabolites.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      These findings characterize a distinct microbiota\u2013metabolite profile in\n                      <jats:italic>Rhinolophus ferrumequinum<\/jats:italic>\n                      and suggest that gut microbial communities may contribute to metabolic adaptation in insectivorous bats.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmicb.2026.1938216","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:49:09Z","timestamp":1790142549000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Functional potential of gut microbiota in Rhinolophus ferrumequinum revealed by 16S rRNA sequencing and metabolomics"],"prefix":"10.3389","volume":"17","author":[{"given":"Boyu","family":"Liu","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Jilin Agricultural Science and Technology College","place":["Jilin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinlei","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Life Science, Jilin Agricultural University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alimire","family":"Tulake","sequence":"additional","affiliation":[{"name":"College of Life Science, Jilin Agricultural University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghan","family":"Tian","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Jilin Agricultural University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Jilin Agricultural Science and Technology College","place":["Jilin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujia","family":"Chu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Jilin Agricultural Science and Technology College","place":["Jilin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Jilin Agricultural Science and Technology College","place":["Jilin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tai","family":"Song","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Jilin Agricultural Science and Technology College","place":["Jilin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Feng","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Jilin Agricultural University","place":["Changchun, China"]},{"name":"Jilin Provincial Key Laboratory of Animal Resource and Ecological Security, Jilin Agricultural University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/s42523-021-00137-w","article-title":"The role of the gut microbiota in the dietary niche expansion of fishing bats","volume":"3","author":"Aizpurua","year":"2021","journal-title":"Animal Microbiome"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"3303","DOI":"10.3390\/ani14223303","article-title":"Learning to hunt on the go: dietary changes during development of Rhinolophid bats","volume":"14","author":"Aldasoro","year":"2024","journal-title":"Animals"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"12","DOI":"10.5141\/jee.23.060","article-title":"Bacterial communities in the feces of insectivorous bats in South Korea","volume":"48","author":"An","year":"2024","journal-title":"J. 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