{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T14:02:46Z","timestamp":1789740166079,"version":"4.0.1"},"reference-count":76,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Bacterial infection seriously restricts the healthy culture of Monopterus albus.\n                      <jats:italic>Scutellaria baicalensis<\/jats:italic>\n                      extract (SBE) is a natural plant\u2011derived additive with antioxidant and anti\u2011inflammatory properties. This study aimed to evaluate the effects of dietary SBE supplementation on growth performance, intestinal health, gut microbiota and resistance against\n                      <jats:italic>Aeromonas hydrophila<\/jats:italic>\n                      infection in juvenile Asian swamp eel.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A 60\u2011day feeding trial was performed. Five diets were formulated with 0%, 0.5%, 1%, 2% and 3% SBE (CK, SBE\u2011A, SBE\u2011B, SBE\u2011C, SBE\u2011D). Growth indices, intestinal antioxidant status, intestinal histology, gut microbiota were detected. An\n                      <jats:italic>A. hydrophila<\/jats:italic>\n                      challenge test was carried out, followed by transcriptome analysis and qRT\u2011PCR verification of inflammation\u2011 and apoptosis\u2011related genes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Supplementation with 0.5% and 1% SBE significantly improved final body weight, weight gain rate and specific growth rate, and decreased feed conversion ratio. SBE increased intestinal GSH, SOD, T\u2011AOC and reduced MDA; antioxidant\u2011related genes (\n                      <jats:italic>CAT<\/jats:italic>\n                      ,\n                      <jats:italic>GSH<\/jats:italic>\n                      ,\n                      <jats:italic>SOD<\/jats:italic>\n                      ,\n                      <jats:italic>Keap1<\/jats:italic>\n                      ) were markedly up\u2011regulated in the 1% SBE group. SBE optimized intestinal villus morphology, raised gut microbial diversity and the relative abundance of\n                      <jats:italic>Cetobacterium<\/jats:italic>\n                      , and decreased potential pathogens (\n                      <jats:italic>Plesiomonas<\/jats:italic>\n                      ,\n                      <jats:italic>Brevinema<\/jats:italic>\n                      ). After bacterial challenge, SBE improved survival rate, lowered tissue bacterial load and partially restored tight\u2011junction gene expression. Transcriptomics identified 5216 differentially expressed genes linked to inflammation, oxidative stress, metabolism and intestinal barrier. qRT\u2011PCR confirmed that dietary SBE regulated the expression of inflammatory and apoptotic genes induced by infection. Under current conditions, 1% dietary SBE produced the optimal beneficial effects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      In summary, dietary SBE could enhance growth performance, maintain intestinal homeostasis and improve resistance to\n                      <jats:italic>A. hydrophila<\/jats:italic>\n                      in juvenile\n                      <jats:italic>M. albus<\/jats:italic>\n                      . 1% is the recommended supplemental level in this trial.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmicb.2026.1940498","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T13:13:52Z","timestamp":1789737232000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Dietary Scutellaria baicalensis extract enhances growth, intestinal health, and resistance to Aeromonas hydrophila in juvenile Asian swamp eel (Monopterus albus)"],"prefix":"10.3389","volume":"17","author":[{"given":"Yingbing","family":"Su","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Yangtze University","place":["Jingzhou, Hubei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinuo","family":"Gong","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Yangtze University","place":["Jingzhou, Hubei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Liu","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Veterinary Chinese Medicine and Animal Health, College of Animal Science, Fujian Agriculture and Forestry University","place":["Fuzhou, Fujian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haishan","family":"Cheng","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Yangtze University","place":["Jingzhou, Hubei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongtao","family":"Liao","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Yangtze University","place":["Jingzhou, Hubei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyan","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Yangtze University","place":["Jingzhou, Hubei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumeng","family":"Ban","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Yangtze University","place":["Jingzhou, Hubei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pupu","family":"Yan","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Yangtze University","place":["Jingzhou, Hubei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwei","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Yangtze University","place":["Jingzhou, Hubei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiqin","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Yangtze University","place":["Jingzhou, Hubei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"7671","DOI":"10.1007\/s10499-024-01535-y","article-title":"Aquaculture and Aeromonas hydrophila: a complex interplay of environmental factors and virulence","volume":"32","author":"Abdella","year":"2024","journal-title":"Aquac. Int."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1016\/0006-2952(89)90410-3","article-title":"Chelating and free radical scavenging mechanisms of inhibitory action of rutin and quercetin in lipid peroxidation","volume":"38","author":"Afanas'ev","year":"1989","journal-title":"Biochem. Pharmacol."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/nature18849","article-title":"Interactions between the microbiota and pathogenic bacteria in the gut","volume":"535","author":"B\u00e4umler","year":"2016","journal-title":"Nature"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"735287","DOI":"10.1016\/j.aquaculture.2020.735287","article-title":"Selection on a plant-based diet reveals changes in oral tolerance, microbiota and growth in rainbow trout (Oncorhynchus mykiss) when fed a high soy diet","volume":"525","author":"Blaufuss","year":"2020","journal-title":"Aquaculture"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"744020","DOI":"10.1016\/j.aquaculture.2026.744020","article-title":"Bioprocessed plant protein diets enriched with hydrolyzed microalgae-grape marc extracts improve growth and welfare in Sparus aurata juveniles","volume":"621","author":"Caderno","year":"2026","journal-title":"Aquaculture"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"761981","DOI":"10.3389\/fimmu.2021.761981","article-title":"Interaction between commensal Bacteria, immune response and the intestinal barrier in inflammatory bowel disease","volume":"12","author":"Chen","year":"2021","journal-title":"Front. Immunol."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"11908","DOI":"10.1021\/acs.jafc.0c03996","article-title":"Antibiotics and food safety in aquaculture","volume":"68","author":"Chen","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"742463","DOI":"10.1016\/j.aquaculture.2025.742463","article-title":"Effects of dietary fish meal replacement with American cockroach residue on the growth, metabolism, antioxidant capacity, intestinal health, and aquaculture water quality of juvenile rainbow trout","volume":"604","author":"Chen","year":"2025","journal-title":"Aquaculture"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"90","DOI":"10.5713\/ajas.2012.12147","article-title":"Effects of dietary Scutellaria baicalensis extract on growth, feed utilization and challenge test of olive flounder (Paralichthys olivaceus)","volume":"26","author":"Cho","year":"2013","journal-title":"Asian Australas. J. Anim. Sci."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"741399","DOI":"10.1016\/j.aquaculture.2024.741399","article-title":"Effects of dietary fish oil replacement with rice bran oil on growth performance, serum biochemical index, antioxidant capacity, lipid metabolism and inflammatory response of large yellow croaker (Larimichthys crocea) juveniles","volume":"595","author":"Chukwuma","year":"2025","journal-title":"Aquaculture"},{"key":"ref11","first-page":"417","volume-title":"Virulence","author":"Citterio","year":"2015"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.copbio.2021.09.007","article-title":"Zebrafish: a big fish in the study of the gut microbiota","volume":"73","author":"Cornuault","year":"2022","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"6512136","DOI":"10.1155\/2023\/6512136","article-title":"Dietary epigallocatechin-3-gallate (EGCG) improves nonspecific immune response of Chinese rice field eel (Monopterus albus)","author":"Deng","year":"2023","journal-title":"Aquac. Nutr."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"101421","DOI":"10.1016\/j.aqrep.2022.101421","article-title":"Dietary baicalein improves growth performance, antioxidant activity, and intestinal flora of koi carp (Cyprinus carpio)","volume":"27","author":"Du","year":"2022","journal-title":"Aquac. Rep."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/s41401-020-0411-9","article-title":"Baicalin prevents LPS-induced activation of TLR4\/NF-\u03baB p65 pathway and inflammation in mice via inhibiting the expression of CD14","volume":"42","author":"Fu","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.freeradbiomed.2004.04.034","article-title":"Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties","volume":"37","author":"Galati","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"109504","DOI":"10.1016\/j.fsi.2024.109504","article-title":"Transcriptome analysis of host anti-Aeromonas hydrophila infection revealed the pathogenicity of A. hydrophila to American eels (Anguilla rostrata)","volume":"148","author":"Guo","year":"2024","journal-title":"Fish Shellfish Immunol."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"744032","DOI":"10.1016\/j.aquaculture.2026.744032","article-title":"Growth, appetite regulation, intestine health, and functionality of gilthead seabream (Sparus aurata) fed different oilseed-based diets","volume":"622","author":"Guttuso","year":"2026","journal-title":"Aquaculture"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"736506","DOI":"10.1016\/j.aquaculture.2021.736506","article-title":"Effects of dietary soy isoflavone and soy saponin on growth performance, intestinal structure, intestinal immunity and gut microbiota community on rice field eel (Monopterus albus)","volume":"537","author":"Hu","year":"2021","journal-title":"Aquaculture"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"108914","DOI":"10.1016\/j.cbpc.2020.108914","article-title":"Effects of dietary baicalin supplementation on growth performance, antioxidative status and protection against oxidative stress-induced liver injury in GIFT tilapia (Oreochromis niloticus)","volume":"240","author":"Jia","year":"2021","journal-title":"Comp Biochem Physiol C Toxicol Pharmacol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12122095","article-title":"Multi-omics analysis to understand the effects of dietary proanthocyanidins on antioxidant capacity, muscle nutrients, lipid metabolism, and intestinal microbiota in Cyprinus carpio","volume":"12","author":"Jia","year":"2023","journal-title":"Antioxidants"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/j.fsi.2019.01.056","article-title":"Vitamin a deficiency impairs intestinal physical barrier function of fish","volume":"87","author":"Jiang","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s40364-020-00228-x","article-title":"Roles of IFN-\u03b3 in tumor progression and regression: a review","volume":"8","author":"Jorgovanovic","year":"2020","journal-title":"Biomark. Res."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1111\/j.1365-2109.2012.03157.x","article-title":"Effects of dietary inclusion of various concentrations of Scutellaria baicalensis Georgi extract on growth, body composition, serum chemistry and challenge test of far eastern catfish (Silurus asotus)","volume":"44","author":"Kim","year":"2013","journal-title":"Aquac. Res."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"108883","DOI":"10.1016\/j.fsi.2023.108883","article-title":"Baicalin suppressed necroptosis and inflammation against chlorpyrifos toxicity; involving in ER stress and oxidative stress in carp gills","volume":"139","author":"Li","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mib.2017.07.003","article-title":"Dysbiotic proteobacteria expansion: a microbial signature of epithelial dysfunction","volume":"39","author":"Litvak","year":"2017","journal-title":"Curr. Opin. Microbiol."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.fsi.2019.02.064","article-title":"Sodium butyrate supplementation in high-soybean meal diets for turbot (Scophthalmus maximus L.): effects on inflammatory status, mucosal barriers and microbiota in the intestine","volume":"88","author":"Liu","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"104678","DOI":"10.1016\/j.psj.2024.104678","article-title":"Microbiome and metabolome reveal beneficial effects of baicalin on broiler growth performance and intestinal health","volume":"104","author":"Liu","year":"2025","journal-title":"Poult. Sci."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"113563","DOI":"10.1016\/j.ecoenv.2022.113563","article-title":"Difenoconazole causes spleen tissue damage and immune dysfunction of carp through oxidative stress and apoptosis","volume":"237","author":"Liu","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.envpol.2017.01.003","article-title":"Usage, residue, and human health risk of antibiotics in Chinese aquaculture: a review","volume":"223","author":"Liu","year":"2017","journal-title":"Environ. Pollut."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"109618","DOI":"10.1016\/j.fsi.2024.109618","article-title":"LTA and PGN from Bacillus siamensis can alleviate soybean meal-induced enteritis and microbiota dysbiosis in Lateolabrax maculatus","volume":"149","author":"Liu","year":"2024","journal-title":"Fish Shellfish Immunol."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"4132","DOI":"10.1021\/acs.jafc.2c08580","article-title":"New insights into baicalein's effect on chlorpyrifos-induced liver injury in carp: involving macrophage polarization and pyroptosis","volume":"71","author":"Liu","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"101273","DOI":"10.1016\/j.cbd.2024.101273","article-title":"Effects of dietary melatonin supplementation on growth performance and intestinal health of rice field eel (Monopterus albus)","volume":"52","author":"Lv","year":"2024","journal-title":"Comp. Biochem. Physiol. Part D Genomics Proteomics"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.rvsc.2023.04.025","article-title":"Effects of dietary Scutellaria baicalensis extract on growth performance, immune-related genes expression, and resistance against Vibrio parahaemolyticus in white shrimp (Litopenaeus vannamei)","volume":"159","author":"Maurus","year":"2023","journal-title":"Res. Vet. Sci."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1111\/raq.12762","article-title":"Fish disease and intestinal microbiota: a close and indivisible relationship","volume":"15","author":"Medina-F\u00e9lix","year":"2023","journal-title":"Rev. Aquac."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1111\/raq.12706","article-title":"The changing role and definitions of aquaculture for environmental purposes","volume":"15","author":"Mizuta","year":"2023","journal-title":"Rev. Aquac."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s43094-020-00161-8","article-title":"Flavonoids as natural phenolic compounds and their role in therapeutics: an overview","volume":"7","author":"Mutha","year":"2021","journal-title":"Futur J Pharm Sci"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/s41586-021-03308-6","article-title":"A 20-year retrospective review of global aquaculture","volume":"591","author":"Naylor","year":"2021","journal-title":"Nature"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"107354","DOI":"10.1016\/j.fitote.2026.107354","article-title":"Wogonoside: chemistry, pharmacology, and pharmacokinetics","volume":"193","author":"Ni","year":"2026","journal-title":"Fitoterapia"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1016\/j.molcel.2025.01.008","article-title":"SLFN11-mediated ribosome biogenesis impairment induces TP53-independent apoptosis","volume":"85","author":"Ogawa","year":"2025","journal-title":"Mol. Cell"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.cbpc.2005.07.009","article-title":"mRNA expression of antioxidant enzymes (SOD, CAT and GSH-Px) and lipid peroxidative stress in liver of Atlantic salmon (Salmo salar) exposed to hyperoxic water during smoltification","volume":"141","author":"Olsvik","year":"2005","journal-title":"Comp Biochem Physiol C Toxicol Pharmacol"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/j.immuni.2012.03.014","article-title":"JAK and STAT signaling molecules in immunoregulation and immune-mediated disease","volume":"36","author":"O'Shea","year":"2012","journal-title":"Immunity"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"740752","DOI":"10.1016\/j.aquaculture.2024.740752","article-title":"Tilapia lake virus infection disrupts the gut microbiota of red hybrid tilapia (Oreochromis spp.)","volume":"586","author":"Paimeeka","year":"2024","journal-title":"Aquaculture"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/mi.2010.12","article-title":"Host-microbiota interactions within the fish intestinal ecosystem","volume":"3","author":"P\u00e9rez","year":"2010","journal-title":"Mucosal Immunol."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"737129","DOI":"10.1016\/j.aquaculture.2021.737129","article-title":"Micro-encapsulated grape pomace extract (MGPE) as a feed additive improves growth performance, antioxidant capacity, and shifts the gut microbiome of rainbow trout","volume":"544","author":"Pulgar","year":"2021","journal-title":"Aquaculture"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"1615029","DOI":"10.3389\/fmicb.2025.1615029","article-title":"Antibacterial activity of baicalein against Aeromonas hydrophila: in vitro and in vivo evaluation","volume":"16","author":"Qiu","year":"2025","journal-title":"Front. Microbiol."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.aquaculture.2014.05.048","article-title":"Use of plant extracts in fish aquaculture as an alternative to chemotherapy: current status and future perspectives","volume":"433","author":"Reverter","year":"2014","journal-title":"Aquaculture"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1002\/path.2264","article-title":"The role of TLR activation in inflammation","volume":"214","author":"Sabroe","year":"2008","journal-title":"J. Pathol."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"735291","DOI":"10.1016\/j.aquaculture.2020.735291","article-title":"The growth promoting and immunomodulatory effects of a medicinal plant leaf extract obtained from Salvia officinalis and Lippia citriodora in gilthead seabream (Sparus aurata)","volume":"524","author":"Salom\u00f3n","year":"2020","journal-title":"Aquaculture"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"e14088","DOI":"10.1016\/j.heliyon.2023.e14088","article-title":"A review on pathogenicity of Aeromonas hydrophila and their mitigation through medicinal herbs in aquaculture","volume":"9","author":"Semwal","year":"2023","journal-title":"Heliyon"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"357","DOI":"10.32604\/biocell.2022.015958","article-title":"The potential toxic side effects of flavonoids","volume":"46","author":"Tang","year":"2021","journal-title":"Biocell"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.ab.2016.10.021","article-title":"Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: analytical and biological challenges","volume":"524","author":"Tsikas","year":"2017","journal-title":"Anal. Biochem."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1038\/nature05414","article-title":"An obesity-associated gut microbiome with increased capacity for energy harvest","volume":"444","author":"Turnbaugh","year":"2006","journal-title":"Nature"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1080\/13880209.2018.1492620","article-title":"A comprehensive review on phytochemistry, pharmacology, and flavonoid biosynthesis of Scutellaria baicalensis","volume":"56","author":"Wang","year":"2018","journal-title":"Pharm. Biol."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"116538","DOI":"10.1016\/j.jep.2023.116538","article-title":"Modified Gegen Qinlian decoction ameliorated ulcerative colitis by attenuating inflammation and oxidative stress and enhancing intestinal barrier function in vivo and in vitro","volume":"313","author":"Wang","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1186\/s40168-022-01433-6","article-title":"Rice flowering improves the muscle nutrient, intestinal microbiota diversity, and liver metabolism profiles of tilapia (Oreochromis niloticus) in rice-fish symbiosis","volume":"10","author":"Wang","year":"2022","journal-title":"Microbiome"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"459","DOI":"10.3390\/ani13030459","article-title":"An evaluation of laminarin additive in the diets of juvenile largemouth bass (Micropterus salmoides): growth, antioxidant capacity, immune response and intestinal microbiota","volume":"13","author":"Wu","year":"2023","journal-title":"Animals"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"739140","DOI":"10.1016\/j.aquaculture.2022.739140","article-title":"The extract from aerial part of Scutellaria baicalensis regulates gut microbiota in rabbit fish: replacement of antibiotic fighting against pathogenic bacteria","volume":"565","author":"Xia","year":"2023","journal-title":"Aquaculture"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"4827","DOI":"10.1002\/fsn3.2410","article-title":"Feeding containing the aerial part of Scutellaria baicalensis promotes the growth and nutritive value of rabbit fish Siganus fuscescens","volume":"9","author":"Xia","year":"2021","journal-title":"Food Sci. 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Microbiol."},{"key":"ref74","doi-asserted-by":"publisher","first-page":"108511","DOI":"10.1016\/j.fsi.2022.108511","article-title":"Protective effects of chlorogenic acid on growth, intestinal inflammation, hepatic antioxidant capacity, muscle development and skin color in channel catfish Ictalurus punctatus fed an oxidized fish oil diet","volume":"134","author":"Zhang","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"ref75","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1007\/s00253-023-12934-1","article-title":"The interactions between the host immunity and intestinal microorganisms in fish","volume":"108","author":"Zhang","year":"2024","journal-title":"Appl. Microbiol. 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