{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:56:46Z","timestamp":1790751406355,"version":"4.1.0"},"reference-count":57,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Aspergillus flavus<\/jats:italic>\n                      causes severs postharvest spoilage and aflatoxins contamination of agricultural commodities, posing major threats to food safety and human health and underscoring the need for safe, effective biocontrol strategies. This study aimed to identify an antagonistic endophytic bacterium against\n                      <jats:italic>A. flavus<\/jats:italic>\n                      and to integrate whole-genome mining, metabolomics, and mechanistic assays to elucidate the molecular basis of its antifungal activity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      An endophytic isolate was identified as\n                      <jats:italic>Bacillus velezensis<\/jats:italic>\n                      802. Its crude extract was evaluated\n                      <jats:italic>in vitro<\/jats:italic>\n                      , and SEM, CLSM, and physiological assays were used to assess hyphal morphology, membrane integrity, mitochondrial function, energy metabolism, and apoptosis. Bioinformatic analysis of the whole-genome sequence was used to predict biosynthetic gene clusters (BGCs) and their associated pathways. UHPLC\u2013MS\/MS was used to identify metabolites in the active extract.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Bacillus velezensis<\/jats:italic>\n                      802 inhibited\n                      <jats:italic>A. flavus<\/jats:italic>\n                      by 70.16%. The crude extract induced hyphal wrinkling and swelling, disrupted membrane integrity, reduced mitochondrial membrane potential, suppressed key energy-metabolism enzymes, and activated the Caspase-9-mediated apoptotic pathway. Genome analysis revealed a 3,951,806 bp circular chromosome containing 13 BGCs. Metabolomics identified six secondary metabolites, among which isobutyric acid showed the strongest antifungal activity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      By coupling whole-genome mining with metabolomic profiling and mechanistic validation, this study demonstrates that\n                      <jats:italic>B. velezensis<\/jats:italic>\n                      802 suppresses\n                      <jats:italic>A. flavus<\/jats:italic>\n                      through multi-target interference with cell structure, energy metabolism, and apoptosis. The strain and its metabolites, especially isobutyric acid, are promising biocontrol candidates for improving grain storage safety.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmicb.2026.1942172","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:06:09Z","timestamp":1790748369000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Bacillus velezensis 802 with antagonistic activity against Aspergillus flavus: genome characterization, secondary metabolites and antifungal mechanism"],"prefix":"10.3389","volume":"17","author":[{"given":"Li","family":"Zhang","sequence":"first","affiliation":[{"name":"National Engineering Research Center of Wheat and Corn Further Processing, Henan University of Technology","place":["Zhengzhou, China"]},{"name":"School of Biological Engineering, Henan University of Technology","place":["Zhengzhou, China"]},{"name":"Chi Tian Hua Biotechnology Co., LTD.","place":["Shangqiu, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaomiao","family":"Yang","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Wheat and Corn Further Processing, Henan University of Technology","place":["Zhengzhou, China"]},{"name":"School of Biological Engineering, Henan University of Technology","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Wheat and Corn Further Processing, Henan University of Technology","place":["Zhengzhou, China"]},{"name":"School of Biological Engineering, Henan University of Technology","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Li","sequence":"additional","affiliation":[{"name":"School of Biological Engineering, Henan University of Technology","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhu","family":"Shao","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of Wheat and Corn Further Processing, Henan University of Technology","place":["Zhengzhou, China"]},{"name":"School of Biological Engineering, Henan University of Technology","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Wang","sequence":"additional","affiliation":[{"name":"School of International Education, Henan University of Technology","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yating","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Biological Engineering, Henan University of Technology","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwen","family":"Tang","sequence":"additional","affiliation":[{"name":"School of Biological Engineering, Henan University of Technology","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuansen","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Biological Engineering, Henan University of Technology","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Li","sequence":"additional","affiliation":[{"name":"Institute for Complexity Science, Henan University of Technology","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongke","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Biological Engineering, Henan University of Technology","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Biological Engineering, Henan University of Technology","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"108225","DOI":"10.1016\/j.toxicon.2024.108225","article-title":"A silent killer in the word: review on Aspergillus flavus strains","volume":"255","author":"Adjovi","year":"2025","journal-title":"Toxicon"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"797","DOI":"10.3390\/jof9080797","article-title":"The extracellular lipopeptides and volatile organic compounds of Bacillus subtilis DHA41 display broad-spectrum antifungal activity against soil-borne phytopathogenic fungi","volume":"9","author":"Al-Mutar","year":"2023","journal-title":"J. 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