{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:56:50Z","timestamp":1790751410939,"version":"4.1.0"},"reference-count":62,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    Peste des petits ruminants virus (PPRV) is recognized as one of the most economically significant transboundary pathogens affecting small ruminants. However, despite the increasing availability of whole-genome sequences, comprehensive global analyses integrating evolutionary history, phylogeography, and genome-wide lineage-defining molecular markers remain limited. This study investigated the global genomic diversity, evolutionary history, and molecular characteristics of PPRV using whole-genome sequences. A total of 212 temporally informative whole-genome sequences, retrieved from GenBank (between 1969 and 2025) representing all four recognized PPRV lineages, were analyzed using comparative genomics, Bayesian time-scaled phylogenetic reconstruction, and genome-wide candidate phylogenetic marker; single nucleotide polymorphism (SNP) analysis and codon-based selective-pressure analyses. The results demonstrated high genomic conservation across all genomes despite their broad geographic distribution. Bayesian analysis estimated a mean evolutionary rate of 5.07\u202f\u00d7\u202f10\n                    <jats:sup>\u22124<\/jats:sup>\n                    substitutions per site per year (95% HPD: 4.79\u202f\u00d7\u202f10\n                    <jats:sup>\u22124<\/jats:sup>\n                    to 5.35\u202f\u00d7\u202f10\n                    <jats:sup>\u22124<\/jats:sup>\n                    ) and dated the most recent common ancestor of PPRV to 1839 (95% HPD: 1829 to 1848) which likely reflects the ancestry of currently sampled viral diversity rather than the historical emergence of PPRV. Lineage IV, the predominant contemporary lineage, was further subdivided into four geographically structured subclades: A, B.1, B.2a, and B.2b. A total of 125 subclade-associated fixed SNP signatures were identified, primarily within the L gene, with most variants resulting in nonsynonymous substitutions. The overlapping P, V, and C coding regions underscored the complex functional consequences of lineage-defining mutations. Gene-wide dN\/dS values were below 1 for all six genes, indicating predominant purifying selection, while functional mapping identified several SNP related amino acid substitutions within experimentally characterized antigenic regions; however, these substitutions were not supported as positively selected in the present analyses. These results provide a comprehensive genomic framework for understanding PPRV evolution and identify candidate phylogenetic markers for lineage discrimination to support genomic surveillance, molecular epidemiology, and the Food and Agriculture Organization (FAO)-World Organisation for Animal Health (WOAH) Global PPR Eradication Programme.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2026.1944163","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:06:58Z","timestamp":1790748418000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Global evolutionary dynamics of peste des petits ruminants virus reveals geographic lineage structuring and clade-defining mutational signatures"],"prefix":"10.3389","volume":"17","author":[{"given":"Sarowar","family":"Haque","sequence":"first","affiliation":[{"name":"Department of Microbiology and Hygiene, Bangladesh Agricultural University","place":["Mymensingh, Bangladesh"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Mahfuj","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Hygiene, Bangladesh Agricultural University","place":["Mymensingh, Bangladesh"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anupam","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Hygiene, Bangladesh Agricultural University","place":["Mymensingh, Bangladesh"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safayet Hossain","family":"Piyel","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Hygiene, Bangladesh Agricultural University","place":["Mymensingh, Bangladesh"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanvir","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Hygiene, Bangladesh Agricultural University","place":["Mymensingh, Bangladesh"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roni","family":"Mia","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Hygiene, Bangladesh Agricultural University","place":["Mymensingh, Bangladesh"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharmin","family":"Akter","sequence":"additional","affiliation":[{"name":"Department of Physiology, Bangladesh Agricultural University","place":["Mymensingh, Bangladesh"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tofazzal","family":"Islam","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology and Genetic Engineering, Gazipur Agricultural University","place":["Gazipur, Bangladesh"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. M. N.","family":"Azim","sequence":"additional","affiliation":[{"name":"Department of Physiology, College of Veterinary Medicine, Jeonbuk National University","place":["Iksan, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salima","family":"Akter","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Korean Medicine, Kyung Hee University","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Yaseen","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Korean Medicine, Kyung Hee University","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amama","family":"Rani","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Korean Medicine, Kyung Hee University","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonglee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Korean Medicine, Kyung Hee University","place":["Seoul, Republic of Korea"]},{"name":"Dr. B Lab Co., Ltd., Samuiwon Startup Center Kyung Hee University","place":["Seoul, Republic of Korea"]},{"name":"Medical Convergence Research Center, Kyung Hee University Hospital","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Golzar","family":"Hossain","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Hygiene, Bangladesh Agricultural University","place":["Mymensingh, Bangladesh"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"831752","DOI":"10.3389\/fvets.2022.831752","article-title":"Who has access to livestock vaccines? Using the social-ecological model and intersectionality frameworks to identify the social barriers to Peste des Petits ruminants vaccines in Karamoja, Uganda","volume":"9","author":"Acosta","year":"2022","journal-title":"Front. Vet. 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Dis."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"2030","DOI":"10.3390\/ani12162030","article-title":"Peste des Petits ruminants in central and eastern Asia\/West Eurasia: epidemiological situation and status of control and eradication activities after the first phase of the PPR global eradication programme (2017\u20132021)","volume":"12","author":"Legnardi","year":"2022","journal-title":"Animals (Basel)"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"107312","DOI":"10.1016\/j.psj.2026.107312","article-title":"Genomic signatures of host adaptation in Pasteurella multocida from poultry, cattle, swine, and cats: insights from interpretable machine learning","volume":"105","author":"Li","year":"2026","journal-title":"Poult. Sci."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"14","DOI":"10.2527\/af.2014-0003","article-title":"Evolutionary genetics underlying the spread of peste des petits ruminants virus","volume":"4","author":"Libeau","year":"2014","journal-title":"Anim. Front."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"2144","DOI":"10.3390\/v13112144","article-title":"Ongoing assessment of the molecular evolution of Peste des Petits ruminants virus continues to question viral origins","volume":"13","author":"Mahapatra","year":"2021","journal-title":"Viruses"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.4102\/ojvr.v86i1.1677","article-title":"Peste des petits ruminants in Africa: meta-analysis of the virus isolation in molecular epidemiology studies","volume":"86","author":"Mantip","year":"2019","journal-title":"Onderstepoort J. Vet. Res."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"iyaf200","DOI":"10.1093\/genetics\/iyaf200","article-title":"The impact of non-neutral synonymous mutations when inferring selection on nonsynonymous mutations","volume":"231","author":"Martinez","year":"2025","journal-title":"Genetics"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.3201\/eid2012.140684","article-title":"Molecular evolution of peste des petits ruminants virus","volume":"20","author":"Muniraju","year":"2014","journal-title":"Emerg. Infect. Dis."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1093\/molbev\/msu300","article-title":"IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies","volume":"32","author":"Nguyen","year":"2015","journal-title":"Mol. Biol. Evol."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1093\/bioinformatics\/bts091","article-title":"Unipro UGENE: a unified bioinformatics toolkit","volume":"28","author":"Okonechnikov","year":"2012","journal-title":"Bioinformatics"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"7040","DOI":"10.1038\/srep07040","article-title":"Genetic and epidemiological insights into the emergence of peste des petits ruminants virus (PPRV) across Asia and Africa","volume":"4","author":"Padhi","year":"2014","journal-title":"Sci. Rep."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.vetmic.2015.08.009","article-title":"Peste des petits ruminants","volume":"181","author":"Parida","year":"2015","journal-title":"Vet. Microbiol."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1016\/j.meegid.2009.05.014","article-title":"Phylogenetic understanding of clonal populations in an era of whole genome sequencing","volume":"9","author":"Pearson","year":"2009","journal-title":"Infect. Genet. Evol."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"e1000602","DOI":"10.1371\/journal.pbio.1000602","article-title":"Resolving difficult phylogenetic questions: why more sequences are not enough","volume":"9","author":"Philippe","year":"2011","journal-title":"PLoS Biol."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1093\/bioinformatics\/bti079","article-title":"HyPhy: hypothesis testing using phylogenies","volume":"21","author":"Pond","year":"2005","journal-title":"Bioinformatics"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"729","DOI":"10.3390\/v11080729","article-title":"Host cellular receptors for the Peste des Petits ruminant virus","volume":"11","author":"Prajapati","year":"2019","journal-title":"Viruses"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1007\/s13596-025-00845-7","article-title":"Piceatannol: a multifaceted polyphenol\u2014from pharmacological actions to formulation development and clinical trials","volume":"25","author":"Rajan","year":"2025","journal-title":"Adv. Tradit. Med."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1093\/sysbio\/syy032","article-title":"Posterior summarization in Bayesian phylogenetics using tracer 1.7","volume":"67","author":"Rambaut","year":"2018","journal-title":"Syst. Biol."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"vew007","DOI":"10.1093\/ve\/vew007","article-title":"Exploring the temporal structure of heterochronous sequences using TempEst (formerly path-O-gen)","volume":"2","author":"Rambaut","year":"2016","journal-title":"Virus Evol"},{"key":"ref49","author":"Sarkozi","year":"2021"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/s41598-019-54714-w","article-title":"A comprehensive global perspective on phylogenomics and evolutionary dynamics of small ruminant morbillivirus","volume":"10","author":"Shabbir","year":"2020","journal-title":"Sci. Rep."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"119899","DOI":"10.1016\/j.ecoenv.2026.119899","article-title":"Mammalian AHR2 loss: evolutionary patterns, mechanisms, and relevance of biological factors","volume":"311","author":"Song","year":"2026","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"e91","DOI":"10.1017\/ash.2021.241","article-title":"Whole-genome sequencing surveillance and machine learning for healthcare outbreak detection and investigation: a systematic review and summary","volume":"2","author":"Sundermann","year":"2022","journal-title":"Antimicrob Steward Healthc Epidemiol"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1848","DOI":"10.3390\/life15121848","article-title":"Genomics in epidemiology and disease surveillance: an exploratory analysis","volume":"15","author":"Tiwari","year":"2025","journal-title":"Life (Basel)"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"3107","DOI":"10.1111\/tbed.14066","article-title":"Persistence of the historical lineage I of West Africa against the ongoing spread of the Asian lineage of peste des petits ruminants virus","volume":"68","author":"Tounkara","year":"2021","journal-title":"Transbound. Emerg. 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Virol."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.vetmic.2017.07.008","article-title":"Fine mapping and conservation analysis of linear B-cell epitopes of peste des petits ruminants virus hemagglutinin protein","volume":"208","author":"Yu","year":"2017","journal-title":"Vet. Microbiol."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1038\/s41576-025-00850-1","article-title":"Functional synonymous mutations and their evolutionary consequences","volume":"26","author":"Zhang","year":"2025","journal-title":"Nat. Rev. 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