{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T06:12:16Z","timestamp":1788415936705,"version":"build-2803163510"},"reference-count":60,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017700","name":"Henan Science and Technology Research Project","doi-asserted-by":"crossref","award":["262102310148"],"award-info":[{"award-number":["262102310148"]}],"id":[{"id":"10.13039\/501100017700","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100017700","name":"Henan Science and Technology Research Project","doi-asserted-by":"crossref","award":["252102310194"],"award-info":[{"award-number":["252102310194"]}],"id":[{"id":"10.13039\/501100017700","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100017700","name":"Henan Science and Technology Research Project","doi-asserted-by":"crossref","award":["242102111077"],"award-info":[{"award-number":["242102111077"]}],"id":[{"id":"10.13039\/501100017700","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100017700","name":"Henan Science and Technology Research Project","doi-asserted-by":"crossref","award":["242102310490"],"award-info":[{"award-number":["242102310490"]}],"id":[{"id":"10.13039\/501100017700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Microbiol."],"abstract":"<jats:p>\n                    Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract infections in infants, young children, immunocompromised adults, and elderly individuals with comorbidities. Its high pathogenicity and associated mortality impose a substantial disease burden on public health. Vaccination represents a key strategy for preventing RSV infection. However, currently approved RSV vaccines exhibit limitations. For instance, Abrysvo and Arexvy pose potential safety risks in clinical use, and the long-term protective efficacy of mRESVIA may wane over time. Therefore, this article proposes and explores a novel RSV vaccine strategy utilizing\n                    <jats:italic>Bacteroides thetaiotaomicron<\/jats:italic>\n                    outer membrane vesicles (Bt OMVs) as a delivery platform. This strategy capitalizes on the unique advantages of Bt OMVs, including efficient mucosal delivery, low inherent toxicity, and targeted modulation of T cell homeostasis\u2014specifically enhancing Treg and Th1 responses while suppressing excessive Th2 and Th17 activation, which serves as the core mechanism for preventing vaccine-enhanced disease (VED)\u2014to effectively present the RSV F protein antigen. It offers a novel approach to develop next-generation RSV vaccines that combine durable protection with enhanced clinical safety.\n                  <\/jats:p>","DOI":"10.3389\/fmicb.2026.1956909","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:13:46Z","timestamp":1788412426000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Construction and application of a novel respiratory syncytial virus vaccine based on Bacteroides thetaiotaomicron outer membrane vesicles"],"prefix":"10.3389","volume":"17","author":[{"given":"Xuejiao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Basic Medicine Science, North Henan Medical University","place":["Xinxiang, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Basic Medicine Science, North Henan Medical University","place":["Xinxiang, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Basic Medicine Science, North Henan Medical University","place":["Xinxiang, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Basic Medicine Science, North Henan Medical University","place":["Xinxiang, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghe","family":"You","sequence":"additional","affiliation":[{"name":"Department of Basic Medicine Science, North Henan Medical University","place":["Xinxiang, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongsheng","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Basic Medicine Science, North Henan Medical University","place":["Xinxiang, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Basic Medicine Science, North Henan Medical University","place":["Xinxiang, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leqi","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Basic Medicine Science, North Henan Medical University","place":["Xinxiang, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiding","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Basic Medicine Science, North Henan Medical University","place":["Xinxiang, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fukang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Basic Medicine Science, North Henan Medical University","place":["Xinxiang, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Basic Medicine Science, North Henan Medical University","place":["Xinxiang, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e1648","DOI":"10.1002\/hsr2.1648","article-title":"Revitalizing hope for older adults: the use of the novel Arexvy for immunization against respiratory syncytial virus","volume":"6","author":"Abbasi","year":"2023","journal-title":"Health Sci. 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