{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T22:24:21Z","timestamp":1788301461772,"version":"build-2803163510"},"reference-count":218,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Med"],"abstract":"<jats:p>Metabolic diseases are becoming more common and more severe in populations adhering to western lifestyle. Since metabolic conditions are highly diet and lifestyle dependent, it is suggested that certain diets are the cause for a wide range of metabolic dysfunctions. Oxidative stress, excess calcium excretion, inflammation, and metabolic acidosis are common features in the origins of most metabolic disease. These primary manifestations of \u201cmetabolic syndrome\u201d can lead to insulin resistance, diabetes, obesity, and hypertension. Further complications of the conditions involve kidney disease, cardiovascular disease, osteoporosis, and cancers. Dietary analysis shows that a modern \u201cWestern-style\u201d diet may facilitate a disruption in pH homeostasis and drive disease progression through high consumption of exogenous acids. Because so many physiological and cellular functions rely on acid-base reactions and pH equilibrium, prolonged exposure of the body to more acids than can effectively be buffered, by chronic adherence to poor diet, may result in metabolic stress followed by disease. This review addresses relevant molecular pathways in mammalian cells discovered to be sensitive to acid - base equilibria, their cellular effects, and how they can cascade into an organism-level manifestation of Metabolic Syndromes. We will also discuss potential ways to help mitigate this digestive disruption of pH and metabolic homeostasis through dietary change.<\/jats:p>","DOI":"10.3389\/fmmed.2021.777088","type":"journal-article","created":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T06:33:22Z","timestamp":1637044402000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["The Molecular Effects of Dietary Acid Load on Metabolic Disease (The Cellular PasaDoble: The Fast-Paced Dance of pH Regulation)"],"prefix":"10.3389","volume":"1","author":[{"given":"Morgan","family":"Williamson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naima","family":"Moustaid-Moussa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Gollahon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,11,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e0216547","DOI":"10.1371\/journal.pone.0216547","article-title":"Higher Dietary Acid Load Potentially Increases Serum Triglyceride and Obesity Prevalence in Adults: An Updated Systematic Review and Meta-Analysis","volume":"14","author":"Abbasalizad Farhangi","year":"2019","journal-title":"PLoS One"},{"key":"B2","doi-asserted-by":"publisher","first-page":"3511","DOI":"10.1681\/ASN.2016030305","article-title":"Acidosis and Urinary Calcium Excretion: Insights from Genetic Disorders","volume":"27","author":"Alexander","year":"2016","journal-title":"Jasn"},{"key":"B3","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.cmet.2015.06.010","article-title":"Calcium Homeostasis and Organelle Function in the Pathogenesis of Obesity and Diabetes","volume":"22","author":"Arruda","year":"2015","journal-title":"Cel Metab."},{"key":"B4","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1007\/s12603-012-0064-6","article-title":"Dietary Protein and Beef Consumption Predict for Markers of Muscle Mass and Nutrition Status in Older Adults","volume":"16","author":"Asp","year":"2012","journal-title":"J. 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