{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T22:55:27Z","timestamp":1776207327168,"version":"3.50.1"},"reference-count":83,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Psoriasis, an immune-mediated systemic inflammatory disease affecting skin, vessels, and joints, often co-occurs with depression. Routine depression screening is vital, as mood disorders link to inflammation, visible lesions, and functional limitations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study integrated Mendelian randomization (MR), transcriptomics, and single-cell omics via public databases to explore comorbidity mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      MR identified 340 psoriasis-related and 307 depression-related eQTL-gene associations; 9 intersected. LASSO found 4 key Genes (\n                      <jats:italic>MAP3K20, WARS2, TBXAS1, ABHD15<\/jats:italic>\n                      ), enriched in IL-17\/NF-\u03baB\/FoxO pathways, cholesterol metabolism, and synaptic cycling. They correlated with immune infiltration, ferroptosis, and specific cell localization. Folic acid (from CTD) targeted 3 genes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These 4 genes mediate comorbidity via inflammation, immune metabolism, and ferroptosis. Folic acid pathways have therapeutic value, laying a foundation for precision therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmmed.2026.1770665","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T22:10:10Z","timestamp":1776204610000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Molecular mechanisms underlying psoriasis and depression: an integrated analysis using mendelian randomization, transcriptomics, and single-cell sequencing"],"prefix":"10.3389","volume":"6","author":[{"given":"Baojun","family":"De","sequence":"first","affiliation":[{"name":"Department of Psychosomatic Medicine, Inner Mongolia Traditional Chinese and Mongolian Medical Research Institute","place":["Hohhot, Inner Mongolia, China"]},{"name":"Mongolian Psychosomatic Medicine Department, Inner Mongolia Ajitai Mongolian Hospital","place":["Ordos, Inner Mongolia, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenfeng","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine, Inner Mongolia Traditional Chinese and Mongolian Medical Research Institute","place":["Hohhot, Inner Mongolia, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagongbilige","family":"Hea","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine, Inner Mongolia Traditional Chinese and Mongolian Medical Research Institute","place":["Hohhot, Inner Mongolia, China"]},{"name":"Mongolian Psychosomatic Medicine Department, Inner Mongolia Ajitai Mongolian Hospital","place":["Ordos, Inner Mongolia, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine, Inner Mongolia Traditional Chinese and Mongolian Medical Research Institute","place":["Hohhot, Inner Mongolia, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1038\/nmeth.4463","article-title":"SCENIC: single-cell regulatory network inference and clustering","volume":"14","author":"Aibar","year":"2017","journal-title":"Nat. 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