{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:43:41Z","timestamp":1790081021216,"version":"4.0.1"},"reference-count":75,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Biosci."],"DOI":"10.3389\/fmolb.2015.00054","type":"journal-article","created":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T08:37:34Z","timestamp":1443429454000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":143,"title":["Molecular diagnostics of neurodegenerative disorders"],"prefix":"10.3389","volume":"2","author":[{"given":"Megha","family":"Agrawal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhijit","family":"Biswas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2015,9,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.nbd.2011.01.029","article-title":"Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission","volume":"42","author":"Alvarez-Erviti","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"B2","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.parkreldis.2010.02.009","article-title":"Sleep and circadian rhythm alterations correlate with depression and cognitive impairment in Huntington's disease","volume":"16","author":"Aziz","year":"2010","journal-title":"Parkinsonism Relat. Disord."},{"key":"B3","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1177\/0891988710383571","article-title":"Genetics of Alzheimer disease","volume":"23","author":"Bekris","year":"2010","journal-title":"J. Geriatr. Psychiatry Neurol."},{"key":"B4","doi-asserted-by":"crossref","first-page":"4560","DOI":"10.1523\/JNEUROSCI.23-11-04560.2003","article-title":"Amyloid precursor protein associates with a nicastrin-dependent docking site on the presenilin 1-gamma-secretase complex in cells demonstrated by fluorescence lifetime imaging","volume":"23","author":"Berezovska","year":"2003","journal-title":"J. Neurosci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1016\/S0891-5849(00)00349-X","article-title":"Increased oxidative damage to DNA in ALS patients","volume":"29","author":"Bogdanov","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/978-1-84996-011-3_2","article-title":"Advances in diagnostics for neurodegenerative disorders","volume":"2","author":"Bokde","year":"2011","journal-title":"Neurodegener. Dis."},{"key":"B7","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1126\/science.1077209","article-title":"Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism","volume":"299","author":"Bonifati","year":"2003","journal-title":"Science"},{"key":"B8","doi-asserted-by":"publisher","first-page":"11023","DOI":"10.1073\/pnas.0504921102","article-title":"Genome-wide expression profiling of human blood reveals biomarkers for Huntington's disease","volume":"102","author":"Borovecki","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B9","doi-asserted-by":"publisher","first-page":"925101","DOI":"10.1155\/2014\/925101","article-title":"Amyotrophic lateral sclerosis: a focus on disease progression","volume":"2014","author":"Calvo","year":"2014","journal-title":"Biomed Res. Int."},{"key":"B10","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.bbrc.2007.05.093","article-title":"Increased oxidative damage and mitochondrial abnormalities in the peripheral blood of Huntington's disease patients","volume":"359","author":"Chen","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1046\/j.1460-9568.2002.02255.x","article-title":"Genetic engineering of mouse embryonic stem cells by Nurr1 enhances differentiation and maturation into dopaminergic neurons","volume":"16","author":"Chung","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"519816","DOI":"10.1155\/2014\/519816","article-title":"Magnetic resonance spectroscopy: an in vivo molecular imaging biomarker for Parkinson's disease?","volume":"2014","author":"Ciurleo","year":"2014","journal-title":"Biomed Res. Int."},{"key":"B13","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/j.neuint.2010.02.004","article-title":"Time course of oxidant markers and antioxidant defenses in subgroups of amyotrophic lateral sclerosis patients","volume":"56","author":"Cova","year":"2010","journal-title":"Neurochem. Int."},{"key":"B14","doi-asserted-by":"publisher","first-page":"2833","DOI":"10.1021\/pr0700753","article-title":"Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates","volume":"6","author":"Dalrymple","year":"2007","journal-title":"J. Proteome Res."},{"key":"B15","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/S1474-4422(03)00262-X","article-title":"Mild cognitive impairment: prevalence, prognosis, aetiology, and treatment","volume":"2","author":"DeCarli","year":"2003","journal-title":"Lancet Neurol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.neuron.2011.09.011","article-title":"Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS","volume":"72","author":"DeJesus-Hernandez","year":"2011","journal-title":"Neuron"},{"key":"B17","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1002\/mds.10422","article-title":"Clinical features and neuroimaging of PARK7-linked parkinsonism","volume":"18","author":"Dekker","year":"2003","journal-title":"Mov. Disord."},{"key":"B18","first-page":"277","article-title":"Lewy bodies, a misleading marker for Parkinson's disease?","volume":"187","author":"Duyckaerts","year":"2003","journal-title":"Bull. Acad. Natl. Med."},{"key":"B19","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1042\/bst0300559","article-title":"Aggregation and neurotoxicity of alpha-synuclein and related peptides","volume":"30","author":"el-Agnaf","year":"2002","journal-title":"Biochem. Soc. Trans."},{"key":"B20","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1159\/000089624","article-title":"Reticulons as markers of neurological diseases: focus on amyotrophic lateral sclerosis","volume":"2","author":"Fergani","year":"2005","journal-title":"Neurodegener. Dis."},{"key":"B21","doi-asserted-by":"publisher","first-page":"e52672","DOI":"10.1371\/journal.pone.0052672","article-title":"Identification of epigenetically altered genes in sporadic amyotrophic lateral sclerosis","volume":"7","author":"Figueroa-Romero","year":"2012","journal-title":"PLoS ONE"},{"key":"B22","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/mds.10338","article-title":"State of the art review: molecular diagnosis of inherited movement disorders. Movement Disorders Society task force on molecular diagnosis","volume":"18","author":"Gasser","year":"2003","journal-title":"Mov. Disord."},{"key":"B23","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1046\/j.1468-1331.2001.00226.x","article-title":"EFNS Task Force on Molecular Diagnosis of Neurologic Disorders: guidelines for the molecular diagnosis of inherited neurologic diseases. First of two parts","volume":"8","author":"Gasser","year":"2001a","journal-title":"Eur. J. Neurol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1046\/j.1468-1331.2001.00228.x","article-title":"EFNS Task Force on Molecular Diagnosis of Neurologic Disorders: guidelines for the molecular diagnosis of inherited neurologic diseases. Second of two parts","volume":"8","author":"Gasser","year":"2001b","journal-title":"Eur. J. Neurol."},{"issue":"178","key":"B25","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2013.00178","article-title":"Neuronal dark matter: the emerging role of microRNAs in neurodegeneration","volume":"7","author":"Goodall","year":"2013","journal-title":"Front. Cell. Neurosci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"6891","DOI":"10.3390\/molecules19056891","article-title":"Circulating miRNAs as biomarkers for neurodegenerative disorders","volume":"19","author":"Grasso","year":"2014","journal-title":"Molecules"},{"key":"B27","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"B28","doi-asserted-by":"crossref","first-page":"91","DOI":"10.31887\/DCNS.2012.14.1\/pharvey","article-title":"Clinical applications of neuropsychological assessment","volume":"14","author":"Harvey","year":"2012","journal-title":"Dialogues Clin. Neurosci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"17141","DOI":"10.1073\/pnas.1104409108","article-title":"Transcriptional modulator H2A histone family, member Y (H2AFY) marks Huntington disease activity in man and mouse","volume":"108","author":"Hu","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B30","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1001\/archneur.57.3.369","article-title":"The evolution of diagnosis in early Parkinson disease. Parkinson Study Group","volume":"57","author":"Jankovic","year":"2000","journal-title":"Arch. Neurol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"S89","DOI":"10.1016\/j.pmrj.2013.03.020","article-title":"Electrodiagnosis in persons with amyotrophic lateral sclerosis","volume":"5","author":"Joyce","year":"2013","journal-title":"PM R"},{"key":"B32","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.mcn.2010.11.004","article-title":"Release of exosomes from differentiated neurons and its regulation by synaptic glutamatergic activity","volume":"46","author":"Lachenal","year":"2011","journal-title":"Mol. Cell. Neurosci."},{"key":"B33","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1038\/26652","article-title":"The ubiquitin pathway in Parkinson's disease","volume":"395","author":"Leroy","year":"1998","journal-title":"Nature"},{"key":"B34","doi-asserted-by":"publisher","first-page":"657086","DOI":"10.1155\/2015\/657086","article-title":"Exosomes: novel biomarkers for clinical diagnosis","volume":"2015","author":"Lin","year":"2015","journal-title":"ScientificWorldJournal"},{"key":"B35","first-page":"323","article-title":"Positron emission tomography neuroimaging in Parkinson's disease","volume":"3","author":"Loane","year":"2011","journal-title":"Am. J. Transl. Res."},{"key":"B36","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.1002\/mds.22477","article-title":"Gene expression changes in blood as a putative biomarker for Huntington's disease","volume":"24","author":"Lovrecic","year":"2009","journal-title":"Mov. Disord."},{"key":"B37","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/nm.3466","article-title":"Plasma phospholipids identify antecedent memory impairment in older adults","volume":"20","author":"Mapstone","year":"2014","journal-title":"Nat. Med."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1212\/WNL.55.10.1540","article-title":"A multicenter assessment of dopamine transporter imaging with DOPASCAN\/SPECT in parkinsonism. Parkinson Study Group","volume":"55","author":"Marek","year":"2000","journal-title":"Neurology"},{"key":"B39","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.jbiotec.2011.01.023","article-title":"Identification of blood microRNAs associated to Parkinsonis disease","volume":"152","author":"Margis","year":"2011","journal-title":"J. Biotechnol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1007\/s13311-013-0205-6","article-title":"Aberrant regulation of DNA methylation in amyotrophic lateral sclerosis: a new target of disease mechanisms","volume":"10","author":"Martin","year":"2013","journal-title":"Neurotherapeutics"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2014.281","article-title":"Huntington's disease biomarker progression profile identified by transcriptome sequencing in peripheral blood","author":"Mastrokolias","year":"2015","journal-title":"Eur. J. Hum. Genet"},{"key":"B42","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/1755-8794-3-15","article-title":"Peripheral blood gene expression patterns discriminate among chronic inflammatory diseases and healthy controls and identify novel targets","volume":"3","author":"Mesko","year":"2010","journal-title":"BMC Med. Genomics"},{"key":"B43","doi-asserted-by":"publisher","first-page":"S40","DOI":"10.1016\/j.metabol.2014.10.030","article-title":"Biomarkers of Parkinson's disease: present and future","volume":"64","author":"Miller","year":"2015","journal-title":"Metabolism"},{"key":"B44","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/1750-1326-7-26","article-title":"A molecular signature in blood identifies early Parkinson's disease","volume":"7","author":"Molochnikov","year":"2012","journal-title":"Mol. Neurodegener."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1086\/374383","article-title":"Significant linkage of Parkinson disease to chromosome 2q36-37","volume":"72","author":"Pankratz","year":"2003","journal-title":"Am. J. Hum. Genet."},{"key":"B46","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/S1471-4892(01)00118-7","article-title":"Stem cells in brain plasticity and repair","volume":"2","author":"Peterson","year":"2002","journal-title":"Curr. Opin. Pharmacol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/S1474-4422(11)70015-1","article-title":"Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease","volume":"10","author":"Philips","year":"2011","journal-title":"Lancet Neurol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"S56","DOI":"10.1016\/j.jalz.2012.10.008","article-title":"Establishing the psychometric underpinning of cognition measures for clinical trials of Alzheimer's disease and its precursors: a new approach","volume":"9","author":"Posner","year":"2013","journal-title":"Alzheimers Dement."},{"key":"B49","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1002\/ana.20675","article-title":"Reduced expression of metabotropic glutamate receptor 2mRNA in T cells of ALS patients","volume":"58","author":"Poulopoulou","year":"2005","journal-title":"Ann. Neurol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/sj.cr.7290235","article-title":"Biomarkers of neurodegenerative disorders: how good are they?","volume":"14","author":"Rachakonda","year":"2004","journal-title":"Cell Res."},{"key":"B51","doi-asserted-by":"publisher","first-page":"11172","DOI":"10.1073\/pnas.0603838103","article-title":"Alzheimer's disease beta-amyloid peptides are released in association with exosomes","volume":"103","author":"Rajendran","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B52","doi-asserted-by":"publisher","first-page":"525097","DOI":"10.1155\/2014\/525097","article-title":"Blood biomarkers for amyotrophic lateral sclerosis: myth or reality?","volume":"2014","author":"Robelin","year":"2014","journal-title":"Biomed Res. Int."},{"key":"B53","doi-asserted-by":"publisher","first-page":"9723","DOI":"10.1523\/JNEUROSCI.3044-08.2008","article-title":"Dysregulation of gene expression in primary neuron models of Huntington's disease shows that polyglutamine-related effects on the striatal transcriptome may not be dependent on brain circuitry","volume":"28","author":"Runne","year":"2008","journal-title":"J. Neurosci."},{"key":"B54","first-page":"217","article-title":"Exosomes-associated neurodegeneration and progression of Parkinson's disease","volume":"1","author":"Russo","year":"2012","journal-title":"Am. J. Neurodegener. Dis."},{"key":"B55","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s00234-003-1034-9","article-title":"In vivo amyloid imaging in Alzheimer's disease","volume":"46","author":"Sair","year":"2004","journal-title":"Neuroradiology"},{"key":"B56","doi-asserted-by":"publisher","first-page":"3842","DOI":"10.1074\/jbc.M111.277061","article-title":"Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease","volume":"287","author":"Saman","year":"2012","journal-title":"J. Biol. Chem."},{"key":"B57","doi-asserted-by":"crossref","first-page":"590","DOI":"10.18632\/aging.100486","article-title":"Plasma microRNA biomarkers for detection of mild cognitive impairment","volume":"4","author":"Sheinerman","year":"2012","journal-title":"Aging"},{"key":"B58","doi-asserted-by":"publisher","first-page":"15","DOI":"10.3934\/medsci.2015.1.15","article-title":"Biofluid-based microRNA biomarkers for Parkinsons disease: an overview and update","volume":"2","author":"Shinde","year":"2015","journal-title":"AIMS Med. Sci."},{"key":"B59","doi-asserted-by":"publisher","first-page":"178","DOI":"10.4103\/1450-1147.144818","article-title":"Correlative (99m)tc-labeled tropane derivative single photon emission computer tomography and clinical assessment in the staging of Parkinson disease","volume":"13","author":"Shinto","year":"2014","journal-title":"World J. Nucl. Med."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0009-8981(03)00121-9","article-title":"Advances in the detection of Alzheimer's disease-use of cerebrospinal fluid biomarkers","volume":"332","author":"Sj\u00f6gren","year":"2003","journal-title":"Clin. Chim. Acta"},{"issue":"10","key":"B61","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2013.00010","article-title":"Small RNA sequencing-microarray analyses in Parkinson leukocytes reveal deep brain stimulation-induced splicing changes that classify brain region transcriptomes","volume":"6","author":"Soreq","year":"2013","journal-title":"Front. Mol. Neurosci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1002\/mds.26118","article-title":"A longitudinal study of magnetic resonance spectroscopy Huntington's disease biomarkers","volume":"30","author":"Sturrock","year":"2015","journal-title":"Mov. Disord."},{"key":"B63","doi-asserted-by":"publisher","first-page":"2094","DOI":"10.1001\/jama.289.16.2094","article-title":"Decreased beta-amyloid1-42 and increased tau levels in cerebrospinal fluid of patients with Alzheimer disease","volume":"289","author":"Sunderland","year":"2003","journal-title":"JAMA"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1007\/BF01254252","article-title":"[123I]beta-CIT single-photon emission tomography in Parkinson's disease reveals a smaller decline in dopamine transporters with age than in controls","volume":"24","author":"Tissingh","year":"1997","journal-title":"Eur. J. Nucl. Med."},{"key":"B65","doi-asserted-by":"publisher","first-page":"548","DOI":"10.3390\/jcm4040548","article-title":"Using iPS cells toward the understanding of Parkinson's disease","volume":"4","author":"Torrent","year":"2015","journal-title":"J. Clin. Med."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1126\/science.1096284","article-title":"Hereditary early-onset Parkinson's disease caused by mutations in PINK1","volume":"304","author":"Valente","year":"2004","journal-title":"Science"},{"key":"B67","doi-asserted-by":"publisher","first-page":"377","DOI":"10.3233\/JHD-140117","article-title":"Longitudinal metabolite changes in Huntington's disease during disease onset","volume":"3","author":"van Den Bogaard","year":"2014","journal-title":"J. Huntingtons. Dis."},{"key":"B68","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1093\/bioinformatics\/btp647","article-title":"CYSTM, a novel cysteine-rich transmembrane module with a role in stress tolerance across eukaryotes","volume":"26","author":"Venancio","year":"2010","journal-title":"Bioinformatics"},{"key":"B69","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/S1474-4422(11)70070-9","article-title":"Development of biomarkers for Huntington's disease","volume":"10","author":"Weir","year":"2011","journal-title":"Lancet Neurol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1172\/JCI80743","article-title":"Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington's disease patients","volume":"125","author":"Wild","year":"2015","journal-title":"J. Clin. Invest."},{"key":"B71","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.brainresbull.2007.12.007","article-title":"Increased thirst and drinking in Huntington's disease and the R6\/2 mouse","volume":"76","author":"Wood","year":"2008","journal-title":"Brain Res. Bull."},{"key":"B72","doi-asserted-by":"publisher","first-page":"S47","DOI":"10.1016\/j.metabol.2014.10.034","article-title":"Biomarkers in the diagnosis and management of Alzheimer's disease","volume":"64","author":"Wurtman","year":"2015","journal-title":"Metabolism"},{"key":"B73","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1261\/rna.642907","article-title":"Systematic analysis of microRNA expression of RNA extracted from fresh frozen and formalin-fixed paraffin-embedded samples","volume":"13","author":"Xi","year":"2007","journal-title":"RNA"},{"key":"B74","doi-asserted-by":"publisher","first-page":"12722","DOI":"10.1523\/JNEUROSCI.3767-09.2009","article-title":"Four decades of neurodegenerative disease research: how far we have come!","volume":"29","author":"Young","year":"2009","journal-title":"J. Neurosci."},{"key":"B75","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1016\/j.cell.2005.10.030","article-title":"In vitro analysis of huntingtin-mediated transcriptional repression reveals multiple transcription factor targets","volume":"123","author":"Zhai","year":"2005","journal-title":"Cell"}],"container-title":["Frontiers in Molecular Biosciences"],"original-title":[],"deposited":{"date-parts":[[2022,5,22]],"date-time":"2022-05-22T10:33:13Z","timestamp":1653215593000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fmolb.2015.00054\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,22]]},"references-count":75,"URL":"https:\/\/doi.org\/10.3389\/fmolb.2015.00054","relation":{},"ISSN":["2296-889X"],"issn-type":[{"value":"2296-889X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,22]]}}}