{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:46:31Z","timestamp":1791341191389,"version":"4.3.1"},"reference-count":55,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100002426","name":"Fondazione Telethon","doi-asserted-by":"publisher","award":["GGP12047"],"award-info":[{"award-number":["GGP12047"]}],"id":[{"id":"10.13039\/501100002426","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Biosci."],"DOI":"10.3389\/fmolb.2016.00053","type":"journal-article","created":{"date-parts":[[2016,9,12]],"date-time":"2016-09-12T07:33:27Z","timestamp":1473665607000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Melusin Promotes a Protective Signal Transduction Cascade in Stressed Hearts"],"prefix":"10.3389","volume":"3","author":[{"given":"Matteo","family":"Sorge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Brancaccio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2016,9,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.bbagen.2015.09.005","article-title":"Multidimensional significance of crystallin protein-protein interactions and their implications in various human diseases.","volume":"1860(1 Pt B)","author":"Anbarasu","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"B2","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.yjmcc.2004.11.004","article-title":"STRESS signaling pathways that modulate cardiac myocyte apoptosis","volume":"38","author":"Baines","year":"2005","journal-title":"J. Mol. Cell. Cardiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.bbapap.2014.12.019","article-title":"Small heat shock proteins: role in cellular functions and pathology","volume":"1854","author":"Bakthisaran","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"B4","doi-asserted-by":"publisher","first-page":"aac4354","DOI":"10.1126\/science.aac4354","article-title":"In vivo aspects of protein folding and quality control","volume":"353","author":"Balchin","year":"2016","journal-title":"Science"},{"key":"B5","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.pbiomolbio.2014.02.005","article-title":"Cell biological roles of alphaB-crystallin","volume":"115","author":"Boelens","year":"2014","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/nm805","article-title":"Melusin, a muscle-specific integrin beta1-interacting protein, is required to prevent cardiac failure in response to chronic pressure overload","volume":"9","author":"Brancaccio","year":"2003","journal-title":"Nat. Med."},{"key":"B7","doi-asserted-by":"publisher","first-page":"29282","DOI":"10.1074\/jbc.274.41.29282","article-title":"Melusin is a new muscle-specific interactor for beta(1) integrin cytoplasmic domain","volume":"274","author":"Brancaccio","year":"1999","journal-title":"J. Biol. Chem."},{"key":"B8","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.cardiores.2005.12.015","article-title":"Integrin signalling: the tug-of-war in heart hypertrophy","volume":"70","author":"Brancaccio","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"B9","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1016\/j.ejheart.2007.02.009","article-title":"Altered melusin expression in the hearts of aortic stenosis patients","volume":"9","author":"Brokat","year":"2007","journal-title":"Eur. J. Heart Fail."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1038\/sj.gt.3300994","article-title":"Immune responses to adenovirus and adeno-associated virus in humans","volume":"6","author":"Chirmule","year":"1999","journal-title":"Gene Ther."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.1016\/j.biocel.2012.06.006","article-title":"Small heat shock proteins in redox metabolism: implications for cardiovascular diseases","volume":"44","author":"Christians","year":"2012","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1161\/01.RES.0000168028.36081.e0","article-title":"Cardiac overexpression of melusin protects from dilated cardiomyopathy due to long-standing pressure overload","volume":"96","author":"De Acetis","year":"2005","journal-title":"Circ. Res."},{"key":"B13","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1002\/prca.201400037","article-title":"Protein post-translational modifications and misfolding: new concepts in heart failure","volume":"8","author":"Del Monte","year":"2014","journal-title":"Proteomics Clin. Appl."},{"key":"B14","doi-asserted-by":"publisher","first-page":"H2324","DOI":"10.1152\/ajpheart.00392.2006","article-title":"Impact of acute and enduring volume overload on mechanotransduction and cytoskeletal integrity of canine left ventricular myocardium","volume":"292","author":"Donker","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1016\/j.yjmcc.2010.09.013","article-title":"Small heat shock protein 20 (HspB6) in cardiac hypertrophy and failure","volume":"51","author":"Fan","year":"2011","journal-title":"J. Mol. Cell. Cardiol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"e87","DOI":"10.1161\/01.RES.0000079028.31393.15","article-title":"Role of the cytosolic chaperones Hsp70 and Hsp90 in maturation of the cardiac potassium channel HERG","volume":"92","author":"Ficker","year":"2003","journal-title":"Circ. Res."},{"key":"B17","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1074\/mcp.M900261-MCP200","article-title":"A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein","volume":"9","author":"Gano","year":"2010","journal-title":"Mol. Cell. Proteomics"},{"key":"B18","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/S0014-5793(02)03321-5","article-title":"p23 and HSP20\/alpha-crystallin proteins define a conserved sequence domain present in other eukaryotic protein families","volume":"529","author":"Garcia-Ranea","year":"2002","journal-title":"FEBS Lett."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1016\/j.biocel.2012.02.022","article-title":"The small heat shock proteins family: the long forgotten chaperones","volume":"44","author":"Garrido","year":"2012","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.carpath.2011.03.002","article-title":"Altered melusin pathways involved in cardiac remodeling following acute myocardial infarction","volume":"21","author":"Gu","year":"2012","journal-title":"Cardiovasc. Pathol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"4513","DOI":"10.1016\/j.febslet.2005.07.024","article-title":"Regulation of Nod1 by Hsp90 chaperone complex","volume":"579","author":"Hahn","year":"2005","journal-title":"FEBS Lett."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1016\/j.jmb.2015.02.002","article-title":"A first line of stress defense: small heat shock proteins and their function in protein homeostasis","volume":"427","author":"Haslbeck","year":"2015","journal-title":"J. Mol. Biol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.cardiores.2003.09.024","article-title":"New directions for protecting the heart against ischaemia-reperfusion injury: targeting the Reperfusion Injury Salvage Kinase (RISK)-pathway","volume":"61","author":"Hausenloy","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1016\/S0140-6736(14)60107-0","article-title":"Cardiovascular remodelling in coronary artery disease and heart failure","volume":"383","author":"Heusch","year":"2014","journal-title":"Lancet"},{"key":"B25","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1074\/jbc.M112.398636","article-title":"Dynamic nucleotide-dependent interactions of cysteine- and histidine-rich domain (CHORD)-containing Hsp90 cochaperones Chp-1 and melusin with cochaperones PP5 and Sgt1","volume":"288","author":"Hong","year":"2013","journal-title":"J. Biol. Chem."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1161\/01.ATV.0000134300.87476.d1","article-title":"Heat shock protein 90 transfection reduces ischemia-reperfusion-induced myocardial dysfunction via reciprocal endothelial NO synthase serine 1177 phosphorylation and threonine 495 dephosphorylation","volume":"24","author":"Kupatt","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"16511","DOI":"10.1074\/jbc.M400215200","article-title":"Human Sgt1 binds HSP90 through the CHORD-Sgt1 domain and not the tetratricopeptide repeat domain","volume":"279","author":"Lee","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B28","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1016\/j.bbamcr.2011.09.003","article-title":"The Hsp90 chaperone machinery: conformational dynamics and regulation by co-chaperones","volume":"1823","author":"Li","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"B29","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1016\/j.bbamcr.2011.09.001","article-title":"The role of Hsp90 in protein complex assembly","volume":"1823","author":"Makhnevych","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"B30","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1172\/JCI62834","article-title":"Calcium cycling proteins and heart failure: mechanisms and therapeutics","volume":"123","author":"Marks","year":"2013","journal-title":"J. Clin. Invest."},{"key":"B31","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1042\/BST20130272","article-title":"The cardioprotective role of small heat-shock protein 20","volume":"42","author":"Martin","year":"2014","journal-title":"Biochem. Soc. Trans."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.1161\/CIRCRESAHA.116.305372","article-title":"Proteotoxicity and cardiac dysfunction","volume":"116","author":"McLendon","year":"2015","journal-title":"Circ. Res."},{"key":"B33","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1186\/1471-2350-10-140","article-title":"Melusin gene (ITGB1BP2) nucleotide variations study in hypertensive and cardiopathic patients","volume":"10","author":"Palumbo","year":"2009","journal-title":"BMC Med. Genet."},{"issue":"25","key":"B34","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2015.00025","article-title":"Functional amyloid signaling via the inflammasome, necrosome, and signalosome: new therapeutic targets in heart failure","volume":"2","author":"Parry","year":"2015","journal-title":"Front. Cardiovasc. Med."},{"key":"B35","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1007\/s00395-014-0418-9","article-title":"Overexpression of the muscle-specific protein, melusin, protects from cardiac ischemia\/reperfusion injury","volume":"109","author":"Penna","year":"2014","journal-title":"Basic Res. Cardiol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"186","DOI":"10.4330\/wjc.v3.i6.186","article-title":"Ischemia\/reperfusion injury and cardioprotective mechanisms: role of mitochondria and reactive oxygen species","volume":"3","author":"Perrelli","year":"2011","journal-title":"World J. Cardiol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1089\/hum.1997.8.3-275","article-title":"Lack of site-specific integration of the recombinant adeno-associated virus 2 genomes in human cells","volume":"8","author":"Ponnazhagan","year":"1997","journal-title":"Hum. Gene Ther."},{"key":"B38","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.gene.2012.10.055","article-title":"Identification of a missense mutation in the melusin-encoding ITGB1BP2 gene in a patient with dilated cardiomyopathy","volume":"512","author":"Ruppert","year":"2013","journal-title":"Gene"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1788","DOI":"10.1016\/j.febslet.2008.04.058","article-title":"The mammalian CHORD-containing protein melusin is a stress response protein interacting with Hsp90 and Sgt1","volume":"582","author":"Sbroggi\u00f2","year":"2008","journal-title":"FEBS Lett."},{"key":"B40","doi-asserted-by":"publisher","first-page":"3515","DOI":"10.1242\/jcs.091140","article-title":"ERK1\/2 activation in heart is controlled by melusin, focal adhesion kinase and the scaffold protein IQGAP1.","volume":"124(Pt 20)","author":"Sbroggi\u00f2","year":"2011a","journal-title":"J. Cell Sci."},{"key":"B41","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1093\/cvr\/cvr103","article-title":"IQGAP1 regulates ERK1\/2 and AKT signalling in the heart and sustains functional remodelling upon pressure overload","volume":"91","author":"Sbroggi\u00f2","year":"2011b","journal-title":"Cardiovasc. Res."},{"key":"B42","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.cardiores.2004.04.031","article-title":"Adaptive and maladaptive hypertrophic pathways: points of convergence and divergence","volume":"63","author":"Selvetella","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"B43","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/S0092-8674(00)81522-6","article-title":"A novel class of eukaryotic zinc-binding proteins is required for disease resistance signaling in barley and development","volume":"99","author":"Shirasu","year":"1999","journal-title":"C. elegans. Cell"},{"key":"B44","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1093\/cvr\/cvu049","article-title":"Keep your heart in shape: molecular chaperone networks for treating heart disease","volume":"102","author":"Tarone","year":"2014","journal-title":"Cardiovasc. Res."},{"key":"B45","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/S1471-4914(03)00164-3","article-title":"Molecular interplay between mechanical and humoral signalling in cardiac hypertrophy","volume":"9","author":"Tarone","year":"2003","journal-title":"Trends Mol. Med."},{"key":"B46","doi-asserted-by":"publisher","first-page":"4047","DOI":"10.1007\/s00018-013-1321-5","article-title":"Key role of ERK1\/2 molecular scaffolds in heart pathology","volume":"70","author":"Tarone","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"B47","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1093\/cvr\/cvt235","article-title":"Melusin protects from cardiac rupture and improves functional remodelling after myocardial infarction","volume":"101","author":"Uns\u00f6ld","year":"2014","journal-title":"Cardiovasc. Res."},{"key":"B48","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.biochi.2016.05.018","article-title":"Hsp90: friends, clients and natural foes","volume":"127","author":"Verma","year":"2016","journal-title":"Biochimie"},{"key":"B49","doi-asserted-by":"publisher","first-page":"7001","DOI":"10.1021\/bi800639z","article-title":"Structural and functional diversities between members of the human HSPB, HSPH, HSPA, and DNAJ chaperone families","volume":"47","author":"Vos","year":"2008","journal-title":"Biochemistry"},{"key":"B50","doi-asserted-by":"publisher","first-page":"101","DOI":"10.4161\/auto.7.1.13935","article-title":"Small heat shock proteins, protein degradation and protein aggregation diseases","volume":"7","author":"Vos","year":"2011","journal-title":"Autophagy"},{"key":"B51","doi-asserted-by":"publisher","first-page":"30837","DOI":"10.1074\/jbc.M111.271684","article-title":"Phosphoinositide 3-kinase (PI3K(p110alpha)) directly regulates key components of the Z-disc and cardiac structure","volume":"286","author":"Waardenberg","year":"2011","journal-title":"J. Biol. Chem."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1740","DOI":"10.1161\/CIRCULATIONAHA.110.942250","article-title":"Hold me tight: role of the heat shock protein family of chaperones in cardiac disease","volume":"122","author":"Willis","year":"2010","journal-title":"Circulation"},{"key":"B53","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1056\/NEJMra1106180","article-title":"Proteotoxicity and cardiac dysfunction\u2013Alzheimer's disease of the heart?","volume":"368","author":"Willis","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1056\/NEJMra071667","article-title":"Myocardial reperfusion injury","volume":"357","author":"Yellon","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"B55","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.molcel.2010.05.010","article-title":"Structural basis for assembly of Hsp90-Sgt1-CHORD protein complexes: implications for chaperoning of NLR innate immunity receptors","volume":"39","author":"Zhang","year":"2010","journal-title":"Mol. Cell"}],"container-title":["Frontiers in Molecular Biosciences"],"original-title":[],"deposited":{"date-parts":[[2016,10,4]],"date-time":"2016-10-04T13:04:44Z","timestamp":1475586284000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fmolb.2016.00053\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,12]]},"references-count":55,"URL":"https:\/\/doi.org\/10.3389\/fmolb.2016.00053","relation":{},"ISSN":["2296-889X"],"issn-type":[{"value":"2296-889X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,12]]}}}