{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:55:59Z","timestamp":1790722559078,"version":"4.1.0"},"reference-count":82,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T00:00:00Z","timestamp":1543363200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP15H01350"],"award-info":[{"award-number":["JP15H01350"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP17H05596"],"award-info":[{"award-number":["JP17H05596"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP17H03633"],"award-info":[{"award-number":["JP17H03633"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP15KK0252"],"award-info":[{"award-number":["JP15KK0252"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Biosci."],"DOI":"10.3389\/fmolb.2018.00105","type":"journal-article","created":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T05:21:07Z","timestamp":1543382467000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":74,"title":["Alternative Splicing Regulator RBM20 and Cardiomyopathy"],"prefix":"10.3389","volume":"5","author":[{"given":"Takeshi","family":"Watanabe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinori","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidehito","family":"Kuroyanagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,11,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1261\/rna.064394.117","article-title":"Cardiac circRNAs arise mainly from constitutive exons rather than alternatively spliced exons","volume":"24","author":"Aufiero","year":"2018","journal-title":"RNA"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1161\/hh2301.100981","article-title":"The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system","volume":"89","author":"Bang","year":"2001","journal-title":"Circ. Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1093\/cvr\/cvw192","article-title":"A mutation in the glutamate-rich region of RNA-binding motif protein 20 causes dilated cardiomyopathy through missplicing of titin and impaired Frank\u2013Starling mechanism","volume":"112","author":"Beqqali","year":"2016","journal-title":"Cardiovasc. Res."},{"key":"B4","doi-asserted-by":"publisher","first-page":"3779","DOI":"10.1093\/hmg\/ddu091","article-title":"Rbm20-deficient cardiogenesis reveals early disruption of RNA processing and sarcomere remodeling establishing a developmental etiology for dilated cardiomyopathy","volume":"23","author":"Beraldi","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"B5","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1161\/CIRCRESAHA.108.191130","article-title":"Transcriptional and Posttranslational Modifications of Titin","volume":"104","author":"Borb\u00e9ly","year":"2008","journal-title":"Circ. Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1016\/j.jacc.2009.05.038","article-title":"Mutations in ribonucleic acid binding protein gene cause familial dilated cardiomyopathy","volume":"54","author":"Brauch","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1085\/jgp.201311129","article-title":"Removal of immunoglobulin-like domains from titin's spring segment alters titin splicing in mouse skeletal muscle and causes myopathy","volume":"143","author":"Buck","year":"2014","journal-title":"J. Gen. Physiol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1161\/CIRCRESAHA.116.308904","article-title":"Alternative splicing of titin restores diastolic function in an HFpEF-like genetic murine model (Ttn\u0394IAjxn)novelty and significance","volume":"119","author":"Bull","year":"2016","journal-title":"Circ. Res."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1016\/j.cjca.2014.09.030","article-title":"Nonsense mutations in BAG3 are associated with early-onset dilated cardiomyopathy in French Canadians","volume":"30","author":"Chami","year":"2014","journal-title":"Can. J. Cardiol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1161\/CIRCULATIONAHA.112.001268","article-title":"Shortening of the elastic tandem immunoglobulin segment of titin leads to diastolic dysfunction","volume":"128","author":"Chung","year":"2013","journal-title":"Circulation"},{"key":"B11","first-page":"303","article-title":"Matrin3: connecting gene expression with the nuclear matrix","volume-title":"Wiley Interdiscip. Rev. RNA","author":"Coelho","year":"2016"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1042\/CS20160170","article-title":"Molecular mechanisms in cardiomyopathy","volume":"131","author":"Dadson","year":"2017","journal-title":"Clin. Sci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"5227","DOI":"10.1093\/nar\/gky165","article-title":"Molecular basis of titin exon exclusion by RBM20 and the novel titin splice regulator PTB4","volume":"46","author":"Dauksaite","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"B14","doi-asserted-by":"publisher","first-page":"2733","DOI":"10.1093\/eurheartj\/ehu284","article-title":"2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy","volume":"35","author":"Elliott","year":"2014","journal-title":"Eur. Heart J."},{"key":"B15","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1097\/HCO.0000000000000382","article-title":"Titin-truncating mutations in dilated cardiomyopathy","volume":"32","author":"Fatkin","year":"2017","journal-title":"Curr. Opin. Cardiol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"2989","DOI":"10.1016\/j.febslet.2013.07.018","article-title":"Identification of nuclear retention domains in the RBM20 protein","volume":"587","author":"Filippello","year":"2013","journal-title":"FEBS Lett."},{"key":"B17","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1113\/jphysiol.2003.049759","article-title":"Titin isoform variance and length dependence of activation in skinned bovine cardiac muscle","volume":"553","author":"Fukuda","year":"2003","journal-title":"J. Physiol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3389\/fcvm.2016.00021","article-title":"A review of the giant protein titin in clinical molecular diagnostics of cardiomyopathies","volume":"3","author":"Gigli","year":"2016","journal-title":"Front. Cardiovasc. Med."},{"key":"B19","doi-asserted-by":"publisher","first-page":"14589","DOI":"10.1073\/pnas.1411493111","article-title":"Deleting titin's I-band\/A-band junction reveals critical roles for titin in biomechanical sensing and cardiac function","volume":"111","author":"Granzier","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B20","doi-asserted-by":"publisher","first-page":"753675","DOI":"10.1155\/2010\/753675","article-title":"Titin diversity\u2013alternative splicing gone wild","volume":"2010","author":"Guo","year":"2010","journal-title":"J. Biomed. Biotechnol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1038\/nm.2693","article-title":"RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing","volume":"18","author":"Guo","year":"2012","journal-title":"Nat. Med."},{"key":"B22","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s12551-017-0267-5","article-title":"RBM20, a potential target for treatment of cardiomyopathy via titin isoform switching","volume":"10","author":"Guo","year":"2017","journal-title":"Biophys. Rev."},{"key":"B23","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/nature11993","article-title":"Natural RNA circles function as efficient microRNA sponges","volume":"495","author":"Hansen","year":"2013","journal-title":"Nature"},{"key":"B24","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1056\/NEJMoa1110186","article-title":"Truncations of titin causing dilated cardiomyopathy","volume":"366","author":"Herman","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"B25","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1038\/nrcardio.2013.105","article-title":"Dilated cardiomyopathy: the complexity of a diverse genetic architecture","volume":"10","author":"Hershberger","year":"2013","journal-title":"Nat. Rev. Cardiol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.tcm.2012.10.005","article-title":"Tuning the molecular giant titin through phosphorylation: role in health and disease","volume":"23","author":"Hidalgo","year":"2013","journal-title":"Trends Cardiovasc. Med."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1007\/s00109-016-1483-3","article-title":"Reducing RBM20 activity improves diastolic dysfunction and cardiac atrophy","volume":"94","author":"Hinze","year":"2016","journal-title":"J. Mol. Med."},{"key":"B28","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1038\/323160a0","article-title":"A physiological role for titin and nebulin in skeletal muscle","volume":"323","author":"Horowits","year":"1986","journal-title":"Nature"},{"key":"B29","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/s00392-016-1033-6","article-title":"Genotype-phenotype associations in dilated cardiomyopathy: meta-analysis on more than 8000 individuals","volume":"106","author":"Kayvanpour","year":"2017","journal-title":"Clin. Res. Cardiol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1161\/CIRCRESAHA.116.309568","article-title":"RBM20 regulates circular RNA production from the titin gene","volume":"119","author":"Khan","year":"2016","journal-title":"Circ. Res."},{"key":"B31","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/jhg.2015.83","article-title":"Molecular genetics and pathogenesis of cardiomyopathy","volume":"61","author":"Kimura","year":"2016","journal-title":"J. Hum. Genet."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1016\/j.healun.2009.05.027","article-title":"Outcome of pediatric patients with dilated cardiomyopathy listed for transplant: a multi-institutional study","volume":"28","author":"Kirk","year":"2009","journal-title":"J. Heart Lung Transplant."},{"key":"B33","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1161\/CIRCRESAHA.107.162719","article-title":"Thyroid hormone regulates developmental titin isoform transitions via the phosphatidylinositol-3-kinase\/ AKT pathway","volume":"102","author":"Kr\u00fcger","year":"2008","journal-title":"Circ. Res."},{"key":"B34","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1038\/nmeth944","article-title":"Transgenic alternative-splicing reporters reveal tissue-specific expression profiles and regulation mechanisms in vivo","volume":"3","author":"Kuroyanagi","year":"2006","journal-title":"Nat. Methods"},{"key":"B35","doi-asserted-by":"publisher","first-page":"8612","DOI":"10.1128\/MCB.01508-07","article-title":"The Fox-1 family and SUP-12 coordinately regulate tissue-specific alternative splicing in vivo","volume":"27","author":"Kuroyanagi","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"e1003337","DOI":"10.1371\/journal.pgen.1003337","article-title":"CELF family RNA\u2013binding protein UNC-75 regulates two sets of mutually exclusive exons of the unc-32 gene in neuron-specific manners in Caenorhabditis elegans","volume":"9","author":"Kuroyanagi","year":"2013","journal-title":"PLoS Genet."},{"key":"B37","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1038\/345273a0","article-title":"A regular pattern of two types of 100-residue motif in the sequence of titin","volume":"345","author":"Labeit","year":"1990","journal-title":"Nature"},{"key":"B38","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1161\/01.RES.0000115522.52554.86","article-title":"Developmental control of titin isoform expression and passive stiffness in fetal and neonatal myocardium","volume":"94","author":"Lahmers","year":"2004","journal-title":"Circ. Res."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1126\/science.1110463","article-title":"The kinase domain of titin controls muscle gene expression and protein turnover","volume":"308","author":"Lange","year":"2005","journal-title":"Science"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cca.2006.06.035","article-title":"Cardiac titin: Structure, functions and role in disease","volume":"375","author":"Lewinter","year":"2007","journal-title":"Clin. Chim. Acta"},{"key":"B41","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1111\/j.1752-8062.2010.00198.x","article-title":"Identification of novel mutations in RBM20 in patients with dilated cardiomyopathy","volume":"3","author":"Li","year":"2010","journal-title":"Clin. Transl. Sci."},{"key":"B42","doi-asserted-by":"publisher","first-page":"2659","DOI":"10.1093\/nar\/gks1362","article-title":"Rbm20 regulates titin alternative splicing as a splicing repressor","volume":"41","author":"Li","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"B43","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/j.molcel.2018.06.034","article-title":"The biogenesis, functions, and challenges of circular RNAs","volume":"71","author":"Li","year":"2018","journal-title":"Mol. Cell"},{"key":"B44","doi-asserted-by":"publisher","first-page":"e0198492","DOI":"10.1371\/journal.pone.0198492","article-title":"Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling","volume":"13","author":"Liss","year":"2018","journal-title":"PLoS ONE"},{"key":"B45","doi-asserted-by":"publisher","first-page":"3419","DOI":"10.1172\/JCI74523","article-title":"RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing","volume":"124","author":"Maatz","year":"2014","journal-title":"J. Clin. Invest."},{"key":"B46","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1161\/01.RES.0000143901.37063.2f","article-title":"Passive stiffness changes caused by upregulation of compliant titin isoforms in human dilated cardiomyopathy hearts","volume":"95","author":"Makarenko","year":"2004","journal-title":"Circ. Res."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2012\/796926","article-title":"Cardiomyopathy classification: ongoing debate in the genomics era","volume":"2012","author":"McCartan","year":"2012","journal-title":"Biochem. Res. Int."},{"key":"B48","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1161\/CIRCRESAHA.117.309711","article-title":"Classification, epidemiology, and global burden of cardiomyopathies","volume":"121","author":"McKenna","year":"2017","journal-title":"Circ. Res."},{"key":"B49","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/nature11928","article-title":"Circular RNAs are a large class of animal RNAs with regulatory potency","volume":"495","author":"Memczak","year":"2013","journal-title":"Nature"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.1161\/CIRCULATIONAHA.113.005610","article-title":"Experimentally increasing titin compliance in a novel mouse model attenuates the frank-starling mechanism but has a beneficial effect on diastole","volume":"129","author":"Methawasin","year":"2014","journal-title":"Circulation"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1161\/CIRCULATIONAHA.116.023003","article-title":"Experimentally increasing the compliance of titin through RNA binding Motif-20 (RBM20) inhibition improves diastolic function in a mouse model of heart failure with preserved ejection fractionclinical perspective","volume":"134","author":"Methawasin","year":"2016","journal-title":"Circulation"},{"key":"B52","doi-asserted-by":"publisher","first-page":"e570","DOI":"10.1016\/j.ejmg.2011.07.005","article-title":"Clinical and mutational spectrum in a cohort of 105 unrelated patients with dilated cardiomyopathy","volume":"54","author":"Millat","year":"2011","journal-title":"Eur. J. Med. Genet."},{"key":"B53","doi-asserted-by":"publisher","first-page":"8970","DOI":"10.1038\/s41598-018-26624-w","article-title":"Phosphorylation of the RSRSP stretch is critical for splicing regulation by RNA-Binding Motif Protein 20 (RBM20) through nuclear localization","volume":"8","author":"Murayama","year":"2018","journal-title":"Sci. Rep."},{"key":"B54","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1161\/01.CIR.0000135591.37759.AF","article-title":"Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy","volume":"110","author":"Nagueh","year":"2004","journal-title":"Circulation"},{"key":"B55","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1023\/A:1026053530766","article-title":"Gigantic variety: expression patterns of titin isoforms in striated muscles and consequences for myofibrillar passive stiffness","volume":"24","author":"Neagoe","year":"2003","journal-title":"J. Muscle Res. Cell Motil."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1038\/s41588-018-0171-3","article-title":"Biobank-driven genomic discovery yields new insight into atrial fibrillation biology","volume":"50","author":"Nielsen","year":"2018","journal-title":"Nat. Genet."},{"key":"B57","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1161\/01.RES.0000124301.48193.E1","article-title":"Developmentally regulated switching of titin size alters myofibrillar stiffness in the perinatal heart","volume":"94","author":"Opitz","year":"2004","journal-title":"Circ. Res."},{"key":"B58","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/s10974-005-9040-7","article-title":"Plasticity of cardiac titin\/connectin in heart development","volume":"26","author":"Opitz","year":"2005","journal-title":"J. Muscle Res. Cell Motil."},{"key":"B59","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.ijcard.2016.09.068","article-title":"Genetic basis of dilated cardiomyopathy","volume":"224","author":"P\u00e9rez-Serra","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"3444","DOI":"10.1073\/pnas.0608543104","article-title":"Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy","volume":"104","author":"Radke","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B61","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.ppedcard.2010.11.008","article-title":"Rare variant mutations identified in pediatric patients with dilated cardiomyopathy","volume":"31","author":"Rampersaud","year":"2011","journal-title":"Prog. Pediatr. Cardiol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/j.hrthm.2011.10.016","article-title":"Genetic variation in the alternative splicing regulator RBM20 is associated with dilated cardiomyopathy","volume":"9","author":"Refaat","year":"2012","journal-title":"HRTHM"},{"key":"B63","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1016\/j.celrep.2016.01.025","article-title":"Work done by titin protein folding assists muscle contraction","volume":"14","author":"Rivas-Pardo","year":"2016","journal-title":"Cell Rep."},{"key":"B64","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/cge.13027","article-title":"Genetics of hypertrophic cardiomyopathy: a review of current state","volume":"93","author":"Sabater-Molina","year":"2018","journal-title":"Clin. Genet."},{"key":"B65","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.bbagrm.2013.02.005","article-title":"Nonsense-mediated mRNA decay \u2014 mechanisms of substrate mRNA recognition and degradation in mammalian cells","volume":"1829","author":"Schweingruber","year":"2013","journal-title":"Biochim. Biophys. Acta Gene Regul. Mech."},{"key":"B66","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.yjmcc.2017.09.008","article-title":"Severe DCM phenotype of patient harboring RBM20 mutation S635A can be modeled by patient-specific induced pluripotent stem cell-derived cardiomyocytes","volume":"113","author":"Streckfuss-B\u00f6meke","year":"2017","journal-title":"J. Mol. Cell. Cardiol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1161\/CIRCULATIONAHA.117.031947","article-title":"RBM20 mutations induce an arrhythmogenic dilated cardiomyopathy related to disturbed calcium handling","volume":"138","author":"van den Hoogenhof","year":"2018","journal-title":"Circulation"},{"key":"B68","doi-asserted-by":"publisher","first-page":"3698","DOI":"10.1073\/pnas.76.8.3698","article-title":"Titin: major myofibrillar components of striated muscle","volume":"76","author":"Wang","year":"1979","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B69","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/S0008-6363(03)00328-6","article-title":"Titin isoform expression in normal and hypertensive myocardium","volume":"59","author":"Warren","year":"2003","journal-title":"Cardiovasc. Res."},{"key":"B70","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1016\/j.mod.2004.07.003","article-title":"Titin isoform changes in rat myocardium during development","volume":"121","author":"Warren","year":"2004","journal-title":"Mech. Dev."},{"key":"B71","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1161\/CIRCGENETICS.113.000011","article-title":"Whole exome sequencing identifies a causal RBM20 mutation in a large pedigree with familial dilated cardiomyopathy","volume":"6","author":"Wells","year":"2013","journal-title":"Circ. Cardiovasc. Genet."},{"key":"B72","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1111\/cts.12393","article-title":"Pharmacological modulation of calcium homeostasis in familial dilated cardiomyopathy: an in vitro analysis from an RBM20 patient-derived iPSC model","volume":"9","author":"Wyles","year":"","journal-title":"Clin. Transl. Sci."},{"key":"B73","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1093\/hmg\/ddv468","article-title":"Modeling structural and functional deficiencies of RBM20 familial dilated cardiomyopathy using human induced pluripotent stem cells","volume":"25","author":"Wyles","year":"","journal-title":"Hum. Mol. Genet."},{"key":"B74","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1101\/gad.11.3.334","article-title":"Phosphorylation of the ASF\/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing","volume":"11","author":"Xiao","year":"1997","journal-title":"Genes Dev."},{"key":"B75","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1083\/jcb.145.3.447","article-title":"Phosphorylation regulates in vivo interaction and molecular targeting of serine\/arginine-rich pre-mRNA splicing factors","volume":"145","author":"Yeakley","year":"1999","journal-title":"J. Cell Biol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1101\/gad.6.5.837","article-title":"SR proteins: a conserved family of pre-mRNA splicing factors","volume":"6","author":"Zahler","year":"1992","journal-title":"Genes Dev."},{"key":"B77","doi-asserted-by":"publisher","first-page":"231","DOI":"10.3389\/fgene.2018.00231","article-title":"Exploring the crosstalk between LMNA and splicing machinery gene mutations in dilated cardiomyopathy","volume":"9","author":"Zahr","year":"2018","journal-title":"Front. Genet."},{"key":"B78","doi-asserted-by":"publisher","first-page":"D754","DOI":"10.1093\/nar\/gkx1098","article-title":"Ensembl 2018","volume":"46","author":"Zerbino","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"B79","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.3892\/ijmm.2015.2361","article-title":"Targeted next-generation sequencing of candidate genes reveals novel mutations in patients with dilated cardiomyopathy","volume":"36","author":"Zhao","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"B80","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.mex.2017.09.007","article-title":"Detection and quantification of the giant protein titin by SDS-agarose gel electrophoresis","volume":"4","author":"Zhu","year":"2017","journal-title":"MethodsX"},{"key":"B81","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1093\/jmcb\/mjv002","article-title":"RBM20 is an essential factor for thyroid hormone-regulated titin isoform transition","volume":"7","author":"Zhu","year":"2015","journal-title":"J. Mol. Cell Biol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"2363","DOI":"10.1016\/j.bbadis.2017.06.023","article-title":"Insulin regulates titin pre-mRNA splicing through the PI3K-Akt-mTOR kinase axis in a RBM20-dependent manner","volume":"1863","author":"Zhu","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."}],"container-title":["Frontiers in Molecular Biosciences"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmolb.2018.00105\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T05:21:10Z","timestamp":1543382470000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fmolb.2018.00105\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,28]]},"references-count":82,"alternative-id":["10.3389\/fmolb.2018.00105"],"URL":"https:\/\/doi.org\/10.3389\/fmolb.2018.00105","relation":{},"ISSN":["2296-889X"],"issn-type":[{"value":"2296-889X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,28]]},"article-number":"105"}}