{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T23:13:24Z","timestamp":1787094804146,"version":"build-2736575974"},"reference-count":441,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Biosci."],"abstract":"<jats:p>Mitochondrial dysfunction is a central feature of neurodegeneration within the central and peripheral nervous system, highlighting a strong dependence on proper mitochondrial function of neurons with especially high energy consumptions. The fitness of mitochondria critically depends on preservation of distinct processes, including the maintenance of their own genome, mitochondrial dynamics, quality control, and Ca<jats:sup>2+<\/jats:sup> handling. These processes appear to be differently affected in common neurodegenerative diseases, such as Alzheimer\u2019s and Parkinson\u2019s disease, as well as in rare neurological disorders, including Huntington\u2019s disease, Amyotrophic Lateral Sclerosis and peripheral neuropathies. Strikingly, particular neuron populations of different morphology and function perish in these diseases, suggesting that cell-type specific factors contribute to the vulnerability to distinct mitochondrial defects. Here we review the disruption of mitochondrial processes in common as well as in rare neurological disorders and its impact on selective neurodegeneration. Understanding discrepancies and commonalities regarding mitochondrial dysfunction as well as individual neuronal demands will help to design new targets and to make use of already established treatments in order to improve treatment of these diseases.<\/jats:p>","DOI":"10.3389\/fmolb.2021.676187","type":"journal-article","created":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T07:07:24Z","timestamp":1625036844000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":32,"title":["Selective Neuron Vulnerability in Common and Rare Diseases\u2014Mitochondria in the Focus"],"prefix":"10.3389","volume":"8","author":[{"given":"Thomas","family":"Pa\u00df","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf J.","family":"Wiesner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Pla-Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,6,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1002\/acn3.281","article-title":"A LRSAM1 Mutation Links Charcot-Marie-Tooth Type 2 to P Arkinson\u2019s Disease","volume":"3","author":"Aerts","year":"2016","journal-title":"Ann. Clin. Transl Neurol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1046\/j.1471-4159.1997.69031196.x","article-title":"Oxidative DNA Damage in the Parkinsonian Brain: an Apparent Selective Increase in 8-hydroxyguanine Levels in Substantia Nigra","volume":"69","author":"Alam","year":"1997","journal-title":"J. Neurochem."},{"key":"B3","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.baga.2015.06.001","article-title":"The Vulnerable Ventral Tegmental Area in Parkinson's Disease","volume":"5","author":"Alberico","year":"2015","journal-title":"Basal Ganglia"},{"key":"B4","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1002\/ana.410360608","article-title":"The Role of Calcium-Binding Proteins in Selective Motoneuron Vulnerability in Amyotrophic Lateral Sclerosis","volume":"36","author":"Alexianu","year":"1994","journal-title":"Ann. Neurol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"4048","DOI":"10.1172\/jci64604","article-title":"AFG3L2 Supports Mitochondrial Protein Synthesis and Purkinje Cell Survival","volume":"122","author":"Almajan","year":"2012","journal-title":"J. Clin. Invest."},{"key":"B6","doi-asserted-by":"publisher","first-page":"5562","DOI":"10.1073\/pnas.91.12.5562","article-title":"Role of Abnormally Phosphorylated Tau in the Breakdown of Microtubules in Alzheimer Disease","volume":"91","author":"Alonso","year":"1994","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1038\/39885","article-title":"Anterograde Transport of Brain-Derived Neurotrophic Factor and its Role in the Brain","volume":"389","author":"Altar","year":"1997","journal-title":"Nature"},{"key":"B8","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1002\/ana.20681","article-title":"OPA1 R445H Mutation in Optic Atrophy Associated with Sensorineural Deafness","volume":"58","author":"Amati-Bonneau","year":"2005","journal-title":"Ann. Neurol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.neulet.2014.07.045","article-title":"Detailed Analysis of Mitochondrial Respiratory Chain Defects Caused by Loss of PINK1","volume":"580","author":"Amo","year":"2014","journal-title":"Neurosci. Lett."},{"key":"B10","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1016\/j.neurobiolaging.2008.07.005","article-title":"Vesicle Associated Membrane Protein B (VAPB) Is Decreased in ALS Spinal Cord","volume":"31","author":"Anagnostou","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"B11","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1083\/jcb.201308006","article-title":"The I-AAA Protease YME1L and OMA1 Cleave OPA1 to Balance Mitochondrial Fusion and Fission","volume":"204","author":"Anand","year":"2014","journal-title":"J. Cel Biol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.mcn.2008.04.007","article-title":"CEP-1347 Reduces Mutant Huntingtin-Associated Neurotoxicity and Restores BDNF Levels in R6\/2 Mice","volume":"39","author":"Apostol","year":"2008","journal-title":"Mol. Cell Neurosci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1096\/fj.201601309","article-title":"On the Pathogenesis of Alzheimer's Disease: The MAM Hypothesis","volume":"31","author":"Area-Gomez","year":"2017","journal-title":"FASEB j."},{"key":"B14","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1113\/jphysiol.1979.sp012745","article-title":"Activity Patterns of Cerebellar Cortical Neurones and Climbing Fibre Afferents in the Awake Cat","volume":"289","author":"Armstrong","year":"1979","journal-title":"J. Physiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1093\/cercor\/1.1.103","article-title":"The Topographical and Neuroanatomical Distribution of Neurofibrillary Tangles and Neuritic Plaques in the Cerebral Cortex of Patients with Alzheimer's Disease","volume":"1","author":"Arnold","year":"1991","journal-title":"Cereb. Cortex"},{"key":"B16","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1083\/jcb.201401070","article-title":"Mitophagy of Damaged Mitochondria Occurs Locally in Distal Neuronal Axons and Requires PINK1 and Parkin","volume":"206","author":"Ashrafi","year":"2014","journal-title":"J. Cel Biol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/bf00691318","article-title":"The Ultrastructure of Intramuscular Nerves in Amyotrophic Lateral Sclerosis","volume":"55","author":"Atsumi","year":"1981","journal-title":"Acta Neuropathol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1097\/00004647-200110000-00001","article-title":"An Energy Budget for Signaling in the Grey Matter of the Brain","volume":"21","author":"Attwell","year":"2001","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B20","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1083\/jcb.136.4.833","article-title":"Mitochondrial Participation in the Intracellular Ca2+ Network","volume":"136","author":"Babcock","year":"1997","journal-title":"J. Cel Biol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"2313","DOI":"10.1111\/j.1460-9568.2008.06192.x","article-title":"Intratelencephalic Corticostriatal Neurons Equally Excite Striatonigral and Striatopallidal Neurons and Their Discharge Activity Is Selectively Reduced in Experimental Parkinsonism","volume":"27","author":"Ballion","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1001\/archneur.64.7.998","article-title":"Familial Parkinsonism and Ophthalmoplegia from a Mutation in the Mitochondrial DNA Helicase Twinkle","volume":"64","author":"Baloh","year":"2007","journal-title":"Arch. Neurol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"4250","DOI":"10.1523\/jneurosci.3920-03.2004","article-title":"Early Striatal Dendrite Deficits Followed by Neuron Loss with Advanced Age in the Absence of Anterograde Cortical Brain-Derived Neurotrophic Factor","volume":"24","author":"Baquet","year":"2004","journal-title":"J. Neurosci."},{"key":"B24","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1073\/pnas.1811021116","article-title":"Mitochondria Modulate Programmed Neuritic Retraction","volume":"116","author":"Baranov","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"B25","doi-asserted-by":"publisher","first-page":"e1005115","DOI":"10.1371\/journal.pgen.1005115","article-title":"Lack of GDAP1 Induces Neuronal Calcium and Mitochondrial Defects in a Knockout Mouse Model of Charcot-Marie-Tooth Neuropathy","volume":"11","author":"Barneo-Munoz","year":"2015","journal-title":"Plos Genet."},{"key":"B26","doi-asserted-by":"publisher","first-page":"3469","DOI":"10.1523\/jneurosci.23-08-03469.2003","article-title":"Calbindin in Cerebellar Purkinje Cells Is a Critical Determinant of the Precision of Motor Coordination","volume":"23","author":"Barski","year":"2003","journal-title":"J. Neurosci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1073\/pnas.1004744108","article-title":"TrkB Receptor Controls Striatal Formation by Regulating the Number of Newborn Striatal Neurons","volume":"108","author":"Baydyuk","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B28","doi-asserted-by":"publisher","first-page":"254","DOI":"10.3389\/fncel.2014.00254","article-title":"BDNF Signaling and Survival of Striatal Neurons","volume":"8","author":"Baydyuk","year":"2014","journal-title":"Front Cel Neurosci"},{"key":"B29","doi-asserted-by":"publisher","first-page":"18338","DOI":"10.1523\/jneurosci.1249-11.2011","article-title":"Role of the Glyoxalase System in Astrocyte-Mediated Neuroprotection","volume":"31","author":"Belanger","year":"2011","journal-title":"J. Neurosci."},{"key":"B30","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1038\/ng1769","article-title":"High Levels of Mitochondrial DNA Deletions in Substantia Nigra Neurons in Aging and Parkinson Disease","volume":"38","author":"Bender","year":"2006","journal-title":"Nat. Genet."},{"key":"B31","doi-asserted-by":"publisher","first-page":"5094","DOI":"10.1038\/s41467-019-12834-x","article-title":"Cav2.3 Channels Contribute to Dopaminergic Neuron Loss in a Model of Parkinson's Disease","volume":"10","author":"Benkert","year":"2019","journal-title":"Nat. Commun."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1093\/hmg\/ddaa066","article-title":"Impaired Mitochondrial-Endoplasmic Reticulum Interaction and Mitophagy in Miro1-Mutant Neurons in Parkinson's Disease","volume":"29","author":"Berenguer-Escuder","year":"2020","journal-title":"Hum. Mol. Genet."},{"key":"B33","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1093\/brain\/awv008","article-title":"Dysfunction in Endoplasmic Reticulum-Mitochondria Crosstalk Underlies SIGMAR1 Loss of Function Mediated Motor Neuron Degeneration","volume":"138","author":"Bernard-Marissal","year":"2015","journal-title":"Brain"},{"key":"B34","doi-asserted-by":"publisher","first-page":"2328","DOI":"10.1073\/pnas.1810932116","article-title":"Altered Interplay between Endoplasmic Reticulum and Mitochondria in Charcot-Marie-Tooth Type 2A Neuropathy","volume":"116","author":"Bernard-Marissal","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1038\/81834","article-title":"Chronic Systemic Pesticide Exposure Reproduces Features of Parkinson's Disease","volume":"3","author":"Betarbet","year":"2000","journal-title":"Nat. Neurosci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1002\/acn3.412","article-title":"A Novel Design of a Phase III Trial of Isradipine in Early Parkinson Disease (STEADY-PD III)","volume":"4","author":"Biglan","year":"2017","journal-title":"Ann. Clin. Transl Neurol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"5840","DOI":"10.1523\/jneurosci.22-14-05840.2002","article-title":"Presynaptic Mitochondrial Calcium Sequestration Influences Transmission at Mammalian central Synapses","volume":"22","author":"Billups","year":"2002","journal-title":"J. Neurosci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1002\/ana.21235","article-title":"Dynamin 2 Mutations Cause Sporadic Centronuclear Myopathy with Neonatal Onset","volume":"62","author":"Bitoun","year":"2007","journal-title":"Ann. Neurol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.1002\/mds.25135","article-title":"Living on the edge with too many mouths to feed: why dopamine neurons die","volume":"27","author":"Bolam","year":"2012","journal-title":"Mov. Disord."},{"key":"B40","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/bf00308809","article-title":"Neuropathological Stageing of Alzheimer-Related Changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s00441-004-0956-9","article-title":"Stages in the Development of Parkinson's Disease-Related Pathology","volume":"318","author":"Braak","year":"2004","journal-title":"Cell Tissue Res"},{"key":"B42","doi-asserted-by":"publisher","first-page":"3232","DOI":"10.1093\/hmg\/ddw173","article-title":"A Reduction in Drp1-Mediated Fission Compromises Mitochondrial Health in Autosomal Recessive Spastic Ataxia of Charlevoix Saguenay","volume":"25","author":"Bradshaw","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1016\/j.cub.2010.05.066","article-title":"Vps35 Mediates Vesicle Transport between the Mitochondria and Peroxisomes","volume":"20","author":"Braschi","year":"2010","journal-title":"Curr. Biol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1212\/wnl.0000000000010674","article-title":"Twinkle-associated Familial Parkinsonism with Lewy Pathology","volume":"95","author":"Breen","year":"2020","journal-title":"Neurology"},{"key":"B45","doi-asserted-by":"publisher","first-page":"338ra366","DOI":"10.1126\/scitranslmed.aaf2362","article-title":"Tau and Abeta Imaging, CSF Measures, and Cognition in Alzheimer's Disease","volume":"8","author":"Brier","year":"2016","journal-title":"Sci. Transl Med."},{"key":"B46","doi-asserted-by":"publisher","first-page":"102150","DOI":"10.1016\/j.ceca.2019.102150","article-title":"Tau Inhibits Mitochondrial Calcium Efflux and Makes Neurons Vulnerable to Calcium-Induced Cell Death","volume":"86","author":"Britti","year":"2020","journal-title":"Cell Calcium"},{"key":"B47","doi-asserted-by":"publisher","first-page":"6634","DOI":"10.1038\/s41598-019-43024-w","article-title":"Cortical Circuit Alterations Precede Motor Impairments in Huntington's Disease Mice","volume":"9","author":"Burgold","year":"2019","journal-title":"Sci. Rep."},{"key":"B48","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1126\/science.174.4010.709","article-title":"Mammalian Motor Units: Physiological-Histochemical Correlation in Three Types in Cat Gastrocnemius","volume":"174","author":"Burke","year":"1971","journal-title":"Science"},{"key":"B49","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1113\/jphysiol.1973.sp010370","article-title":"Anatomy and Innervation Ratios in Motor Units of Cat Gastrocnemius","volume":"234","author":"Burke","year":"1973","journal-title":"J. Physiol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"2835","DOI":"10.1093\/hmg\/ddz107","article-title":"Altered Calcium Dynamics and Glutamate Receptor Properties in iPSC-Derived Motor Neurons from ALS Patients with C9orf72, FUS, SOD1 or TDP43 Mutations","volume":"28","author":"Bursch","year":"2019","journal-title":"Hum. Mol. Genet."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1126\/science.1162844","article-title":"Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer's Disease","volume":"321","author":"Busche","year":"2008","journal-title":"Science"},{"key":"B52","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1002\/cne.10760","article-title":"Progressive Degeneration of Nonphosphorylated Neurofilament Protein-Enriched Pyramidal Neurons Predicts Cognitive Impairment in Alzheimer's Disease: Stereologic Analysis of Prefrontal Cortex Area 9","volume":"463","author":"Bussi\u00e8re","year":"2003","journal-title":"J. Comp. Neurol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.cub.2012.02.005","article-title":"Spatial Parkin Translocation and Degradation of Damaged Mitochondria via Mitophagy in Live Cortical Neurons","volume":"22","author":"Cai","year":"2012","journal-title":"Curr. Biol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"17914","DOI":"10.1074\/jbc.m111.302794","article-title":"\u03b1-Synuclein Controls Mitochondrial Calcium Homeostasis by Enhancing Endoplasmic Reticulum-Mitochondria Interactions","volume":"287","author":"Cal\u00ec","year":"2012","journal-title":"J. Biol. Chem."},{"key":"B55","doi-asserted-by":"publisher","first-page":"546","DOI":"10.3109\/21678421.2013.803576","article-title":"Eye Tracking Communication Devices in Amyotrophic Lateral Sclerosis: Impact on Disability and Quality of Life","volume":"14","author":"Caligari","year":"2013","journal-title":"Amyotroph. Lateral Scler. Frontotemporal Degener"},{"key":"B56","doi-asserted-by":"publisher","first-page":"D1251","DOI":"10.1093\/nar\/gkv1003","article-title":"MitoCarta2.0: an Updated Inventory of Mammalian Mitochondrial Proteins","volume":"44","author":"Calvo","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"B57","doi-asserted-by":"publisher","first-page":"207","DOI":"10.3233\/jad-151189","article-title":"Aging Enables Ca2+ Overload and Apoptosis Induced by Amyloid-\u03b2 Oligomers in Rat Hippocampal Neurons: Neuroprotection by Non-steroidal Anti-inflammatory Drugs and R-Flurbiprofen in Aging Neurons","volume":"54","author":"Calvo-Rodr\u00edguez","year":"2016","journal-title":"Jad"},{"key":"B58","doi-asserted-by":"publisher","first-page":"22","DOI":"10.3389\/fncel.2019.00022","article-title":"Amyloid Beta Oligomers Increase ER-Mitochondria Ca(2+) Cross Talk in Young Hippocampal Neurons and Exacerbate Aging-Induced Intracellular Ca(2+) Remodeling","volume":"13","author":"Calvo-Rodriguez","year":"2019","journal-title":"Front. Cel Neurosci"},{"key":"B59","doi-asserted-by":"publisher","first-page":"2146","DOI":"10.1038\/s41467-020-16074-2","article-title":"Increased Mitochondrial Calcium Levels Associated with Neuronal Death in a Mouse Model of Alzheimer's Disease","volume":"11","author":"Calvo-Rodriguez","year":"2020","journal-title":"Nat. Commun."},{"key":"B60","article-title":"Mitochondria-lysosome Membrane Contacts Are Defective in GDAP1-Related Charcot-Marie-Tooth Disease","volume":"29","author":"Cantarero","year":"2020","journal-title":"Hum. Mol. Genet."},{"key":"B61","doi-asserted-by":"publisher","first-page":"E3544","DOI":"10.1073\/pnas.1413201111","article-title":"Calcineurin Determines Toxic versus Beneficial Responses to -synuclein","volume":"111","author":"Caraveo","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/s0014-5793(97)01051-x","article-title":"Expression of a Cu,Zn Superoxide Dismutase Typical of Familial Amyotrophic Lateral Sclerosis Induces Mitochondrial Alteration and Increase of Cytosolic Ca2+ Concentration in Transfected Neuroblastoma SH-Sy5y Cells","volume":"414","author":"Carr\u00ec","year":"1997","journal-title":"FEBS Lett."},{"key":"B63","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/nrn3886","article-title":"Redefining the Cerebellar Cortex as an Assembly of Non-uniform Purkinje Cell Microcircuits","volume":"16","author":"Cerminara","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"B64","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1038\/nature05865","article-title":"\u2018Rejuvenation' Protects Neurons in Mouse Models of Parkinson's Disease","volume":"447","author":"Chan","year":"2007","journal-title":"Nature"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1726","DOI":"10.1093\/hmg\/ddr048","article-title":"Broad Activation of the Ubiquitin-Proteasome System by Parkin Is Critical for Mitophagy","volume":"20","author":"Chan","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"B66","doi-asserted-by":"publisher","first-page":"18195","DOI":"10.1074\/jbc.m000040200","article-title":"Presenilin-1 Mutations Increase Levels of Ryanodine Receptors and Calcium Release in PC12 Cells and Cortical Neurons","volume":"275","author":"Chan","year":"2000","journal-title":"J. Biol. Chem."},{"key":"B67","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.nbd.2005.12.007","article-title":"Mutant Huntingtin Aggregates Impair Mitochondrial Movement and Trafficking in Cortical Neurons","volume":"22","author":"Chang","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1016\/j.ymthe.2018.02.029","article-title":"Targeting Amyloid-\u03b2 Precursor Protein, APP, Splicing with Antisense Oligonucleotides Reduces Toxic Amyloid-\u03b2 Production","volume":"26","author":"Chang","year":"2018","journal-title":"Mol. Ther."},{"key":"B69","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1083\/jcb.200211046","article-title":"Mitofusins Mfn1 and Mfn2 Coordinately Regulate Mitochondrial Fusion and Are Essential for Embryonic Development","volume":"160","author":"Chen","year":"2003","journal-title":"J. Cel Biol"},{"key":"B70","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1016\/j.cell.2007.06.026","article-title":"Mitochondrial Fusion Protects against Neurodegeneration in the Cerebellum","volume":"130","author":"Chen","year":"2007","journal-title":"Cell"},{"key":"B71","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.cell.2010.02.026","article-title":"Mitochondrial Fusion Is Required for mtDNA Stability in Skeletal Muscle and Tolerance of mtDNA Mutations","volume":"141","author":"Chen","year":"2010","journal-title":"Cell"},{"key":"B72","doi-asserted-by":"publisher","first-page":"2533","DOI":"10.1016\/j.neurobiolaging.2015.05.018","article-title":"NLRP3 Inflammasome Activation by Mitochondrial Reactive Oxygen Species Plays a Key Role in Long-Term Cognitive Impairment Induced by Paraquat Exposure","volume":"36","author":"Chen","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"B73","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1126\/science.1171091","article-title":"S-nitrosylation of Drp1 Mediates \u03b2-Amyloid-Related Mitochondrial Fission and Neuronal Injury","volume":"324","author":"Cho","year":"2009","journal-title":"Science"},{"key":"B74","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1111\/nan.12282","article-title":"Investigating Complex I Deficiency in P Urkinje Cells and Synapses in Patients with Mitochondrial Disease","volume":"42","author":"Chrysostomou","year":"2016","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1126\/science.aaa3650","article-title":"Exome Sequencing in Amyotrophic Lateral Sclerosis Identifies Risk Genes and Pathways","volume":"347","author":"Cirulli","year":"2015","journal-title":"Science"},{"key":"B76","doi-asserted-by":"publisher","first-page":"105300","DOI":"10.1016\/j.nbd.2021.105300","article-title":"Mitochondria and Calcium Defects Correlate with Axonal Dysfunction in GDAP1-Related Charcot-Marie-Tooth Mouse Model","volume":"152","author":"Civera-Treg\u00f3n","year":"2021","journal-title":"Neurobiol. Dis."},{"key":"B77","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/978-981-32-9358-8_7","article-title":"Tau and Axonal Transport Misregulation in Tauopathies","volume":"1184","author":"Combs","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1177\/0883073814537380","article-title":"Defects of Mitochondrial DNA Replication","volume":"29","author":"Copeland","year":"2014","journal-title":"J. Child. Neurol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"10726","DOI":"10.1073\/pnas.0403649101","article-title":"Alzheimer's Brains Harbor Somatic mtDNA Control-Region Mutations that Suppress Mitochondrial Transcription and Replication","volume":"101","author":"Coskun","year":"2004","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B80","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/j.bbagen.2011.08.008","article-title":"A Mitochondrial Etiology of Alzheimer and Parkinson Disease","volume":"1820","author":"Coskun","year":"2012","journal-title":"Biochim. Biophys. Acta (Bba) - Gen. Subjects"},{"key":"B81","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1016\/j.stemcr.2020.03.023","article-title":"Impairment of Mitochondrial Calcium Buffering Links Mutations in C9ORF72 and TARDBP in iPS-Derived Motor Neurons from Patients with ALS\/FTD","volume":"14","author":"Dafinca","year":"2020","journal-title":"Stem Cel Rep."},{"key":"B82","first-page":"1271","article-title":"Development of central Nervous System Pathology in a Murine Transgenic Model of Human Amyotrophic Lateral Sclerosis","volume":"145","author":"Dal Canto","year":"1994","journal-title":"Am. J. Pathol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1111\/j.1471-4159.2006.03619.x","article-title":"Neural Mitochondrial Ca2+capacity Impairment Precedes the Onset of Motor Symptoms in G93A Cu\/Zn-Superoxide Dismutase Mutant Mice","volume":"96","author":"Damiano","year":"2006","journal-title":"J. Neurochem."},{"key":"B84","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1093\/brain\/122.8.1421","article-title":"The Substantia Nigra of the Human Brain. I. Nigrosomes and the Nigral Matrix, a Compartmental Organization Based on Calbindin D(28K) Immunohistochemistry","volume":"122","author":"Damier","year":"1999","journal-title":"Brain"},{"key":"B85","doi-asserted-by":"publisher","first-page":"3267","DOI":"10.1113\/jphysiol.2008.151977","article-title":"Analysis of Cardiac Mitochondrial Na+-Ca2+ exchanger Kinetics with a Biophysical Model of Mitochondrial Ca2+handing Suggests a 3: 1 Stoichiometry","volume":"586","author":"Dash","year":"2008","journal-title":"J. Physiol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.nbd.2014.06.009","article-title":"Phenotypic Characterization of Recessive Gene Knockout Rat Models of Parkinson's Disease","volume":"70","author":"Dave","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"B87","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1038\/nature07534","article-title":"Mitofusin 2 Tethers Endoplasmic Reticulum to Mitochondria","volume":"456","author":"de Brito","year":"2008","journal-title":"Nature"},{"key":"B88","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1016\/j.neuron.2017.01.010","article-title":"Axonal Endoplasmic Reticulum Ca2+ Content Controls Release Probability in CNS Nerve Terminals","volume":"93","author":"de Juan-Sanz","year":"2017","journal-title":"Neuron"},{"key":"B89","doi-asserted-by":"publisher","first-page":"2720","DOI":"10.1093\/hmg\/ddm226","article-title":"Familial Amyotrophic Lateral Sclerosis-Linked SOD1 Mutants Perturb Fast Axonal Transport to Reduce Axonal Mitochondria Content","volume":"16","author":"De Vos","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"B90","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1093\/hmg\/ddr559","article-title":"VAPB Interacts with the Mitochondrial Protein PTPIP51 to Regulate Calcium Homeostasis","volume":"21","author":"De Vos","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"B91","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1093\/hmg\/ddq526","article-title":"PINK1 Cleavage at Position A103 by the Mitochondrial Protease PARL","volume":"20","author":"Deas","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"B92","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/978-3-319-42139-1_2","article-title":"Dopamine Metabolism and Reactive Oxygen Species Production","volume-title":"Mitochondrial Mechanisms of Degeneration and Repair in Parkinson's Disease","author":"Delcambre","year":"2016"},{"key":"B93","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/79936","article-title":"Nuclear Gene OPA1, Encoding a Mitochondrial Dynamin-Related Protein, Is Mutated in Dominant Optic Atrophy","volume":"26","author":"Delettre","year":"2000","journal-title":"Nat. Genet."},{"key":"B94","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1080\/15548627.2019.1644076","article-title":"ALS-FTLD-linked Mutations of SQSTM1\/p62 Disrupt Selective Autophagy and NFE2L2\/NRF2 Anti-oxidative Stress Pathway","volume":"16","author":"Deng","year":"2020","journal-title":"Autophagy"},{"key":"B95","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.tcb.2017.01.001","article-title":"Autophagy Receptors and Neurodegenerative Diseases","volume":"27","author":"Deng","year":"2017","journal-title":"Trends Cel Biol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1093\/hmg\/ddm314","article-title":"Hindlimb Gait Defects Due to Motor Axon Loss and Reduced Distal Muscles in a Transgenic Mouse Model of Charcot-Marie-Tooth Type 2A","volume":"17","author":"Detmer","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aag0481","article-title":"Tau Reduction Prevents Neuronal Loss and Reverses Pathological Tau Deposition and Seeding in Mice with Tauopathy","volume":"9","author":"DeVos","year":"2017","journal-title":"Sci. Transl Med."},{"key":"B98","doi-asserted-by":"crossref","first-page":"5042","DOI":"10.1038\/s41598-017-05334-9","article-title":"alphaSynuclein Control of Mitochondrial Homeostasis in Human-Derived Neurons Is Disrupted by Mutations Associated with Parkinson's Disease","volume":"7","author":"Devoto","year":"2017","journal-title":"Sci. Rep."},{"key":"B99","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.nbd.2006.12.023","article-title":"Inhibition of P38 Mitogen Activated Protein Kinase Activation and Mutant SOD1G93A-Induced Motor Neuron Death","volume":"26","author":"Dewil","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"B100","doi-asserted-by":"publisher","first-page":"342ra78","DOI":"10.1126\/scitranslmed.aaf3634","article-title":"\u03b1-Synuclein Binds to TOM20 and Inhibits Mitochondrial Protein Import in Parkinson's Disease","volume":"8","author":"Di Maio","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"B101","doi-asserted-by":"publisher","first-page":"3975","DOI":"10.1093\/hmg\/ddu112","article-title":"Overexpression of the Calpain-specific Inhibitor Calpastatin Reduces Human Alpha-Synuclein Processing, Aggregation and Synaptic Impairment in [A30P]\u03b1Syn Transgenic Mice","volume":"23","author":"Diepenbroek","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"B102","doi-asserted-by":"publisher","first-page":"13548","DOI":"10.1038\/ncomms13548","article-title":"Defective Mitochondrial DNA Homeostasis in the Substantia Nigra in Parkinson Disease","volume":"7","author":"Dolle","year":"2016","journal-title":"Nat. Commun."},{"key":"B103","doi-asserted-by":"publisher","first-page":"146","DOI":"10.3389\/fnana.2014.00146","article-title":"Calbindin Content and Differential Vulnerability of Midbrain Efferent Dopaminergic Neurons in Macaques","volume":"8","author":"Dopeso-Reyes","year":"2014","journal-title":"Front. Neuroanat."},{"key":"B104","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.tins.2013.03.002","article-title":"Why Size Matters - Balancing Mitochondrial Dynamics in Alzheimer's Disease","volume":"36","author":"DuBoff","year":"2013","journal-title":"Trends Neurosciences"},{"key":"B105","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1111\/jnc.13572","article-title":"Converging Roles of Ion Channels, Calcium, Metabolic Stress, and Activity Pattern of Substantia Nigra Dopaminergic Neurons in Health and Parkinson's Disease","volume":"139","author":"Duda","year":"2016","journal-title":"J. Neurochem."},{"key":"B106","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.2353\/ajpath.2007.061232","article-title":"Calpain-Cleavage of \u03b1-Synuclein","volume":"170","author":"Dufty","year":"2007","journal-title":"Am. J. Pathol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/s1474-4422(10)70183-6","article-title":"Autosomal Dominant Cerebellar Ataxias: Polyglutamine Expansions and beyond","volume":"9","author":"Durr","year":"2010","journal-title":"Lancet Neurol."},{"key":"B108","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1113\/jphysiol.1966.sp007824","article-title":"The Excitatory Synaptic Action of Climbing Fibres on the Purkinje Cells of the Cerebellum","volume":"182","author":"Eccles","year":"1966","journal-title":"J. Physiol."},{"key":"B109","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1083\/jcb.200906084","article-title":"Regulation of OPA1 Processing and Mitochondrial Fusion by M-AAA Protease Isoenzymes and OMA1","volume":"187","author":"Ehses","year":"2009","journal-title":"J. Cel Biol"},{"key":"B110","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1073\/pnas.0605208103","article-title":"Progressive Parkinsonism in Mice with Respiratory-Chain-Deficient Dopamine Neurons","volume":"104","author":"Ekstrand","year":"2007","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B111","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1097\/00004691-199511000-00002","article-title":"Morphological Features and Activation Patterns of Motor Units","volume":"12","author":"Enoka","year":"1995","journal-title":"J. Clin. Neurophysiol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"5167","DOI":"10.1523\/jneurosci.0482-06.2006","article-title":"Reduction in Mitochondrial Superoxide Dismutase Modulates Alzheimer's Disease-like Pathology and Accelerates the Onset of Behavioral Changes in Human Amyloid Precursor Protein Transgenic Mice","volume":"26","author":"Esposito","year":"2006","journal-title":"J. Neurosci."},{"key":"B113","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1093\/jb\/mvg150","article-title":"Two Mitofusin Proteins, Mammalian Homologues of FZO, with Distinct Functions Are Both Required for Mitochondrial Fusion","volume":"134","author":"Eura","year":"2003","journal-title":"J. Biochem."},{"key":"B114","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.nbd.2018.07.005","article-title":"Autophagy and Mitophagy in ALS","volume":"122","author":"Evans","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"B115","doi-asserted-by":"publisher","first-page":"2002","DOI":"10.1002\/ajmg.a.37721","article-title":"A Novel De Novo Dominant Negative Mutation inDNM1Limpairs Mitochondrial Fission and Presents as Childhood Epileptic Encephalopathy","volume":"170","author":"Fahrner","year":"2016","journal-title":"Am. J. Med. Genet."},{"key":"B116","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/s41593-018-0332-9","article-title":"Mitophagy Inhibits Amyloid-\u03b2 and Tau Pathology and Reverses Cognitive Deficits in Models of Alzheimer's Disease","volume":"22","author":"Fang","year":"2019","journal-title":"Nat. Neurosci."},{"key":"B117","doi-asserted-by":"publisher","first-page":"1690","DOI":"10.1212\/wnl.0b013e31821a441e","article-title":"MFN2 Mutations Cause Severe Phenotypes in Most Patients with CMT2A","volume":"76","author":"Feely","year":"2011","journal-title":"Neurology"},{"key":"B118","doi-asserted-by":"publisher","first-page":"2377","DOI":"10.1002\/acn3.50928","article-title":"Novel Mutation in Optineurin Causing Aggressive ALS+\/\u2212frontotemporal Dementia","volume":"6","author":"Feng","year":"2019","journal-title":"Ann. Clin. Transl Neurol."},{"key":"B119","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.nbd.2008.02.003","article-title":"The Release of Calcium from the Endoplasmic Reticulum Induced by Amyloid-Beta and Prion Peptides Activates the Mitochondrial Apoptotic Pathway","volume":"30","author":"Ferreiro","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"B120","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/s0006-8993(00)02237-x","article-title":"Brain-derived Neurotrophic Factor in Huntington Disease","volume":"866","author":"Ferrer","year":"2000","journal-title":"Brain Res."},{"key":"B121","doi-asserted-by":"publisher","first-page":"4529","DOI":"10.1093\/hmg\/ddq383","article-title":"Glutaredoxin 2 Prevents Aggregation of Mutant SOD1 in Mitochondria and Abolishes its Toxicity","volume":"19","author":"Ferri","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"B122","doi-asserted-by":"publisher","first-page":"2226","DOI":"10.1016\/j.celrep.2016.05.013","article-title":"Presenilin 2 Modulates Endoplasmic Reticulum-Mitochondria Coupling by Tuning the Antagonistic Effect of Mitofusin 2","volume":"15","author":"Filadi","year":"2016","journal-title":"Cel Rep."},{"key":"B123","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.cell.2006.03.022","article-title":"A Mammalian Organelle Map by Protein Correlation Profiling","volume":"125","author":"Foster","year":"2006","journal-title":"Cell"},{"key":"B124","doi-asserted-by":"publisher","first-page":"e1600947","DOI":"10.1126\/sciadv.1600947","article-title":"A Protein Homeostasis Signature in Healthy Brains Recapitulates Tissue Vulnerability to Alzheimer's Disease","volume":"2","author":"Freer","year":"2016","journal-title":"Sci. Adv."},{"key":"B125","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1038\/nn.4000","article-title":"Haploinsufficiency of TBK1 Causes Familial ALS and Fronto-Temporal Dementia","volume":"18","author":"Freischmidt","year":"2015","journal-title":"Nat. Neurosci."},{"key":"B126","doi-asserted-by":"publisher","first-page":"2534","DOI":"10.1523\/jneurosci.20-07-02534.2000","article-title":"Early and Selective Loss of Neuromuscular Synapse Subtypes with Low Sprouting Competence in Motoneuron Diseases","volume":"20","author":"Frey","year":"2000","journal-title":"J. Neurosci."},{"key":"B127","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1126\/science.1207385","article-title":"ER Tubules Mark Sites of Mitochondrial Division","volume":"334","author":"Friedman","year":"2011","journal-title":"Science"},{"key":"B128","doi-asserted-by":"publisher","first-page":"4007","DOI":"10.1523\/jneurosci.14-07-04007.1994","article-title":"An FCCP-Sensitive Ca2+ Store in Bullfrog Sympathetic Neurons and its Participation in Stimulus-Evoked Changes in [Ca2+]i","volume":"14","author":"Friel","year":"1994","journal-title":"J. Neurosci."},{"key":"B129","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/s41593-018-0298-7","article-title":"A Tau Homeostasis Signature Is Linked with the Cellular and Regional Vulnerability of Excitatory Neurons to Tau Pathology","volume":"22","author":"Fu","year":"2019","journal-title":"Nat. Neurosci."},{"key":"B130","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.neuron.2016.12.023","article-title":"Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer's Disease","volume":"93","author":"Fu","year":"2017","journal-title":"Neuron"},{"key":"B131","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.mcn.2015.12.006","article-title":"Mitochondrial Fission Protein Drp1 Regulates Mitochondrial Transport and Dendritic Arborization in Cerebellar Purkinje Cells","volume":"71","author":"Fukumitsu","year":"2016","journal-title":"Mol. Cell Neurosci."},{"key":"B132","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1046\/j.1440-1819.2000.00747.x","article-title":"Neuronal Loss and Neurofibrillary Degeneration in the Hippocampal Cortex in Late\u2010onset Sporadic Alzheimer's Disease","volume":"54","author":"Fukutani","year":"2000","journal-title":"Psychiatry Clin. Neurosciences"},{"key":"B133","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.cell.2004.06.018","article-title":"Huntingtin Controls Neurotrophic Support and Survival of Neurons by Enhancing BDNF Vesicular Transport along Microtubules","volume":"118","author":"Gauthier","year":"2004","journal-title":"Cell"},{"key":"B134","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.cmet.2020.03.005","article-title":"Mitochondria-Endoplasmic Reticulum Contacts in Reactive Astrocytes Promote Vascular Remodeling","volume":"31","author":"Gbel","year":"2020","journal-title":"Cell Metab"},{"key":"B135","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1111\/j.1749-6632.1992.tb24523.x","article-title":"Midbrain Dopaminergic Cell Loss in Parkinson's Disease and MPTP-Induced Parkinsonism: Sparing of Calbindin-D25k?Containing Cells","volume":"648","author":"German","year":"1992","journal-title":"Ann. NY Acad. Sci."},{"key":"B136","doi-asserted-by":"publisher","first-page":"10814","DOI":"10.1523\/jneurosci.2660-08.2008","article-title":"Dichotomous Anatomical Properties of Adult Striatal Medium Spiny Neurons","volume":"28","author":"Gertler","year":"2008","journal-title":"J. Neurosci."},{"key":"B137","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1111\/j.1471-4159.2007.05137.x","article-title":"Brain-derived Neurotrophic Factor Over-expression in the Forebrain Ameliorates Huntington's Disease Phenotypes in Mice","volume":"105","author":"Gharami","year":"2008","journal-title":"J. Neurochem."},{"key":"B138","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.ceca.2012.02.008","article-title":"Mitochondrial Ca2+ and Apoptosis","volume":"52","author":"Giorgi","year":"2012","journal-title":"Cell Calcium"},{"key":"B139","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/s41580-018-0052-8","article-title":"The Machineries, Regulation and Cellular Functions of Mitochondrial Calcium","volume":"19","author":"Giorgi","year":"2018","journal-title":"Nat. Rev. Mol. Cel Biol"},{"key":"B140","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1073\/pnas.1113166109","article-title":"Mitochondrial Dysfunction and Purkinje Cell Loss in Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS)","volume":"109","author":"Girard","year":"2012","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B141","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1111\/j.1471-4159.2011.07318.x","article-title":"Parkin Promotes the Ubiquitination and Degradation of the Mitochondrial Fusion Factor Mitofusin 1","volume":"118","author":"Glauser","year":"2011","journal-title":"J. Neurochem."},{"key":"B142","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1038\/nature02263","article-title":"Protein Degradation and protection against Misfolded or Damaged Proteins","volume":"426","author":"Goldberg","year":"2003","journal-title":"Nature"},{"key":"B143","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/cns.12655","article-title":"Mitochondrial Dysfunction and Biogenesis in Neurodegenerative Diseases: Pathogenesis and Treatment","volume":"23","author":"Golpich","year":"2017","journal-title":"CNS Neurosci. Ther."},{"key":"B144","doi-asserted-by":"publisher","first-page":"4491","DOI":"10.1523\/jneurosci.16-14-04491.1996","article-title":"Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer's Disease","volume":"16","author":"G\u00f3mez-Isla","year":"1996","journal-title":"J. Neurosci."},{"key":"B145","doi-asserted-by":"publisher","first-page":"42993","DOI":"10.1038\/srep42993","article-title":"CMT-linked Loss-Of-Function Mutations in GDAP1 Impair Store-Operated Ca(2+) Entry-Stimulated Respiration","volume":"7","author":"Gonzalez-Sanchez","year":"2017","journal-title":"Sci. Rep."},{"key":"B146","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1080\/15548627.2016.1170257","article-title":"Defective Recognition of LC3B by Mutant SQSTM1\/p62 Implicates Impairment of Autophagy as a Pathogenic Mechanism in ALS-FTLD","volume":"12","author":"Goode","year":"2016","journal-title":"Autophagy"},{"key":"B147","doi-asserted-by":"publisher","first-page":"8774","DOI":"10.1523\/jneurosci.2315-06.2006","article-title":"Complete Dissociation of Motor Neuron Death from Motor Dysfunction by Bax Deletion in a Mouse Model of ALS","volume":"26","author":"Gould","year":"2006","journal-title":"J. Neurosci."},{"key":"B148","doi-asserted-by":"publisher","first-page":"29519","DOI":"10.1074\/jbc.m114.607150","article-title":"Short Mitochondrial ARF Triggers Parkin\/PINK1-dependent Mitophagy","volume":"289","author":"Grenier","year":"2014","journal-title":"J. Biol. Chem."},{"key":"B149","doi-asserted-by":"publisher","first-page":"100","DOI":"10.3389\/fneur.2013.00100","article-title":"Parkin- and PINK1-dependent Mitophagy in Neurons: Will the Real Pathway Please Stand up?","volume":"4","author":"Grenier","year":"2013","journal-title":"Front. Neurol."},{"key":"B150","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.ceca.2009.12.002","article-title":"Calcium Dysregulation in Amyotrophic Lateral Sclerosis","volume":"47","author":"Grosskreutz","year":"2010","journal-title":"Cell Calcium"},{"key":"B151","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1089\/ars.2018.7718","article-title":"Mutations in RHOT1 Disrupt Endoplasmic Reticulum-Mitochondria Contact Sites Interfering with Calcium Homeostasis and Mitochondrial Dynamics in Parkinson's Disease","volume":"31","author":"Grossmann","year":"2019","journal-title":"Antioxid. Redox Signaling"},{"key":"B152","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1002\/ana.24571","article-title":"Mitochondrial DNA Depletion in Respiratory Chain-Deficient P Arkinson Disease Neurons","volume":"79","author":"Gr\u00fcnewald","year":"2016","journal-title":"Ann. Neurol."},{"key":"B153","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1523\/jneurosci.2507-13.2014","article-title":"-Synuclein Is Localized to Mitochondria-Associated ER Membranes","volume":"34","author":"Guardia-Laguarta","year":"2014","journal-title":"J. Neurosci."},{"key":"B154","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.nbd.2007.07.002","article-title":"Altered Calcium Homeostasis in Motor Neurons Following AMPA Receptor but Not Voltage-dependent Calcium Channels' Activation in a Genetic Model of Amyotrophic Lateral Sclerosis","volume":"28","author":"Guatteo","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"B155","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1146\/annurev-biochem-060815-014402","article-title":"Maintenance and Expression of Mammalian Mitochondrial DNA","volume":"85","author":"Gustafsson","year":"2016","journal-title":"Annu. Rev. Biochem."},{"key":"B156","doi-asserted-by":"publisher","first-page":"2266","DOI":"10.1172\/jci95898","article-title":"Systemic Isradipine Treatment Diminishes Calcium-dependent Mitochondrial Oxidant Stress","volume":"128","author":"Guzman","year":"2018","journal-title":"J. Clin. Invest."},{"key":"B157","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1038\/nature09536","article-title":"Oxidant Stress Evoked by Pacemaking in Dopaminergic Neurons Is Attenuated by DJ-1","volume":"468","author":"Guzman","year":"2010","journal-title":"Nature"},{"key":"B158","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1111\/j.1474-9726.2012.00817.x","article-title":"Oxidative Lipid Modification of Nicastrin Enhances Amyloidogenic \u03b3-secretase Activity in Alzheimer's Disease","volume":"11","author":"Gwon","year":"2012","journal-title":"Aging Cell"},{"key":"B159","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/j.ajhg.2016.06.026","article-title":"Absence of the Autophagy Adaptor SQSTM1\/p62 Causes Childhood-Onset Neurodegeneration with Ataxia, Dystonia, and Gaze Palsy","volume":"99","author":"Haack","year":"2016","journal-title":"Am. J. Hum. Genet."},{"key":"B160","doi-asserted-by":"publisher","first-page":"e9805","DOI":"10.1371\/journal.pone.0009805","article-title":"Loss of ALS2\/Alsin Exacerbates Motor Dysfunction in a SOD1-Expressing Mouse ALS Model by Disturbing Endolysosomal Trafficking","volume":"5","author":"Hadano","year":"2010","journal-title":"PLoS One"},{"key":"B161","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1086\/444548","article-title":"Mitochondrial DNA Polymerase W748S Mutation: a Common Cause of Autosomal Recessive Ataxia with Ancient European Origin","volume":"77","author":"Hakonen","year":"2005","journal-title":"Am. J. Hum. Genet."},{"key":"B162","doi-asserted-by":"publisher","first-page":"3032","DOI":"10.1093\/brain\/awm242","article-title":"Recessive Twinkle Mutations in Early Onset Encephalopathy with mtDNA Depletion","volume":"130","author":"Hakonen","year":"2007","journal-title":"Brain"},{"key":"B163","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1006\/exnr.1998.6919","article-title":"Regional Specificity of Brain Atrophy in Huntington's Disease","volume":"154","author":"Halliday","year":"1998","journal-title":"Exp. Neurol."},{"key":"B164","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1002\/mds.28365","article-title":"Mitochondrial and Clearance Impairment in p.D620N VPS35 Patient-Derived Neurons","volume":"36","author":"Hanss","year":"2020","journal-title":"Mov Disord"},{"key":"B165","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/s0166-2236(02)00040-1","article-title":"The Yin and Yang of NMDA Receptor Signalling","volume":"26","author":"Hardingham","year":"2003","journal-title":"Trends Neurosciences"},{"key":"B166","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1016\/j.neuron.2012.08.019","article-title":"Synaptic Energy Use and Supply","volume":"75","author":"Harris","year":"2012","journal-title":"Neuron"},{"key":"B167","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1083\/jcb.200906083","article-title":"Inducible Proteolytic Inactivation of OPA1 Mediated by the OMA1 Protease in Mammalian Cells","volume":"187","author":"Head","year":"2009","journal-title":"J. Cel Biol"},{"key":"B168","doi-asserted-by":"publisher","first-page":"7916","DOI":"10.1073\/pnas.1300677110","article-title":"Modulation of the Endoplasmic Reticulum-Mitochondria Interface in Alzheimer's Disease and Related Models","volume":"110","author":"Hedskog","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B169","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.molcel.2015.08.016","article-title":"The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN\/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy","volume":"60","author":"Heo","year":"2015","journal-title":"Mol. Cel"},{"key":"B170","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1002\/cne.903260310","article-title":"Entorhinal Cortex of the Human, Monkey, and Rat: Metabolic Map as Revealed by Cytochrome Oxidase","volume":"326","author":"Hevner","year":"1992","journal-title":"J. Comp. Neurol."},{"key":"B171","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1471-2202-4-16","article-title":"ALS-associated Mutant SOD1G93A Causes Mitochondrial Vacuolation by Expansion of the Intermembrane Space and by Involvement of SOD1 Aggregation and Peroxisomes","volume":"4","author":"Higgins","year":"2003","journal-title":"BMC Neurosci."},{"key":"B172","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1002\/cne.902080407","article-title":"Comparison of the Morphology of Physiologically Identified Abducens Motor and Internuclear Neurons in the Cat: a Light Microscopic Study Employing the Intracellular Injection of Horseradish Peroxidase","volume":"208","author":"Highstein","year":"1982","journal-title":"J. Comp. Neurol."},{"key":"B173","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1126\/science.aan6009","article-title":"ER-mitochondria Tethering by PDZD8 Regulates Ca2+dynamics in Mammalian Neurons","volume":"358","author":"Hirabayashi","year":"2017","journal-title":"Science"},{"key":"B174","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/0304-3940(93)90504-e","article-title":"Calretinin-immunoreactive Neocortical Interneurons Are Unaffected in Alzheimer's Disease","volume":"152","author":"Hof","year":"1993","journal-title":"Neurosci. Lett."},{"key":"B175","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1111\/j.1471-4159.2005.03493.x","article-title":"The Mitochondrial Complex I Inhibitor Rotenone Triggers a Cerebral Tauopathy","volume":"95","author":"Hoglinger","year":"2005","journal-title":"J. Neurochem."},{"key":"B176","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.neulet.2012.10.003","article-title":"Full-length TDP-43 and its C-Terminal Fragments Activate Mitophagy in NSC34 Cell Line","volume":"530","author":"Hong","year":"2012","journal-title":"Neurosci. Lett."},{"key":"B177","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1038\/jcbfm.2012.35","article-title":"Updated Energy Budgets for Neural Computation in the Neocortex and Cerebellum","volume":"32","author":"Howarth","year":"2012","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B178","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/j.stem.2016.08.002","article-title":"Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson's Disease","volume":"19","author":"Hsieh","year":"2016","journal-title":"Cell Stem Cell"},{"key":"B179","doi-asserted-by":"publisher","first-page":"196","DOI":"10.3389\/fnmol.2017.00196","article-title":"The Truncated C-Terminal Fragment of Mutant ATXN3 Disrupts Mitochondria Dynamics in Spinocerebellar Ataxia Type 3 Models","volume":"10","author":"Hsu","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"B180","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1007\/s00401-019-01993-2","article-title":"Alpha-synuclein Suppresses Mitochondrial Protease ClpP to Trigger Mitochondrial Oxidative Damage and Neurotoxicity","volume":"137","author":"Hu","year":"2019","journal-title":"Acta Neuropathol."},{"key":"B181","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.neulet.2018.02.004","article-title":"Why Do So many Genetic Insults lead to Purkinje Cell Degeneration and Spinocerebellar Ataxia?","volume":"688","author":"Huang","year":"2019","journal-title":"Neurosci. Lett."},{"key":"B182","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1212\/01.wnl.0000149767.51152.83","article-title":"Sensory Ataxic Neuropathy Due to a Novel C10Orf2 Mutation with Probable Germline Mosaicism","volume":"64","author":"Hudson","year":"2005","journal-title":"Neurology"},{"key":"B183","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1001\/archneur.64.4.553","article-title":"Mutation of the Linker Region of the Polymerase \u03b3-1 (POLG1Gene Associated with Progressive External Ophthalmoplegia and Parkinsonism","volume":"64","author":"Hudson","year":"2007","journal-title":"Arch. Neurol."},{"key":"B184","doi-asserted-by":"publisher","first-page":"3549","DOI":"10.1073\/pnas.1214912110","article-title":"Cortical Energy Demands of Signaling and Nonsignaling Components in Brain Are Conserved across Mammalian Species and Activity Levels","volume":"110","author":"Hyder","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"B185","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1126\/science.6474172","article-title":"Alzheimer's Disease: Cell-specific Pathology Isolates the Hippocampal Formation","volume":"225","author":"Hyman","year":"1984","journal-title":"Science"},{"key":"B186","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1038\/ncb1907","article-title":"Mitochondrial Fission Factor Drp1 Is Essential for Embryonic Development and Synapse Formation in Mice","volume":"11","author":"Ishihara","year":"2009","journal-title":"Nat. Cel Biol"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.1172\/jci150328","article-title":"Melatonin Inhibits Cytosolic Mitochondrial DNA-Induced Neuroinflammatory Signaling in Accelerated Aging and Neurodegeneration","volume":"131","author":"Jauhari","year":"2021","journal-title":"J. Clin. Invest."},{"key":"B188","doi-asserted-by":"publisher","first-page":"S161","DOI":"10.1212\/wnl.47.6_suppl_3.161s","article-title":"Oxidative Stress and the Pathogenesis of Parkinson's Disease","volume":"47","author":"Jenner","year":"1996","journal-title":"Neurology"},{"key":"B189","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1016\/j.bbadis.2013.09.007","article-title":"Mitochondria-targeted Antioxidants for Treatment of Parkinson's Disease: Preclinical and Clinical Outcomes","volume":"1842","author":"Jin","year":"2014","journal-title":"Biochim. Biophys. Acta (Bba) - Mol. Basis Dis."},{"key":"B190","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1083\/jcb.201008084","article-title":"Mitochondrial Membrane Potential Regulates PINK1 Import and Proteolytic Destabilization by PARL","volume":"191","author":"Jin","year":"2010","journal-title":"J. Cel Biol"},{"key":"B191","doi-asserted-by":"publisher","first-page":"279","DOI":"10.4161\/auto.7.3.14487","article-title":"Selective Autophagy Mediated by Autophagic Adapter Proteins","volume":"7","author":"Johansen","year":"2011","journal-title":"Autophagy"},{"key":"B192","doi-asserted-by":"publisher","first-page":"13807","DOI":"10.1073\/pnas.96.24.13807","article-title":"Regulation of Mitochondrial ATP Synthesis by Calcium: Evidence for a Long-Term Metabolic Priming","volume":"96","author":"Jouaville","year":"1999","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B193","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1074\/jbc.270.2.672","article-title":"The Sodium-Calcium Antiport of Heart Mitochondria Is Not Electroneutral","volume":"270","author":"Jung","year":"1995","journal-title":"J. Biol. Chem."},{"key":"B194","doi-asserted-by":"publisher","first-page":"3571","DOI":"10.1038\/emboj.2010.223","article-title":"Inhibition of Mitochondrial Fusion by \u03b1-synuclein Is Rescued by PINK1, Parkin and DJ-1","volume":"29","author":"Kamp","year":"2010","journal-title":"EMBO J."},{"key":"B195","volume-title":"Principles of Neural Science","author":"Kandel","year":"2000"},{"key":"B196","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s00401-007-0308-4","article-title":"Amyotrophic Lateral Sclerosis Models and Human Neuropathology: Similarities and Differences","volume":"115","author":"Kato","year":"2008","journal-title":"Acta Neuropathol."},{"key":"B197","doi-asserted-by":"publisher","first-page":"12292","DOI":"10.1073\/pnas.1606171113","article-title":"PPAR\u03b3-coactivator-1\u03b1 Gene Transfer Reduces Neuronal Loss and Amyloid-\u03b2 Generation by Reducing \u03b2-secretase in an Alzheimer's Disease Model","volume":"113","author":"Katsouri","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"B198","doi-asserted-by":"publisher","first-page":"3225","DOI":"10.1091\/mbc.e07-05-0404","article-title":"The Mitochondrial Transcription Factor TFAM Coordinates the Assembly of Multiple DNA Molecules into Nucleoid-like Structures","volume":"18","author":"Kaufman","year":"2007","journal-title":"MBoC"},{"key":"B199","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s00401-018-1855-6","article-title":"Tau Seeding Activity Begins in the Transentorhinal\/entorhinal Regions and Anticipates Phospho-Tau Pathology in Alzheimer's Disease and PART","volume":"136","author":"Kaufman","year":"2018","journal-title":"Acta Neuropathol."},{"key":"B200","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/ng1194-221","article-title":"CAG Expansions in a Novel Gene for Machado-Joseph Disease at Chromosome 14q32.1","volume":"8","author":"Kawaguchi","year":"1994","journal-title":"Nat. Genet."},{"key":"B201","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/1750-1326-5-21","article-title":"ALS Spinal Neurons Show Varied and Reduced mtDNA Gene Copy Numbers and Increased mtDNA Gene Deletions","volume":"5","author":"Keeney","year":"2010","journal-title":"Mol. Neurodegener"},{"key":"B202","doi-asserted-by":"publisher","first-page":"7401","DOI":"10.1523\/jneurosci.0143-10.2010","article-title":"Pacemaking in Dopaminergic Ventral Tegmental Area Neurons: Depolarizing Drive from Background and Voltage-dependent Sodium Conductances","volume":"30","author":"Khaliq","year":"2010","journal-title":"J. Neurosci."},{"key":"B203","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neulet.2013.09.034","article-title":"Twinkle Mutation in an Italian Family with External Progressive Ophthalmoplegia and Parkinsonism: a Case Report and an Update on the State of Art","volume":"556","author":"Kiferle","year":"2013","journal-title":"Neurosci. Lett."},{"key":"B204","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1002\/mds.25132","article-title":"Systematic Review and UK-based Study of PARK2 (Parkin), PINK1, PARK7 (DJ-1) and LRRK2 in Early-Onset Parkinson's Disease","volume":"27","author":"Kilarski","year":"2012","journal-title":"Mov. Disord."},{"key":"B205","doi-asserted-by":"publisher","first-page":"3919","DOI":"10.1093\/hmg\/ddq306","article-title":"Mitochondrial Loss, Dysfunction and Altered Dynamics in Huntington's Disease","volume":"19","author":"Kim","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"B206","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1002\/embj.201387009","article-title":"Loss of the M-AAA Protease Subunit AFG3L2 Causes Mitochondrial Transport Defects and Tau Hyperphosphorylation","volume":"33","author":"Kondadi","year":"2014","journal-title":"EMBO J."},{"key":"B207","doi-asserted-by":"publisher","first-page":"120080","DOI":"10.1098\/rsob.120080","article-title":"PINK1 Is Activated by Mitochondrial Membrane Potential Depolarization and Stimulates Parkin E3 Ligase Activity by Phosphorylating Serine 65","volume":"2","author":"Kondapalli","year":"2012","journal-title":"Open Biol."},{"key":"B208","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.molcel.2016.08.020","article-title":"The M -AAA Protease Associated with Neurodegeneration Limits MCU Activity in Mitochondria","volume":"64","author":"K\u00f6nig","year":"2016","journal-title":"Mol. Cel"},{"key":"B209","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1126\/science.1175088","article-title":"An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen","volume":"325","author":"Kornmann","year":"2009","journal-title":"Science"},{"key":"B210","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/j.celrep.2015.08.079","article-title":"PKA Phosphorylation of NCLX Reverses Mitochondrial Calcium Overload and Depolarization, Promoting Survival of PINK1-Deficient Dopaminergic Neurons","volume":"13","author":"Kostic","year":"2015","journal-title":"Cel Rep."},{"key":"B211","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1038\/ng1778","article-title":"Mitochondrial DNA Deletions Are Abundant and Cause Functional Impairment in Aged Human Substantia Nigra Neurons","volume":"38","author":"Kraytsberg","year":"2006","journal-title":"Nat. Genet."},{"key":"B212","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/ng.f.94","article-title":"What Causes Mitochondrial DNA Deletions in Human Cells?","volume":"40","author":"Krishnan","year":"2008","journal-title":"Nat. Genet."},{"key":"B213","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1017\/s0012162200000116","article-title":"New Ocular Movement Detector System as a Communication Tool in Ventilator-Assisted Werdnig-Hoffmann Disease","volume":"42","author":"Kubota","year":"2000","journal-title":"Dev. Med. Child. Neurol."},{"key":"B214","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.neuron.2008.06.008","article-title":"A\u03b2 Plaques Lead to Aberrant Regulation of Calcium Homeostasis In Vivo Resulting in Structural and Functional Disruption of Neuronal Networks","volume":"59","author":"Kuchibhotla","year":"2008","journal-title":"Neuron"},{"key":"B215","doi-asserted-by":"publisher","first-page":"11288","DOI":"10.1073\/pnas.1512131112","article-title":"Cross-strand Binding of TFAM to a Single mtDNA Molecule Forms the Mitochondrial Nucleoid","volume":"112","author":"Kukat","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"B216","doi-asserted-by":"publisher","first-page":"e1002516","DOI":"10.1371\/journal.pbio.1002516","article-title":"LKB1 Regulates Mitochondria-dependent Presynaptic Calcium Clearance and Neurotransmitter Release Properties at Excitatory Synapses along Cortical Axons","volume":"14","author":"Kwon","year":"2016","journal-title":"Plos Biol."},{"key":"B217","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.brainres.2017.05.010","article-title":"RNA-seq Analyses Reveal that Cervical Spinal Cords and Anterior Motor Neurons from Amyotrophic Lateral Sclerosis Subjects Show Reduced Expression of Mitochondrial DNA-Encoded Respiratory Genes, and rhTFAM May Correct This Respiratory Deficiency","volume":"1667","author":"Ladd","year":"2017","journal-title":"Brain Res."},{"key":"B218","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1038\/nrn960","article-title":"Calcium Dyshomeostasis and Intracellular Signalling in Alzheimer's Disease","volume":"3","author":"LaFerla","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"B219","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1002\/pds.3781","article-title":"Calcium Channel Blocker Use and Risk of Parkinson's Disease: a Meta-Analysis","volume":"24","author":"Lang","year":"2015","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"B220","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1089\/ars.2016.6905","article-title":"Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, and Progressive Neurodegeneration in MitoPark Transgenic Mice","volume":"27","author":"Langley","year":"2017","journal-title":"Antioxid. Redox Signaling"},{"key":"B221","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1126\/science.6823561","article-title":"Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis","volume":"219","author":"Langston","year":"1983","journal-title":"Science"},{"key":"B222","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/ng0398-231","article-title":"Mitochondrial Transcription Factor A Is Necessary for mtDNA Maintance and Embryogenesis in Mice","volume":"18","author":"Larsson","year":"1998","journal-title":"Nat. Genet."},{"key":"B223","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1093\/hmg\/ddw425","article-title":"Mitochondrial Morphology and Cellular Distribution Are Altered in SPG31 Patients and Are Linked to DRP1 Hyperphosphorylation","volume":"26","author":"Lavie","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"B224","doi-asserted-by":"publisher","first-page":"200061","DOI":"10.1098\/rsob.200061","article-title":"The Rise and Rise of Mitochondrial DNA Mutations","volume":"10","author":"Lawless","year":"2020","journal-title":"Open Biol."},{"key":"B225","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1097\/nen.0b013e318244477d","article-title":"Cerebellar Ataxia in Patients with Mitochondrial DNA Disease","volume":"71","author":"Lax","year":"2012","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B226","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.devcel.2011.12.014","article-title":"Role of PINK1 Binding to the TOM Complex and Alternate Intracellular Membranes in Recruitment and Activation of the E3 Ligase Parkin","volume":"22","author":"Lazarou","year":"2012","journal-title":"Dev. Cel"},{"key":"B227","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/nature14893","article-title":"The Ubiquitin Kinase PINK1 Recruits Autophagy Receptors to Induce Mitophagy","volume":"524","author":"Lazarou","year":"2015","journal-title":"Nature"},{"key":"B228","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1001\/jamaneurol.2013.3849","article-title":"SQSTM1 Mutations in French Patients with Frontotemporal Dementia or Frontotemporal Dementia with Amyotrophic Lateral Sclerosis","volume":"70","author":"Le Ber","year":"2013","journal-title":"JAMA Neurol."},{"key":"B229","doi-asserted-by":"publisher","first-page":"36406","DOI":"10.1074\/jbc.m803519200","article-title":"FTDP-17 Mutations in Tau Alter the Regulation of Microtubule Dynamics","volume":"283","author":"LeBoeuf","year":"2008","journal-title":"J. Biol. Chem."},{"key":"B230","doi-asserted-by":"publisher","first-page":"4827","DOI":"10.1093\/hmg\/dds352","article-title":"Mitofusin 2 Is Necessary for Striatal Axonal Projections of Midbrain Dopamine Neurons","volume":"21","author":"Lee","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"B231","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/s41582-019-0211-3","article-title":"Antisense Oligonucleotide Reduces Mutant Protein in Patients with HD","volume":"15","author":"Lempri\u00e8re","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"B232","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1007\/s12035-012-8300-y","article-title":"Peripheral Mitochondrial Dysfunction in Alzheimer's Disease: Focus on Lymphocytes","volume":"46","author":"Leuner","year":"2012","journal-title":"Mol. Neurobiol."},{"key":"B233","doi-asserted-by":"publisher","DOI":"10.1523\/eneuro.0167-17.2017","article-title":"Alpha-Synuclein-Dependent Calcium Entry Underlies Differential Sensitivity of Cultured SN and VTA Dopaminergic Neurons to a Parkinsonian Neurotoxin","volume":"4","author":"Lieberman","year":"2017","journal-title":"eNeuro"},{"key":"B234","doi-asserted-by":"publisher","first-page":"5780","DOI":"10.1074\/jbc.m704704200","article-title":"Calcium Homeostasis and Mitochondrial Dysfunction in Striatal Neurons of Huntington Disease","volume":"283","author":"Lim","year":"2008","journal-title":"J. Biol. Chem."},{"key":"B235","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.neuron.2017.04.004","article-title":"Releasing Syntaphilin Removes Stressed Mitochondria from Axons Independent of Mitophagy under Pathophysiological Conditions","volume":"94","author":"Lin","year":"2017","journal-title":"Neuron"},{"key":"B236","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1111\/j.1471-4159.2008.05398.x","article-title":"Characterization of PINK1 Processing, Stability, and Subcellular Localization","volume":"106","author":"Lin","year":"2008","journal-title":"J. Neurochem."},{"key":"B237","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1080\/09687680110047373","article-title":"Molecular Physiology of Neuronal K-ATP Channels (Review)","volume":"18","author":"Liss","year":"2001","journal-title":"Mol. Membr. Biol."},{"key":"B238","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1038\/nn1570","article-title":"K-ATP Channels Promote the Differential Degeneration of Dopaminergic Midbrain Neurons","volume":"8","author":"Liss","year":"2005","journal-title":"Nat. Neurosci."},{"key":"B239","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1016\/j.celrep.2016.07.011","article-title":"MICU1 Serves as a Molecular Gatekeeper to Prevent In Vivo Mitochondrial Calcium Overload","volume":"16","author":"Liu","year":"","journal-title":"Cel Rep."},{"key":"B240","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3389\/fphys.2015.00069","article-title":"Store-operated Calcium Entry and the Localization of STIM1 and Orai1 Proteins in Isolated Mouse Sinoatrial Node Cells","volume":"6","author":"Liu","year":"2015","journal-title":"Front. Physiol."},{"key":"B241","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s11658-016-0031-z","article-title":"p62 Links the Autophagy Pathway and the Ubiqutin-Proteasome System upon Ubiquitinated Protein Degradation","volume":"21","author":"Liu","year":"","journal-title":"Cell Mol Biol Lett"},{"key":"B242","doi-asserted-by":"publisher","first-page":"222","DOI":"10.2174\/15672026113109990060","article-title":"Mitochondrial Fusion and Fission Proteins Expression Dynamically Change in a Murine Model of Amyotrophic Lateral Sclerosis","volume":"10","author":"Liu","year":"2013","journal-title":"Cnr"},{"key":"B243","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1093\/brain\/awp045","article-title":"Recessive Twinkle Mutations Cause Severe Epileptic Encephalopathy","volume":"132","author":"Lonnqvist","year":"2009","journal-title":"Brain"},{"key":"B244","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1016\/s0140-6736(04)16983-3","article-title":"Parkinsonism, Premature Menopause, and Mitochondrial DNA Polymerase \u03b3 Mutations: Clinical and Molecular Genetic Study","volume":"364","author":"Luoma","year":"2004","journal-title":"The Lancet"},{"key":"B19","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-e","article-title":"A Novel Gene Containing a Trinucleotide Repeat that Is Expanded and Unstable on Huntington's Disease Chromosomes. The Huntington's Disease Collaborative Research Group","volume":"72","author":"MacDonald","year":"1993","journal-title":"Cell"},{"key":"B245","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22020740","article-title":"Mitophagy Modulation, a New Player in the Race against ALS","volume":"22","author":"Madruga","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B246","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1093\/hmg\/ddt528","article-title":"Abnormal Mitochondrial Transport and Morphology Are Common Pathological Denominators in SOD1 and TDP43 ALS Mouse Models","volume":"23","author":"Magran\u00e9","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"B247","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1172\/jci74770","article-title":"Purkinje Neuron Ca2+ Influx Reduction Rescues Ataxia in SCA28 Model","volume":"125","author":"Maltecca","year":"2015","journal-title":"J. Clin. Invest."},{"key":"B248","doi-asserted-by":"publisher","first-page":"2495","DOI":"10.1093\/hmg\/ddr139","article-title":"Impaired Mitochondrial Dynamics and Abnormal Interaction of Amyloid Beta with Mitochondrial Protein Drp1 in Neurons from Patients with Alzheimer's Disease: Implications for Neuronal Damage","volume":"20","author":"Manczak","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"B249","doi-asserted-by":"publisher","first-page":"2973","DOI":"10.1093\/hmg\/dds128","article-title":"Mitochondria-targeted Catalase Reduces Abnormal APP Processing, Amyloid Production and BACE1 in a Mouse Model of Alzheimer's Disease: Implications for Neuroprotection and Lifespan Extension","volume":"21","author":"Mao","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"B250","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.ceca.2017.05.003","article-title":"Mitochondrial and Endoplasmic Reticulum Calcium Homeostasis and Cell Death","volume":"69","author":"Marchi","year":"2018","journal-title":"Cell Calcium"},{"key":"B251","doi-asserted-by":"publisher","first-page":"2080","DOI":"10.1074\/jbc.m115.686956","article-title":"Mitochondrial Calcium Uptake Modulates Synaptic Vesicle Endocytosis in Central Nerve Terminals","volume":"291","author":"Marland","year":"2016","journal-title":"J. Biol. Chem."},{"key":"B252","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1083\/jcb.200910140","article-title":"PINK1 Stabilized by Mitochondrial Depolarization Recruits Parkin to Damaged Mitochondria and Activates Latent Parkin for Mitophagy","volume":"189","author":"Matsuda","year":"2010","journal-title":"J. Cel Biol"},{"key":"B253","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1523\/jneurosci.4029-08.2009","article-title":"Single Nigrostriatal Dopaminergic Neurons Form Widely Spread and Highly Dense Axonal Arborizations in the Neostriatum","volume":"29","author":"Matsuda","year":"2009","journal-title":"J. Neurosci."},{"key":"B254","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1042\/bj1800533","article-title":"The Effects of Calcium Ions and Adenine Nucleotides on the Activity of Pig Heart 2-oxoglutarate Dehydrogenase Complex","volume":"180","author":"McCormack","year":"1979","journal-title":"Biochem. J."},{"key":"B255","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1016\/j.neuron.2019.03.004","article-title":"Circuit Mechanisms of Parkinson's Disease","volume":"101","author":"McGregor","year":"2019","journal-title":"Neuron"},{"key":"B256","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.1080\/15548627.2018.1505154","article-title":"MFN2 Retrotranslocation Boosts Mitophagy by Uncoupling Mitochondria from the ER","volume":"14","author":"McLelland","year":"2018","journal-title":"Autophagy"},{"key":"B257","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1002\/embj.201385902","article-title":"Parkin and PINK1 Function in a Vesicular Trafficking Pathway Regulating Mitochondrial Quality Control","volume":"33","author":"McLelland","year":"2014","journal-title":"EMBO J."},{"key":"B258","doi-asserted-by":"publisher","DOI":"10.7554\/elife.32866","article-title":"Mfn2 Ubiquitination by PINK1\/parkin gates the P97-dependent Release of ER from Mitochondria to Drive Mitophagy","volume":"7","author":"McLelland","year":"2018","journal-title":"Elife"},{"key":"B259","doi-asserted-by":"publisher","first-page":"15703","DOI":"10.1523\/jneurosci.0552-11.2011","article-title":"The Mitochondria-Targeted Antioxidant MitoQ Prevents Loss of Spatial Memory Retention and Early Neuropathology in a Transgenic Mouse Model of Alzheimer's Disease","volume":"31","author":"McManus","year":"2011","journal-title":"J. Neurosci."},{"key":"B260","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s00018-017-2590-1","article-title":"Regulation of Long-Distance Transport of Mitochondria along Microtubules","volume":"75","author":"Melkov","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"B261","doi-asserted-by":"publisher","first-page":"e536","DOI":"10.1371\/journal.pone.0000536","article-title":"Mitochondrial Oxidative Stress Causes Hyperphosphorylation of Tau","volume":"2","author":"Melov","year":"2007","journal-title":"PLoS One"},{"key":"B262","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.neuron.2016.03.038","article-title":"Understanding Dopaminergic Cell Death Pathways in Parkinson Disease","volume":"90","author":"Michel","year":"2016","journal-title":"Neuron"},{"key":"B263","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/j.neuron.2017.09.055","article-title":"Mitostasis in Neurons: Maintaining Mitochondria in an Extended Cellular Architecture","volume":"96","author":"Misgeld","year":"2017","journal-title":"Neuron"},{"key":"B264","doi-asserted-by":"publisher","first-page":"4232","DOI":"10.1523\/jneurosci.6248-09.2010","article-title":"Mitofusin 2 Is Necessary for Transport of Axonal Mitochondria and Interacts with the Miro\/Milton Complex","volume":"30","author":"Misko","year":"2010","journal-title":"J. Neurosci."},{"key":"B265","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.jns.2006.05.060","article-title":"Immunoreactivities of P62, an Ubiqutin-Binding Protein, in the Spinal Anterior Horn Cells of Patients with Amyotrophic Lateral Sclerosis","volume":"249","author":"Mizuno","year":"2006","journal-title":"J. Neurol. Sci."},{"key":"B266","doi-asserted-by":"publisher","first-page":"264","DOI":"10.3389\/fnmol.2017.00264","article-title":"Reversible Axonal Dystrophy by Calcium Modulation in Frataxin-Deficient Sensory Neurons of YG8R Mice","volume":"10","author":"Molla","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"B267","doi-asserted-by":"publisher","first-page":"37","DOI":"10.3389\/fnmol.2020.00037","article-title":"Protein Aggregation and Dysfunction of Autophagy-Lysosomal Pathway: A Vicious Cycle in Lysosomal Storage Diseases","volume":"13","author":"Monaco","year":"2020","journal-title":"Front. Mol. Neurosci."},{"key":"B268","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1007\/s00401-016-1570-0","article-title":"Brain Imaging of Neurovascular Dysfunction in Alzheimer's Disease","volume":"131","author":"Montagne","year":"2016","journal-title":"Acta Neuropathol."},{"key":"B269","doi-asserted-by":"publisher","first-page":"E3349","DOI":"10.1073\/pnas.1523810113","article-title":"Dynamic Recruitment and Activation of ALS-Associated TBK1 with its Target Optineurin Are Required for Efficient Mitophagy","volume":"113","author":"Moore","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"B270","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1093\/hmg\/dds011","article-title":"Amyotrophic Lateral Sclerosis-Associated Mutant VAPBP56S Perturbs Calcium Homeostasis to Disrupt Axonal Transport of Mitochondria","volume":"21","author":"Morotz","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"B271","doi-asserted-by":"publisher","first-page":"2017","DOI":"10.1212\/wnl.0b013e3181ff9685","article-title":"Mitochondrial Impairment in Patients with Parkinson Disease with the G2019S Mutation in LRRK2","volume":"75","author":"Mortiboys","year":"2010","journal-title":"Neurology"},{"key":"B272","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1016\/j.cmet.2014.07.024","article-title":"Amyloid-\u03b2 Peptide Induces Mitochondrial Dysfunction by Inhibition of Preprotein Maturation","volume":"20","author":"Mossmann","year":"2014","journal-title":"Cel Metab."},{"key":"B273","doi-asserted-by":"publisher","first-page":"e319","DOI":"10.1212\/wnl.0000000000005869","article-title":"Biallelic SQSTM1 Mutations in Early-Onset, Variably Progressive Neurodegeneration","volume":"91","author":"Muto","year":"2018","journal-title":"Neurology"},{"key":"B274","doi-asserted-by":"publisher","first-page":"897","DOI":"10.14348\/molcells.2017.0226","article-title":"Emerging Paradigm of Crosstalk between Autophagy and the Ubiquitin-Proteasome System","volume":"40","author":"Nam","year":"2017","journal-title":"Mol. Cell"},{"key":"B275","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1093\/hmg\/dds503","article-title":"Defective Mitochondrial Disulfide Relay System, Altered Mitochondrial Morphology and Function in Huntington's Disease","volume":"22","author":"Napoli","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"B276","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1093\/brain\/awt291","article-title":"Catecholamine Metabolism Drives Generation of Mitochondrial DNA Deletions in Dopaminergic Neurons","volume":"137","author":"Neuhaus","year":"2014","journal-title":"Brain"},{"key":"B277","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1159\/000444680","article-title":"Catecholamine Metabolism Induces Mitochondrial DNA Deletions and Leads to Severe Adrenal Degeneration during Aging","volume":"104","author":"Neuhaus","year":"2017","journal-title":"Neuroendocrinology"},{"key":"B278","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1038\/nsmb.2159","article-title":"The Mitochondrial Transcription and Packaging Factor Tfam Imposes a U-Turn on Mitochondrial DNA","volume":"18","author":"Ngo","year":"2011","journal-title":"Nat. Struct. Mol. Biol."},{"key":"B279","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1007\/s00401-017-1708-8","article-title":"Motor Neuron Vulnerability and Resistance in Amyotrophic Lateral Sclerosis","volume":"133","author":"Nijssen","year":"2017","journal-title":"Acta Neuropathol."},{"key":"B280","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1086\/425287","article-title":"A Mutation in the Vesicle-Trafficking Protein VAPB Causes Late-Onset Spinal Muscular Atrophy and Amyotrophic Lateral Sclerosis","volume":"75","author":"Nishimura","year":"2004","journal-title":"Am. J. Hum. Genet."},{"key":"B281","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1038\/nm.3232","article-title":"The Role of Autophagy in Neurodegenerative Disease","volume":"19","author":"Nixon","year":"2013","journal-title":"Nat. Med."},{"key":"B282","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1002\/hbm.22733","article-title":"Basal Ganglia-Cortical Structural Connectivity in Huntington's Disease","volume":"36","author":"Novak","year":"2015","journal-title":"Hum. Brain Mapp."},{"key":"B283","doi-asserted-by":"publisher","first-page":"100301","DOI":"10.1016\/j.ensci.2020.100301","article-title":"SQSTM1L341V Variant that Is Linked to Sporadic ALS Exhibits Impaired Association with MAP1LC3 in Cultured Cells","volume":"22","author":"Nozaki","year":"2021","journal-title":"eNeurologicalSci"},{"key":"B284","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1002\/mds.27115","article-title":"Past, Present, and Future of Parkinson's Disease: A Special Essay on the 200th Anniversary of the Shaking Palsy","volume":"32","author":"Obeso","year":"2017","journal-title":"Mov Disord."},{"key":"B285","doi-asserted-by":"publisher","first-page":"16889","DOI":"10.1073\/pnas.1420103111","article-title":"Potential Function for the Huntingtin Protein as a Scaffold for Selective Autophagy","volume":"111","author":"Ochaba","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"B286","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1111\/j.1471-4159.2006.04361.x","article-title":"Mitochondrial Dysfunction in Huntington's Disease: the Bioenergetics of Isolated and In Situ Mitochondria from Transgenic Mice","volume":"101","author":"Oliveira","year":"2007","journal-title":"J. Neurochem."},{"key":"B287","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s40478-016-0316-5","article-title":"Gene-specific Mitochondria Dysfunctions in Human TARDBP and C9ORF72 Fibroblasts","volume":"4","author":"Onesto","year":"2016","journal-title":"Acta Neuropathol. Commun."},{"key":"B288","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.molcel.2014.09.007","article-title":"Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis","volume":"56","author":"Ordureau","year":"2014","journal-title":"Mol. Cel"},{"key":"B289","doi-asserted-by":"publisher","first-page":"2783","DOI":"10.1523\/jneurosci.0106-08.2008","article-title":"N-terminal Mutant Huntingtin Associates with Mitochondria and Impairs Mitochondrial Trafficking","volume":"28","author":"Orr","year":"2008","journal-title":"J. Neurosci."},{"key":"B290","doi-asserted-by":"publisher","first-page":"6761","DOI":"10.1523\/jneurosci.2946-16.2017","article-title":"Lower Affinity of Isradipine for L-type Ca2+ Channels during Substantia Nigra Dopamine Neuron-like Activity: Implications for Neuroprotection in Parkinson's Disease","volume":"37","author":"Ortner","year":"2017","journal-title":"J. Neurosci."},{"key":"B291","doi-asserted-by":"publisher","first-page":"2349","DOI":"10.1016\/j.cub.2015.07.050","article-title":"Elevated Mitochondrial Bioenergetics and Axonal Arborization Size Are Key Contributors to the Vulnerability of Dopamine Neurons","volume":"25","author":"Pacelli","year":"2015","journal-title":"Curr. Biol."},{"key":"B292","doi-asserted-by":"publisher","first-page":"14440","DOI":"10.1074\/jbc.m909882199","article-title":"Presenilin 2 Interacts with Sorcin, a Modulator of the Ryanodine Receptor","volume":"275","author":"Pack-Chung","year":"2000","journal-title":"J. Biol. Chem."},{"key":"B293","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1038\/s41467-019-08335-6","article-title":"LC3\/GABARAPs Drive Ubiquitin-independent Recruitment of Optineurin and NDP52 to Amplify Mitophagy","volume":"10","author":"Padman","year":"2019","journal-title":"Nat. Commun."},{"key":"B294","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s00401-017-1704-z","article-title":"\u03b1-Synuclein Binds to the ER-Mitochondria Tethering Protein VAPB to Disrupt Ca2+ Homeostasis and Mitochondrial ATP Production","volume":"134","author":"Paillusson","year":"2017","journal-title":"Acta Neuropathol."},{"key":"B295","doi-asserted-by":"publisher","first-page":"2379","DOI":"10.1093\/brain\/awt160","article-title":"Mesencephalic Complex I Deficiency Does Not Correlate with Parkinsonism in Mitochondrial DNA Maintenance Disorders","volume":"136","author":"Palin","year":"2013","journal-title":"Brain"},{"key":"B296","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1038\/nn884","article-title":"Early Mitochondrial Calcium Defects in Huntington's Disease Are a Direct Effect of Polyglutamines","volume":"5","author":"Panov","year":"2002","journal-title":"Nat. Neurosci."},{"key":"B297","doi-asserted-by":"publisher","first-page":"591","DOI":"10.7326\/M19-2534","article-title":"Isradipine versus Placebo in Early Parkinson Disease: A Randomized Trial","volume":"172","year":"2020","journal-title":"Ann. Intern. Med."},{"key":"B298","doi-asserted-by":"publisher","first-page":"3646","DOI":"10.1007\/s12035-020-01947-w","article-title":"The Impact of Mitochondrial Dysfunction on Dopaminergic Neurons in the Olfactory Bulb and Odor Detection","volume":"57","author":"Pass","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"B299","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1038\/cr.2018.17","article-title":"m-AAA Proteases, Mitochondrial Calcium Homeostasis and Neurodegeneration","volume":"28","author":"Patron","year":"2018","journal-title":"Cell Res"},{"key":"B300","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1038\/nrn.2017.92","article-title":"Polyglutamine Spinocerebellar Ataxias - from Genes to Potential Treatments","volume":"18","author":"Paulson","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"B301","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1111\/jnc.13165","article-title":"Ca2+ Handling in Isolated Brain Mitochondria and Cultured Neurons Derived from the YAC128 Mouse Model of Huntington's Disease","volume":"134","author":"Pellman","year":"2015","journal-title":"J. Neurochem."},{"key":"B302","doi-asserted-by":"publisher","first-page":"64","DOI":"10.3389\/fnmol.2018.00064","article-title":"The LRRK2 Variant E193K Prevents Mitochondrial Fission upon MPP+ Treatment by Altering LRRK2 Binding to DRP1","volume":"11","author":"Perez Carrion","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"B303","doi-asserted-by":"publisher","first-page":"2174","DOI":"10.1073\/pnas.0409598102","article-title":"Parkin-deficient Mice Are Not a Robust Model of Parkinsonism","volume":"102","author":"Perez","year":"2005","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B304","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1097\/nen.0b013e3181a1fc49","article-title":"Increased Association between Rough Endoplasmic Reticulum Membranes and Mitochondria in Transgenic Mice that Express P301L Tau","volume":"68","author":"Perreault","year":"2009","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B305","doi-asserted-by":"publisher","first-page":"4817","DOI":"10.1093\/hmg\/dds311","article-title":"Loss of Mfn2 Results in Progressive, Retrograde Degeneration of Dopaminergic Neurons in the Nigrostriatal Circuit","volume":"21","author":"Pham","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"B306","doi-asserted-by":"publisher","first-page":"7234","DOI":"10.1523\/jneurosci.0459-16.2016","article-title":"Differential Somatic Ca2+ Channel Profile in Midbrain Dopaminergic Neurons","volume":"36","author":"Philippart","year":"2016","journal-title":"J. Neurosci."},{"key":"B307","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.cmet.2016.06.024","article-title":"Expanding Our Understanding of mtDNA Deletions","volume":"24","author":"Picard","year":"2016","journal-title":"Cel Metab."},{"key":"B308","doi-asserted-by":"publisher","first-page":"2190","DOI":"10.1172\/JCI33585","article-title":"The Autophagy-Related Protein Beclin 1 Shows Reduced Expression in Early Alzheimer Disease and Regulates Amyloid Beta Accumulation in Mice","volume":"118","author":"Pickford","year":"2008","journal-title":"J. Clin. Invest."},{"key":"B309","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.neuron.2015.06.034","article-title":"Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons Following Mitochondrial DNA Mutagenic Stress","volume":"87","author":"Pickrell","year":"2015","journal-title":"Neuron"},{"key":"B310","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1093\/hmg\/ddu440","article-title":"Junctophilin-1 Is a Modifier Gene of GDAP1-Related Charcot-Marie-Tooth Disease","volume":"24","author":"Pla-Mart\u00edn","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"B311","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.nbd.2013.03.010","article-title":"Silencing of the Charcot-Marie-Tooth Disease-Associated Gene GDAP1 Induces Abnormal Mitochondrial Distribution and Affects Ca2+ Homeostasis by Reducing Store-Operated Ca2+ Entry","volume":"55","author":"Pla-Mart\u00edn","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"B312","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1126\/science.276.5321.2045","article-title":"Mutation in the -Synuclein Gene Identified in Families with Parkinson's Disease","volume":"276","author":"Polymeropoulos","year":"1997","journal-title":"Science"},{"key":"B313","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.jprot.2012.12.018","article-title":"In-depth Proteomic Analysis of Mammalian Mitochondria-Associated Membranes (MAM)","volume":"79","author":"Poston","year":"2013","journal-title":"J. Proteomics"},{"key":"B314","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1002\/mds.24996","article-title":"Identifying Prodromal Parkinson's Disease: Pre-motor Disorders in Parkinson's Disease","volume":"27","author":"Postuma","year":"2012","journal-title":"Mov. Disord."},{"key":"B315","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/1750-1326-8-45","article-title":"Mitochondrial Permeability Transition Pore Induces Mitochondria Injury in Huntington Disease","volume":"8","author":"Quintanilla","year":"2013","journal-title":"Mol. Neurodegeneration"},{"key":"B316","doi-asserted-by":"publisher","first-page":"18754","DOI":"10.1074\/jbc.m808908200","article-title":"Caspase-cleaved Tau Expression Induces Mitochondrial Dysfunction in Immortalized Cortical Neurons","volume":"284","author":"Quintanilla","year":"2009","journal-title":"J. Biol. Chem."},{"key":"B317","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1038\/mt.2014.108","article-title":"Nonallele Specific Silencing of Ataxin-7 Improves Disease Phenotypes in a Mouse Model of SCA7","volume":"22","author":"Ramachandran","year":"2014","journal-title":"Mol. Ther."},{"key":"B318","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/j.cell.2013.12.042","article-title":"Activity-driven Local ATP Synthesis Is Required for Synaptic Function","volume":"156","author":"Rangaraju","year":"2014","journal-title":"Cell"},{"key":"B319","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.neuroscience.2011.08.052","article-title":"Pathophysiology of Huntington's Disease: Time-dependent Alterations in Synaptic and Receptor Function","volume":"198","author":"Raymond","year":"2011","journal-title":"Neuroscience"},{"key":"B320","doi-asserted-by":"publisher","first-page":"795","DOI":"10.3390\/biom4030795","article-title":"Interactions between Calcium and Alpha-Synuclein in Neurodegeneration","volume":"4","author":"Rcom-H'cheo-Gauthier","year":"2014","journal-title":"Biomolecules"},{"key":"B321","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1093\/hmg\/ddx129","article-title":"Mitochondria-targeted Small Molecule SS31: a Potential Candidate for the Treatment of Alzheimer's Disease","volume":"26","author":"Reddy","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"B322","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.ajhg.2007.09.018","article-title":"Nature of Mitochondrial DNA Deletions in Substantia Nigra Neurons","volume":"82","author":"Reeve","year":"2008","journal-title":"Am. J. Hum. Genet."},{"key":"B323","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/j.nmd.2010.08.001","article-title":"168th ENMC International Workshop: Outcome Measures and Clinical Trials in Charcot-Marie-Tooth Disease (CMT)","volume":"20","author":"Reilly","year":"2010","journal-title":"Neuromuscul. Disord."},{"key":"B324","doi-asserted-by":"publisher","first-page":"319","DOI":"10.3233\/jad-131715","article-title":"Mitochondrial DNA Copy Numbers in Pyramidal Neurons Are Decreased and Mitochondrial Biogenesis Transcriptome Signaling Is Disrupted in Alzheimer's Disease Hippocampi","volume":"40","author":"Rice","year":"2014","journal-title":"Jad"},{"key":"B325","doi-asserted-by":"publisher","first-page":"4039","DOI":"10.1073\/pnas.1523926113","article-title":"Phosphorylation of OPTN by TBK1 Enhances its Binding to Ub Chains and Promotes Selective Autophagy of Damaged Mitochondria","volume":"113","author":"Richter","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"B326","doi-asserted-by":"publisher","first-page":"1975","DOI":"10.1523\/jneurosci.1345-19.2019","article-title":"Mitochondrial Dysfunction Combined with High Calcium Load Leads to Impaired Antioxidant Defense Underlying the Selective Loss of Nigral Dopaminergic Neurons","volume":"40","author":"Ricke","year":"2020","journal-title":"J. Neurosci."},{"key":"B327","doi-asserted-by":"publisher","first-page":"4266","DOI":"10.1093\/hmg\/ddw258","article-title":"Selective Mitochondrial Depletion, Apoptosis Resistance, and Increased Mitophagy in Human Charcot-Marie-Tooth 2A Motor Neurons","volume":"25","author":"Rizzo","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"B328","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1038\/nrm3412","article-title":"Mitochondria as Sensors and Regulators of Calcium Signalling","volume":"13","author":"Rizzuto","year":"2012","journal-title":"Nat. Rev. Mol. Cel Biol"},{"key":"B329","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1126\/science.280.5370.1763","article-title":"Close Contacts with the Endoplasmic Reticulum as Determinants of Mitochondrial Ca2+ Responses","volume":"280","author":"Rizzuto","year":"1998","journal-title":"Science"},{"key":"B330","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1126\/science.aao1785","article-title":"MFN2 Agonists Reverse Mitochondrial Defects in Preclinical Models of Charcot-Marie-Tooth Disease Type 2A","volume":"360","author":"Rocha","year":"2018","journal-title":"Science"},{"key":"B331","doi-asserted-by":"publisher","first-page":"101762","DOI":"10.1016\/j.redox.2020.101762","article-title":"Oxidative Stress Modulates Rearrangement of Endoplasmic Reticulum-Mitochondria Contacts and Calcium Dysregulation in a Friedreich's Ataxia Model","volume":"37","author":"Rodr\u00edguez","year":"2020","journal-title":"Redox Biol."},{"key":"B332","doi-asserted-by":"publisher","first-page":"102355","DOI":"10.1016\/j.ceca.2021.102355","article-title":"\u03b1-Synuclein Emerges as a Potent Regulator of VDAC-Facilitated Calcium Transport","volume":"95","author":"Rosencrans","year":"2021","journal-title":"Cell Calcium"},{"key":"B333","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/j.neuron.2020.06.010","article-title":"Selective Neuronal Vulnerability in Alzheimer's Disease: A Network-Based Analysis","volume":"107","author":"Roussarie","year":"2020","journal-title":"Neuron"},{"key":"B334","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1212\/wnl.0b013e31826e25df","article-title":"SQSTM1 Mutations in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis","volume":"79","author":"Rubino","year":"2012","journal-title":"Neurology"},{"key":"B335","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/j.cell.2011.07.030","article-title":"Autophagy and Aging","volume":"146","author":"Rubinsztein","year":"2011","journal-title":"Cell"},{"key":"B336","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1038\/emboj.2012.38","article-title":"Mitochondrial Quality Control: a Matter of Life and Death for Neurons","volume":"31","author":"Rugarli","year":"2012","journal-title":"EMBO J."},{"key":"B337","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1038\/ncb3101","article-title":"Huntingtin Functions as a Scaffold for Selective Macroautophagy","volume":"17","author":"Rui","year":"2015","journal-title":"Nat. Cel Biol"},{"key":"B338","doi-asserted-by":"publisher","first-page":"2427","DOI":"10.1016\/j.celrep.2019.07.075","article-title":"Junctophilin Proteins Tether a Cav1-RyR2-KCa3.1 Tripartite Complex to Regulate Neuronal Excitability","volume":"28","author":"Sahu","year":"2019","journal-title":"Cel Rep."},{"key":"B339","doi-asserted-by":"publisher","first-page":"e2718","DOI":"10.1371\/journal.pone.0002718","article-title":"Mitochondrial Ca2+ Overload Underlies Abeta Oligomers Neurotoxicity Providing an Unexpected Mechanism of Neuroprotection by NSAIDs","volume":"3","author":"Sanz-Blasco","year":"2008","journal-title":"PLoS One"},{"key":"B340","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1002\/ana.22166","article-title":"Charcot-Marie-Tooth Disease Subtypes and Genetic Testing Strategies","volume":"69","author":"Saporta","year":"2011","journal-title":"Ann. Neurol."},{"key":"B341","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1038\/nature12043","article-title":"Landscape of the PARKIN-dependent Ubiquitylome in Response to Mitochondrial Depolarization","volume":"496","author":"Sarraf","year":"2013","journal-title":"Nature"},{"key":"B342","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1097\/nen.0b013e3182160690","article-title":"Autophagy in Spinal Cord Motor Neurons in Sporadic Amyotrophic Lateral Sclerosis","volume":"70","author":"Sasaki","year":"2011","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B343","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1097\/nen.0b013e31802c396b","article-title":"Mitochondrial Alterations in the Spinal Cord of Patients with Sporadic Amyotrophic Lateral Sclerosis","volume":"66","author":"Sasaki","year":"2007","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B344","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s001090000077","article-title":"Molecular Mechanisms of Calcium-dependent Excitotoxicity","volume":"78","author":"Sattler","year":"2000","journal-title":"J. Mol. Med."},{"key":"B345","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1002\/cne.20620","article-title":"A Compensatory Subpopulation of Motor Neurons in a Mouse Model of Amyotrophic Lateral Sclerosis","volume":"490","author":"Schaefer","year":"2005","journal-title":"J. Comp. Neurol."},{"key":"B346","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1016\/s0140-6736(11)61305-6","article-title":"Mitochondrial Diseases","volume":"379","author":"Schapira","year":"2012","journal-title":"The Lancet"},{"key":"B347","doi-asserted-by":"publisher","first-page":"5566","DOI":"10.1242\/jcs.129668","article-title":"NCX3 Regulates Mitochondrial Ca(2+) Handling through the AKAP121-Anchored Signaling Complex and Prevents Hypoxia-Induced Neuronal Death","volume":"126","author":"Scorziello","year":"2013","journal-title":"J. Cel Sci"},{"key":"B348","doi-asserted-by":"publisher","first-page":"4693","DOI":"10.1242\/jcs.103440","article-title":"The Retromer Complex - Endosomal Protein Recycling and beyond","volume":"125","author":"Seaman","year":"2012","journal-title":"J. Cel Sci"},{"key":"B349","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s12915-017-0470-7","article-title":"PINK1 Import Regulation; a fine System to Convey Mitochondrial Stress to the Cytosol","volume":"16","author":"Sekine","year":"2018","journal-title":"BMC Biol."},{"key":"B350","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1007\/s00401-018-1873-4","article-title":"Alpha-synuclein Delays Mitophagy and Targeting Miro Rescues Neuron Loss in Parkinson's Models","volume":"136","author":"Shaltouki","year":"2018","journal-title":"Acta Neuropathol."},{"key":"B351","doi-asserted-by":"publisher","first-page":"1972","DOI":"10.1083\/jcb.201807068","article-title":"Rhes Travels from Cell to Cell and Transports Huntington Disease Protein via TNT-like Protrusion","volume":"218","author":"Sharma","year":"2019","journal-title":"J. Cel Biol"},{"key":"B352","doi-asserted-by":"publisher","first-page":"16510","DOI":"10.1073\/pnas.1119738109","article-title":"Mammalian Transcription Factor A Is a Core Component of the Mitochondrial Transcription Machinery","volume":"109","author":"Shi","year":"2012","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B353","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1093\/hmg\/ddr024","article-title":"Abnormal Mitochondrial Dynamics, Mitochondrial Loss and Mutant Huntingtin Oligomers in Huntington's Disease: Implications for Selective Neuronal Damage","volume":"20","author":"Shirendeb","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"B354","doi-asserted-by":"publisher","first-page":"13207","DOI":"10.1073\/pnas.2135385100","article-title":"The Proteome of Saccharomyces cerevisiae Mitochondria","volume":"100","author":"Sickmann","year":"2003","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B355","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1002\/ana.410390210","article-title":"Ultrastructural Evidence for Altered Calcium in Motor Nerve Terminals in Amyotrophc Lateral Sclerosis","volume":"39","author":"Sikl\u00f3s","year":"1996","journal-title":"Ann. Neurol."},{"key":"B356","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1097\/00005072-199806000-00005","article-title":"Intracellular Calcium Parallels Motoneuron Degeneration in SOD-1 Mutant Mice","volume":"57","author":"Sikl\u00f3s","year":"1998","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B357","doi-asserted-by":"publisher","first-page":"5161","DOI":"10.1007\/s12035-015-9435-4","article-title":"Fibroblast Biomarkers of Sporadic Parkinson's Disease and LRRK2 Kinase Inhibition","volume":"53","author":"Smith","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"B358","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1002\/mds.23148","article-title":"A Double-Blind, Placebo-Controlled Study to Assess the Mitochondria-Targeted Antioxidant MitoQ as a Disease-Modifying Therapy in Parkinson's Disease","volume":"25","author":"Snow","year":"2010","journal-title":"Mov. Disord."},{"key":"B359","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1038\/nm.2313","article-title":"Mutant Huntingtin Binds the Mitochondrial Fission GTPase Dynamin-Related Protein-1 and Increases its Enzymatic Activity","volume":"17","author":"Song","year":"2011","journal-title":"Nat. Med."},{"key":"B360","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.nbd.2012.07.004","article-title":"Mutant SOD1G93A Triggers Mitochondrial Fragmentation in Spinal Cord Motor Neurons: Neuroprotection by SIRT3 and PGC-1\u03b1","volume":"51","author":"Song","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"B361","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1038\/42166","article-title":"\u03b1-Synuclein in Lewy Bodies","volume":"388","author":"Spillantini","year":"1997","journal-title":"Nature"},{"key":"B362","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1038\/s42255-021-00385-9","article-title":"Cellular Pyrimidine Imbalance Triggers Mitochondrial DNA-dependent Innate Immunity","volume":"3","author":"Sprenger","year":"2021","journal-title":"Nat. Metab."},{"key":"B363","doi-asserted-by":"publisher","first-page":"2055","DOI":"10.1093\/hmg\/ddt600","article-title":"Functional Interaction of Parkinson's Disease-Associated LRRK2 with Members of the Dynamin GTPase Superfamily","volume":"23","author":"Stafa","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"B364","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1002\/1873-3468.12902","article-title":"The Role of Mitochondrial ROS in the Aging Brain","volume":"592","author":"Stefanatos","year":"2018","journal-title":"FEBS Lett."},{"key":"B365","doi-asserted-by":"publisher","first-page":"12937","DOI":"10.1073\/pnas.1103295108","article-title":"Impaired Mitochondrial Transport and Parkin-independent Degeneration of Respiratory Chain-Deficient Dopamine Neurons In Vivo","volume":"108","author":"Sterky","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B366","doi-asserted-by":"publisher","first-page":"293","DOI":"10.3389\/fncel.2014.00293","article-title":"Motor Neurons and the Generation of Spinal Motor Neuron Diversity","volume":"8","author":"Stifani","year":"2014","journal-title":"Front. Cel Neurosci"},{"key":"B367","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.ymgme.2016.07.001","article-title":"Mutations in TFAM, Encoding Mitochondrial Transcription Factor A, Cause Neonatal Liver Failure Associated with mtDNA Depletion","volume":"119","author":"Stiles","year":"2016","journal-title":"Mol. Genet. Metab."},{"key":"B368","doi-asserted-by":"publisher","first-page":"3996","DOI":"10.1038\/ncomms4996","article-title":"ER-mitochondria Associations Are Regulated by the VAPB-PTPIP51 Interaction and Are Disrupted by ALS\/FTD-associated TDP-43","volume":"5","author":"Stoica","year":"2014","journal-title":"Nat. Commun."},{"key":"B369","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.15252\/embr.201541726","article-title":"ALS\/FTD \u2010associated FUS Activates GSK \u20103\u03b2 to Disrupt the VAPB - PTPIP 51 Interaction and ER -mitochondria Associations","volume":"17","author":"Stoica","year":"2016","journal-title":"EMBO Rep."},{"key":"B370","doi-asserted-by":"publisher","first-page":"4545","DOI":"10.1093\/hmg\/ddt301","article-title":"Inhibition of Excessive Mitochondrial Fission Reduced Aberrant Autophagy and Neuronal Damage Caused by LRRK2 G2019S Mutation","volume":"22","author":"Su","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"B371","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1126\/science.1172871","article-title":"Rhes, a Striatal Specific Protein, Mediates Mutant-Huntingtin Cytotoxicity","volume":"324","author":"Subramaniam","year":"2009","journal-title":"Science"},{"key":"B372","doi-asserted-by":"publisher","first-page":"2142","DOI":"10.15252\/embj.201488104","article-title":"A New Pathway for Mitochondrial Quality Control: Mitochondrial\u2010derived Vesicles","volume":"33","author":"Sugiura","year":"2014","journal-title":"EMBO J."},{"key":"B373","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1212\/wnl.48.5.1244","article-title":"Autosomal Dominant Progressive External Ophthalmoplegia with Multiple Deletions of mtDNA: Clinical, Biochemical, and Molecular Genetic Features of the 1Oq-Linked Disease","volume":"48","author":"Suomalainen","year":"1997","journal-title":"Neurology"},{"key":"B374","doi-asserted-by":"publisher","first-page":"a009290","DOI":"10.1101\/cshperspect.a009290","article-title":"Physiological Phenotype and Vulnerability in Parkinson's Disease","volume":"2","author":"Surmeier","year":"2012","journal-title":"Cold Spring Harbor Perspect. Med."},{"key":"B375","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.ceca.2009.12.003","article-title":"Calcium, Cellular Aging, and Selective Neuronal Vulnerability in Parkinson's Disease","volume":"47","author":"Surmeier","year":"2010","journal-title":"Cell Calcium"},{"key":"B376","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.bbrc.2012.10.107","article-title":"Calcium Leak through Ryanodine Receptor Is Involved in Neuronal Death Induced by Mutant Huntingtin","volume":"429","author":"Suzuki","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B377","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.nbd.2015.05.011","article-title":"Ectopic Expression of the Striatal-Enriched GTPase Rhes Elicits Cerebellar Degeneration and an Ataxia Phenotype in Huntington's Disease","volume":"82","author":"Swarnkar","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"B378","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1016\/j.bbadis.2013.09.010","article-title":"The Alzheimer's Disease Mitochondrial cascade Hypothesis: Progress and Perspectives","volume":"1842","author":"Swerdlow","year":"2014","journal-title":"Biochim. Biophys. Acta (Bba) - Mol. Basis Dis."},{"key":"B379","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/bs.irn.2019.10.019","article-title":"Parkinsonism in Neurodegenerative Diseases Predominantly Presenting with Ataxia","volume":"149","author":"Synofzik","year":"2019","journal-title":"Int. Rev. Neurobiol."},{"key":"B380","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1007\/s12311-012-0378-2","article-title":"Characterizing POLG Ataxia: Clinics, Electrophysiology and Imaging","volume":"11","author":"Synofzik","year":"2012","journal-title":"Cerebellum"},{"key":"B381","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1016\/j.stemcr.2018.09.006","article-title":"T-Type Calcium Channels Determine the Vulnerability of Dopaminergic Neurons to Mitochondrial Stress in Familial Parkinson Disease","volume":"11","author":"Tabata","year":"2018","journal-title":"Stem Cel Rep."},{"key":"B382","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1083\/jcb.201007013","article-title":"Proteasome and P97 Mediate Mitophagy and Degradation of Mitofusins Induced by Parkin","volume":"191","author":"Tanaka","year":"2010","journal-title":"J. Cel Biol"},{"key":"B383","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1016\/j.celrep.2015.08.001","article-title":"VPS35 Deficiency or Mutation Causes Dopaminergic Neuronal Loss by Impairing Mitochondrial Fusion and Function","volume":"12","author":"Tang","year":"2015","journal-title":"Cel Rep."},{"key":"B384","doi-asserted-by":"publisher","first-page":"2602","DOI":"10.1073\/pnas.0409402102","article-title":"Disturbed Ca2+ Signaling and Apoptosis of Medium Spiny Neurons in Huntington\u2019s Disease","volume":"102","author":"Tang","year":"2005","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B385","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/s0896-6273(03)00366-0","article-title":"Huntingtin and Huntingtin-Associated Protein 1 Influence Neuronal Calcium Signaling Mediated by Inositol-(1,4,5) Triphosphate Receptor Type 1","volume":"39","author":"Tang","year":"2003","journal-title":"Neuron"},{"key":"B386","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1212\/wnl.58.12.1791","article-title":"Phases of A\u03b2-Deposition in the Human Brain and its Relevance for the Development of AD","volume":"58","author":"Thal","year":"2002","journal-title":"Neurology"},{"key":"B387","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1097\/nen.0b013e318275df4b","article-title":"Decreased mRNA Expression of PGC-1\u03b1 and PGC-1\u03b1-Regulated Factors in the SOD1G93AALS Mouse Model and in Human Sporadic ALS","volume":"71","author":"Thau","year":"2012","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B388","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1007\/s12264-013-1393-0","article-title":"Soluble N-Terminal Fragment of Mutant Huntingtin Protein Impairs Mitochondrial Axonal Transport in Cultured Hippocampal Neurons","volume":"30","author":"Tian","year":"2014","journal-title":"Neurosci. Bull."},{"key":"B389","doi-asserted-by":"publisher","first-page":"35200","DOI":"10.1038\/srep35200","article-title":"Antisense Oligonucleotide-Mediated Exon Skipping as a Strategy to Reduce Proteolytic Cleavage of Ataxin-3","volume":"6","author":"Toonen","year":"2016","journal-title":"Sci. Rep."},{"key":"B390","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/ng0595-104","article-title":"Cellular Localization of the Huntington's Disease Protein and Discrimination of the normal and Mutated Form","volume":"10","author":"Trottier","year":"1995","journal-title":"Nat. Genet."},{"key":"B391","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3233\/jpd-160989","article-title":"PINK1, Parkin, and Mitochondrial Quality Control: What Can We Learn about Parkinson's Disease Pathobiology?","volume":"7","author":"Truban","year":"2017","journal-title":"Jpd"},{"key":"B392","doi-asserted-by":"publisher","DOI":"10.7554\/elife.15545","article-title":"Dual Functions of a Small Regulatory Subunit in the Mitochondrial Calcium Uniporter Complex","volume":"5","author":"Tsai","year":"2016","journal-title":"Elife"},{"key":"B393","doi-asserted-by":"publisher","first-page":"17687","DOI":"10.1073\/pnas.0505551102","article-title":"Mutant Mitochondrial Helicase Twinkle Causes Multiple mtDNA Deletions and a Late-Onset Mitochondrial Disease in Mice","volume":"102","author":"Tyynismaa","year":"2005","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B394","doi-asserted-by":"publisher","first-page":"2393","DOI":"10.1093\/brain\/awt103","article-title":"Severe Nigrostriatal Degeneration without Clinical Parkinsonism in Patients with Polymerase Gamma Mutations","volume":"136","author":"Tzoulis","year":"2013","journal-title":"Brain"},{"key":"B395","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1002\/cne.902020410","article-title":"A Quantitative Light Microscopic Study of the Dendrites of Cat Spinal \u03b3-motoneurons after Intracellular Staining with Horseradish Peroxidase","volume":"202","author":"Ulfhake","year":"1981","journal-title":"J. Comp. Neurol."},{"key":"B396","doi-asserted-by":"publisher","first-page":"231","DOI":"10.15252\/embr.201642710","article-title":"Miro1\u2010dependent Mitochondrial Positioning Drives the Rescaling of Presynaptic Ca 2+ Signals during Homeostatic Plasticity","volume":"18","author":"Vaccaro","year":"2017","journal-title":"EMBO Rep."},{"key":"B397","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/s0022-510x(00)00414-7","article-title":"Ca(2+)-permeable AMPA Receptors and Selective Vulnerability of Motor Neurons","volume":"180","author":"Van Den Bosch","year":"2000","journal-title":"J. Neurol. Sci."},{"key":"B398","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1212\/01.wnl.0000140494.58732.83","article-title":"POLG Mutations in Neurodegenerative Disorders with Ataxia but No Muscle Involvement","volume":"63","author":"Van Goethem","year":"2004","journal-title":"Neurology"},{"key":"B399","doi-asserted-by":"publisher","first-page":"e22031","DOI":"10.1371\/journal.pone.0022031","article-title":"Misfolded SOD1 Associated with Motor Neuron Mitochondria Alters Mitochondrial Shape and Distribution Prior to Clinical Onset","volume":"6","author":"Vande Velde","year":"2011","journal-title":"PLoS One"},{"key":"B400","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1038\/ejhg.2015.243","article-title":"DNM1L-related Mitochondrial Fission Defect Presenting as Refractory Epilepsy","volume":"24","author":"Vanstone","year":"2016","journal-title":"Eur. J. Hum. Genet."},{"key":"B401","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1080\/13816810.2019.1666414","article-title":"Homozygous Sequestosome 1 (SQSTM1) Mutation: a Rare Cause for Childhood-Onset Progressive Cerebellar Ataxia with Vertical Gaze Palsy","volume":"40","author":"Vedartham","year":"2019","journal-title":"Ophthalmic Genet."},{"key":"B402","doi-asserted-by":"publisher","first-page":"2093","DOI":"10.1093\/brain\/awl126","article-title":"MFN2 Mutation Distribution and Genotype\/phenotype Correlation in Charcot-Marie-Tooth Type 2","volume":"129","author":"Verhoeven","year":"2006","journal-title":"Brain"},{"key":"B403","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.ajhg.2011.06.001","article-title":"VPS35 Mutations in Parkinson Disease","volume":"89","author":"Vilari\u00f1o-G\u00fcell","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"B404","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1016\/j.tcb.2018.07.004","article-title":"No Parkin Zone: Mitophagy without Parkin","volume":"28","author":"Villa","year":"2018","journal-title":"Trends Cel Biol."},{"key":"B405","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s00401-007-0306-6","article-title":"Huntington Disease Models and Human Neuropathology: Similarities and Differences","volume":"115","author":"Vonsattel","year":"2008","journal-title":"Acta Neuropathol."},{"key":"B406","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.3233\/jad-160763","article-title":"Role of Glutamate and NMDA Receptors in Alzheimer's Disease","volume":"57","author":"Wang","year":"2017","journal-title":"Jad"},{"key":"B407","doi-asserted-by":"publisher","first-page":"4706","DOI":"10.1093\/hmg\/ddt319","article-title":"The ALS Disease-Associated Mutant TDP-43 Impairs Mitochondrial Dynamics and Function in Motor Neurons","volume":"22","author":"Wang","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"B408","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1038\/nm.3983","article-title":"Parkinson's Disease-Associated Mutant VPS35 Causes Mitochondrial Dysfunction by Recycling DLP1 Complexes","volume":"22","author":"Wang","year":"2016","journal-title":"Nat. Med."},{"key":"B409","doi-asserted-by":"publisher","first-page":"4118","DOI":"10.1093\/hmg\/ddx299","article-title":"Inhibition of Mitochondrial Fragmentation Protects against Alzheimer's Disease in Rodent Model","volume":"26","author":"Wang","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"B410","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s40478-019-0696-4","article-title":"Pathogenic Alpha-Synuclein Aggregates Preferentially Bind to Mitochondria and Affect Cellular Respiration","volume":"7","author":"Wang","year":"2019","journal-title":"Acta Neuropathol. Commun."},{"key":"B411","doi-asserted-by":"publisher","first-page":"470","DOI":"10.2353\/ajpath.2008.071208","article-title":"Dynamin-like Protein 1 Reduction Underlies Mitochondrial Morphology and Distribution Abnormalities in Fibroblasts from Sporadic Alzheimer's Disease Patients","volume":"173","author":"Wang","year":"2008","journal-title":"Am. J. Pathol."},{"key":"B412","doi-asserted-by":"publisher","first-page":"9090","DOI":"10.1523\/jneurosci.1357-09.2009","article-title":"Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease","volume":"29","author":"Wang","year":"2009","journal-title":"J. Neurosci."},{"key":"B413","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1093\/hmg\/dds003","article-title":"LRRK2 Regulates Mitochondrial Dynamics and Function through Direct Interaction with DLP1","volume":"21","author":"Wang","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"B414","doi-asserted-by":"publisher","first-page":"21742","DOI":"10.1074\/jbc.m110.160697","article-title":"Mitochondrial Dysfunction and Oxidative Stress Contribute to the Pathogenesis of Spinocerebellar Ataxia Type 12 (SCA12)","volume":"286","author":"Wang","year":"2011","journal-title":"J. Biol. Chem."},{"key":"B415","doi-asserted-by":"publisher","first-page":"3070","DOI":"10.1074\/jbc.m112.407726","article-title":"Dysregulation of Mitochondrial Calcium Signaling and Superoxide Flashes Cause Mitochondrial Genomic DNA Damage in Huntington Disease","volume":"288","author":"Wang","year":"2013","journal-title":"J. Biol. Chem."},{"key":"B416","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1016\/j.celrep.2019.01.028","article-title":"Metabolic and Organelle Morphology Defects in Mice and Human Patients Define Spinocerebellar Ataxia Type 7 as a Mitochondrial Disease","volume":"26","author":"Ward","year":"2019","journal-title":"Cel Rep."},{"key":"B417","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a020396","article-title":"The Astrocyte: Powerhouse and Recycling Center","volume":"7","author":"Weber","year":"2015","journal-title":"Cold Spring Harb Perspect. Biol."},{"key":"B418","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s40478-017-0419-7","article-title":"Mitochondrial DNA point Mutations and Relative Copy Number in 1363 Disease and Control Human Brains","volume":"5","author":"Wei","year":"2017","journal-title":"Acta Neuropathol. Commun."},{"key":"B419","doi-asserted-by":"publisher","first-page":"E4439","DOI":"10.1073\/pnas.1405752111","article-title":"Optineurin Is an Autophagy Receptor for Damaged Mitochondria in Parkin-Mediated Mitophagy that Is Disrupted by an ALS-Linked Mutation","volume":"111","author":"Wong","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"B420","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1111\/j.1471-4159.2012.07769.x","article-title":"Alpha-synuclein Impairs normal Dynamics of Mitochondria in Cell and Animal Models of Parkinson's Disease","volume":"122","author":"Xie","year":"2012","journal-title":"J. Neurochem."},{"key":"B421","doi-asserted-by":"publisher","first-page":"10851","DOI":"10.1523\/jneurosci.1630-10.2010","article-title":"Wild-type Human TDP-43 Expression Causes TDP-43 Phosphorylation, Mitochondrial Aggregation, Motor Deficits, and Early Mortality in Transgenic Mice","volume":"30","author":"Xu","year":"2010","journal-title":"J. Neurosci."},{"key":"B422","doi-asserted-by":"publisher","first-page":"4100","DOI":"10.1093\/nar\/gkt1360","article-title":"Organization of the Human Mitochondrial Transcription Initiation Complex","volume":"42","author":"Yakubovskaya","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"B423","doi-asserted-by":"publisher","first-page":"7070","DOI":"10.1073\/pnas.0711845105","article-title":"Pink1 Regulates Mitochondrial Dynamics through Interaction with the Fission\/fusion Machinery","volume":"105","author":"Yang","year":"2008","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B424","doi-asserted-by":"publisher","first-page":"14670","DOI":"10.1073\/pnas.0903563106","article-title":"Mitochondrial Bioenergetic Deficit Precedes Alzheimer's Pathology in Female Mouse Model of Alzheimer's Disease","volume":"106","author":"Yao","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B425","doi-asserted-by":"publisher","first-page":"2938","DOI":"10.1093\/hmg\/ddv056","article-title":"Parkin-mediated Mitophagy in Mutant hAPP Neurons and Alzheimer's Disease Patient Brains","volume":"24","author":"Ye","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"B426","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.neurobiolaging.2019.10.018","article-title":"SQSTM1\/p62 Variants in 486 Patients with Familial ALS from Germany and Sweden","volume":"87","author":"Yilmaz","year":"2020","journal-title":"Neurobiol. Aging"},{"key":"B427","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1126\/science.1219855","article-title":"Mitochondrial Fission, Fusion, and Stress","volume":"337","author":"Youle","year":"2012","journal-title":"Science"},{"key":"B428","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.nbd.2015.02.031","article-title":"Progressive Dopaminergic Alterations and Mitochondrial Abnormalities in LRRK2 G2019S Knock-In Mice","volume":"78","author":"Yue","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"B429","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1093\/brain\/awm335","article-title":"OPA1 Mutations Associated with Dominant Optic Atrophy Impair Oxidative Phosphorylation and Mitochondrial Fusion","volume":"131","author":"Zanna","year":"2008","journal-title":"Brain"},{"key":"B430","doi-asserted-by":"publisher","first-page":"11929","DOI":"10.1523\/jneurosci.1860-14.2014","article-title":"An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex","volume":"34","author":"Zhang","year":"2014","journal-title":"J. Neurosci."},{"key":"B431","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/s0092-8674(01)00363-4","article-title":"Charcot-Marie-Tooth Disease Type 2A Caused by Mutation in a Microtubule Motor KIF1B\u03b2","volume":"105","author":"Zhao","year":"2001","journal-title":"Cell"},{"key":"B432","doi-asserted-by":"publisher","first-page":"12022","DOI":"10.1073\/pnas.0802814105","article-title":"The Kinase Domain of Mitochondrial PINK1 Faces the Cytoplasm","volume":"105","author":"Zhou","year":"2008","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B433","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1172\/jci124194","article-title":"Restoring Mitofusin Balance Prevents Axonal Degeneration in a Charcot-Marie-Tooth Type 2A Model","volume":"129","author":"Zhou","year":"2019","journal-title":"J. Clin. Invest."},{"key":"B434","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.neuint.2018.04.013","article-title":"Mitochondrial Alterations in Parkinson's Disease Human Samples and Cellular Models","volume":"118","author":"Zilocchi","year":"2018","journal-title":"Neurochem. Int."},{"key":"B435","doi-asserted-by":"publisher","first-page":"2784","DOI":"10.1523\/jneurosci.4116-12.2013","article-title":"Axons Giving Rise to the Palisade Endings of Feline Extraocular Muscles Display Motor Features","volume":"33","author":"Zimmermann","year":"2013","journal-title":"J. Neurosci."},{"key":"B436","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1212\/wnl.0b013e318228fc70","article-title":"Dominant GDAP1 Mutations Cause Predominantly Mild CMT Phenotypes","volume":"77","author":"Zimon","year":"2011","journal-title":"Neurology"},{"key":"B437","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.ajhg.2011.06.008","article-title":"A Mutation in VPS35, Encoding a Subunit of the Retromer Complex, Causes Late-Onset Parkinson Disease","volume":"89","author":"Zimprich","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"B438","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.neuron.2004.11.005","article-title":"Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology","volume":"44","author":"Zimprich","year":"2004","journal-title":"Neuron"},{"key":"B439","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1136\/jnnp-2016-315018","article-title":"Genetic Epidemiology of Amyotrophic Lateral Sclerosis: a Systematic Review and Meta-Analysis","volume":"88","author":"Zou","year":"2017","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B440","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1126\/science.1059581","article-title":"Loss of Huntingtin-Mediated BDNF Gene Transcription in Huntington's Disease","volume":"293","author":"Zuccato","year":"2001","journal-title":"Science"},{"key":"B441","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1002\/ana.20797","article-title":"Axonal Neuropathy with Optic Atrophy Is Caused by Mutations in Mitofusin 2","volume":"59","author":"Z\u00fcchner","year":"2006","journal-title":"Ann. Neurol."}],"container-title":["Frontiers in Molecular Biosciences"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmolb.2021.676187\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T08:00:46Z","timestamp":1625558446000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmolb.2021.676187\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,30]]},"references-count":441,"alternative-id":["10.3389\/fmolb.2021.676187"],"URL":"https:\/\/doi.org\/10.3389\/fmolb.2021.676187","relation":{},"ISSN":["2296-889X"],"issn-type":[{"value":"2296-889X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,30]]},"article-number":"676187"}}