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Therefore, a better understanding of the potential role of \u03c9-3 PUFAs in the development and progression of T1DM will help to improve the clinical management of the disease. In this review, we explored the current understanding of molecular mechanisms and signaling pathways induced by \u03c9-3 PUFAs and the beneficial effects of \u03c9-3 PUFAs intake in the prevention and treatment of T1DM, as well as the underlying possible metabolomic (lipidomics) changes.<\/jats:p>","DOI":"10.3389\/fmolb.2021.783065","type":"journal-article","created":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T05:56:18Z","timestamp":1638510978000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["Metabolic and Metabolomic Insights Regarding the Omega-3 PUFAs Intake in Type 1 Diabetes Mellitus"],"prefix":"10.3389","volume":"8","author":[{"given":"Carmen","family":"Purdel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca","family":"Ungurianu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denisa","family":"Margina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,12,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/metabo9100207","article-title":"Feasibility of Localized Metabolomics in the Study of Pancreatic Islets and Diabetes","volume":"9","author":"Alcazar","year":"2019","journal-title":"Metabolites"},{"key":"B2","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1146\/annurev.immunol.23.021704.115643","article-title":"The NOD Mouse: a Model of Immune Dysregulation","volume":"23","author":"Anderson","year":"2005","journal-title":"Annu. 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