{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T15:59:10Z","timestamp":1765382350131,"version":"3.41.2"},"reference-count":77,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T00:00:00Z","timestamp":1641168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Biosci."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> COVID-19 is a novel coronavirus infectious disease associated with the severe acute respiratory syndrome. More and more patients are being cured due to the development of clinical guidelines for COVID-19 pneumonia diagnosis, treatment, and vaccines. However, the long-term impact of COVID-19 on patients after recovery is unclear. Currently available reports have shown that patients recovered from COVID-19 continue to experience health problems in respiratory and other organ systems. Oral problem is one of the important complications which has serious impacts on the rehabilitation and future quality of life, such as ageusia and macroglossia, but the oral complication is often being neglected.<\/jats:p><jats:p><jats:bold>Aim of Review:<\/jats:bold> From the perspective of stomatology, we summarized and elaborated in detail the types, pathogenesis of oral complications from COVID-19 patients after rehabilitation, and the reported prevention or treatment recommendations which may improve the COVID-19 patients associated oral diseases.<\/jats:p><jats:p><jats:bold>Key Scientific Concepts of Review:<\/jats:bold> 1) To understand the common oral complications and the mechanisms of the development of oral complications after the COVID-19 recovery; 2) To summary the practical strategies to prevent the oral complications and construct the rehabilitation plans for patients with oral complications.<\/jats:p>","DOI":"10.3389\/fmolb.2021.803785","type":"journal-article","created":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T08:05:53Z","timestamp":1641197153000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["The Oral Complications of COVID-19"],"prefix":"10.3389","volume":"8","author":[{"given":"Xinxuan","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiajia","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biao","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,1,3]]},"reference":[{"volume-title":"COVID-19 Cause Missing Teeth","year":"2021","author":"Abdalla","key":"B1"},{"key":"B2","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1097\/01.ccm.0000726848.74570.4c","article-title":"240: Tongue in Cheek: A Case Series of Macroglossia in Mechanically Ventilated Patients with COVID-19","volume":"49","author":"Akhavan","year":"2021","journal-title":"Crit. Care Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1000296","DOI":"10.15761\/ifnm.1000296","article-title":"Zinc May Have a Potential Role in Taste Malfunctions Treatment for COVID-19 Patients","volume":"7","author":"Al-Awfi","year":"2021","journal-title":"J. Rev. article. Integr. Food Nutr. Metab."},{"key":"B4","doi-asserted-by":"publisher","first-page":"e225","DOI":"10.4317\/medoral.21319","article-title":"Beckwith-Wiedemann Syndrome: Open Bite Evolution after Tongue Reduction","volume":"23","author":"Alonso-Rodriguez","year":"2018","journal-title":"Med. Oral"},{"key":"B5","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1177\/0022034520957289","article-title":"Oral Manifestations in Patients with COVID-19: A Living Systematic Review","volume":"100","author":"Amorim Dos Santos","year":"2021","journal-title":"J. Dent Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.ijid.2020.06.012","article-title":"Oral Mucosal Lesions in a COVID-19 Patient: New Signs or Secondary Manifestations","volume":"97","author":"Amorim Dos Santos","year":"2020","journal-title":"Int. J. Infect. Dis."},{"key":"B8","doi-asserted-by":"publisher","first-page":"e237108","DOI":"10.1136\/bcr-2020-237108","article-title":"Lingual Compression for Acute Macroglossia in a COVID-19 Positive Patient","volume":"13","author":"Andrews","year":"2020","journal-title":"BMJ Case Rep."},{"key":"B9","doi-asserted-by":"publisher","first-page":"211","DOI":"10.3390\/jof6040211","article-title":"COVID-19-Associated Candidiasis (CAC): An Underestimated Complication in the Absence of Immunological Predispositions","volume":"6","author":"Arastehfar","year":"2020","journal-title":"J. Fungi"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1053\/j.gastro.2020.05.003","article-title":"Taste Changes (Dysgeusia) in COVID-19: A Systematic Review and Meta-Analysis","volume":"159","author":"Aziz","year":"2020","journal-title":"Gastroenterology"},{"key":"B11","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/j.anai.2020.06.039","article-title":"Idiopathic Nonhistaminergic Acquired Angioedema in a Patient with Coronavirus Disease 2019","volume":"125","author":"Azmy","year":"2020","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/s13365-020-00840-5","article-title":"COVID-19 and the Nervous System","volume":"26","author":"Berger","year":"2020","journal-title":"J. Neurovirol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.bj.2020.05.016","article-title":"Is There an Association between Oral Health and Severity of COVID-19 Complications","volume":"43","author":"Botros","year":"2020","journal-title":"Biomed. J."},{"key":"B14","doi-asserted-by":"publisher","first-page":"e45","DOI":"10.1016\/j.oooo.2020.07.014","article-title":"Oral Lesions in Patients with SARS-CoV-2 Infection: Could the Oral Cavity Be a Target Organ","volume":"131","author":"Brand\u00e3o","year":"2021","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"078","DOI":"10.4103\/jnacc-jnacc-64.16","article-title":"Macroglossia in Neurosurgery","volume":"4","author":"Brockerville","year":"2017","journal-title":"J. Neuroanaesthesiology Crit. Care"},{"key":"B16","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/j.jvoice.2020.08.001","article-title":"Voice Therapy in the Context of the COVID-19 Pandemic: Guidelines for Clinical Practice","volume":"35","author":"Castillo-Allendes","year":"2021","journal-title":"J. Voice"},{"key":"B17","doi-asserted-by":"publisher","first-page":"2774","DOI":"10.1021\/acschemneuro.0c00447","article-title":"Taste and Smell Disorders in COVID-19 Patients: Role of Interleukin-6","volume":"11","author":"Cazzolla","year":"2020","journal-title":"ACS Chem. Neurosci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/S0140-6736(20)30211-7","article-title":"Epidemiological and Clinical Characteristics of 99 Cases of 2019 Novel Coronavirus Pneumonia in Wuhan, China: a Descriptive Study","volume":"395","author":"Chen","year":"","journal-title":"The Lancet"},{"key":"B19","doi-asserted-by":"publisher","first-page":"m1091","DOI":"10.1136\/bmj.m1091","article-title":"Clinical Characteristics of 113 Deceased Patients with Coronavirus Disease 2019: Retrospective Study","volume":"368","author":"Chen","year":"","journal-title":"BMJ"},{"key":"B20","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1016\/j.ijom.2020.01.005","article-title":"Comprehensive Treatment of Massive Macroglossia Due to Venous and Lymphatic Malformations","volume":"49","author":"Chen","year":"","journal-title":"Int. J. Oral Maxill. Surg."},{"key":"B21","doi-asserted-by":"publisher","first-page":"7777","DOI":"10.1007\/s00253-020-10814-6","article-title":"The Microbial Coinfection in COVID-19","volume":"104","author":"Chen","year":"","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/j.jcma.2013.07.009","article-title":"Lymphangiomatous Macroglossia Associated with Extensive Cervicomediastinal Cystic Hygromas","volume":"76","author":"Cheng","year":"2013","journal-title":"J. Chin. Med. Assoc."},{"key":"B23","doi-asserted-by":"publisher","first-page":"e63","DOI":"10.7861\/clinmed.2020-0896","article-title":"Autonomic Dysfunction in 'long COVID': Rationale, Physiology and Management Strategies","volume":"21","author":"Dani","year":"2021","journal-title":"Clin. Med."},{"key":"B24","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1001\/archotol.1991.01870170065015","article-title":"Smell and Taste Disorders, a Study of 750 Patients from the University of Pennsylvania Smell and Taste Center","volume":"117","author":"Deems","year":"1991","journal-title":"Arch. Otolaryngol. - Head Neck Surg."},{"key":"B25","doi-asserted-by":"publisher","first-page":"351","DOI":"10.5312\/wjo.v6.i3.351","article-title":"Complications Associated with Prone Positioning in Elective Spinal Surgery","volume":"6","author":"DePasse","year":"2015","journal-title":"World J. Orthopedics"},{"key":"B26","doi-asserted-by":"publisher","first-page":"4","DOI":"10.52010\/ijom.1989.15.2.2","article-title":"Macroglossia: Clinical Considerations","volume":"15","author":"Dolan","year":"1989","journal-title":"Int. J. Orofacial Myology"},{"key":"B27","doi-asserted-by":"publisher","first-page":"e287","DOI":"10.4317\/jced.57981","article-title":"COVID-19 and Oral Lesions, Short Communication and Review","volume":"13","author":"Egido-Moreno","year":"2021","journal-title":"J. Clin. Exp. Dent"},{"key":"B28","doi-asserted-by":"publisher","first-page":"757","DOI":"10.3390\/jcm10040757","article-title":"Covid-19 Symptomatic Patients with Oral Lesions: Clinical and Histopathological Study on 123 Cases of the University Hospital Policlinic of Bari with a Purpose of a New Classification","volume":"10","author":"Favia","year":"2021","journal-title":"J. Clin. Med."},{"key":"B29","first-page":"A05200340","article-title":"Prolonged Complaints of Chemosensory Loss after COVID-19","volume":"67","author":"Fjaeldstad","year":"2020","journal-title":"Dan Med. J."},{"key":"B30","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1111\/bjd.19163","article-title":"Classification of the Cutaneous Manifestations of COVID \u201019: a Rapid Prospective Nationwide Consensus Study in Spain with 375 Cases","volume":"183","author":"Galv\u00e1n Casas","year":"2020","journal-title":"Br. J Dermatol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1024\/0300-9831.70.3.110","article-title":"Reduction in Carbonic Anhydrase Activity in the Tongue Epithelium and Submandibular Gland in Zinc-Deficient Rats","volume":"70","author":"Goto","year":"2000","journal-title":"Int. J. Vitamin Nutr. Res."},{"key":"B32","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1093\/jn\/131.2.305","article-title":"Long-term Zinc Deficiency Decreases Taste Sensitivity in Rats","volume":"131","author":"Goto","year":"2001","journal-title":"J. Nutr."},{"key":"B33","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1111\/odi.13350","article-title":"Emergency Measures for Acute Oral Mucosa Diseases during the Outbreak of COVID\u201019","volume":"27","author":"Guo","year":"2021","journal-title":"Oral Dis."},{"key":"B34","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1902\/jop.2004.75.1.57","article-title":"Efficacy of a Fluoridated Hydrogen Peroxide-Based Mouthrinse for the Treatment of Gingivitis: a Randomized Clinical Trial","volume":"75","author":"Hasturk","year":"2004","journal-title":"J. Periodontol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1177\/154405910508400105","article-title":"Zinc Gluconate in the Treatment of Dysgeusia-A Randomized Clinical Trial","volume":"84","author":"Heckmann","year":"2005","journal-title":"J. Dent Res."},{"key":"B36","doi-asserted-by":"publisher","first-page":"581","DOI":"10.3390\/jcm10040581","article-title":"Oral Complications of ICU Patients with COVID-19: Case-Series and Review of Two Hundred Ten Cases","volume":"10","author":"Hockov\u00e1","year":"2021","journal-title":"J. Clin. Med."},{"key":"B37","first-page":"219","article-title":"Difficult Airway Due to Protruding Macroglossia in a Child with Lymphangioma","volume":"6","author":"Horasanli","year":"2010","journal-title":"B-ENT"},{"key":"B38","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.neubiorev.2020.10.012","article-title":"Neurotropism of SARS-CoV-2 and its Neuropathological Alterations: Similarities with Other Coronaviruses","volume":"119","author":"Hu","year":"2020","journal-title":"Neurosci. Biobehavioral Rev."},{"key":"B39","doi-asserted-by":"publisher","first-page":"623","DOI":"10.4193\/rhin20.251","article-title":"Comparison of Covid-19 and Common Cold Chemosensory Dysfunction","volume":"58","author":"Huart","year":"2020","journal-title":"Rhinology"},{"key":"B40","doi-asserted-by":"publisher","first-page":"2473974X2095797","DOI":"10.1177\/2473974x20957975","article-title":"Systematic Review and Meta-Analysis of Smell and Taste Disorders in COVID-19","volume":"4","author":"Ibekwe","year":"2020","journal-title":"OTO Open"},{"key":"B41","doi-asserted-by":"publisher","first-page":"e14578","DOI":"10.1111\/dth.14578","article-title":"Oral Manifestations of COVID \u201019 Disease: A Review Article","volume":"34","author":"Iranmanesh","year":"2021","journal-title":"Dermatol. Ther."},{"key":"B42","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1007\/s11882-021-00989-x","article-title":"Management of Allergic Diseases during COVID-19 Outbreak","volume":"21","author":"Izquierdo-Dom\u00ednguez","year":"2021","journal-title":"Curr. Allergy Asthma Rep."},{"key":"B43","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1007\/s00431-011-1567-6","article-title":"Massive Macroglossia after Palatoplasty","volume":"171","author":"Junghaenel","year":"2012","journal-title":"Eur. J. Pediatr."},{"key":"B44","article-title":"Macroglossia","volume-title":"StatPearls. Treasure Island","author":"Kutti Sridharan","year":"2021"},{"key":"B45","doi-asserted-by":"publisher","first-page":"e174","DOI":"10.3346\/jkms.2020.35.e174","article-title":"Prevalence and Duration of Acute Loss of Smell or Taste in COVID-19 Patients","volume":"35","author":"Lee","year":"2020","journal-title":"J. Korean Med. Sci."},{"key":"B46","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1001\/jamaoto.2020.1378","article-title":"Treatment Recommendations for Persistent Smell and Taste Dysfunction Following COVID-19-The Coming Deluge","volume":"146","author":"Levy","year":"2020","journal-title":"JAMA Otolaryngol. Head Neck Surg."},{"key":"B47","doi-asserted-by":"publisher","first-page":"111","DOI":"10.3109\/15360288.2012.676618","article-title":"A Randomized, Placebo Controlled Trial of Oral Zinc for Chemotherapy-Related Taste and Smell Disorders","volume":"26","author":"Lyckholm","year":"2012","journal-title":"J. Pain Palliat. Care Pharmacother."},{"key":"B48","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1038\/s41392-021-00614-3","article-title":"Metagenomic Analysis Reveals Oropharyngeal Microbiota Alterations in Patients with COVID-19","volume":"6","author":"Ma","year":"2021","journal-title":"Sig Transduct Target. Ther."},{"key":"B49","doi-asserted-by":"publisher","first-page":"106081","DOI":"10.1016\/j.intimp.2019.106081","article-title":"ACE Inhibitor-Mediated Angioedema","volume":"78","author":"Montinaro","year":"2020","journal-title":"Int. Immunopharmacology"},{"key":"B50","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1186\/s12903-021-01635-8","article-title":"Tongue Ulcer in a Patient with COVID-19: a Case Presentation","volume":"21","author":"Nejabi","year":"2021","journal-title":"BMC Oral Health"},{"key":"B51","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1016\/j.cmi.2020.12.021","article-title":"Long-term Persistence of Olfactory and Gustatory Disorders in COVID-19 Patients","volume":"27","author":"Nguyen","year":"2021","journal-title":"Clin. Microbiol. Infect."},{"key":"B52","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1007\/s10096-020-04056-7","article-title":"Prevalence of Hyposmia and Hypogeusia in 390 COVID-19 Hospitalized Patients and Outpatients: a Cross-Sectional Study","volume":"40","author":"Nouchi","year":"2021","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"B53","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.adengl.2021.05.010","article-title":"Are Oral Mucosal Changes a Sign of COVID-19? A Cross-Sectional Study at a Field Hospital","volume":"112","author":"Nu\u00f1o Gonz\u00e1lez","year":"2021","journal-title":"Actas Dermo-Sifiliogr\u00e1ficas (English Edition)"},{"key":"B54","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.jdsr.2021.07.001","article-title":"Pathogenesis of Taste Impairment and Salivary Dysfunction in COVID-19 Patients","volume":"57","author":"Okada","year":"2021","journal-title":"Jpn. Dental Sci. Rev."},{"volume-title":"Advice for the Public: Coronavirus Disease (COVID-19)","year":"2021","key":"B55"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13499","article-title":"Oral Mucosa Lesions in COVID\u201019","author":"Petrescu","year":"2020","journal-title":"Oral Dis."},{"key":"B57","article-title":"Multimodal Chemosensory Interactions and Perception of Flavor","volume-title":"The Neural Bases of Multisensory Processes","author":"Prescott","year":"2012"},{"key":"B58","doi-asserted-by":"publisher","first-page":"2280","DOI":"10.3390\/nu11102280","article-title":"Reduced Salivary Mucin Binding and Glycosylation in Older Adults Influences Taste in an In Vitro Cell Model","volume":"11","author":"Pushpass","year":"2019","journal-title":"Nutrients"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1111\/ors.12561","article-title":"Oral Candidiasis in Non\u2010severe COVID\u201019 Patients: Call for Antibiotic Stewardship","author":"Riad","year":"","journal-title":"Oral Surg."},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13516","article-title":"COVID\u201019\u2010Related Oral Manifestations: Early Disease Features","author":"Riad","year":"","journal-title":"Oral Dis."},{"key":"B61","doi-asserted-by":"publisher","first-page":"e244224","DOI":"10.1136\/bcr-2021-244224","article-title":"Macroglossia Secondary to Prolonged Prone Positioning for Management of COVID-19 Respiratory Failure","volume":"14","author":"Sharma","year":"2021","journal-title":"BMJ Case Rep."},{"key":"B62","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1590\/1806-9282.66.S2.96","article-title":"Impact of Oral hygiene in Patients Undergoing Mechanical Ventilation in the COVID-19 Pandemic","volume":"66","author":"Silva","year":"2020","journal-title":"Rev. Assoc. Med. Bras."},{"key":"B63","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1007\/s11282-020-00497-0","article-title":"The Relationship between COVID-19 and the Dental Damage Stage Determined by Radiological Examination","volume":"37","author":"Sirin","year":"2021","journal-title":"Oral Radiol."},{"key":"B64","first-page":"15","article-title":"Taste Alterations in Liver Cirrhosis: Are They Related to Zinc Deficiency","volume":"6","author":"Sturniolo","year":"1992","journal-title":"J. Trace Elem. Electrolytes Health Dis."},{"key":"B65","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1080\/00016480260046526","article-title":"Secretory Function of the Salivary Gland in Patients with Taste Disorders or Xerostomia: Correlation with Zinc Deficiency","volume":"122","author":"Tanaka","year":"2002","journal-title":"Acta Oto-Laryngologica"},{"key":"B66","doi-asserted-by":"publisher","first-page":"e13528","DOI":"10.1111\/dth.13528","article-title":"Cutaneous Manifestations of the Coronavirus Disease 2019 ( COVID \u201019): A Brief Review","volume":"33","author":"Tang","year":"2020","journal-title":"Dermatol. Ther."},{"key":"B67","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1097\/00006534-198678060-00001","article-title":"Macroglossia:","volume":"78","author":"Vogel","year":"1986","journal-title":"Plast. Reconstr. Surg."},{"key":"B68","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1017\/s0074180900088604","article-title":"Macroglossia: a review","volume":"142","author":"Weiss","year":"1990","journal-title":"J La State. Med Soc"},{"key":"B69","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/BF00315876","article-title":"Comparative lectin histochemistry on taste buds in foliate, circumvallate and fungiform papillae of the rabbit tongue","volume":"98","author":"Witt","year":"1992","journal-title":"Histochemistry"},{"key":"B70","first-page":"574","article-title":"A review of smell and taste dysfunction in COVID-19 patients","volume":"75","author":"Wong","year":"2020","journal-title":"Med J Malaysia"},{"key":"B71","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/s41368-020-0074-x","article-title":"High Expression of ACE2 Receptor of 2019-nCoV on the Epithelial Cells of Oral Mucosa","volume":"12","author":"Xu","year":"","journal-title":"Int. J. Oral Sci."},{"key":"B72","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1111\/bjd.19484","article-title":"Co\u2010reactivation of the Human Herpesvirus Alpha Subfamily (Herpes Simplex Virus\u20101 and Varicella Zoster Virus) in a Critically Ill Patient with COVID\u201019","volume":"183","author":"Xu","year":"","journal-title":"Br. J. Dermatol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1177\/0003489415583330","article-title":"Successful Treatment of Macroglossia Due to Lymphatic Malformation with Sirolimus","volume":"124","author":"Yesil","year":"2015","journal-title":"Ann. Otol Rhinol Laryngol."},{"key":"B74","doi-asserted-by":"crossref","DOI":"10.1016\/j.jadr.2021.100156","volume-title":"Association of COVID19-Induced Anosmia and Ageusia with Depression and Suicidal Ideation","author":"Yom-Tov","year":"2021"},{"key":"B75","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1177\/0022034518804531","article-title":"SIS-ECM Laden with GMSC-Derived Exosomes Promote Taste Bud Regeneration","volume":"98","author":"Zhang","year":"2019","journal-title":"J. Dent Res."},{"key":"B76","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1016\/S0140-6736(20)30566-3","article-title":"Clinical Course and Risk Factors for Mortality of Adult Inpatients with COVID-19 in Wuhan, China: a Retrospective Cohort Study","volume":"395","author":"Zhou","year":"2020","journal-title":"The Lancet"},{"key":"B77","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1056\/NEJMoa2001017","article-title":"A Novel Coronavirus from Patients with Pneumonia in China, 2019","volume":"382","author":"Zhu","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"B78","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/s11684-020-0754-0","article-title":"Single-cell RNA-Seq Data Analysis on the Receptor ACE2 Expression Reveals the Potential Risk of Different Human Organs Vulnerable to 2019-nCoV Infection","volume":"14","author":"Zou","year":"2020","journal-title":"Front. Med."}],"container-title":["Frontiers in Molecular Biosciences"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmolb.2021.803785\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T08:06:00Z","timestamp":1641197160000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmolb.2021.803785\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,3]]},"references-count":77,"alternative-id":["10.3389\/fmolb.2021.803785"],"URL":"https:\/\/doi.org\/10.3389\/fmolb.2021.803785","relation":{},"ISSN":["2296-889X"],"issn-type":[{"type":"electronic","value":"2296-889X"}],"subject":[],"published":{"date-parts":[[2022,1,3]]},"article-number":"803785"}}