{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T20:04:49Z","timestamp":1788379489906,"version":"build-2803163510"},"reference-count":110,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T00:00:00Z","timestamp":1665532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Biosci."],"abstract":"<jats:p>Ferroptosis is a newly discovered type of programmed cell death, which is closely related to the imbalance of iron metabolism and oxidative stress. Ferroptosis has become an important research topic in the fields of cardiomyopathy, tumors, neuronal injury disorders, and ischemia perfusion disorders. As an important part of non-coding RNA, microRNAs regulate various metabolic pathways in the human body at the post-transcriptional level and play a crucial role in the occurrence and development of many diseases. The present review introduces the mechanisms of ferroptosis and describes the relevant pathways by which microRNAs affect cardiomyopathy, tumors, neuronal injury disorders and ischemia perfusion disorders through regulating ferroptosis. In addition, it provides important insights into ferroptosis-related microRNAs, aiming to uncover new methods for treatment of the above diseases, and discusses new ideas for the implementation of possible microRNA-based ferroptosis-targeted therapies in the future.<\/jats:p>","DOI":"10.3389\/fmolb.2022.1003045","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T04:40:22Z","timestamp":1665549622000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":33,"title":["The role of microRNAs in ferroptosis"],"prefix":"10.3389","volume":"9","author":[{"given":"Liqing","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingkun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuehui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,10,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.cbpa.2017.06.002","article-title":"Lipid homeostasis and regulated cell death","volume":"39","author":"Agmon","year":"2017","journal-title":"Curr. Opin. Chem. Biol."},{"key":"B2","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S0092-8674(01)00616-X","article-title":"microRNAs: Tiny regulators with great potential","volume":"107","author":"Ambros","year":"2001","journal-title":"Cell"},{"key":"B3","doi-asserted-by":"publisher","first-page":"5637","DOI":"10.1002\/jcp.29496","article-title":"MicroRNA-214-3p enhances erastin-induced ferroptosis by targeting ATF4 in hepatoma cells","volume":"235","author":"Bai","year":"2020","journal-title":"J. Cell Physiol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1080\/10715762.2021.1962009","article-title":"MicroRNA-670-3p suppresses ferroptosis of human glioblastoma cells through targeting ACSL4","volume":"55","author":"Bao","year":"2021","journal-title":"Free Radic. Res."},{"key":"B5","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/s41586-019-1705-2","article-title":"The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis","volume":"575","author":"Bersuker","year":"2019","journal-title":"Nature"},{"key":"B6","doi-asserted-by":"publisher","first-page":"5593","DOI":"10.1038\/onc.2017.146","article-title":"ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner","volume":"36","author":"Chen","year":"2017","journal-title":"Oncogene"},{"key":"B7","doi-asserted-by":"publisher","first-page":"637162","DOI":"10.3389\/fcell.2021.637162","article-title":"Characteristics and biomarkers of ferroptosis","volume":"9","author":"Chen","year":"","journal-title":"Front. Cell Dev. Biol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2054","DOI":"10.1080\/15548627.2020.1810918","article-title":"Ferroptosis: Machinery and regulation","volume":"17","author":"Chen","year":"","journal-title":"Autophagy"},{"key":"B9","doi-asserted-by":"publisher","first-page":"688605","DOI":"10.3389\/fcell.2021.688605","article-title":"Ferroptosis: A novel therapeutic target for ischemia-reperfusion injury","volume":"9","author":"Chen","year":"","journal-title":"Front. Cell Dev. Biol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.3892\/ijo.2019.4720","article-title":"Iron metabolism and its contribution to cancer (Review)","volume":"54","author":"Chen","year":"2019","journal-title":"Int. J. Oncol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.bbrc.2021.02.077","article-title":"miR-324-3p reverses cisplatin resistance by inducing GPX4-mediated ferroptosis in lung adenocarcinoma cell line A549","volume":"549","author":"Deng","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B12","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1038\/s41419-020-03135-z","article-title":"miR-182-5p and miR-378a-3p regulate ferroptosis in I\/R-induced renal injury","volume":"11","author":"Ding","year":"2020","journal-title":"Cell Death Dis."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: An iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"B14","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/s41586-019-1707-0","article-title":"FSP1 is a glutathione-independent ferroptosis suppressor","volume":"575","author":"Doll","year":"2019","journal-title":"Nature"},{"key":"B15","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/nchembio.2239","article-title":"ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition","volume":"13","author":"Doll","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"20","DOI":"10.2478\/jtim-2020-0004","article-title":"Concise review: Harnessing iPSC-derived cells for ischemic heart disease treatment","volume":"8","author":"Duan","year":"2020","journal-title":"J. Transl. Int. Med."},{"key":"B17","doi-asserted-by":"publisher","first-page":"12021","DOI":"10.1080\/21655979.2022.2054194","article-title":"MiR-19a suppresses ferroptosis of colorectal cancer cells by targeting IREB2","volume":"13","author":"Fan","year":"2022","journal-title":"Bioengineered"},{"key":"B18","doi-asserted-by":"publisher","first-page":"174403","DOI":"10.1016\/j.ejphar.2021.174403","article-title":"The Egr-1\/miR-15a-5p\/GPX4 axis regulates ferroptosis in acute myocardial infarction","volume":"909","author":"Fan","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201800311","article-title":"GPX4 at the crossroads of lipid homeostasis and ferroptosis","volume":"19","author":"Forcina","year":"2019","journal-title":"Proteomics"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.115021","article-title":"Rehmannioside A improves cognitive impairment and alleviates ferroptosis via activating PI3K\/AKT\/Nrf2 and SLC7A11\/GPX4 signaling pathway after ischemia","volume":"289","author":"Fu","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgg.2022.06.002","article-title":"Understanding the mechanistic regulation of ferroptosis in cancer: Gene matters","author":"Gao","year":"2022","journal-title":"J. Genet. Genomics"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1038\/cr.2016.95","article-title":"Ferroptosis is an autophagic cell death process","volume":"26","author":"Gao","year":"2016","journal-title":"Cell Res."},{"key":"B23","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.molcel.2015.06.011","article-title":"Glutaminolysis and transferrin regulate ferroptosis","volume":"59","author":"Gao","year":"2015","journal-title":"Mol. Cell"},{"key":"B24","doi-asserted-by":"publisher","first-page":"3826","DOI":"10.26355\/eurrev_201806_15267","article-title":"Knockdown of ferroportin accelerates erastin-induced ferroptosis in neuroblastoma cells","volume":"22","author":"Geng","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-53174-6","article-title":"Epigenetic regulation of AURKA by miR-4715-3p in upper gastrointestinal cancers","volume":"9","author":"Gomaa","year":"2019","journal-title":"Sci. Rep."},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.911564","article-title":"Roles of ferroptosis in cardiovascular diseases","volume":"9","author":"Guo","year":"2022","journal-title":"Front. Cardiovasc Med."},{"key":"B27","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.redox.2015.03.003","article-title":"Expression of xCT and activity of system xc(-) are regulated by NRF2 in human breast cancer cells in response to oxidative stress","volume":"5","author":"Habib","year":"2015","journal-title":"Redox Biol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.neuroscience.2021.03.009","article-title":"SLC40A1 mediates ferroptosis and cognitive dysfunction in type 1 diabetes","volume":"463","author":"Hao","year":"2021","journal-title":"Neuroscience"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1080\/15548627.2016.1187366","article-title":"Autophagy promotes ferroptosis by degradation of ferritin","volume":"12","author":"Hou","year":"2016","journal-title":"Autophagy"},{"key":"B30","doi-asserted-by":"publisher","first-page":"754","DOI":"10.21037\/jgo-21-916","article-title":"Exosomal miR-142-3p secreted by Hepatitis B virus (HBV)-hepatocellular carcinoma (HCC) cells promotes ferroptosis of M1-type macrophages through SLC3A2 and the mechanism of HCC progression","volume":"13","author":"Hu","year":"2022","journal-title":"J. Gastrointest. Oncol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"9327","DOI":"10.1523\/jneurosci.1749-20.2020","article-title":"Ferroptosis mediates cuprizone-induced loss of oligodendrocytes and demyelination","volume":"40","author":"Jhelum","year":"2020","journal-title":"J. Neurosci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: Mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.858462","article-title":"The role of cystine\/glutamate antiporter slc7a11\/xCT in the pathophysiology of cancer","volume":"12","author":"Jyotsana","year":"2022","journal-title":"Front. Oncol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/nchembio.2238","article-title":"Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis","volume":"13","author":"Kagan","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3390\/cells11091399","article-title":"The role of ferroptosis in adverse left ventricular remodeling following acute myocardial infarction","volume":"11","author":"Komai","year":"2022","journal-title":"Cells"},{"key":"B36","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s40880-018-0288-x","article-title":"Amino acid transporter SLC7A11\/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer","volume":"38","author":"Koppula","year":"2018","journal-title":"Cancer Commun. (Lond)"},{"key":"B37","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s13238-020-00789-5","article-title":"Cystine transporter slc7a11\/xCT in cancer: Ferroptosis, nutrient dependency, and cancer therapy","volume":"12","author":"Koppula","year":"2021","journal-title":"Protein Cell"},{"key":"B38","doi-asserted-by":"publisher","first-page":"4860","DOI":"10.1038\/s41467-021-24859-2","article-title":"GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis","volume":"12","author":"Kremer","year":"2021","journal-title":"Nat. Commun."},{"key":"B39","doi-asserted-by":"publisher","first-page":"916664","DOI":"10.3389\/fimmu.2022.916664","article-title":"Ferroptosis and autoimmune diseases","volume":"13","author":"Lai","year":"2022","journal-title":"Front. Immunol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"104645","DOI":"10.1016\/j.yexmp.2021.104645","article-title":"Inhibition of miR-1224 suppresses hypoxia\/reoxygenation-induced oxidative stress and apoptosis in cardiomyocytes through targeting GPX4","volume":"121","author":"Li","year":"","journal-title":"Exp. Mol. Pathol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"105466","DOI":"10.1016\/j.phrs.2021.105466","article-title":"Ferroptosis and its emerging roles in cardiovascular diseases","volume":"166","author":"Li","year":"","journal-title":"Pharmacol. Res."},{"key":"B42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3892\/ijmm.2021.4894","article-title":"MiR-335 promotes ferroptosis by targeting ferritin heavy chain 1 in in vivo and in vitro models of Parkinson's disease","volume":"47","author":"Li","year":"2021","journal-title":"Int. J. Mol. Med."},{"key":"B43","doi-asserted-by":"publisher","first-page":"6520789","DOI":"10.1155\/2022\/6520789","article-title":"MiR-29a-3p in exosomes from heme oxygenase-1 modified bone marrow mesenchymal stem cells alleviates steatotic liver ischemia-reperfusion injury in rats by suppressing ferroptosis via iron responsive element binding protein 2","volume":"2022","author":"Li","year":"2022","journal-title":"Oxid. Med. Cell Longev."},{"key":"B44","doi-asserted-by":"publisher","first-page":"101651","DOI":"10.1016\/j.tice.2021.101651","article-title":"Exosomes derived from mesenchyml stem cells ameliorate oxygen-glucose deprivation\/reoxygenation-induced neuronal injury via transferring MicroRNA-194 and targeting Bach1","volume":"73","author":"Li","year":"","journal-title":"Tissue Cell"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-020-01836-y","article-title":"MiR-137 boosts the neuroprotective effect of endothelial progenitor cell-derived exosomes in oxyhemoglobin-treated SH-SY5Y cells partially via COX2\/PGE2 pathway","volume":"11","author":"Li","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"B46","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1007\/s11064-021-03477-w","article-title":"Ferritinophagy is involved in experimental subarachnoid hemorrhage-induced neuronal ferroptosis","volume":"47","author":"Liang","year":"2022","journal-title":"Neurochem. Res."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1007\/s13577-021-00557-5","article-title":"Suppressive role of microRNA-130b-3p in ferroptosis in melanoma cells correlates with DKK1 inhibition and Nrf2-HO-1 pathway activation","volume":"34","author":"Liao","year":"2021","journal-title":"Hum. Cell"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2022\/3961495","article-title":"Cardiac fibroblasts promote ferroptosis in atrial fibrillation by secreting exo-miR-23a-3p targeting SLC7A11","volume":"2022","author":"Liu","year":"","journal-title":"Oxidative Med. Cell. Longev."},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16059","article-title":"Signaling pathways and defense mechanisms of ferroptosis","author":"Liu","year":"2021","journal-title":"Febs J."},{"key":"B50","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1002\/mc.23367","article-title":"MiR-15a-3p regulates ferroptosis via targeting glutathione peroxidase GPX4 in colorectal cancer","volume":"61","author":"Liu","year":"","journal-title":"Mol. Carcinog."},{"key":"B51","doi-asserted-by":"publisher","first-page":"368","DOI":"10.21037\/atm-21-6942","article-title":"The critical role and molecular mechanisms of ferroptosis in antioxidant systems: A narrative review","volume":"10","author":"Liu","year":"","journal-title":"Ann. Transl. Med."},{"key":"B52","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1038\/s41418-022-00943-y","article-title":"p53 in ferroptosis regulation: the new weapon for the old guardian","volume":"29","author":"Liu","year":"2022","journal-title":"Cell Death Differ."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1038\/s41418-017-0053-8","article-title":"miR-137 regulates ferroptosis by targeting glutamine transporter SLC1A5 in melanoma","volume":"25","author":"Luo","year":"2018","journal-title":"Cell Death Differ."},{"key":"B54","doi-asserted-by":"publisher","first-page":"165","DOI":"10.4149\/neo_2020_200707N705","article-title":"Tumor suppressor miR-424-5p abrogates ferroptosis in ovarian cancer through targeting ACSL4","volume":"68","author":"Ma","year":"2021","journal-title":"Neoplasma"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21051651","article-title":"Reclassifying hepatic cell death during liver damage: Ferroptosis-A novel form of non-apoptotic cell death?","volume":"21","author":"Mac\u00edas-Rodr\u00edguez","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B56","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.freeradbiomed.2018.09.033","article-title":"Striking while the iron is hot: Iron metabolism and ferroptosis in neurodegeneration","volume":"133","author":"Masaldan","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-022-01760-x","article-title":"The regulation of necroptosis and perspectives for the development of new drugs preventing ischemic\/reperfusion of cardiac injury","author":"Maslov","year":"2022","journal-title":"Apoptosis"},{"key":"B58","doi-asserted-by":"publisher","first-page":"2603","DOI":"10.1007\/s00204-020-02838-8","article-title":"Glutaminases regulate glutathione and oxidative stress in cancer","volume":"94","author":"Mat\u00e9s","year":"2020","journal-title":"Arch. Toxicol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.3389\/fnins.2019.01195","article-title":"Iron, ferritin, hereditary ferritinopathy, and neurodegeneration","volume":"13","author":"Muhoberac","year":"2019","journal-title":"Front. Neurosci."},{"key":"B60","doi-asserted-by":"publisher","first-page":"108930","DOI":"10.1016\/j.cbi.2019.108930","article-title":"Functional role of ferroptosis on cancers, activation and deactivation by various therapeutic candidates-an update","volume":"317","author":"Nguyen","year":"2020","journal-title":"Chem. Biol. Interact."},{"key":"B61","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1186\/s13287-021-02394-7","article-title":"MiR-375 reduces the stemness of gastric cancer cells through triggering ferroptosis","volume":"12","author":"Ni","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16382","article-title":"Ferroptosis: Regulation by competition between NRF2 and BACH1 and propagation of the death signal","author":"Nishizawa","year":"2022","journal-title":"Febs J."},{"key":"B63","first-page":"974","article-title":"Role of dietary iron revisited: In metabolism, ferroptosis and pathophysiology of cancer","volume":"12","author":"Pandrangi","year":"2022","journal-title":"Am. J. Cancer Res."},{"key":"B64","doi-asserted-by":"publisher","first-page":"e2385","DOI":"10.1016\/j.cub.2018.05.094","article-title":"AMPK-mediated BECN1 phosphorylation promotes ferroptosis by directly blocking system X(c)(-) activity","volume":"28","author":"Song","year":"2018","journal-title":"Curr. Biol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"119399","DOI":"10.1016\/j.lfs.2021.119399","article-title":"Exosomal miR-4443 promotes cisplatin resistance in non-small cell lung carcinoma by regulating FSP1 m6A modification-mediated ferroptosis","volume":"276","author":"Song","year":"2021","journal-title":"Life Sci."},{"key":"B66","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","article-title":"Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications","volume":"185","author":"Stockwell","year":"2022","journal-title":"Cell"},{"key":"B67","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: A regulated cell death nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"key":"B68","doi-asserted-by":"publisher","first-page":"153778","DOI":"10.1016\/j.prp.2022.153778","article-title":"MiR-34c-3p upregulates erastin-induced ferroptosis to inhibit proliferation in oral squamous cell carcinomas by targeting SLC7A11","volume":"231","author":"Sun","year":"2022","journal-title":"Pathol. Res. Pract."},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.23736\/s0031-0808.20.03979-8","article-title":"MiR-30d inhibits cardiomyocytes autophagy promoting ferroptosis after myocardial infarction","author":"Tang","year":"2020","journal-title":"Panminerva Med."},{"key":"B70","doi-asserted-by":"publisher","first-page":"47","DOI":"10.3892\/ol.2021.13165","article-title":"Research progress on SLC7A11 in the regulation of cystine\/cysteine metabolism in tumors","volume":"23","author":"Tang","year":"2022","journal-title":"Oncol. Lett."},{"key":"B71","doi-asserted-by":"publisher","first-page":"789927","DOI":"10.3389\/fmolb.2021.789927","article-title":"miR-3587 inhibitor attenuates ferroptosis following renal ischemia-reperfusion through HO-1","volume":"8","author":"Tao","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"B72","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1016\/j.bbrc.2019.08.117","article-title":"MiR-7-5p is a key factor that controls radioresistance via intracellular Fe(2+) content in clinically relevant radioresistant cells","volume":"518","author":"Tomita","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22158300","article-title":"MiR-7-5p is involved in ferroptosis signaling and radioresistance thru the generation of ROS in radioresistant HeLa and SAS cell lines","volume":"22","author":"Tomita","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B74","doi-asserted-by":"publisher","first-page":"52","DOI":"10.2478\/jtim-2021-0003","article-title":"Experiences on the administration of botulinum toxin in movement disorders","volume":"9","author":"Tugan Yildiz","year":"2021","journal-title":"J. Transl. Int. Med."},{"key":"B75","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.freeradbiomed.2022.06.227","article-title":"A white paper on Phospholipid Hydroperoxide Glutathione Peroxidase (GPx4) forty years later","volume":"188","author":"Ursini","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"B76","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1007\/s13577-022-00699-0","article-title":"Non-coding RNAs in ferroptotic cancer cell death pathway: Meet the new masters","volume":"35","author":"Valashedi","year":"2022","journal-title":"Hum. Cell"},{"key":"B77","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1038\/s41467-022-28718-6","article-title":"Targeting ferroptosis protects against experimental (multi)organ dysfunction and death","volume":"13","author":"Van Coillie","year":"2022","journal-title":"Nat. Commun."},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.3390\/cells11142134","article-title":"Progress and setbacks in translating a decade of ferroptosis research into clinical practice","volume":"11","author":"von Samson-Himmelstjerna","year":"2022","journal-title":"Cells"},{"key":"B79","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2022\/6041612","article-title":"miR-672-3p promotes functional recovery in rats with contusive spinal cord injury by inhibiting ferroptosis suppressor protein 1","volume":"2022","author":"Wang","year":"","journal-title":"Oxidative Med. Cell. Longev."},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2022.113639","article-title":"MiR-378a-3p\/SLC7A11 regulate ferroptosis in nerve injury induced by lead exposure","volume":"239","author":"Wang","year":"","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.809457","article-title":"Ferroptosis signaling and regulators in atherosclerosis","volume":"9","author":"Wang","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10040891","article-title":"The selenoprotein glutathione peroxidase 4: From molecular mechanisms to novel therapeutic opportunities","volume":"10","author":"Weaver","year":"2022","journal-title":"Biomedicines"},{"key":"B83","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1080\/10715762.2021.1947503","article-title":"MicroRNA-302a-3p induces ferroptosis of non-small cell lung cancer cells via targeting ferroportin","volume":"55","author":"Wei","year":"2021","journal-title":"Free Radic. Res."},{"key":"B84","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s12031-018-1155-6","article-title":"Ferroptosis, a recent defined form of critical cell death in neurological disorders","volume":"66","author":"Wu","year":"2018","journal-title":"J. Mol. Neurosci."},{"key":"B85","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2478\/jtim-2021-0014","article-title":"Potential new therapeutic intervention for ischemic stroke","volume":"9","author":"Wu","year":"2021","journal-title":"J. Transl. Int. Med."},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-022-01407-8","article-title":"miR-124-3p delivered by exosomes from heme oxygenase-1 modified bone marrow mesenchymal stem cells inhibits ferroptosis to attenuate ischemia\u2013reperfusion injury in steatotic grafts","volume":"20","author":"Wu","year":"","journal-title":"J. Nanobiotechnology"},{"key":"B87","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1038\/s41467-022-29018-9","article-title":"Cancer stem cell regulated phenotypic plasticity protects metastasized cancer cells from ferroptosis","volume":"13","author":"Wu","year":"","journal-title":"Nat. Commun."},{"key":"B88","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.bbrc.2019.05.147","article-title":"miRNA-17-92 protects endothelial cells from erastin-induced ferroptosis through targeting the A20-ACSL4 axis","volume":"515","author":"Xiao","year":"","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B89","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s13041-019-0501-0","article-title":"miR-212-5p attenuates ferroptotic neuronal death after traumatic brain injury by targeting Ptgs2","volume":"12","author":"Xiao","year":"","journal-title":"Mol. Brain"},{"key":"B90","doi-asserted-by":"publisher","first-page":"800925","DOI":"10.3389\/fcell.2022.800925","article-title":"SLC1A5 prefers to play as an accomplice rather than an opponent in pancreatic adenocarcinoma","volume":"10","author":"Xu","year":"","journal-title":"Front. Cell Dev. Biol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"203","DOI":"10.2478\/jtim-2020-0032","article-title":"The application of traditional Chinese medicine against the tumor immune escape","volume":"8","author":"Xu","year":"2020","journal-title":"J. Transl. Int. Med."},{"key":"B92","doi-asserted-by":"publisher","first-page":"67","DOI":"10.3892\/ol.2022.13186","article-title":"MicroRNA-15a promotes prostate cancer cell ferroptosis by inhibiting GPX4 expression","volume":"23","author":"Xu","year":"","journal-title":"Oncol. Lett."},{"key":"B93","doi-asserted-by":"publisher","first-page":"234","DOI":"10.2478\/jtim-2021-0017","article-title":"The challenges and optimization of cell-based therapy for cardiovascular disease","volume":"9","author":"Xu","year":"","journal-title":"J. Transl. Int. Med."},{"key":"B94","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1080\/10715762.2021.2024816","article-title":"MicroRNA-1287-5p promotes ferroptosis of osteosarcoma cells through inhibiting GPX4","volume":"55","author":"Xu","year":"","journal-title":"Free Radic. Res."},{"key":"B95","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.canlet.2021.09.033","article-title":"SLC7A11\/xCT is a target of miR-5096 and its restoration partially rescues miR-5096-mediated ferroptosis and anti-tumor effects in human breast cancer cells","volume":"522","author":"Yadav","year":"2021","journal-title":"Cancer Lett."},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.743046","article-title":"Downregulated ferroptosis-related gene STEAP3 as a novel diagnostic and prognostic target for hepatocellular carcinoma and its roles in immune regulation","volume":"9","author":"Yan","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"B97","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1038\/s41420-021-00659-x","article-title":"miR-539 activates the SAPK\/JNK signaling pathway to promote ferropotosis in colorectal cancer by directly targeting TIPE","volume":"7","author":"Yang","year":"2021","journal-title":"Cell Death Discov."},{"key":"B98","doi-asserted-by":"publisher","first-page":"143","DOI":"10.12122\/j.issn.1673-4254.2022.01.18","article-title":"MicroRNA-132 promotes atherosclerosis by inducing mitochondrial oxidative stressmediated ferroptosis","volume":"421","author":"Zexin","year":"2022","journal-title":"Nan Fang. Yi Ke Da Xue Xue Bao"},{"key":"B99","doi-asserted-by":"publisher","first-page":"101402","DOI":"10.1016\/j.redox.2019.101402","article-title":"miR-30-5p-mediated ferroptosis of trophoblasts is implicated in the pathogenesis of preeclampsia","volume":"29","author":"Zhang","year":"","journal-title":"Redox Biol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1002\/mc.22878","article-title":"miR-9 regulates ferroptosis by targeting glutamic-oxaloacetic transaminase GOT1 in melanoma","volume":"57","author":"Zhang","year":"2018","journal-title":"Mol. Carcinog."},{"key":"B101","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1038\/s41419-020-02772-8","article-title":"Crosstalk between noncoding RNAs and ferroptosis: New dawn for overcoming cancer progression","volume":"11","author":"Zhang","year":"","journal-title":"Cell Death Dis."},{"key":"B102","doi-asserted-by":"crossref","first-page":"26137","DOI":"10.18632\/aging.203801","article-title":"miR-545 promotes colorectal cancer by inhibiting transferring in the non-normal ferroptosis signaling","volume":"13","author":"Zheng","year":"2021","journal-title":"AGING"},{"key":"B103","doi-asserted-by":"publisher","first-page":"686906","DOI":"10.3389\/fcell.2021.686906","article-title":"Ferroptosis holds novel promise in treatment of cancer mediated by non-coding RNAs","volume":"9","author":"Zhi","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1007\/s12192-022-01271-3","article-title":"MicroRNA-214-3p aggravates ferroptosis by targeting GPX4 in cisplatin-induced acute kidney injury","author":"Zhou","year":"2022","journal-title":"Cell Stress Chaperones"},{"key":"B105","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.bbrc.2021.05.100","article-title":"miR-190a-5p regulates cardiomyocytes response to ferroptosis via directly targeting GLS2","volume":"566","author":"Zhou","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B106","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2022\/4213401","article-title":"MicroRNA-4735-3p facilitates ferroptosis in clear cell renal cell carcinoma by targeting SLC40A1","volume":"2022","author":"Zhu","year":"","journal-title":"Anal. Cell. Pathol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1186\/s12935-022-02544-8","article-title":"Ferroptosis-related gene SLC1A5 is a novel prognostic biomarker and correlates with immune infiltrates in stomach adenocarcinoma","volume":"22","author":"Zhu","year":"","journal-title":"Cancer Cell Int."},{"key":"B108","doi-asserted-by":"publisher","first-page":"2064","DOI":"10.1158\/0008-5472.Can-16-1979","article-title":"HSPA5 regulates ferroptotic cell death in cancer cells","volume":"77","author":"Zhu","year":"2017","journal-title":"Cancer Res."},{"key":"B109","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2022\/9629158","article-title":"MiR-375-3p promotes cardiac fibrosis by regulating the ferroptosis mediated by GPX4","volume":"2022","author":"Zhuang","year":"2022","journal-title":"Comput. Intell. Neurosci."},{"key":"B110","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.7150\/ijbs.66917","article-title":"Ferroptosis in cancer progression: Role of noncoding RNAs","volume":"18","author":"Zuo","year":"2022","journal-title":"Int. J. Biol. Sci."}],"container-title":["Frontiers in Molecular Biosciences"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmolb.2022.1003045\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T04:40:31Z","timestamp":1665549631000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmolb.2022.1003045\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,12]]},"references-count":110,"alternative-id":["10.3389\/fmolb.2022.1003045"],"URL":"https:\/\/doi.org\/10.3389\/fmolb.2022.1003045","relation":{},"ISSN":["2296-889X"],"issn-type":[{"value":"2296-889X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,12]]},"article-number":"1003045"}}