{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:07:55Z","timestamp":1753891675318,"version":"3.41.2"},"reference-count":73,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T00:00:00Z","timestamp":1652140800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Biosci."],"abstract":"<jats:p>The occurrence of coronavirus disease 2019 (COVID-19) has become a serious challenge to global public health. Definitive and effective treatments for COVID-19 are still lacking, and targeted antiviral drugs are not available. In addition, viruses can regulate host innate immunity and antiviral processes through the epigenome to promote viral self-replication and disease progression. In this study, we first analyzed the methylation dataset of COVID-19 using the Monte Carlo feature selection method to obtain a feature list. This feature list was subjected to the incremental feature selection method combined with a decision tree algorithm to extract key biomarkers, build effective classification models and classification rules that can remarkably distinguish patients with or without COVID-19. EPSTI1, NACAP1, SHROOM3, C19ORF35, and MX1 as the essential features play important roles in the infection and immune response to novel coronavirus. The six significant rules extracted from the optimal classifier quantitatively explained the expression pattern of COVID-19. Therefore, these findings validated that our method can distinguish COVID-19 at the methylation level and provide guidance for the diagnosis and treatment of COVID-19.<\/jats:p>","DOI":"10.3389\/fmolb.2022.908080","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T08:12:27Z","timestamp":1652170347000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Identifying Methylation Signatures and Rules for COVID-19 With Machine Learning Methods"],"prefix":"10.3389","volume":"9","author":[{"given":"Zhandong","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi","family":"Mei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shijian","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaiyan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Dong","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,5,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1007\/s10875-006-9041-3","article-title":"Inhibition of Alpha Nascent Polypeptide Associated Complex Protein May Induce Proliferation, Differentiation and Enhance the Cytotoxic Activity of Human CD8+ T Cells","volume":"26","author":"Al-Shanti","year":"2006","journal-title":"J. Clin. Immunol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1186\/s13148-021-01102-9","article-title":"Blood DNA Methylation and COVID-19 Outcomes","volume":"13","author":"Balnis","year":"2021","journal-title":"Clin. Epigenet"},{"key":"B3","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1097\/ccm.0000000000004097","article-title":"Epigenetic Profiling in Severe Sepsis","volume":"48","author":"Binnie","year":"2020","journal-title":"Crit. care Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"101585","DOI":"10.1016\/j.isci.2020.101585","article-title":"SARS-CoV-2 Infection Boosts MX1 Antiviral Effector in COVID-19 Patients","volume":"23","author":"Bizzotto","year":"2020","journal-title":"Iscience"},{"key":"B5","doi-asserted-by":"publisher","first-page":"321","DOI":"10.3390\/cancers12020321","article-title":"The RNA-Binding Ubiquitin Ligase MEX3A Affects Glioblastoma Tumorigenesis by Inducing Ubiquitylation and Degradation of RIG-I","volume":"12","author":"Bufalieri","year":"2020","journal-title":"Cancers"},{"key":"B6","doi-asserted-by":"publisher","first-page":"e0115352","DOI":"10.1371\/journal.pone.0115352","article-title":"Breast Cancer Genes PSMC3IP and EPSTI1 Play a Role in Apoptosis Regulation","volume":"10","author":"Capdevila-Busquets","year":"2015","journal-title":"PLoS One"},{"key":"B7","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1613\/jair.953","article-title":"SMOTE: Synthetic Minority Over-sampling Technique","volume":"16","author":"Chawla","year":"2002","journal-title":"jair"},{"key":"B8","doi-asserted-by":"publisher","first-page":"4035462","DOI":"10.1155\/2022\/4035462","article-title":"Predicting RNA 5-methylcytosine Sites by Using Essential Sequence Features and Distributions","volume":"2022","author":"Chen","year":"2022","journal-title":"Biomed. Res. Int."},{"key":"B9","doi-asserted-by":"publisher","first-page":"7681497","DOI":"10.1155\/2021\/7681497","article-title":"iMPT-FDNPL: Identification of Membrane Protein Types with Functional Domains and a Natural Language Processing Approach","volume":"2021","author":"Chen","year":"2021","journal-title":"Comput. Math. Methods Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"2535","DOI":"10.3892\/or.2014.3133","article-title":"DNA Methylation Status of a Distinctively Different Subset of Genes Is Associated with Each Histologic Lauren Classification Subtype in Early Gastric Carcinogenesis","volume":"31","author":"Chong","year":"2014","journal-title":"Oncol. Rep."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.2353\/ajpath.2010.090648","article-title":"Epithelial-stromal Interaction 1 (EPSTI1) Substitutes for Peritumoral Fibroblasts in the Tumor Microenvironment","volume":"176","author":"De Neergaard","year":"2010","journal-title":"Am. J. pathology"},{"key":"B12","doi-asserted-by":"publisher","first-page":"228","DOI":"10.3390\/life12020228","article-title":"Predicting Heart Cell Types by Using Transcriptome Profiles and a Machine Learning Method","volume":"12","author":"Ding","year":"2022","journal-title":"Life"},{"key":"B13","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1093\/bioinformatics\/btm486","article-title":"Monte Carlo Feature Selection for Supervised Classification","volume":"24","author":"Draminski","year":"2007","journal-title":"Bioinformatics"},{"key":"B14","doi-asserted-by":"publisher","first-page":"200131e","DOI":"10.2807\/1560-7917.ES.2020.25.5.200131e","article-title":"Note from the Editors: World Health Organization Declares Novel Coronavirus (2019-nCoV) Sixth Public Health Emergency of International Concern","volume":"25","year":"2020","journal-title":"Euro Surveill."},{"key":"B15","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1084\/jem.20112343","article-title":"Histone H3 Lysine 9 Di-methylation as an Epigenetic Signature of the Interferon Response","volume":"209","author":"Fang","year":"2012","journal-title":"J. Exp. Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"6671","DOI":"10.1158\/0008-5472.can-14-1031","article-title":"A Hypusine-eIF5A-PEAK1 Switch Regulates the Pathogenesis of Pancreatic Cancer","volume":"74","author":"Fujimura","year":"2014","journal-title":"Cancer Res."},{"key":"B17","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.bbaexp.2007.01.009","article-title":"DNA Methylation Dynamics in Plant Genomes","volume":"1769","author":"Gehring","year":"2007","journal-title":"Biochimica Biophysica Acta (BBA) - Gene Struct. Expr."},{"key":"B18","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/S2213-2600(20)30046-1","article-title":"Effect of Early Parenteral Nutrition during Paediatric Critical Illness on DNA Methylation as a Potential Mediator of Impaired Neurocognitive Development: a Pre-planned Secondary Analysis of the PEPaNIC International Randomised Controlled Trial","volume":"8","author":"G\u00fciza","year":"2020","journal-title":"Lancet Respir. Med."},{"key":"B19","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1038\/nature13544","article-title":"The DNA Methylation Landscape of Human Early Embryos","volume":"511","author":"Guo","year":"2014","journal-title":"Nature"},{"key":"B20","doi-asserted-by":"publisher","first-page":"2125","DOI":"10.1016\/j.cub.2003.11.054","article-title":"Shroom Induces Apical Constriction and Is Required for Hingepoint Formation during Neural Tube Closure","volume":"13","author":"Haigo","year":"2003","journal-title":"Curr. Biol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.tim.2014.12.003","article-title":"Mx GTPases: Dynamin-like Antiviral Machines of Innate Immunity","volume":"23","author":"Haller","year":"2015","journal-title":"Trends Microbiol."},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.4850\/arXiv.2003.1105","article-title":"Covidx-net: A Framework of Deep Learning Classifiers to Diagnose Covid-19 in X-Ray Images","author":"Hemdan","year":"2020"},{"key":"B23","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.celrep.2017.12.043","article-title":"Genomic Circuitry Underlying Immunological Response to Pediatric Acute Respiratory Infection","volume":"22","author":"Henrickson","year":"2018","journal-title":"Cell Rep."},{"key":"B24","doi-asserted-by":"publisher","first-page":"5191","DOI":"10.1242\/jcs.02626","article-title":"Shroom Regulates Epithelial Cell Shape via the Apical Positioning of an Actomyosin Network","volume":"118","author":"Hildebrand","year":"2005","journal-title":"J. Cell Sci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1126\/science.187.4173.226","article-title":"DNA Modification Mechanisms and Gene Activity during Development","volume":"187","author":"Holliday","year":"1975","journal-title":"Science"},{"key":"B26","doi-asserted-by":"publisher","first-page":"940","DOI":"10.3390\/life11090940","article-title":"Identifying Lung Cancer Cell Markers with Machine Learning Methods and Single-Cell RNA-Seq Data","volume":"11","author":"Huang","year":"2021","journal-title":"Life"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1001\/jama.2017.1365","article-title":"Diagnosis of Bacterial Infection Using a 2-transcript Host RNA Signature in Febrile Infants 60 Days or Younger","volume":"317","author":"Kaforou","year":"2017","journal-title":"Jama"},{"key":"B28","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.cell.2015.02.043","article-title":"The BRAF Pseudogene Functions as a Competitive Endogenous RNA and Induces Lymphoma In Vivo","volume":"161","author":"Karreth","year":"2015","journal-title":"Cell"},{"key":"B29","doi-asserted-by":"publisher","first-page":"2554","DOI":"10.1158\/0008-5472.can-11-3552","article-title":"KRas Induces a Src\/PEAK1\/ErbB2 Kinase Amplification Loop that Drives Metastatic Growth and Therapy Resistance in Pancreatic Cancer","volume":"72","author":"Kelber","year":"2012","journal-title":"Cancer Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"2965","DOI":"10.1681\/asn.2015060621","article-title":"Developmental Origins for Kidney Disease Due to Shroom3 Deficiency","volume":"27","author":"Khalili","year":"2016","journal-title":"Journal of the American Society of Nephrology"},{"key":"B31","doi-asserted-by":"publisher","first-page":"293","DOI":"10.2310\/6650.2002.33287","article-title":"Human Brain Nascent Polypeptide-Associated Complex \u03b1 Subunit Is Decreased in Patients with Alzheimer's Disease and Down Syndrome","volume":"50","author":"Kim","year":"2002","journal-title":"J. Investig. Med."},{"key":"B32","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1016\/j.bbrc.2017.12.014","article-title":"Regulation of Inflammatory Gene Expression in Macrophages by Epithelial-Stromal Interaction 1 (Epsti1)","volume":"496","author":"Kim","year":"2018","journal-title":"Biochem. Biophysical Res. Commun."},{"article-title":"A Study of Cross-Validation and Bootstrap for Accuracy Estimation and Model Selection","year":"1995","author":"Kohavi","key":"B33"},{"key":"B34","doi-asserted-by":"publisher","first-page":"3820","DOI":"10.3934\/mbe.2022176","article-title":"Identification of Protein Functions in Mouse with a Label Space Partition Method","volume":"19","author":"Li","year":"","journal-title":"Mbe"},{"key":"B35","doi-asserted-by":"publisher","first-page":"857851","DOI":"10.3389\/fgene.2022.857851","article-title":"Exploring the Genomic Patterns in Human and Mouse Cerebellums via Single-Cell Sequencing and Machine Learning Method","volume":"13","author":"Li","year":"","journal-title":"Front. Genet."},{"key":"B36","doi-asserted-by":"publisher","first-page":"646","DOI":"10.2174\/1570164617999201124142950","article-title":"Identifying Protein Subcellular Location with Embedding Features Learned from Networks","volume":"18","author":"Liu","year":"2021","journal-title":"Cp"},{"key":"B37","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1023\/a:1008363719778","article-title":"Incremental Feature Selection","volume":"9","author":"Liu","year":"1998","journal-title":"Appl. Intell."},{"key":"B38","doi-asserted-by":"publisher","first-page":"15495","DOI":"10.1073\/pnas.1906360116","article-title":"PEAK3\/C19orf35 Pseudokinase, a New NFK3 Kinase Family Member, Inhibits CrkII through Dimerization","volume":"116","author":"Lopez","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1038\/nsmb840","article-title":"Intragenic DNA Methylation Alters Chromatin Structure and Elongation Efficiency in Mammalian Cells","volume":"11","author":"Lorincz","year":"2004","journal-title":"Nat. Struct. Mol. Biol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/nature10888","article-title":"The Microcosmos of Cancer","volume":"482","author":"Lujambio","year":"2012","journal-title":"Nature"},{"key":"B41","doi-asserted-by":"publisher","first-page":"e01174","DOI":"10.1128\/mBio.01174-14","article-title":"Pathogenic Influenza Viruses and Coronaviruses Utilize Similar and Contrasting Approaches to Control Interferon-Stimulated Gene Responses","volume":"5","author":"Menachery","year":"2014","journal-title":"MBio"},{"key":"B42","doi-asserted-by":"publisher","first-page":"E1012","DOI":"10.1073\/pnas.1706928115","article-title":"MERS-CoV and H5N1 Influenza Virus Antagonize Antigen Presentation by Altering the Epigenetic Landscape","volume":"115","author":"Menachery","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B43","doi-asserted-by":"publisher","first-page":"716315","DOI":"10.1155\/2015\/716315","article-title":"EPSTI1 Is Involved in IL-28A-mediated Inhibition of HCV Infection","volume":"2015","author":"Meng","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"B44","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1006\/geno.2002.6755","article-title":"Identification of EPSTI1, a Novel Gene Induced by Epithelial-Stromal Interaction in Human Breast Cancer","volume":"79","author":"Nielsen","year":"2002","journal-title":"Genomics"},{"key":"B46","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1152\/physiolgenomics.00058.2009","article-title":"Longitudinal System-Based Analysis of Transcriptional Responses to Type I Interferons","volume":"38","author":"Pappas","year":"2009","journal-title":"Physiol. genomics"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1038\/nature09144","article-title":"A Coding-independent Function of Gene and Pseudogene mRNAs Regulates Tumour Biology","volume":"465","author":"Poliseno","year":"2010","journal-title":"Nature"},{"key":"B48","first-page":"37","article-title":"Evaluation: From Precision, Recall and F-Measure to roc., Informedness, Markedness & Correlation","volume":"2","author":"Powers","year":"2011","journal-title":"J. Mach. Learn. Technol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1159\/000130315","article-title":"X Inactivation, Differentiation, and DNA Methylation","volume":"14","author":"Riggs","year":"1975","journal-title":"Cytogenet Genome Res."},{"key":"B50","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/nrg1655","article-title":"DNA Methylation and Human Disease","volume":"6","author":"Robertson","year":"2005","journal-title":"Nat. Rev. Genet."},{"key":"B51","doi-asserted-by":"publisher","first-page":"101578","DOI":"10.1016\/j.tmaid.2020.101578","article-title":"Going Global - Travel and the 2019 Novel Coronavirus","volume":"33","author":"Rodr\u00edguez-Morales","year":"2020","journal-title":"Travel Med. Infect. Dis."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.1007\/pl00012490","article-title":"Nascent-polypeptide-associated Complex","volume":"59","author":"Rospert","year":"2002","journal-title":"CMLS, Cell. Mol. Life Sci."},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1109\/21.97458","article-title":"A Survey of Decision Tree Classifier Methodology","volume":"21","author":"Safavian","year":"1991","journal-title":"Systems, Man and Cybernetics"},{"key":"B54","first-page":"1","article-title":"The Truth of the F-Measure","author":"Sasaki","year":"2007","journal-title":"Teach. Tutor mater"},{"key":"B55","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3390\/pathogens6010008","article-title":"Epigenetic Landscape during Coronavirus Infection","volume":"6","author":"Sch\u00e4fer","year":"2017","journal-title":"Pathogens"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.22207\/jpam.14.spl1.40","article-title":"Correlation between Temperature and COVID-19 (Suspected, Confirmed and Death) Cases Based on Machine Learning Analysis","volume":"14","author":"Siddiqui","year":"2020","journal-title":"J. Pure Appl. Microbiol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1016\/s0006-291x(03)00487-x","article-title":"The Alpha-Chain of the Nascent Polypeptide-Associated Complex Binds to and Regulates FADD Function","volume":"303","author":"Stilo","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.2174\/1574893617666220318093000","article-title":"iATC-NFMLP: Identifying Classes of Anatomical Therapeutic Chemicals Based on Drug Networks, Fingerprints and Multilayer Perceptron","author":"Tang","year":"2022","journal-title":"Curr. Bioinforma"},{"key":"B59","doi-asserted-by":"publisher","first-page":"13445","DOI":"10.1128\/jvi.01682-12","article-title":"Interferon-inducible Protein Mx1 Inhibits Influenza Virus by Interfering with Functional Viral Ribonucleoprotein Complex Assembly","volume":"86","author":"Verhelst","year":"2012","journal-title":"J. Virol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"10920","DOI":"10.1073\/pnas.0914776107","article-title":"Pseudopodium-enriched Atypical Kinase 1 Regulates the Cytoskeleton and Cancer Progression","volume":"107","author":"Wang","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"volume-title":"World Health Organization Coronavirus Disease (COVID-19) Pandemic","year":"2020","key":"B45"},{"key":"B61","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.trsl.2017.08.004","article-title":"The Anticancer Functions of RIG-I-like Receptors, RIG-I and MDA5, and Their Applications in Cancer Therapy","volume":"190","author":"Wu","year":"2017","journal-title":"Transl. Res."},{"key":"B62","doi-asserted-by":"publisher","first-page":"9547317","DOI":"10.1155\/2022\/9547317","article-title":"Similarity-based Method with Multiple-Feature Sampling for Predicting Drug Side Effects","volume":"2022","author":"Wu","year":"2022","journal-title":"Comput. Math. Methods Med."},{"key":"B63","doi-asserted-by":"publisher","first-page":"48","DOI":"10.2174\/1574893616666210825115406","article-title":"Identification of Drug-Disease Associations by Using Multiple Drug and Disease Networks","volume":"17","author":"Yang","year":"2022","journal-title":"Cbio"},{"key":"B64","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1101\/gr.182881.114","article-title":"Shroom3 Contributes to the Maintenance of the Glomerular Filtration Barrier Integrity","volume":"25","author":"Yeo","year":"2015","journal-title":"Genome Res."},{"key":"B65","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/1741-7015-10-26","article-title":"Insufficient Maintenance DNA Methylation Is Associated with Abnormal Embryonic Development","volume":"10","author":"Yin","year":"2012","journal-title":"BMC Med."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1128\/mcb.18.3.1303","article-title":"The Alpha Chain of the Nascent Polypeptide-Associated Complex Functions as a Transcriptional Coactivator","volume":"18","author":"Yotov","year":"1998","journal-title":"Mol. Cell Biol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.chom.2009.07.006","article-title":"Gene Expression Signatures Diagnose Influenza and Other Symptomatic Respiratory Viral Infections in Humans","volume":"6","author":"Zaas","year":"2009","journal-title":"Cell Host Microbe"},{"key":"B68","doi-asserted-by":"publisher","first-page":"627302","DOI":"10.3389\/fcell.2020.627302","article-title":"Identifying Transcriptomic Signatures and Rules for SARS-CoV-2 Infection","volume":"8","author":"Zhang","year":"","journal-title":"Front. Cell Dev. Biol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"140621","DOI":"10.1016\/j.bbapap.2021.140621","article-title":"Determining Protein-Protein Functional Associations by Functional Rules Based on Gene Ontology and KEGG Pathway","volume":"1869","author":"Zhang","year":"","journal-title":"Biochimica Biophysica Acta (BBA) - Proteins Proteomics"},{"key":"B70","doi-asserted-by":"publisher","first-page":"1998","DOI":"10.1136\/annrheumdis-2015-208410","article-title":"IFI44L Promoter Methylation as a Blood Biomarker for Systemic Lupus Erythematosus","volume":"75","author":"Zhao","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"B71","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.mbs.2018.09.010","article-title":"A Similarity-Based Method for Prediction of Drug Side Effects with Heterogeneous Information","volume":"306","author":"Zhao","year":"2018","journal-title":"Math. Biosci."},{"key":"B72","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/s41586-020-2012-7","article-title":"A Pneumonia Outbreak Associated with a New Coronavirus of Probable Bat Origin","volume":"579","author":"Zhou","year":"2020","journal-title":"Nature"},{"key":"B73","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1056\/nejmoa2001017","article-title":"A Novel Coronavirus from Patients with Pneumonia in China, 2019","volume":"382","author":"Zhu","year":"2020","journal-title":"N. Engl. J. Med."}],"container-title":["Frontiers in Molecular Biosciences"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmolb.2022.908080\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T08:12:36Z","timestamp":1652170356000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmolb.2022.908080\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,10]]},"references-count":73,"alternative-id":["10.3389\/fmolb.2022.908080"],"URL":"https:\/\/doi.org\/10.3389\/fmolb.2022.908080","relation":{},"ISSN":["2296-889X"],"issn-type":[{"type":"electronic","value":"2296-889X"}],"subject":[],"published":{"date-parts":[[2022,5,10]]},"article-number":"908080"}}