{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T07:23:07Z","timestamp":1769844187951,"version":"3.49.0"},"reference-count":125,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T00:00:00Z","timestamp":1657238400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Biosci."],"abstract":"<jats:p>Primary biliary cholangitis (PBC) is an autoimmune-mediated chronic cholestatic liver disease, fatigue, and skin itching are the most common clinical symptoms. Its main pathological feature is the progressive damage and destruction of bile duct epithelial cells. Non-coding RNA (NcRNA, mainly including microRNA, long non-coding RNA and circular RNA) plays a role in the pathological and biological processes of various diseases, especially autoimmune diseases. Many validated ncRNAs are expected to be biomarkers for the diagnosis or treatment of PBC. This review will elucidate the pathogenesis of PBC and help to identify potential ncRNA biomarkers for PBC.<\/jats:p>","DOI":"10.3389\/fmolb.2022.915993","type":"journal-article","created":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T08:42:26Z","timestamp":1657269746000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Roles of Non-Coding RNAs in Primary Biliary Cholangitis"],"prefix":"10.3389","volume":"9","author":[{"given":"Yaqin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziying","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingwei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zongwen","family":"Shuai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1038\/s41418-017-0019-x","article-title":"miRNA-21 Ablation Protects against Liver Injury and Necroptosis in Cholestasis","volume":"25","author":"Afonso","year":"2018","journal-title":"Cell Death Differ."},{"key":"B2","doi-asserted-by":"publisher","first-page":"4653","DOI":"10.1242\/dev.02073","article-title":"MicroRNA Functions in Animal Development and Human Disease","volume":"132","author":"Alvarez-Garcia","year":"2005","journal-title":"Development"},{"key":"B3","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1074\/jbc.M114.587030","article-title":"Post-Translational Regulation of the Type III Inositol 1,4,5-trisphosphate Receptor by miRNA-506","volume":"290","author":"Ananthanarayanan","year":"2015","journal-title":"J. Biol. Chem."},{"key":"B4","doi-asserted-by":"publisher","first-page":"e64273","DOI":"10.1371\/journal.pone.0064273","article-title":"miR-506 Regulates Epithelial Mesenchymal Transition in Breast Cancer Cell Lines","volume":"8","author":"Arora","year":"2013","journal-title":"PLoS One"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.1002\/hep.25873","article-title":"Circulating microRNAs in Exosomes Indicate Hepatocyte Injury and Inflammation in Alcoholic, Drug-Induced, and Inflammatory Liver Diseases","volume":"56","author":"Bala","year":"2012","journal-title":"Hepatology"},{"key":"B6","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1038\/ni.f.209","article-title":"MicroRNAs: New Regulators of Immune Cell Development and Function","volume":"9","author":"Baltimore","year":"2008","journal-title":"Nat. Immunol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1002\/hep.25691","article-title":"Upregulation of microRNA 506 Leads to Decreased Cl\u2212\/HCO3\u2212 Anion Exchanger 2 Expression in Biliary Epithelium of Patients with Primary Biliary Cirrhosis","volume":"56","author":"Banales","year":"2012","journal-title":"Hepatology"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1016\/j.jhep.2015.06.031","article-title":"Changing Nomenclature for PBC: From 'cirrhosis' to 'cholangitis'","volume":"63","author":"Beuers","year":"2015","journal-title":"J. Hepatology"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1016\/s0140-6736(15)00154-3","article-title":"Primary Biliary Cirrhosis","volume":"386","author":"Carey","year":"2015","journal-title":"Lancet"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.3390\/ijms19051310","article-title":"Noncoding RNA:RNA Regulatory Networks in Cancer","volume":"19","author":"Chan","year":"2018","journal-title":"Ijms"},{"key":"B11","doi-asserted-by":"publisher","first-page":"8215","DOI":"10.1128\/jvi.02575-07","article-title":"Liver-specific microRNA miR-122 Enhances the Replication of Hepatitis C Virus in Nonhepatic Cells","volume":"82","author":"Chang","year":"2008","journal-title":"J. Virol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1038\/454562b","article-title":"Thousands of Proteins Affected by miRNAs","volume":"454","author":"Check Hayden","year":"2008","journal-title":"Nature"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1016\/j.autrev.2016.09.003","article-title":"The Role of microRNAs in the Pathogenesis of Autoimmune Diseases","volume":"15","author":"Chen","year":"2016","journal-title":"Autoimmun. Rev."},{"key":"B14","doi-asserted-by":"publisher","first-page":"2758","DOI":"10.1016\/j.ajpath.2017.08.026","article-title":"miRNA-122 Protects Mice and Human Hepatocytes from Acetaminophen Toxicity by Regulating Cytochrome P450 Family 1 Subfamily A Member 2 and Family 2 Subfamily E Member 1 Expression","volume":"187","author":"Chowdhary","year":"2017","journal-title":"Am. J. Pathology"},{"key":"B15","doi-asserted-by":"publisher","first-page":"3526","DOI":"10.1038\/onc.2009.211","article-title":"Loss of miR-122 Expression in Liver Cancer Correlates with Suppression of the Hepatic Phenotype and Gain of Metastatic Properties","volume":"28","author":"Coulouarn","year":"2009","journal-title":"Oncogene"},{"key":"B16","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1007\/s00296-008-0758-6","article-title":"Comprehensive Analysis of microRNA Expression Patterns in Renal Biopsies of Lupus Nephritis Patients","volume":"29","author":"Dai","year":"2009","journal-title":"Rheumatol. Int."},{"key":"B17","doi-asserted-by":"publisher","first-page":"386","DOI":"10.7555\/jbr.30.20150162","article-title":"Exosomes and Their Role in the Micro-\/macro-environment: a Comprehensive Review","volume":"31","author":"Debabrata","year":"2017","journal-title":"J. Biomed. Res."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1002\/hep.29533","article-title":"MicroRNA-506 Promotes Primary Biliary Cholangitis-like Features in Cholangiocytes and Immune Activation","volume":"67","author":"Erice","year":"2018","journal-title":"Hepatology"},{"key":"B19","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.cmet.2006.01.005","article-title":"miR-122 Regulation of Lipid Metabolism Revealed by In Vivo Antisense Targeting","volume":"3","author":"Esau","year":"2006","journal-title":"Cell Metab."},{"key":"B20","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.path.2018.02.010","article-title":"Primary Biliary Cholangitis and Autoimmune Hepatitis","volume":"11","author":"Gonzalez","year":"2018","journal-title":"Surg. Pathol. Clin."},{"key":"B21","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/s41575-019-0226-7","article-title":"Primary Biliary Cholangitis: Pathogenesis and Therapeutic Opportunities","volume":"17","author":"Gulamhusein","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"280","DOI":"10.3390\/ijms17030280","article-title":"MicroRNAs as Biomarkers for Liver Disease and Hepatocellular Carcinoma","volume":"17","author":"Hayes","year":"2016","journal-title":"Ijms"},{"key":"B23","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1053\/j.gastro.2015.12.037","article-title":"Lipid-Induced Signaling Causes Release of Inflammatory Extracellular Vesicles from Hepatocytes","volume":"150","author":"Hirsova","year":"2016","journal-title":"Gastroenterology"},{"key":"B24","doi-asserted-by":"publisher","first-page":"2219","DOI":"10.1002\/hep.28814","article-title":"Extracellular Vesicles in Liver Pathobiology: Small Particles with Big Impact","volume":"64","author":"Hirsova","year":"2016","journal-title":"Hepatology"},{"key":"B25","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1002\/hep.28573","article-title":"MicroRNA\u2010122 Regulates Polyploidization in the Murine Liver","volume":"64","author":"Hsu","year":"2016","journal-title":"Hepatology"},{"key":"B26","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1007\/s13238-012-2036-3","article-title":"MiR-122 in Hepatic Function and Liver Diseases","volume":"3","author":"Hu","year":"2012","journal-title":"Protein Cell"},{"key":"B27","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1620\/tjem.240.269","article-title":"Interleukin-17A-Induced Epithelial-Mesenchymal Transition of Human Intrahepatic Biliary Epithelial Cells: Implications for Primary Biliary Cirrhosis","volume":"240","author":"Huang","year":"2016","journal-title":"Tohoku J. Exp. Med."},{"key":"B28","doi-asserted-by":"publisher","first-page":"e4","DOI":"10.4110\/in.2019.19.e4","article-title":"Potential Implications of Long Noncoding RNAs in Autoimmune Diseases","volume":"19","author":"Hur","year":"2019","journal-title":"Immune Netw."},{"key":"B29","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1111\/cas.12122","article-title":"Effect of miR-122 and its Target Gene Cationic Amino Acid Transporter 1 on Colorectal Liver Metastasis","volume":"104","author":"Iino","year":"2013","journal-title":"Cancer Sci."},{"key":"B30","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/nbt.2890","article-title":"Detecting and Characterizing Circular RNAs","volume":"32","author":"Jeck","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s40510-021-00377-1","article-title":"MicroRNAs in Oral Fluids (Saliva and Gingival Crevicular Fluid) as Biomarkers in Orthodontics: Systematic Review and Integrated Bioinformatic Analysis","volume":"22","author":"Kapoor","year":"2021","journal-title":"Prog. Orthod."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1038\/labinvest.2016.95","article-title":"MiR-139-5p Is Associated with Inflammatory Regulation through C-FOS Suppression, and Contributes to the Progression of Primary Biliary Cholangitis","volume":"96","author":"Katsumi","year":"2016","journal-title":"Lab. Invest."},{"key":"B33","doi-asserted-by":"publisher","first-page":"E189","DOI":"10.1111\/hepr.12198","article-title":"Expression of Micro-RNAs in Peripheral Blood Mononuclear Cells from Primary Biliary Cirrhosis Patients","volume":"44","author":"Katsushima","year":"2014","journal-title":"Hepatol. Res."},{"key":"B34","doi-asserted-by":"publisher","first-page":"289","DOI":"10.3390\/ijms18020289","article-title":"Decreased Expression of Vitamin D Receptor Affects an Immune Response in Primary Biliary Cholangitis via the VDR-miRNA155-SOCS1 Pathway","volume":"18","author":"Kempinska-Podhorodecka","year":"2017","journal-title":"Ijms"},{"key":"B35","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1111\/j.1872-034X.2010.00752.x","article-title":"Expression Profiles of miRNAs in Human Embryonic Stem Cells during Hepatocyte Differentiation","volume":"41","author":"Kim","year":"2011","journal-title":"Hepatol. Res."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1053\/gast.2000.20197","article-title":"Epidemiology and Natural History of Primary Biliary Cirrhosis in a U.S. Community","volume":"119","author":"Kim","year":"2000","journal-title":"Gastroenterology"},{"key":"B37","doi-asserted-by":"publisher","first-page":"e200","DOI":"10.1111\/liv.12479","article-title":"Geoepidemiology and Space-Time Analysis of Primary Biliary Cirrhosis in Crete, Greece","volume":"34","author":"Koulentaki","year":"2014","journal-title":"Liver Int."},{"key":"B38","doi-asserted-by":"publisher","first-page":"43","DOI":"10.2147\/hmer.s135337","article-title":"Biomarkers for Primary Biliary Cholangitis: Current Perspectives","volume":"10","author":"Kouroumalis","year":"2018","journal-title":"Hmer"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1261\/rna.047126.114","article-title":"Circular RNAs: Diversity of Form and Function","volume":"20","author":"Lasda","year":"2014","journal-title":"Rna"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1042\/bst0381553","article-title":"Regulation and Biological Function of the Liver-specific miR-122","volume":"38","author":"Lewis","year":"2010","journal-title":"Biochem. Soc. Trans."},{"key":"B41","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1186\/s12920-020-00830-w","article-title":"Pinpointing miRNA and Genes Enrichment over Trait-Relevant Tissue Network in Genome-wide Association Studies","volume":"13","author":"Li","year":"2020","journal-title":"BMC Med. Genomics"},{"key":"B42","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1016\/j.jhep.2012.11.011","article-title":"miR-122 Regulates Collagen Production via Targeting Hepatic Stellate Cells and Suppressing P4HA1 Expression","volume":"58","author":"Li","year":"2013","journal-title":"J. Hepatology"},{"key":"B43","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1111\/imm.12940","article-title":"Circular RNA Expression Profile and Potential Function of Hsa_circ_0045272 in Systemic Lupus Erythematosus","volume":"155","author":"Li","year":"2018","journal-title":"Immunology"},{"key":"B44","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1002\/hep.27050","article-title":"Human Bile Contains microRNA-Laden Extracellular Vesicles that Can Be Used for Cholangiocarcinoma Diagnosis","volume":"60","author":"Li","year":"2014","journal-title":"Hepatology"},{"key":"B45","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.cca.2015.02.018","article-title":"Using Circular RNA as a Novel Type of Biomarker in the Screening of Gastric Cancer","volume":"444","author":"Li","year":"2015","journal-title":"Clin. Chim. Acta"},{"key":"B46","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1002\/hep.29838","article-title":"Cholangiocyte-derived Exosomal Long Noncoding RNA H19 Promotes Cholestatic Liver Injury in Mouse and Humans","volume":"68","author":"Li","year":"2018","journal-title":"Hepatology"},{"key":"B47","doi-asserted-by":"publisher","first-page":"190","DOI":"10.3390\/cells9010190","article-title":"Cholangiocyte-Derived Exosomal lncRNA H19 Promotes Macrophage Activation and Hepatic Inflammation under Cholestatic Conditions","volume":"9","author":"Li","year":"2020","journal-title":"Cells"},{"key":"B48","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1002\/hep.29145","article-title":"The Role of Long Noncoding RNA H19 in Gender Disparity of Cholestatic Liver Injury in Multidrug Resistance 2 Gene Knockout Mice","volume":"66","author":"Li","year":"2017","journal-title":"Hepatology"},{"key":"B49","doi-asserted-by":"publisher","first-page":"131","DOI":"10.3892\/ijmm.2016.2610","article-title":"Altered Expression of miR-92a Correlates with Th17 Cell Frequency in Patients with Primary Biliary Cirrhosis","volume":"38","author":"Liang","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"B50","doi-asserted-by":"publisher","first-page":"3","DOI":"10.2478\/jtim-2019-0002","article-title":"LncRNA: An All-Rounder in Rheumatoid Arthritis","volume":"7","author":"Liang","year":"2019","journal-title":"J. Transl. Int. Med."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1002\/hep.30662","article-title":"Cholangiocyte\u2010Derived Exosomal Long Noncoding RNA H19 Promotes Hepatic Stellate Cell Activation and Cholestatic Liver Fibrosis","volume":"70","author":"Liu","year":"2019","journal-title":"Hepatology"},{"key":"B52","doi-asserted-by":"publisher","first-page":"25906","DOI":"10.1038\/srep25906","article-title":"Evolving Trends in Female to Male Incidence and Male Mortality of Primary Biliary Cholangitis","volume":"6","author":"Lleo","year":"2016","journal-title":"Sci. Rep."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1016\/j.cell.2015.02.025","article-title":"Hepatitis C Virus RNA Functionally Sequesters miR-122","volume":"160","author":"Luna","year":"2015","journal-title":"Cell"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1111\/jgh.15329","article-title":"Regional Variation and Temporal Trend of Primary Biliary Cholangitis Epidemiology: A Systematic Review and Meta\u2010analysis","volume":"36","author":"Lv","year":"2021","journal-title":"J. Gastroenterology Hepatology"},{"key":"B55","doi-asserted-by":"publisher","first-page":"388","DOI":"10.3892\/ol.2018.9606","article-title":"circRNA of AR-suppressed PABPC1 91 B-p E-nhances the C-ytotoxicity of N-atural K-iller C-ells against H-epatocellular C-arcinoma via U-pregulating UL16 B-inding P-rotein 1","volume":"17","author":"Ma","year":"2019","journal-title":"Oncol. Lett."},{"key":"B56","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.freeradbiomed.2021.04.034","article-title":"Systematic Review and Network Analysis of microRNAs Involved in Cardioprotection against Myocardial Ischemia\/reperfusion Injury and Infarction: Involvement of Redox Signalling","volume":"172","author":"Makkos","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"B57","doi-asserted-by":"publisher","first-page":"11525","DOI":"10.1038\/s41598-019-47890-2","article-title":"Incidence, Prevalence, and Outcome of Primary Biliary Cholangitis in a Nationwide Swedish Population-Based Cohort","volume":"9","author":"Marschall","year":"2019","journal-title":"Sci. Rep."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.1161\/circresaha.117.309419","article-title":"Extracellular Vesicles in Metabolic Syndrome","volume":"120","author":"Mart\u00ednez","year":"2017","journal-title":"Circ. Res."},{"key":"B59","doi-asserted-by":"publisher","first-page":"G990","DOI":"10.1152\/ajpgi.00093.2010","article-title":"Biliary Exosomes Influence Cholangiocyte Regulatory Mechanisms and Proliferation through Interaction with Primary Cilia","volume":"299","author":"Masyuk","year":"2010","journal-title":"Am. J. Physiology-Gastrointestinal Liver Physiology"},{"key":"B60","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/j.jhep.2013.03.028","article-title":"Exosomes in the Pathogenesis, Diagnostics and Therapeutics of Liver Diseases","volume":"59","author":"Masyuk","year":"2013","journal-title":"J. Hepatology"},{"key":"B61","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/nrg2521","article-title":"Long Non-coding RNAs: Insights into Functions","volume":"10","author":"Mercer","year":"2009","journal-title":"Nat. Rev. Genet."},{"key":"B62","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1093\/ije\/26.4.830","article-title":"Incidence and Prevalence of Primary Biliary Cirrhosis in the City of Newcastle upon Tyne, England","volume":"26","author":"Metcalf","year":"1997","journal-title":"Int. J. Epidemiol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1053\/j.gastro.2007.08.020","article-title":"Cyclic AMP Regulates Bicarbonate Secretion in Cholangiocytes through Release of ATP into Bile","volume":"133","author":"Minagawa","year":"2007","journal-title":"Gastroenterology"},{"key":"B64","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.canlet.2018.01.012","article-title":"Prostate Cancer-Associated lncRNAs","volume":"418","author":"Mitobe","year":"2018","journal-title":"Cancer Lett."},{"key":"B65","first-page":"165","article-title":"Two Triacylglycerol Pathway Genes, CTDNEP1 and LPIN1, Are Down-Regulated by Hsa-miR-122-5p in Hepatocytes","volume":"20","author":"Naderi","year":"2017","journal-title":"Arch. Iran. Med."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1016\/j.jhep.2017.02.002","article-title":"miR-425 Regulates Inflammatory Cytokine Production in CD4+ T Cells via N-Ras Upregulation in Primary Biliary Cholangitis","volume":"66","author":"Nakagawa","year":"2017","journal-title":"J. Hepatology"},{"key":"B67","doi-asserted-by":"publisher","first-page":"e66086","DOI":"10.1371\/journal.pone.0066086","article-title":"Distinct microRNAs Expression Profile in Primary Biliary Cirrhosis and Evaluation of miR 505-3p and miR197-3p as Novel Biomarkers","volume":"8","author":"Ninomiya","year":"2013","journal-title":"PLoS One"},{"key":"B68","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1007\/978-981-13-1426-1_12","article-title":"Emerging Role of Circular RNAs as Potential Biomarkers for the Diagnosis of Human Diseases","volume":"1087","author":"Ojha","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1016\/j.bbadis.2017.06.026","article-title":"MicroRNAs and Extracellular Vesicles in Cholangiopathies","volume":"1864","author":"Olaizola","year":"2018","journal-title":"Biochimica Biophysica Acta (BBA) - Mol. Basis Dis."},{"key":"B70","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1159\/000477883","article-title":"Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis Patients","volume":"42","author":"Ouyang","year":"2017","journal-title":"Cell Physiol. Biochem."},{"key":"B71","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.jaut.2009.02.022","article-title":"Primary Biliary Cirrhosis Is Associated with Altered Hepatic microRNA Expression","volume":"32","author":"Padgett","year":"2009","journal-title":"J. Autoimmun."},{"key":"B72","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1007\/s00432-017-2361-2","article-title":"Exosomes-mediated Transfer of Long Noncoding RNA ZFAS1 Promotes Gastric Cancer Progression","volume":"143","author":"Pan","year":"2017","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"6890423","DOI":"10.1155\/2021\/6890423","article-title":"MicroRNA-34a Promotes EMT and Liver Fibrosis in Primary Biliary Cholangitis by Regulating TGF-\u03b21\/smad Pathway","volume":"2021","author":"Pan","year":"2021","journal-title":"J. Immunol. Res."},{"key":"B74","article-title":"Primary Biliary Cholangitis","volume-title":"StatPearls","author":"Pandit","year":"2022"},{"key":"B75","doi-asserted-by":"publisher","first-page":"7738","DOI":"10.4049\/jimmunol.0900603","article-title":"Genome-Wide Identification of Long Noncoding RNAs in CD8+T Cells","volume":"182","author":"Pang","year":"2009","journal-title":"J. Immunol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1053\/j.gastro.2005.12.029","article-title":"Excellent Long-Term Survival in Patients with Primary Biliary Cirrhosis and Biochemical Response to Ursodeoxycholic Acid","volume":"130","author":"Par\u00e9s","year":"2006","journal-title":"Gastroenterology"},{"key":"B77","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.cell.2009.02.006","article-title":"Evolution and Functions of Long Noncoding RNAs","volume":"136","author":"Ponting","year":"2009","journal-title":"Cell"},{"key":"B78","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/j.jhep.2009.11.027","article-title":"Primary Biliary Cirrhosis: a 2010 Update","volume":"52","author":"Poupon","year":"2010","journal-title":"J. Hepatology"},{"key":"B79","doi-asserted-by":"publisher","first-page":"533","DOI":"10.3760\/cma.j.issn.1007-3418.2013.07.014","article-title":"Abnormal Expression of miR-Let-7b in Primary Biliary Cirrhosis and its Clinical Significance","volume":"21","author":"Qian","year":"2013","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"key":"B80","doi-asserted-by":"publisher","first-page":"194419","DOI":"10.1016\/j.bbagrm.2019.194419","article-title":"The How and Why of lncRNA Function: An Innate Immune Perspective","volume":"1863","author":"Robinson","year":"2020","journal-title":"Biochimica Biophysica Acta (BBA) - Gene Regul. Mech."},{"key":"B81","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1016\/j.jhep.2018.08.020","article-title":"Primary Biliary Cholangitis: A Tale of Epigenetically-Induced Secretory Failure?","volume":"69","author":"Rodrigues","year":"2018","journal-title":"J. Hepatology"},{"key":"B82","doi-asserted-by":"publisher","first-page":"3350","DOI":"10.3892\/mmr.2016.5606","article-title":"Identification of microRNA Profiles Associated with Refractory Primary Biliary Cirrhosis","volume":"14","author":"Sakamoto","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"B83","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.tig.2016.03.002","article-title":"Circular RNA Expression: Its Potential Regulation and Function","volume":"32","author":"Salzman","year":"2016","journal-title":"Trends Genet."},{"key":"B84","volume-title":"Study on the Role of LncRNA XIST in Immune Cells of Primary Biliary Cholangitis","author":"She","year":"2020"},{"key":"B85","first-page":"1142","article-title":"Circular RNAs in Digestive System Cancer: Potential Biomarkers and Therapeutic Targets","volume":"8","author":"Sheng","year":"2018","journal-title":"Am. J. Cancer Res."},{"key":"B86","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1016\/s0016-5085(03)01201-0","article-title":"Loss of Inositol 1,4,5-trisphosphate Receptors from Bile Duct Epithelia Is a Common Event in Cholestasis","volume":"125","author":"Shibao","year":"2003","journal-title":"Gastroenterology"},{"key":"B87","doi-asserted-by":"publisher","first-page":"848790","DOI":"10.1155\/2015\/848790","article-title":"The Emerging Functions of Long Noncoding RNA in Immune Cells: Autoimmune Diseases","volume":"2015","author":"Sigdel","year":"2015","journal-title":"J. Immunol. Res."},{"key":"B88","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.intimp.2018.09.027","article-title":"miR-181a Regulates Th17 Cells Distribution via Up-Regulated BCL-2 in Primary Biliary Cholangitis","volume":"64","author":"Song","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/nrgastro.2017.71","article-title":"Extracellular Vesicles in Liver Disease and Potential as Biomarkers and Therapeutic Targets","volume":"14","author":"Szabo","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"e111424","DOI":"10.1371\/journal.pone.0111424","article-title":"Serum microRNAs as Potential Biomarkers of Primary Biliary Cirrhosis","volume":"9","author":"Tan","year":"2014","journal-title":"PLoS One"},{"key":"B91","volume-title":"The Regulation of Micro RNA on Thl7 Cells in Patients with Primary Biliary Cirrhosis","author":"Tang","year":"2009"},{"key":"B92","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1002\/jcb.26205","article-title":"Altered Expression of MicroRNAs in Rheumatoid Arthritis","volume":"119","author":"Tavasolian","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"B93","doi-asserted-by":"publisher","first-page":"157","DOI":"10.3390\/biology9070157","article-title":"Role of B Cell Lymphoma 2 in the Regulation of Liver Fibrosis in miR-122 Knockout Mice","volume":"9","author":"Teng","year":"2020","journal-title":"Biology"},{"key":"B94","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.omtn.2018.05.018","article-title":"The Impact of lncRNA Dysregulation on Clinicopathology and Survival of Breast Cancer: A Systematic Review and Meta-Analysis","volume":"12","author":"Tian","year":"2018","journal-title":"Mol. Ther. - Nucleic Acids"},{"key":"B95","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1038\/cmi.2015.86","article-title":"The Modulation of Co-stimulatory Molecules by Circulating Exosomes in Primary Biliary Cirrhosis","volume":"14","author":"Tomiyama","year":"2017","journal-title":"Cell Mol. Immunol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1002\/hep.22806","article-title":"MicroRNA-122, a Tumor Suppressor microRNA that Regulates Intrahepatic Metastasis of Hepatocellular Carcinoma","volume":"49","author":"Tsai","year":"2009","journal-title":"Hepatology"},{"key":"B97","doi-asserted-by":"publisher","first-page":"2884","DOI":"10.1172\/jci63455","article-title":"MicroRNA-122 Plays a Critical Role in Liver Homeostasis and Hepatocarcinogenesis","volume":"122","author":"Tsai","year":"2012","journal-title":"J. Clin. Invest."},{"key":"B98","doi-asserted-by":"publisher","first-page":"7","DOI":"10.2152\/jmi.64.7","article-title":"Primary Biliary Cholangitis: Its Pathological Characteristics and Immunopathological Mechanisms","volume":"64","author":"Tsuneyama","year":"2017","journal-title":"J. Med. Invest."},{"key":"B99","doi-asserted-by":"publisher","first-page":"3129","DOI":"10.3389\/fimmu.2019.03129","article-title":"Non-coding RNAs in Rheumatoid Arthritis: From Bench to Bedside","volume":"10","author":"Wang","year":"2019","journal-title":"Front. Immunol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"e0184292","DOI":"10.1371\/journal.pone.0184292","article-title":"MicroRNA-223 and microRNA-21 in Peripheral Blood B Cells Associated with Progression of Primary Biliary Cholangitis Patients","volume":"12","author":"Wang","year":"2017","journal-title":"PLoS One"},{"key":"B101","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1053\/j.gastro.2012.04.007","article-title":"MicroRNAs in Liver Disease","volume":"142","author":"Wang","year":"2012","journal-title":"Gastroenterology"},{"key":"B102","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1186\/s13075-018-1618-8","article-title":"CircIBTK Inhibits DNA Demethylation and Activation of AKT Signaling Pathway via miR-29b in Peripheral Blood Mononuclear Cells in Systemic Lupus Erythematosus","volume":"20","author":"Wang","year":"2018","journal-title":"Arthritis Res. Ther."},{"key":"B103","doi-asserted-by":"publisher","first-page":"729768","DOI":"10.3389\/fgene.2021.729768","article-title":"Clinicopathological and Prognostic Significance of Long Non-coding RNA MIAT in Human Cancers: A Review and Meta-Analysis","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Genet."},{"key":"B104","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1002\/jcb.26659","article-title":"MiR\u2010548a\u20103p Regulates Inflammatory Response via TLR4\/NF\u2010\u03baB Signaling Pathway in Rheumatoid Arthritis","volume":"120","author":"Wang","year":"2018","journal-title":"J. Cell Biochem."},{"key":"B105","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s10020-019-0130-1","article-title":"Enhanced Expression of miR-21 and miR-150 Is a Feature of Anti-mitochondrial Antibody-Negative Primary Biliary Cholangitis","volume":"26","author":"Wasik","year":"2020","journal-title":"Mol. Med."},{"key":"B106","doi-asserted-by":"publisher","first-page":"44769","DOI":"10.1038\/srep44769","article-title":"Protection against Oxidative Stress Mediated by the Nrf2\/Keap1 axis Is Impaired in Primary Biliary Cholangitis","volume":"7","author":"Wasik","year":"2017","journal-title":"Sci. Rep."},{"key":"B107","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1136\/gut.36.6.927","article-title":"Low Prevalence of Primary Biliary Cirrhosis in Victoria, Australia. Melbourne Liver Group","volume":"36","author":"Watson","year":"1995","journal-title":"Gut"},{"key":"B108","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1002\/hep.1840120116","article-title":"The Demography of Primary Biliary Cirrhosis in Ontario, Canada","volume":"12","author":"Witt-Sullivan","year":"1990","journal-title":"Hepatology"},{"key":"B109","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1074\/mcp.M117.068577","article-title":"Database-augmented Mass Spectrometry Analysis of Exosomes Identifies Claudin 3 as a Putative Prostate Cancer Biomarker","volume":"16","author":"Worst","year":"2017","journal-title":"Mol. Cell. Proteomics"},{"key":"B110","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/s13075-015-0632-3","article-title":"Association of Large Intergenic Noncoding RNA Expression with Disease Activity and Organ Damage in Systemic Lupus Erythematosus","volume":"17","author":"Wu","year":"2015","journal-title":"Arthritis Res. Ther."},{"key":"B111","first-page":"1149","article-title":"Differential Expression Analysis of Long-Chain Non-coding RNA in Peripheral Blood of Patients with Primary Biliary Cirrhosis","volume":"48","author":"Xiang","year":"2019","journal-title":"Chongqing Med."},{"key":"B112","doi-asserted-by":"publisher","first-page":"e41159","DOI":"10.7554\/eLife.41159","article-title":"MicroRNA-122 Supports Robust Innate Immunity in Hepatocytes by Targeting the RTKs\/STAT3 Signaling Pathway","volume":"8","author":"Xu","year":"2019","journal-title":"Elife"},{"key":"B113","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1007\/978-981-13-1426-1_25","article-title":"The Role of Circular RNAs in Cerebral Ischemic Diseases: Ischemic Stroke and Cerebral Ischemia\/Reperfusion Injury","volume":"1087","author":"Yang","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"B114","doi-asserted-by":"publisher","first-page":"2977","DOI":"10.3389\/fimmu.2018.02977","article-title":"Circular RNAs and Their Emerging Roles in Immune Regulation","volume":"9","author":"Yang","year":"2018","journal-title":"Front. Immunol."},{"key":"B115","volume-title":"Preliminary Study of microRNA as a New Disease Marker and its Function in Primary Biliary Cirrhosis","author":"Yang","year":"2013"},{"key":"B116","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1007\/s11010-020-03988-0","article-title":"MiR-122-5p Knockdown Protects against APAP-Mediated Liver Injury through Up-Regulating NDRG3","volume":"476","author":"Yang","year":"2021","journal-title":"Mol. Cell Biochem."},{"key":"B117","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.clim.2016.12.005","article-title":"Estrogen-regulated STAT1 Activation Promotes TLR8 Expression to Facilitate Signaling via microRNA-21 in Systemic Lupus Erythematosus","volume":"176","author":"Young","year":"2017","journal-title":"Clin. Immunol."},{"key":"B118","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1007\/s12072-019-09984-x","article-title":"Epidemiology and Clinical Course of Primary Biliary Cholangitis in the Asia-Pacific Region: a Systematic Review and Meta-Analysis","volume":"13","author":"Zeng","year":"2019","journal-title":"Hepatol. Int."},{"key":"B119","first-page":"2656","article-title":"Increased Expression of lncRNA AK053349 in Peripheral Blood Mononuclear Cells from Patients with Primary Biliary Cirrhosis and its Clinical Significance","volume":"34","author":"Zhang","year":"2013","journal-title":"Int. J. Lab. Med."},{"key":"B120","doi-asserted-by":"publisher","first-page":"1830","DOI":"10.1373\/clinchem.2010.147850","article-title":"Plasma microRNA-122 as a Biomarker for Viral-, Alcohol-, and Chemical-Related Hepatic Diseases","volume":"56","author":"Zhang","year":"2010","journal-title":"Clin. Chem."},{"key":"B121","doi-asserted-by":"publisher","first-page":"2407","DOI":"10.3389\/fimmu.2018.02407","article-title":"GDF15 Regulates Malat-1 Circular RNA and Inactivates NF\u03baB Signaling Leading to Immune Tolerogenic DCs for Preventing Alloimmune Rejection in Heart Transplantation","volume":"9","author":"Zhang","year":"2018","journal-title":"Front. Immunol."},{"key":"B122","doi-asserted-by":"publisher","first-page":"39918","DOI":"10.1038\/srep39918","article-title":"Peripheral Blood Circular RNA Hsa_circ_0124644 Can Be Used as a Diagnostic Biomarker of Coronary Artery Disease","volume":"7","author":"Zhao","year":"2017","journal-title":"Sci. Rep."},{"key":"B123","doi-asserted-by":"publisher","first-page":"8029","DOI":"10.3892\/mmr.2017.7638","article-title":"Circular RNA Expression Profiles of Peripheral Blood Mononuclear Cells in Rheumatoid Arthritis Patients, Based on Microarray Chip Technology","volume":"16","author":"Zheng","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"B124","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1159\/000485487","article-title":"Microarray Expression Profile of Circular RNAs in Plasma from Primary Biliary Cholangitis Patients","volume":"44","author":"Zheng","year":"2017","journal-title":"Cell Physiol. Biochem."},{"key":"B125","doi-asserted-by":"publisher","first-page":"e0247556","DOI":"10.1371\/journal.pone.0247556","article-title":"MicroRNA Biomarkers of Type 2 Diabetes: A Protocol for Corroborating Evidence by Computational Genomics and Meta-Analyses","volume":"16","author":"Zhu","year":"2021","journal-title":"PLoS One"}],"container-title":["Frontiers in Molecular Biosciences"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmolb.2022.915993\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T08:42:37Z","timestamp":1657269757000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmolb.2022.915993\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,8]]},"references-count":125,"alternative-id":["10.3389\/fmolb.2022.915993"],"URL":"https:\/\/doi.org\/10.3389\/fmolb.2022.915993","relation":{},"ISSN":["2296-889X"],"issn-type":[{"value":"2296-889X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,8]]},"article-number":"915993"}}