{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T18:42:42Z","timestamp":1779907362627,"version":"3.53.1"},"reference-count":96,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T00:00:00Z","timestamp":1667520000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Biosci."],"abstract":"<jats:p>Notch signaling <jats:italic>via<\/jats:italic> NOTCH1 stimulated by Delta-like ligand 4 (DLL4) is required for the development of T cells in thymus, and NOTCH2 stimulated by Notch ligand DLL1 is required for the development of marginal zone (MZ) B cells in spleen. Notch signaling also regulates myeloid cell production in bone marrow and is an essential contributor to the generation of early hematopoietic stem cells (HSC). The differentiation program in each of these cellular contexts is optimized by the regulation of Notch signaling strength by O-glycans attached to epidermal growth factor-like (EGF) repeats in the extracellular domain of Notch receptors. There are three major types of O-glycan on NOTCH1 and NOTCH2 - O-fucose, O-glucose and O-GlcNAc. The initiating sugar of each O-glycan is added in the endoplasmic reticulum (ER) by glycosyltransferases POFUT1 (fucose), POGLUT1\/2\/3 (glucose) or EOGT (GlcNAc), respectively. Additional sugars are added in the Golgi compartment during passage through the secretory pathway to the plasma membrane. Of particular significance for Notch signaling is the addition of GlcNAc to O-fucose on an EGF repeat by the Fringe GlcNAc-transferases LFNG, MFNG or RFNG. Canonical Notch ligands (DLL1, DLL4, JAG1, JAG2) expressed in stromal cells bind to the extracellular domain of Notch receptors expressed in hematopoietic stem cells and myeloid and lymphoid progenitors to activate Notch signaling. Ligand-receptor binding is differentially regulated by the O-glycans on Notch. This review will summarize our understanding of the regulation of Notch signaling in myeloid and lymphoid cell development by specific O-glycans in mice with dysregulated expression of a particular glycosyltransferase and discuss how this may impact immune system development and malignancy in general, and in individuals with a congenital defect in the synthesis of the O-glycans attached to EGF repeats.<\/jats:p>","DOI":"10.3389\/fmolb.2022.979724","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T06:22:04Z","timestamp":1667542924000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Regulation of myeloid and lymphoid cell development by O-glycans on Notch"],"prefix":"10.3389","volume":"9","author":[{"given":"Pamela","family":"Stanley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankit","family":"Tanwar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,11,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2469","DOI":"10.1002\/ajmg.a.61362","article-title":"Phenotypic expansion of POFUT1 loss of function mutations in a disorder featuring segmental dyspigmentation with eczematous and folliculo-centric lesions","volume":"179","author":"Atzmony","year":"2019","journal-title":"Am. J. Med. Genet. A"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/82_2012_229","article-title":"The Notch pathway in hematopoietic stem cells","volume":"360","author":"Bigas","year":"2012","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.ydbio.2022.04.004","article-title":"Lfng and Dll3 cooperate to modulate protein interactions in cis and coordinate oscillatory Notch pathway activation in the segmentation clock","volume":"487","author":"Bochter","year":"2022","journal-title":"Dev. Biol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"190187","DOI":"10.1098\/rsob.190187","article-title":"Notch signalling in T cell homeostasis and differentiation","volume":"9","author":"Brandstadter","year":"2019","journal-title":"Open Biol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/0006-2952(90)90175-k","article-title":"Structure-function relationships in epidermal growth factor (EGF) and transforming growth factor-alpha (TGF-alpha)","volume":"40","author":"Campbell","year":"1990","journal-title":"Biochem. Pharmacol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"411","DOI":"10.3390\/cancers10110411","article-title":"POFUT1 as a promising novel biomarker of colorectal cancer","volume":"10","author":"Chabanais","year":"2018","journal-title":"Cancers (Basel)"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1038\/s41590-019-0518-7","article-title":"RBPJ-dependent Notch signaling initiates the T cell program in a subset of thymus-seeding progenitors","volume":"20","author":"Chen","year":"2019","journal-title":"Nat. Immunol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"771","DOI":"10.4049\/jimmunol.1501675","article-title":"Notch signaling regulates the homeostasis of tissue-restricted innate-like T cells","volume":"197","author":"Chennupati","year":"2016","journal-title":"J. Immunol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1182\/blood-2017-06-788505","article-title":"Canonical Notch signaling is dispensable for adult steady-state and stress myelo-erythropoiesis","volume":"131","author":"Duarte","year":"2018","journal-title":"Blood"},{"key":"B10","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.bbadis.2008.11.003","article-title":"Mutation of the fucose-specific beta1, 3 N-acetylglucosaminyltransferase LFNG results in abnormal formation of the spine","volume":"1792","author":"Dunwoodie","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"B11","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/0092-8674(91)90111-b","article-title":"TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms","volume":"66","author":"Ellisen","year":"1991","journal-title":"Cell."},{"key":"B12","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1038\/28632","article-title":"Lunatic fringe is an essential mediator of somite segmentation and patterning","volume":"394","author":"Evrard","year":"1998","journal-title":"Nature"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1093\/intimm\/11.7.1017","article-title":"Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: Distinct ligand-receptor interactions in intrathymic T cell development","volume":"11","author":"Felli","year":"1999","journal-title":"Int. Immunol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1242\/dev.060020","article-title":"Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi","volume":"138","author":"Fernandez-Valdivia","year":"2011","journal-title":"Development"},{"key":"B15","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.immuni.2008.10.016","article-title":"Deletion of Notch1 converts pro-T cells to dendritic cells and promotes thymic B cells by cell-extrinsic and cell-intrinsic mechanisms","volume":"30","author":"Feyerabend","year":"2009","journal-title":"Immunity"},{"key":"B16","doi-asserted-by":"publisher","first-page":"8510","DOI":"10.1038\/ncomms9510","article-title":"Notch signal strength controls cell fate in the haemogenic endothelium","volume":"6","author":"Gama-Norton","year":"2015","journal-title":"Nat. Commun."},{"key":"B17","doi-asserted-by":"publisher","first-page":"dev165597","DOI":"10.1242\/dev.165597","article-title":"Dynamic regulation of NOTCH1 activation and Notch ligand expression in human thymus development","volume":"145","author":"Garcia-Leon","year":"2018","journal-title":"Development"},{"key":"B18","doi-asserted-by":"publisher","first-page":"609324","DOI":"10.3389\/fimmu.2020.609324","article-title":"Notch signaling in B cell immune responses","volume":"11","author":"Garis","year":"2021","journal-title":"Front. Immunol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1073\/pnas.0702846105","article-title":"The O-fucose glycan in the ligand-binding domain of Notch1 regulates embryogenesis and T cell development","volume":"105","author":"Ge","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B20","doi-asserted-by":"publisher","first-page":"4242","DOI":"10.1172\/JCI92309","article-title":"Endothelial jagged-2 sustains hematopoietic stem and progenitor reconstitution after myelosuppression","volume":"127","author":"Guo","year":"2017","journal-title":"J. Clin. Invest."},{"key":"B21","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1038\/nrm1228","article-title":"Glycosylation regulates Notch signalling","volume":"4","author":"Haines","year":"2003","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"B22","first-page":"155","article-title":"Other classes of eukaryotic glycans","volume-title":"Essentials of glycobiology","author":"Haltiwanger","year":"2022"},{"key":"B23","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1093\/intimm\/dxf030","article-title":"Inducible gene knockout of transcription factor recombination signal binding protein\u2010J reveals its essential role in T versus B lineage decision","volume":"14","author":"Han","year":"2002","journal-title":"Int. Immunol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1038\/35019553","article-title":"Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2","volume":"2","author":"Hicks","year":"2000","journal-title":"Nat. Cell. Biol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"852427","DOI":"10.3389\/fimmu.2022.852427","article-title":"Dll1 can function as a ligand of Notch1 and Notch2 in the thymic epithelium","volume":"13","author":"Hirano","year":"2022","journal-title":"Front. Immunol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1242\/jcs.127308","article-title":"Notch signaling at a glance","volume":"126","author":"Hori","year":"2013","journal-title":"J. Cell. Sci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"2507","DOI":"10.1084\/jem.20080134","article-title":"Delta-like 4 is indispensable in thymic environment specific for T cell development","volume":"205","author":"Hozumi","year":"2008","journal-title":"J. Exp. Med."},{"key":"B28","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1038\/ni1075","article-title":"Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo","volume":"5","author":"Hozumi","year":"2004","journal-title":"Nat. Immunol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1038\/s41590-020-0687-4","article-title":"ImmGen at 15","volume":"21","year":"2020","journal-title":"Nat. Immunol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"e35710","DOI":"10.7554\/eLife.35710","article-title":"Radical and lunatic fringes modulate notch ligands to support mammalian intestinal homeostasis","volume":"7","author":"Kadur Lakshminarasimha Murthy","year":"2018","journal-title":"Elife"},{"key":"B31","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.devcel.2016.12.013","article-title":"Deciphering the fringe-mediated notch code: Identification of activating and inhibiting sites allowing discrimination between ligands","volume":"40","author":"Kakuda","year":"2017","journal-title":"Dev. Cell."},{"key":"B32","doi-asserted-by":"publisher","first-page":"2515","DOI":"10.1084\/jem.20080829","article-title":"Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment","volume":"205","author":"Koch","year":"2008","journal-title":"J. Exp. Med."},{"key":"B33","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/s1074-7613(01)00189-3","article-title":"Subversion of the T\/B lineage decision in the thymus by lunatic fringe-mediated inhibition of Notch-1","volume":"15","author":"Koch","year":"2001","journal-title":"Immunity"},{"key":"B34","doi-asserted-by":"publisher","first-page":"a011213","DOI":"10.1101\/cshperspect.a011213","article-title":"Notch signaling","volume":"4","author":"Kopan","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.devcel.2017.04.001","article-title":"The canonical notch signaling pathway: Structural and biochemical insights into shape, sugar, and force","volume":"41","author":"Kovall","year":"2017","journal-title":"Dev. Cell."},{"key":"B36","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/s1074-7613(03)00117-1","article-title":"Notch1 but not Notch2 is essential for generating hematopoietic stem cells from endothelial cells","volume":"18","author":"Kumano","year":"2003","journal-title":"Immunity"},{"key":"B37","doi-asserted-by":"publisher","first-page":"622190","DOI":"10.3389\/fcell.2020.622190","article-title":"Deficiency of rbpj leads to defective stress-induced hematopoietic stem cell functions and hif mediated activation of non-canonical notch signaling pathways","volume":"8","author":"Lakhan","year":"2021","journal-title":"Front. Cell. Dev. Biol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1007\/s40778-017-0090-8","article-title":"Notch signaling in the regulation of hematopoietic stem cell","volume":"3","author":"Lampreia","year":"2017","journal-title":"Curr. Stem Cell. Rep."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1038\/s41467-021-21359-1","article-title":"Notch2-mediated plasticity between marginal zone and follicular B cells","volume":"12","author":"Lechner","year":"2021","journal-title":"Nat. Commun."},{"key":"B40","first-page":"599","article-title":"Congenital disorders of glycosylation","volume-title":"Essentials of glycobiology","author":"Lefeber","year":"2022"},{"key":"B41","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/j.ajhg.2013.04.022","article-title":"Mutations in POFUT1, encoding protein O-fucosyltransferase 1, cause generalized Dowling-Degos disease","volume":"92","author":"Li","year":"2013","journal-title":"Am. J. Hum. Genet."},{"key":"B42","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1126\/science.1261093","article-title":"Structural biology. Structural basis for Notch1 engagement of Delta-like 4","volume":"347","author":"Luca","year":"2015","journal-title":"Science"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1126\/science.aaf9739","article-title":"Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity","volume":"355","author":"Luca","year":"2017","journal-title":"Science"},{"key":"B44","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1002\/stem.3169","article-title":"Hes1 deficiency causes hematopoietic stem cell exhaustion","volume":"38","author":"Ma","year":"2020","journal-title":"Stem Cells"},{"key":"B45","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/s1471-4906(00)01828-7","article-title":"Notch1 and T-cell development: Insights from conditional knockout mice","volume":"22","author":"Macdonald","year":"2001","journal-title":"Trends Immunol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1002\/gcc.20806","article-title":"The paradox of 20q11.21 amplification in a subset of cases of myeloid malignancy with chromosome 20 deletion","volume":"49","author":"Mackinnon","year":"2010","journal-title":"Genes. Chromosom. Cancer"},{"key":"B47","doi-asserted-by":"publisher","first-page":"2340","DOI":"10.1182\/blood-2004-08-3207","article-title":"Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation","volume":"105","author":"Mancini","year":"2005","journal-title":"Blood"},{"key":"B48","doi-asserted-by":"publisher","first-page":"102064","DOI":"10.1016\/j.jbc.2022.102064","article-title":"Fringe GlcNAc-transferases differentially extend O-fucose on endogenous NOTCH1 in mouse activated T cells","volume":"298","author":"Matsumoto","year":"2022","journal-title":"J. Biol. Chem."},{"key":"B49","doi-asserted-by":"publisher","first-page":"100938","DOI":"10.1016\/j.mam.2020.100938","article-title":"Diseases related to Notch glycosylation","volume":"79","author":"Matsumoto","year":"2021","journal-title":"Mol. Asp. Med."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.3390\/ijms20081811","article-title":"The dynamics of the skin's immune system","volume":"20","author":"Nguyen","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B51","doi-asserted-by":"publisher","first-page":"2137","DOI":"10.1074\/jbc.M114.598821","article-title":"Impaired O-linked N-acetylglucosaminylation in the endoplasmic reticulum by mutated epidermal growth factor (EGF) domain-specific O-linked N-acetylglucosamine transferase found in Adams-Oliver syndrome","volume":"290","author":"Ogawa","year":"2015","journal-title":"J. Biol. Chem."},{"key":"B52","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.bbrc.2020.03.066","article-title":"Contribution of extracellular O-GlcNAc to the stability of folded epidermal growth factor-like domains and Notch1 trafficking","volume":"526","author":"Ogawa","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B53","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.mod.2008.04.007","article-title":"Pofut1 is required for the proper localization of the Notch receptor during mouse development","volume":"125","author":"Okamura","year":"2008","journal-title":"Mech. Dev."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.1038\/leu.2011.127","article-title":"Notch signaling in mammalian hematopoietic stem cells","volume":"25","author":"Pajcini","year":"2011","journal-title":"Leukemia"},{"key":"B55","doi-asserted-by":"publisher","first-page":"e104270","DOI":"10.15252\/embj.2019104270","article-title":"Notch ligand Dll4 impairs cell recruitment to aortic clusters and limits blood stem cell generation","volume":"39","author":"Porcheri","year":"2020","journal-title":"EMBO J."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1016\/j.celrep.2013.07.048","article-title":"Endothelial Jagged-1 is necessary for homeostatic and regenerative hematopoiesis","volume":"4","author":"Poulos","year":"2013","journal-title":"Cell. Rep."},{"key":"B57","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/s1074-7613(00)80054-0","article-title":"Deficient T cell fate specification in mice with an induced inactivation of Notch1","volume":"10","author":"Radtke","year":"1999","journal-title":"Immunity"},{"key":"B58","doi-asserted-by":"publisher","first-page":"427","DOI":"10.2174\/156652407780831593","article-title":"Notch signaling in normal and disease States: Possible therapies related to glycosylation","volume":"7","author":"Rampal","year":"2007","journal-title":"Curr. Mol. Med."},{"key":"B59","doi-asserted-by":"publisher","first-page":"e202005093","DOI":"10.1083\/jcb.202005093","article-title":"Notch2 complements Notch1 to mediate inductive signaling that initiates early T cell development","volume":"219","author":"Romero-Wolf","year":"2020","journal-title":"J. Cell. Biol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"309","DOI":"10.3390\/biom11020309","article-title":"Current views on the roles of O-glycosylation in controlling notch-ligand interactions","volume":"11","author":"Saiki","year":"2021","journal-title":"Biomolecules"},{"key":"B61","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/s1074-7613(03)00111-0","article-title":"Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development","volume":"18","author":"Saito","year":"2003","journal-title":"Immunity"},{"key":"B62","doi-asserted-by":"publisher","first-page":"e24419","DOI":"10.7554\/eLife.24419","article-title":"O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals","volume":"6","author":"Sawaguchi","year":"2017","journal-title":"eLife"},{"key":"B63","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1038\/nchembio.2520","article-title":"Inhibition of Delta-induced Notch signaling using fucose analogs","volume":"14","author":"Schneider","year":"2018","journal-title":"Nat. Chem. Biol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"2246","DOI":"10.1002\/ajmg.a.61313","article-title":"Adams-Oliver syndrome caused by mutations of the EOGT gene","volume":"179","author":"Schr\u00f6der","year":"2019","journal-title":"Am. J. Med. Genet. A"},{"key":"B65","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1111\/boc.202100009","article-title":"The role of ligand endocytosis in notch signalling","volume":"113","author":"Seib","year":"2021","journal-title":"Biol. Cell."},{"key":"B66","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.imlet.2008.08.001","article-title":"Expression of Delta-like 1 in the splenic non-hematopoietic cells is essential for marginal zone B cell development","volume":"121","author":"Sheng","year":"2008","journal-title":"Immunol. Lett."},{"key":"B67","doi-asserted-by":"publisher","first-page":"20133","DOI":"10.1074\/jbc.M702593200","article-title":"The threonine that carries fucose, but not fucose, is required for Cripto to facilitate Nodal signaling","volume":"282","author":"Shi","year":"2007","journal-title":"J. Biol. Chem."},{"key":"B68","doi-asserted-by":"publisher","first-page":"5234","DOI":"10.1073\/pnas.0831126100","article-title":"Protein O-fucosyltransferase 1 is an essential component of Notch signaling pathways","volume":"100","author":"Shi","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1152\/physrev.00005.2017","article-title":"Notch signaling in development, tissue homeostasis, and disease","volume":"97","author":"Siebel","year":"2017","journal-title":"Physiol. Rev."},{"key":"B70","doi-asserted-by":"publisher","first-page":"232","DOI":"10.4049\/jimmunol.1402421","article-title":"Lunatic, manic, and radical fringe each promote T and B cell development","volume":"196","author":"Song","year":"2016","journal-title":"J. Immunol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"acschembio.1c00601","DOI":"10.1021\/acschembio.1c00601","article-title":"Chemical therapies for congenital disorders of glycosylation","volume":"10","author":"Sosicka","year":"2021","journal-title":"ACS Chem. Biol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1182\/blood-2016-03-708164","article-title":"Developing HSCs become Notch independent by the end of maturation in the AGM region","volume":"128","author":"Souilhol","year":"2016","journal-title":"Blood"},{"key":"B73","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1086\/498879","article-title":"Mutation of the LUNATIC FRINGE gene in humans causes spondylocostal dysostosis with a severe vertebral phenotype","volume":"78","author":"Sparrow","year":"2006","journal-title":"Am. J. Hum. Genet."},{"key":"B74","doi-asserted-by":"publisher","first-page":"E8395","DOI":"10.1073\/pnas.1804005115","article-title":"Two novel protein O-glucosyltransferases that modify sites distinct from POGLUT1 and affect Notch trafficking and signaling","volume":"115","author":"Takeuchi","year":"","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B75","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1093\/glycob\/cwy014","article-title":"Variant in human POFUT1 reduces enzymatic activity and likely causes a recessive microcephaly, global developmental delay with cardiac and vascular features","volume":"28","author":"Takeuchi","year":"","journal-title":"Glycobiology"},{"key":"B76","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.immuni.2008.12.016","article-title":"Lunatic and manic fringe cooperatively enhance marginal zone B cell precursor competition for delta-like 1 in splenic endothelial niches","volume":"30","author":"Tan","year":"2009","journal-title":"Immunity"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1101\/2022.1103.1121.485194","article-title":"Synergistic regulation of notch signaling by different O-glycans promotes hematopoiesis","author":"Tanwar","year":"2022","journal-title":"bioRxiv"},{"key":"B78","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/978-3-030-36422-9_10","article-title":"Molecular mechanisms of notch signaling in lymphoid cell lineages development: NF-\u03baB and beyond","volume":"1227","author":"Tsaouli","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1093\/glycob\/cwac015","article-title":"Glycoproteomics of NOTCH1 EGF repeat fragments overexpressed with different glycosyltransferases in HEK293T cells reveals insights into O-GlcNAcylation of NOTCH1","volume":"32","author":"Tsukamoto","year":"2022","journal-title":"Glycobiology"},{"key":"B80","doi-asserted-by":"publisher","first-page":"8365","DOI":"10.4049\/jimmunol.177.12.8365","article-title":"Lunatic fringe controls T cell differentiation through modulating notch signaling","volume":"177","author":"Tsukumo","year":"2006","journal-title":"J. Immunol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.3390\/cells9051220","article-title":"Xylosyl extension of O-glucose glycans on the extracellular domain of NOTCH1 and NOTCH2 regulates notch cell surface trafficking","volume":"9","author":"Urata","year":"2020","journal-title":"Cells"},{"key":"B82","doi-asserted-by":"publisher","first-page":"3819","DOI":"10.1002\/1873-3468.13251","article-title":"Multiple roles for O\u2010glycans in Notch signalling","volume":"592","author":"Varshney","year":"2018","journal-title":"FEBS Lett."},{"key":"B83","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s12861-019-0199-3","article-title":"A modifier in the 129S2\/SvPasCrl genome is responsible for the viability of Notch1[12f\/12f] mice","volume":"19","author":"Varshney","year":"2019","journal-title":"BMC Dev. Biol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1038\/ni1345","article-title":"Regulation of T lymphopoiesis by Notch1 and Lunatic fringe-mediated competition for intrathymic niches","volume":"7","author":"Visan","year":"2006","journal-title":"Nat. Immunol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"4609","DOI":"10.4049\/jimmunol.1002008","article-title":"Lunatic fringe enhances competition for delta-like Notch ligands but does not overcome defective pre-TCR signaling during thymocyte beta-selection in vivo","volume":"185","author":"Visan","year":"2010","journal-title":"J. Immunol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/j.immuni.2010.11.014","article-title":"Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation","volume":"33","author":"Wendorff","year":"2010","journal-title":"Immunity"},{"key":"B87","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1126\/science.1102160","article-title":"Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia","volume":"306","author":"Weng","year":"2004","journal-title":"Science"},{"key":"B88","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1084\/jem.194.7.1003","article-title":"Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus","volume":"194","author":"Wilson","year":"2001","journal-title":"J. Exp. Med."},{"key":"B89","doi-asserted-by":"publisher","first-page":"2921","DOI":"10.2353\/ajpath.2010.090702","article-title":"O-fucose modulates Notch-controlled blood lineage commitment","volume":"176","author":"Yan","year":"2010","journal-title":"Am. J. Pathol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"5652","DOI":"10.1182\/blood-2010-12-326074","article-title":"Protein O-fucosyltransferase 1 (Pofut1) regulates lymphoid and myeloid homeostasis through modulation of Notch receptor ligand interactions","volume":"117","author":"Yao","year":"2011","journal-title":"Blood"},{"key":"B91","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.sbi.2018.12.001","article-title":"Protein O-glucosylation: Another essential role of glucose in biology","volume":"56","author":"Yu","year":"2019","journal-title":"Curr. Opin. Struct. Biol."},{"key":"B92","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1084\/jem.20141843","article-title":"Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow","volume":"212","author":"Yu","year":"2015","journal-title":"J. Exp. Med."},{"key":"B93","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1182\/blood-2010-07-296616","article-title":"Lunatic Fringe prolongs Delta\/Notch-induced self-renewal of committed \u03b1\u03b2 T-cell progenitors","volume":"117","author":"Yuan","year":"2011","journal-title":"Blood"},{"key":"B94","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1038\/28625","article-title":"Defects in somite formation in lunatic fringe-deficient mice","volume":"394","author":"Zhang","year":"1998","journal-title":"Nature"},{"key":"B95","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/s41392-022-00934-y","article-title":"Notch signaling pathway: Architecture, disease, and therapeutics","volume":"7","author":"Zhou","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"B96","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1182\/blood-2007-11-115204","article-title":"Notch-dependent control of myelopoiesis is regulated by fucosylation","volume":"112","author":"Zhou","year":"2008","journal-title":"Blood"}],"container-title":["Frontiers in Molecular Biosciences"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmolb.2022.979724\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T06:22:10Z","timestamp":1667542930000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmolb.2022.979724\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,4]]},"references-count":96,"alternative-id":["10.3389\/fmolb.2022.979724"],"URL":"https:\/\/doi.org\/10.3389\/fmolb.2022.979724","relation":{},"ISSN":["2296-889X"],"issn-type":[{"value":"2296-889X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,4]]},"article-number":"979724"}}