{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T19:11:45Z","timestamp":1793214705485,"version":"4.5.0"},"reference-count":72,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T00:00:00Z","timestamp":1681257600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Biosci."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Over the last few decades, nanotechnology has entered daily life through various applications, therefore, there has been a trend toward developing new approaches to green-mediated nanotechnology that encourage nanomaterial formation through biological methods such as plants or microorganisms. Algae have gained increasing attention from nanotechnology scientists and have paved the way for the emergence of \u201calgae nanotechnology\u201d as a promising field.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Via using the aqueous extract of the brown alga <jats:italic>Polycladia myrica<\/jats:italic>, selenium nanoparticles were synthesized and characterized by using seven instruments: SEM, TEM, UV spectra, Zeta potential, EDX, X-ray diffraction, and FTIR. <jats:italic>P. myrica<\/jats:italic> selenium nanoparticles (PoSeNPs) were then examined for their antiviral activity against HSV-1 (Herpes simplex I) and anticancer against human colon cancer cell line (HCT-116) <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> alone and in combination with laser therapy of power 2\u00a0mW against Ehrlich carcinoma (EAC).<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> PoSeNPs ranging between 17.48\u00a0nm and 23.01\u00a0nm in size, and EDX revealed the selenium mass and its atoms as 0.46% \u00b1 0.07% and 0.08% \u00b1 0.01% respectively. Their anticancer potentiality <jats:italic>in vitro<\/jats:italic> was with maximum inhibitions of 80.57% and 73% and IC<jats:sub>50<\/jats:sub> = 14.86\u00a0\u03bcg\/mL and 50\u00a0mg\/mL against HCT-116 and EAC cell lines respectively, while their <jats:italic>in vivo<\/jats:italic> alone and in combination with laser therapy of power 2\u00a0mW showed a potent therapy effect against Ehrlich ascites carcinoma (EAC).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> This study concluded that PoSeNPs do not have a toxic effect; they exhibit high effectiveness as a photothermal agent for cancer therapy, with promising applications in future biomedical fields. The combined therapy showed a significant decrease in tumor volume, massive tumor cell necrosis, shrinking, and disappearance. It also showed improvement in liver TEM, histology, kidney function: urea and creatinine, and liver enzymes: ALT, and AST.<\/jats:p>","DOI":"10.3389\/fmolb.2023.1120422","type":"journal-article","created":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T15:10:53Z","timestamp":1681312253000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":22,"title":["Polycladia myrica-based delivery of selenium nanoparticles in combination with radiotherapy induces potent in vitro antiviral and in vivo anticancer activities against Ehrlich ascites tumor"],"prefix":"10.3389","volume":"10","author":[{"given":"Sahar E.","family":"Abo-Neima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelhamid A.","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa","family":"El-Sheekh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mofida E. 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