{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T22:18:08Z","timestamp":1769120288676,"version":"3.49.0"},"reference-count":50,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T00:00:00Z","timestamp":1696291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Biosci."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Hepatocellular carcinoma (HCC) is extremely malignant and difficult to treat. The adenoviral early region 2 binding factors (E2Fs) target pathway is thought to have a major role in tumor growth. This study aimed to identify a predictive E2F target signature and facilitate individualized treatment for HCC patients.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> We constructed an E2F target-related gene profile using univariate COX and LASSO regression models and proved its predictive efficacy in external cohorts. Furthermore, we characterized the role of the E2F target pathway in pathway enrichment, immune cell infiltration, and drug sensitivity of HCC.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Lasso Cox regression created an E2F target-related gene signature of GHR, TRIP13, and CDCA8. HCC patients with high risk were correlated with shorter survival time, immune evasion, tumor stem cell characteristics and high sensitivity to Tipifarnib and Camptothecin drugs.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Hepatocellular carcinoma prognosis was predicted by an E2F target signature. This finding establishes the theoretical usefulness of the E2F target route in customized identification and treatment for future research.<\/jats:p>","DOI":"10.3389\/fmolb.2023.1266515","type":"journal-article","created":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T13:31:07Z","timestamp":1696512667000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Three E2F target-related genes signature for predicting prognosis, immune features, and drug sensitivity in hepatocellular carcinoma"],"prefix":"10.3389","volume":"10","author":[{"given":"Baozhu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boyang","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzhong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,10,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e0277266","DOI":"10.1371\/journal.pone.0277266","article-title":"Down-regulation of hepatic expression of GHR\/STAT5\/IGF-1 signaling pathway fosters development and aggressiveness of HCV-related hepatocellular carcinoma: crosstalk with snail-1 and type 2 transforming growth factor-beta receptor","volume":"17","author":"Abu El-Makarem","year":"2022","journal-title":"PLoS One"},{"key":"B2","doi-asserted-by":"publisher","first-page":"936145","DOI":"10.3389\/fonc.2022.936145","article-title":"Growth hormone receptor antagonism downregulates ATP-binding cassette transporters contributing to improved drug efficacy against melanoma and hepatocarcinoma in vivo","volume":"12","author":"Basu","year":"2022","journal-title":"Front. 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