{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T06:19:48Z","timestamp":1769581188702,"version":"3.49.0"},"reference-count":56,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:00:00Z","timestamp":1697414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Mol. Biosci."],"abstract":"<jats:p>Nucleoporins (NUPs) constitute integral nuclear pore protein (NPC) elements. Although traditional NUP functions have been extensively researched, evidence of additional vital non-NPC roles, referred to herein as non-classical NUP functions, is also emerging. Several NUPs localise at the ciliary base. Indeed, <jats:italic>Nup188<\/jats:italic>, <jats:italic>Nup93<\/jats:italic> or <jats:italic>Nup205<\/jats:italic> knockdown results in cilia loss, impacting cardiac left\u2013right patterning in models and cell lines. Genetic variants of <jats:italic>Nup205<\/jats:italic> and <jats:italic>Nup188<\/jats:italic> have been identified in patients with congenital heart disease and situs inversus totalis or heterotaxy, a prevalent human ciliopathy. These findings link non-classical NUP functions to human diseases. This mini-review summarises pivotal NUP interactions with NIMA-related kinases or nephronophthisis proteins that regulate ciliary function and explores other NUPs potentially implicated in cilia-related disorders. Overall, elucidating the non-classical roles of NUPs will enhance comprehension of ciliopathy aetiology.<\/jats:p>","DOI":"10.3389\/fmolb.2023.1278976","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T15:18:27Z","timestamp":1697469507000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Non-classical functions of nuclear pore proteins in ciliopathy"],"prefix":"10.3389","volume":"10","author":[{"given":"Yan","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangyu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,10,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.cell.2011.06.039","article-title":"Insight into structure and assembly of the nuclear pore complex by utilizing the genome of a eukaryotic thermophile","volume":"146","author":"Amlacher","year":"2011","journal-title":"Cell"},{"key":"B2","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1002\/ana.20902","article-title":"Mutated nup62 causes autosomal recessive infantile bilateral striatal necrosis","volume":"60","author":"Basel-Vanagaite","year":"2006","journal-title":"Ann. 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